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Overview
Discover how the features of Thermo Scientific BioPharma Finder Software are engineered to support the world of complex biopharmaceutical characterization.
Featuring novel data processing algorithms and easy-to-interpret data visualization tools, the software supports users looking to confidently characterize biopharmaceuticals.
Power BioPharma Finder Software with the Thermo Scientific Ardia Platform to automate file centralization during acquisition, expand file access, enable report creation and result sharing, and remove data management barriers from your daily routine.
Complete biotherapeutic characterization
Key benefits
Confident characterization: Explore a solution for confident animo acid sequence characterization with the Peptide Mapping Analysis module featuring a novel MS2 prediction algorithm.
Customized Nucleotide sequence support: Leverage the ability to create customized nucleotide sequences to support confirmation with the Oligonucleotide Analysis module featuring an improved MS2 fragmentation model (available in BioPharma Finder Software version 5.3).
Efficient data handling: Move through vast amounts of data with remarkable efficiency using the Intact Mass Analysis module. With innovative deconvolution algorithms and features, you can generate multi-consensus reports effortlessly, providing a comprehensive view of your results.
Unparalleled Modification Exploration and Flexibility: The Top-Down Analysis module empowers you to search through an extensive range of modifications, even at the per-peak level. With multiple fragmentation modes and a cross-array processing algorithm, you have the flexibility to explore your samples in greater detail.
Seamless integration: See how easy it is to move from sophisticated characterization using BioPharma Finder Software to confident quantitation in Chromeleon CDS software with benefits added by the Ardia Platform including connecting instrument data, supporting global access and centralizing BioPharma Finder reports.
Learn more about BioPharma Finder Software
The right combination of data and software makes all the difference in accurately characterizing molecules, especially for large molecule.
Expand the menu to learn about the key features in our BioPharma Finder applications workflows.
Characterization of a macromolecule comprised of an amino acid sequence can involve a lot of moving targets. Techniques for confident confirmation typically include comparisons of data collected against theoretical knowledge of the sequence. The best processing tools will also give users the ability to model probable sequences against the data collected with easy-to-use tools to increase the confidence of the identification and supply the summary reports with easy-to-interpret results.
Featured in the Peptide Mapping Analysis
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Processing with the novel MS2 algorithm in the Peptide Mapping Analysis module, generates a predictive model that includes Kinetical predictions that are compared with the measured spectra to increase confidence in the identification.
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These processing tools, when combined, produce intuitive result review tools including comprehensive coverage maps, deep dive spectral comparison views and graphical sample comparison options.
Detect and quantify host cell proteins
The sensitivity of the detection algorithm and prediction analytics allow for high confidence even for low abundance targets to support residuals applications like Host Cell Protein (HCP) analysis.
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Streamline Hydrogen Deuterium Exchange workflows
Biopharma Finder Software automates protein folding studies with Hydrogen Deuterium Exchange (HDX) data analysis automation tools.
Identify product quality attributes with high-throughput analytics
BioPharma Finder Software can be used to identify and evaluate relevant product quality attributes (PQAs). Using the built-in peptide workbook, information can be easily transferred and then monitored across multiple samples throughout drug development. Alternatively, for compliant monitoring of critical quality attributes (CQA), the PQAs can be seamlessly transferred to Chromeleon CDS as part of a multi-attribute method (MAM).
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Peptide mapping ›
Sequence confirmation for oligonucleotides can be daunting. Take the question out of sequence confirmation with our enhanced MS2 predictive algorithms that can iteratively create the best array of possibilities without iterating into infinity. Summarize your characterization with visual tools, generate easy-to-interpret results and enhance collaboration by saving and sharing reports in a connected environment.
Featured in the Oligonucleotide Analysis module
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The oligonucleotide sequence editor provides an easy-to-use interface for quickly and easily building and visualizing customized oligonucleotide sequences. Build out multiple expected sequences from custom building block subunits, a wide selection of modifications from the predefined list or with user-defined custom modifications.
