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While growing and expanding your R&D operations is exciting, it does require companies to think bigger to accommodate more samples, more data, and higher production. And thinking big can bring up new questions. What cell-based assays or in vivo assays can be made more high-throughput? Can your cell engineering be automated or outsourced? Does your data storage need to move into a secure, cloud-based system?
We can equip your operation with high-performing solutions for biotech scale up. Our tools and services scale as you scale, empowering your team to rapidly transition from development to production and commercialization.
Products, technologies and services to improve efficiency and scale processes
Click tabs to view our comprehensive list of solutions to help you scale
Sample processing
Enhance your productivity and generate superior outcomes with advanced performing, high-throughput solutions for everything from high-throughput nucleic acid quantification to automated sample prep for mass spectrometry.
Quick links: Sample preparation | Genetic analysis | Protein and cell analysis
Automated Sample Purification Systems
KingFisher purification systems can extract 24 or 96 samples per run of DNA/RNA, protein, or cells.
Microplate Reader
Scan 96- and 384-well plates in 15 and 45 sec respectively for DNA/RNA and protein quantification with Thermo Scientific Varioskan LUX multimode system.
Mass Spectrometry Sample Preparation
Automation-compatible, 96-well plate format Thermo Scientific EasyPep 96 MS sample prep kits for mass spectrometry sample prep in less than 5 hours.
Magnetic bead nucleic acid, cell, and protein extraction
Pair MagMAX isolation kits or Dynabeads magnetic beads with our KingFisher purification systems for fast, consistent results.
PCR Thermal Cyclers
The Applied Biosystems ProFlex PCR System offers ultimate flexibility and throughput, from 3 x 32-well block to dual 384-well for maximized throughput.
Sanger Sequencing
The Applied Biosystems 3730 Genetic Analyzer is 96- or 384-well plate based capillary sequencer with integrated plate stacker for 48-hour uninterrupted run.
Next-Generation Sequencing
Complementary, automated Ion Torrent NGS solutions to support a broad range of applications and throughput needs.
Real-Time PCR
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 mins.
Flow Cytometer with Plate Autosampler
Invitrogen Attune NxT Flow Cytometer with CytKick Max Autosampler can process up to 21 x 96-well plates per day* with acoustic focusing flow cytometry.
*Based on an 8 hour day under normal conditions
High-Content Screening
Scan 96-well plate in 3.5 mins with confocal setting and perform simultaneous image-to-data analysis with Thermo Scientific CellInsight CX7 LZR HCS system.
Higher Throughput Western Blotting Solutions
Separate, transfer, process, and quantitatively detect up to 2 x 26 samples per run in as little as 4 hours.
Robotic Microplate Handler
The Thermo Scientific Orbitor RS2 Microplate Mover enables high-throughput applications and is available in a variety of configurations to match your needs.
Production
Drive performance and achieve optimal bioprocessing outcomes with our custom services, irrespective of batch size.
Cell Processing System
The Gibco CTS Rotea system enables cell processing from research through commercial production. Flexibly separate, concentrate, and wash cells.
Pluripotent Stem Cell Suspension Medium
StemScale PSC Suspension Medium delivers up to10X expansion capability per passage of high-quality pluripotent stem cells.
Custom Cell Culture Media
We are committed to meeting your toughest challenges with high-performing Gibco products and services customized to your research and production needs.
Single-Use Bioprocessing
Our proven, scalable technologies include bioprocessing equipment and automation, and flexible and rigid containment.
Custom Antibody Development
Our service offers customized polyclonal, monoclonal, recombinant antibody, flow antibodies and lot-to-lot reserved services to meet your research needs.
Custom Peptide Synthesis
Our service offers numerous options for synthesis platforms, purity levels, modifications, and formats to meet a variety of research needs.
Bulk and Custom Protein Biology Products
Scale-up your process or product development pipeline with bulk quantities of high quality immunoassay reagents and biochemicals.
