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Keep moving forward with testing based on the gold-standard PCR technology
Prompt and early diagnosis of respiratory pathogens that cause severe illness is critical to help inform patient management, treatment decisions, and reducing the spread of disease. Confidence in testing results allows clinicians and patients to make informed decisions—including seeking medical care and/or avoiding contact with other people. While many testing options are available for respiratory testing, molecular techniques including PCR-based tests are designed to enable early virus detection, even in asymptomatic cases, and help deliver reliable answers.
PCR and RADT are two testing technologies used to detect COVID-19. It’s important to understand what they each do best and how their attributes fit your testing scenario. The infographic below summarizes their differences.
Rely on a tailored portfolio of TaqPath and TaqPath Menu respiratory testing solutions to help meet your lab’s clinical testing needs
Respiratory tract infections (RTIs) can affect the upper and lower respiratory tract(1). According to the World Health Organization (WHO), lower respiratory tract infections (RTIs) are among the leading causes of death and disability worldwide(2). Most RTIs are caused by viruses and bacteria, but diagnosis can be difficult as many respiratory infections have similar clinical presentations(3).
The Applied Biosystems TaqPath COVID-19 and COVID-19 Flu A/B, RSV solutions are designed to detect common viruses including SARS-CoV-2, the influenza virus A and B (Flu A/B), and respiratory syncytial virus (RSV). The TaqPath Respiratory Viral Select Panel expands testing for viral RTIs by detecting adenovirus, parainfluenza virus 1-4 (undifferentiated), human metapneumovirus and rhinovirus /enterovirus (undifferentiated) in a single multiplex test.
The TaqPath Menu | GeneProof RTI testing portfolio offers a great solution for identifying additional important pathogens that can be difficult to detect. The portfolio covers viruses that can lead to serious illnesses (Enterovirus, Adenovirus), commonest pathogens that cause atypical pneumonia (Chlamydia pneumoniae, Mycoplasma pneumoniae) and highly infectious causative agents of tuberculosis or pertussis/parapertussis (Mycobacterium tuberculosis, Bordetella pertussis,and Bordetella parapertussis).
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Trusted worldwide
- Over half a billion tests distributed globally
Built-in redundancy
- (3 targets) compensates for emerging SARS-CoV-2 mutations and variants, helping provide confidence in your results
Compatibility
- Validated for use on some of the most-used real-time PCR instruments in the world
Wide range of validated clinical materials
- Bronchoalveolar lavage (BAL)
- Mid-turbinate swabs
- Nasal swabs
- Nasopharyngeal swabs
- Nasopharyngeal aspirate (nasal aspirate)
- Oropharyngeal swabs
- Saliva collected with the Spectrum Solutions™ SpectrumDNA™ SDN
Single test for SARS-CoV-2, influenza A/B, and RSV
- Simultaneously differentiates between respiratory diseases
- Helps identify cases of co-infection
Affordable and scalable
- Increases testing throughput and lab efficiency
Sensitive and specific RT-PCR detection
- Robust performance for detecting SARS-CoV-2, flu A/B, and RSV A/B
Results automated by Applied Biosystems Pathogen Interpretive Software
- Quickly interprets results to expedite reporting
- Helps reduce risk of user interpretation error
High specificity
- Detection of human Adenovirus subgroups A – G
- Suitable for use in both respiratory and gastrointestinal infections
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR
Compatible with a wide range of real-time PCR devices
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Wide range of validated clinical materials
- Enables detection from a broad spectrum of respiratory and gastrointestinal samples: aspirate, plasma, stool, swab, urine, whole blood
High specificity
- Amplification of the multi-copy insertion sequences IS1002 specific for both Bordetella pertussis/parapertussis and IS1001 specific only for B. parapertussis
- No false positive results for Bordetella holmesii
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR reagents is necessary
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Simple laboratory workflow
- Easily combinable with other PCR kits from the TaqPath Menu |GeneProof portfolio in one workflow
More information with less samples
- Detects and distinguishes Bordetella pertussis and Bordetella parapertussis in a single reaction tube
Compatible with a wide range of real-time PCR devices
High specificity
- Secured by targeting the ompA gene
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR reagents is necessary
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Simple laboratory workflow
- Easily combinable with other PCR kits from the TaqPath Menu | GeneProof portfolio in one workflow
Diagnostic of atypical pneumoniae
- Differential diagnostics of atypical bacterial respiratory pathogens
Compatible with a wide range of real-time PCR devices
High specificity
- Detect Enterovirus species A-D including Coxsackievirus, Echovirus, Enterovirus, Poliovirus and the newly discovered Enterovirus group EV-C104
- Not affected by presence of Rhinovirus
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR reagents is necessary
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Simple laboratory workflow
- Easily combinable with other PCR kits from the TaqPath Menu | GeneProof portfolio in one workflow
Design according ENPEN requirements
- Amplification of a single-copy 5‘ UTR RNA sequence which is required as the target sequence by European Non-Polio Enterovirus Network (ENPEN)
- Suitable for use as a primary screening method
Compatible with a wide range of real-time PCR devices
High specificity and sensitivity
- Secured by targeting the multicopy sequence of the M181 gene
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR reagents is necessary
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Simple laboratory workflow
- Easily combinable with other PCR kits from the TaqPath Menu | GeneProof portfolio in one workflow
Compatible with a wide range of real-time PCR devices
High specificity
- Detection of all species from Mycobacterium tuberculosis complex (M. tuberculosis, M. africanum, M. bovis, M. microti, M. canettii, M.caprae, M. orygis, M. mungi and vaccination strain Bacillus Calmmette-Guérin, BCG)
Easy-to-use concept
- Single tube ready-to-use Master Mix contains all components for PCR amplification
- No additional pipetting of PCR reagents is necessary
Contamination reduction
- Master Mix contains uracil-DNA glycosylase (UNG) and dUTPs reducing carryover contamination
Wide range of validated clinical materials
- Enables detection from a broad spectrum of respiratory and gastrointestinal samples
- Sputum, BAL, swab, urine, CSF, plasma, stool
Dual target detection
- Dual targeting prevents detection failures caused by occurrence of mutations
- Secured by targeting the multi-copy sequence IS6110 and MPB64
Compatible with a wide range of real-time PCR devices
Interested in the effect of mutations on sensitivity of the TaqPath COVID-19 diagnostic tests? Learn more ›
Looking for research solutions for investigating respiratory pathogens? Click below to view Research Use Only (RUO) products covering viral, bacterial, and fungal targets in targeted or syndromic panels.
For Research Use Only. Not for use in diagnostic procedures.
Webinars
Watch our on-demand webinars to learn more about how our COVID-19 Diagnostics Testing Solutions address challenges, or browse our full webinar library.
Clinical blogs
Read our blog discussing how influenza is an underestimated threat, or browse through our full blog library.
References:
1. https://pubmed.ncbi.nlm.nih.gov/21413304/
2. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates
3. https://pubmed.ncbi.nlm.nih.gov/21413304/
For In Vitro Diagnostic Use. Intended use and regulatory statements of products vary. For specific intended use and regulatory statements please refer to the Instructions for Use (IFU). Product availability by country varies. For product availability in your country, check the associated product webpages.
TaqPath™ Menu | GeneProof™ assays are manufactured by GeneProof™ and distributed by Thermo Fisher Scientific
© 2023 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries. GeneProof™ is the property of GeneProof.
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