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Eliminate alternative possibilities based on the entered sequence with the random sequence generator and leverage the in silico digest tools to support confident sequence verification - all using an updated MS2 prediction algorithm (available in BioPharma Finder Software version 5.3).
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Perform mRNA mapping with selected in silico mRNA digestion or define the cleavage locations manually. Dig into the identity of fragments and expected or unexpected modifications and assess the overall coverage with intuitive visual coverage maps.
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Intact analysis on its face is a simple mathematical calculation used to deconvolute a series of m/z values into components but throw in the complexity of large molecule targets with modifications in a mixture of other like-molecules and mass accuracy becomes harder to achieve. No matter your data resolution, leverage innovative software tools engineered to filter and process through complex spectra with the Intact Analysis module. Discover how to quickly acquire and process batches of samples supported by a central data location on the Ardia Platform and speed through large batch-to-batch comparison studies to create summaries with connected multi-consensus reports.
Featured in the Intact Analysis module
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Accurately determine molecular weights utilizing the Sliding Window algorithm coupled with our optimized Xtract (for high resolution) and Respect (for lower resolution) deconvolution algorithms. Achieve comprehensive detection, even for co-eluting, low-intensity components in complex mixtures and account for any shifts in retention time.
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Use the expanded sequence matching capabilities for oligonucleotides which includes the ability to perform Terminal Truncation Searching from either the 3' or 5' terminus, facilitating the identification of impurities with greater ease.
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The intact mass analysis of heavily modified oligonucleotides presents analytical and data processing challenges due to the frequent usage of sulfur modifications. Pairing Thermo Scientific Orbitrap mass spectrometers with BioPharma Finder Software allows for confident intact mass identification of phosphorothioate conversion of oligonucleotides with less than 5 ppm error.
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Higher order structure characterization requires a combination of some of the most variable sample treatment techniques, variable data acquisition techniques, and combined or complex data processing techniques. Looking to gently pry apart large complexes without reducing them to their smallest parts and understand them is an art and a science that can be supported by the Top-Down Analysis module. Explore the tools offered to help refine the field of predicted possibilities without restricting them, the support for multi fragmentation mode data, and the easy-to-use multi-consensus summaries to understand your molecule.
Featured in the Top-Down Analysis module
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With the ProSightBP processing tool users can set variable or static sites for modification, select peak specific deconvolution parameters and even select peak specific sequence searching then let ProSightBP create the predictions. Combine the data from multi fragmentation modes including CID, HCD, ETD, EThcD, and UVPD resulting in confident identification.
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Combining the predictive power of ProSight BP against the deconvoluted accurate mass with the sequence coverage from ETD and UVPD fragmentation reveals a comprehensive set of results to support confident molecule characterization.
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Connect and power BioPharma Finder Software with the Ardia Platform
Living in a world connected by networks that enable people to share everything doesn’t have to stop in the lab. With the Ardia Platform see how easy it can be to automatically centralize files, connect into those files from anywhere and process them with BioPharma Finder Software or any connected application.
Featured enhancements through connection
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Faster data review
- Review a result generated by another colleague without having to import the results, open it from the shared secured Ardia Platform data repository, make comments or changes, and the software will automatically generate a new version to record the changes.
Better data management with centralized secured data
- All results are securely saved in one place, no more finding the “right” computer or hard drive that contains the experiment and data.
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Keep data secure and controlled.
Gain insights into file history, method history, and manage user access with control.
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Save and review individual reports without having to open BioPharma Finder Software for oligonucleotide, peptide mapping and intact mass applications. Utilize default reporting templates to speed development of customized reports and effectively modify templates to achieve desired result summary with the help of the customizable report designer.
Enable collaboration on a global scale in a secure fashion to collaborate, compare, track, and finalize peptide results and workbooks using dynamic versioning history. Accelerate method optimization and review through a shared secure environment.
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Featured resources
Characterization of adeno-associated viral proteins proteoforms
Peptide mapping of trastuzumab using LC-MS workflow
Monoclonal antibody mass confirmation using intact protein deconvolution
HCP identification and monitoring
mRNA Direct Sequence Mapping
Use MAM 2.0 workflow for seamless transition to quality control
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