Phosphoramidites
Synthesize high-quality DNA and RNA oligos at scale with confidence from partnering with a proven global leader in nucleic acid chemistry.
cGMP Custom Manufacturing
Take advantage of our fully validated cGMP media manufacturing services when you are ready for full-scale production.
Multiplexing
Get the most out of your precious samples with multiplex platforms that offer data accuracy and reduced variability through simultaneous measurement. Our solutions detect multiple analytes from a single sample simultaneously and detect multiple samples in a single run.
Quick links: Genetic analysis | Cell analysis | Protein analysis
Transcriptome Profiling with Microarrays
Scalable transcriptome analysis from a minimum input of 50 ng RNA with Applied Biosystems Clariom D and S Assay.
PCR Master Mix
The Applied Biosystems Platinum Multiplex PCR Master Mix is designed specifically for endpoint multiplex PCR and amplify up to 20 amplicons in a single reaction.
Multiplex Gene Expression Analysis
Invitrogen QuantiGene Plex Gene Expression Assays provide direct from sample gene expression measurement of up to 80 targets per sample.
Next-Generation Sequencing
Simple, versatile technology helps you target tens to hundreds of genes and sequence challenging samples with low input requirements across mutation types.
Imaging System
Acquisition in 4 fluorescence and a transmitted light channels with a choice of more than 20 LED cubes possible with Invitrogen EVOS M7000 imaging system.
Flow Cytometer with Antibody Panels
Invitrogen Attune NxT Flow Cytometer with panel builder can analyze up to 16 color detection with free antibody panel design support tool.
High-Content Screening
7-color laser excitation for cell-level multiplex phenotyping with Thermo Scientific CellInsight CX7 LZR High-Content Screening.
Multiplex your imaging experiments
Alexa Fluor Plus secondary antibodies for imaging analysis can provide multiple endpoint data simultaneously.
Western Blot Imaging System
Invitrogen iBright FL1500 enables imaging of up to 4 proteins or protein variants in a single blot with multichannel fluorescence multiplexing.
Quantitative Multiplexed Proteomics
Label up to 16 samples with Thermo Scientific TMTpro 16-plex isobaric mass tags to get results 2x faster than equivalent label-free mass spectrometry.
Multiplex Protein Biomarker Analysis
Measure up to 65 protein targets from a single sample from as little as 25 µL of sample volume with Invitrogen ProcartaPlex multiplex immunoassays.
Luminex instrument
The Invitrogen Luminex FLEXMAP 3D Instrument System is a versatile multiplexing platform for high-throughput protein quantitation.
Outsourcing
Increase efficiency by partnering with trusted experts, and remove inhibitions caused by acquiring new skills and instrumentation.
Research and Development
Our wide range of service capabilities leverages a diverse portfolio of quality and consistency.
Bioprocessing
Partner with us for customized media solutions and cell line development services to meet your early-phase needs and advance your goals.
Product Development and Beyond
Support your product development, clinical trials, and commercialization with global biologics development and manufacturing expertise and network.
Analytical Validation Consulting Services
Let us handle your lab’s AV project and your lab can successfully implement a new test up to 75% faster over doing it yourself.
Data management
Easily manage your data, and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software.
Instruments enabled with 21 CFR Part 11 compliance support software
The FDA released the Electronic Records and Signatures Rule, known as 21 CFR Part 11 in August 1997*. This rule defines the requirements for use of electronic documents in place of paper documents. The law specifies the system elements, controls, and procedures that are necessary to ensure the reliability of electronically stored records.
21 CFR part 11 compliance is composed of both procedural and technical requirements. Procedural requirements are the standard operating procedures instituted by the end user, and technical requirements are the functional characteristics of the compliance management software used. Satisfying the technical requirements does not guarantee 21 CFR part 11 compliance alone. Compliance is the consequence of the end user’s work process and systems used.
Here are our instruments enabled with 21 CFR part 11 compliance support:
Microplate Reader
Flow Cytometer
Cell Processing System
Western Blot Imaging System
* https://www.fda.gov/regulatory-information/search-fda-guidance-documents/part-11-electronic-records-electronic-signatures-scope-and-application#i (accessed February 27, 2020)
Along with the 21 CFR part 11 software license, our service and support organization offers several services to help you validate your instrument, software, and computer. The following programs are available: IQ/OQ and computer software validation services. Find out more at thermofisher.com/csv
Cloud-based Data Storage
Connect is a secure, cloud-based data storage, with scientific analysis apps and peer collaboration tools creating bold new efficiencies in the lab.
Data Management Software
The Thermo Fisher Platform for Science software is the underlying data management infrastructure designed to support your workflows.
Computer System Validation
Storing electronic records? Our CSV consulting service can enable you to meet global regulatory requirements for data integrity.
Instrument Hardware Qualifications
Receive reliable, audit-style documentation to help you meet regulatory requirements and industry standards (IQ/OQ/PQ or IPV).
Instruments with cloud-based software
Instruments with simple and intuitive software that can be used to analyze data away from the bench. Software integration into the Thermo Fisher Cloud platform provides a convenient, centralized analysis and data management solution, enabling you to find more biological info from your data.
Protein analysis
Product development
Ease your transition across the entire product pipeline from research to commercialization, with access to commercial-use rights, assurance of best-input materials, and proven quality standards to achieve regulatory compliance.
Cell Therapy Systems (CTS)
Gibco GMP-grade CTS products have extensive safety testing and regulatory support for clinical filings in cell and gene therapy.
Molecular Diagnostic Test Development
Complete solutions, from easy-to-use instruments to the services and support you need to accelerate your diagnostics test development timeline.
OEM and Commercial Supply
Customization, security of supply, quality, and expertise are values beyond the products and services when you partner with us.
Licensing Our Technology
Explore our extensive industry-leading technologies to help your workflow in biotechnology, clinical, and applied markets.
Sample processing
Enhance your productivity and generate superior outcomes with advanced performing, high-throughput solutions for everything from high-throughput nucleic acid quantification to automated sample prep for mass spectrometry.
Quick links: Sample preparation | Genetic analysis | Protein and cell analysis
Automated Sample Purification Systems
KingFisher purification systems can extract 24 or 96 samples per run of DNA/RNA, protein, or cells.
Microplate Reader
Scan 96- and 384-well plates in 15 and 45 sec respectively for DNA/RNA and protein quantification with Thermo Scientific Varioskan LUX multimode system.
Mass Spectrometry Sample Preparation
Automation-compatible, 96-well plate format Thermo Scientific EasyPep 96 MS sample prep kits for mass spectrometry sample prep in less than 5 hours.
Magnetic bead nucleic acid, cell, and protein extraction
Pair MagMAX isolation kits or Dynabeads magnetic beads with our KingFisher purification systems for fast, consistent results.
PCR Thermal Cyclers
The Applied Biosystems ProFlex PCR System offers ultimate flexibility and throughput, from 3 x 32-well block to dual 384-well for maximized throughput.
Sanger Sequencing
The Applied Biosystems 3730 Genetic Analyzer is 96- or 384-well plate based capillary sequencer with integrated plate stacker for 48-hour uninterrupted run.
Next-Generation Sequencing
Complementary, automated Ion Torrent NGS solutions to support a broad range of applications and throughput needs.
Real-Time PCR
96- or 384-well plate based pre-spotted with dried-down Applied Biosystems TaqMan Gene Expression Assays delivers results in only 30–45 mins.
Flow Cytometer with Plate Autosampler
Invitrogen Attune NxT Flow Cytometer with CytKick Max Autosampler can process up to 21 x 96-well plates per day* with acoustic focusing flow cytometry.
*Based on an 8 hour day under normal conditions
High-Content Screening
Scan 96-well plate in 3.5 mins with confocal setting and perform simultaneous image-to-data analysis with Thermo Scientific CellInsight CX7 LZR HCS system.
Higher Throughput Western Blotting Solutions
Separate, transfer, process, and quantitatively detect up to 2 x 26 samples per run in as little as 4 hours.
Robotic Microplate Handler
The Thermo Scientific Orbitor RS2 Microplate Mover enables high-throughput applications and is available in a variety of configurations to match your needs.
Production
Drive performance and achieve optimal bioprocessing outcomes with our custom services, irrespective of batch size.
Cell Processing System
The Gibco CTS Rotea system enables cell processing from research through commercial production. Flexibly separate, concentrate, and wash cells.
Pluripotent Stem Cell Suspension Medium
StemScale PSC Suspension Medium delivers up to10X expansion capability per passage of high-quality pluripotent stem cells.
Custom Cell Culture Media
We are committed to meeting your toughest challenges with high-performing Gibco products and services customized to your research and production needs.
Single-Use Bioprocessing
Our proven, scalable technologies include bioprocessing equipment and automation, and flexible and rigid containment.
Custom Antibody Development
Our service offers customized polyclonal, monoclonal, recombinant antibody, flow antibodies and lot-to-lot reserved services to meet your research needs.
Custom Peptide Synthesis
Our service offers numerous options for synthesis platforms, purity levels, modifications, and formats to meet a variety of research needs.
Bulk and Custom Protein Biology Products
Scale-up your process or product development pipeline with bulk quantities of high quality immunoassay reagents and biochemicals.
Phosphoramidites
Synthesize high-quality DNA and RNA oligos at scale with confidence from partnering with a proven global leader in nucleic acid chemistry.
cGMP Custom Manufacturing
Take advantage of our fully validated cGMP media manufacturing services when you are ready for full-scale production.
Multiplexing
Get the most out of your precious samples with multiplex platforms that offer data accuracy and reduced variability through simultaneous measurement. Our solutions detect multiple analytes from a single sample simultaneously and detect multiple samples in a single run.
Quick links: Genetic analysis | Cell analysis | Protein analysis
Transcriptome Profiling with Microarrays
Scalable transcriptome analysis from a minimum input of 50 ng RNA with Applied Biosystems Clariom D and S Assay.
PCR Master Mix
The Applied Biosystems Platinum Multiplex PCR Master Mix is designed specifically for endpoint multiplex PCR and amplify up to 20 amplicons in a single reaction.
Multiplex Gene Expression Analysis
Invitrogen QuantiGene Plex Gene Expression Assays provide direct from sample gene expression measurement of up to 80 targets per sample.
Next-Generation Sequencing
Simple, versatile technology helps you target tens to hundreds of genes and sequence challenging samples with low input requirements across mutation types.
Imaging System
Acquisition in 4 fluorescence and a transmitted light channels with a choice of more than 20 LED cubes possible with Invitrogen EVOS M7000 imaging system.
Flow Cytometer with Antibody Panels
Invitrogen Attune NxT Flow Cytometer with panel builder can analyze up to 16 color detection with free antibody panel design support tool.
High-Content Screening
7-color laser excitation for cell-level multiplex phenotyping with Thermo Scientific CellInsight CX7 LZR High-Content Screening.
Multiplex your imaging experiments
Alexa Fluor Plus secondary antibodies for imaging analysis can provide multiple endpoint data simultaneously.
Western Blot Imaging System
Invitrogen iBright FL1500 enables imaging of up to 4 proteins or protein variants in a single blot with multichannel fluorescence multiplexing.
Quantitative Multiplexed Proteomics
Label up to 16 samples with Thermo Scientific TMTpro 16-plex isobaric mass tags to get results 2x faster than equivalent label-free mass spectrometry.
Multiplex Protein Biomarker Analysis
Measure up to 65 protein targets from a single sample from as little as 25 µL of sample volume with Invitrogen ProcartaPlex multiplex immunoassays.
Luminex instrument
The Invitrogen Luminex FLEXMAP 3D Instrument System is a versatile multiplexing platform for high-throughput protein quantitation.
Outsourcing
Increase efficiency by partnering with trusted experts, and remove inhibitions caused by acquiring new skills and instrumentation.
Research and Development
Our wide range of service capabilities leverages a diverse portfolio of quality and consistency.
Bioprocessing
Partner with us for customized media solutions and cell line development services to meet your early-phase needs and advance your goals.
Product Development and Beyond
Support your product development, clinical trials, and commercialization with global biologics development and manufacturing expertise and network.
Analytical Validation Consulting Services
Let us handle your lab’s AV project and your lab can successfully implement a new test up to 75% faster over doing it yourself.
Data management
Easily manage your data, and collaborate with partners across a spectrum of platforms with secure, cloud-based instrumentation and software.
Instruments enabled with 21 CFR Part 11 compliance support software
The FDA released the Electronic Records and Signatures Rule, known as 21 CFR Part 11 in August 1997*. This rule defines the requirements for use of electronic documents in place of paper documents. The law specifies the system elements, controls, and procedures that are necessary to ensure the reliability of electronically stored records.
21 CFR part 11 compliance is composed of both procedural and technical requirements. Procedural requirements are the standard operating procedures instituted by the end user, and technical requirements are the functional characteristics of the compliance management software used. Satisfying the technical requirements does not guarantee 21 CFR part 11 compliance alone. Compliance is the consequence of the end user’s work process and systems used.
Here are our instruments enabled with 21 CFR part 11 compliance support:
Microplate Reader
Flow Cytometer
Cell Processing System
Western Blot Imaging System
* https://www.fda.gov/regulatory-information/search-fda-guidance-documents/part-11-electronic-records-electronic-signatures-scope-and-application#i (accessed February 27, 2020)
Along with the 21 CFR part 11 software license, our service and support organization offers several services to help you validate your instrument, software, and computer. The following programs are available: IQ/OQ and computer software validation services. Find out more at thermofisher.com/csv
Cloud-based Data Storage
Connect is a secure, cloud-based data storage, with scientific analysis apps and peer collaboration tools creating bold new efficiencies in the lab.
Data Management Software
The Thermo Fisher Platform for Science software is the underlying data management infrastructure designed to support your workflows.
Computer System Validation
Storing electronic records? Our CSV consulting service can enable you to meet global regulatory requirements for data integrity.
Instrument Hardware Qualifications
Receive reliable, audit-style documentation to help you meet regulatory requirements and industry standards (IQ/OQ/PQ or IPV).
Instruments with cloud-based software
Instruments with simple and intuitive software that can be used to analyze data away from the bench. Software integration into the Thermo Fisher Cloud platform provides a convenient, centralized analysis and data management solution, enabling you to find more biological info from your data.
Protein analysis
Product development
Ease your transition across the entire product pipeline from research to commercialization, with access to commercial-use rights, assurance of best-input materials, and proven quality standards to achieve regulatory compliance.
Cell Therapy Systems (CTS)
Gibco GMP-grade CTS products have extensive safety testing and regulatory support for clinical filings in cell and gene therapy.
Molecular Diagnostic Test Development
Complete solutions, from easy-to-use instruments to the services and support you need to accelerate your diagnostics test development timeline.
OEM and Commercial Supply
Customization, security of supply, quality, and expertise are values beyond the products and services when you partner with us.
Licensing Our Technology
Explore our extensive industry-leading technologies to help your workflow in biotechnology, clinical, and applied markets.
Biotech scale-up success stories
For biotech companies, finding opportunities to scale processes throughout research and development can save valuable time and increase efficiencies during several stages of your workflow. For example, in the sample preparation stage you can scale recurring steps such as cell isolation, DNA, and RNA isolation to improve time efficiencies. In the drug candidate testing and optimization stage, analyzing samples at a higher throughput and the quality of data are key to progressing drug discovery forward. Additionally, biological function of therapeutic drugs, vaccines and diagnostic tools can be scaled for testing in both cell based assays and in vivo assays by using flow cytometry and imaging. Read our biotech success stories to learn how other companies have successfully scaled stages of their research.
For Research Use Only. Not for use in diagnostic procedures.
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