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As part of our career development and community outreach efforts at Thermo Fisher Scientific, we are excited to offer our Cryo-EM Grant Program for a second year. The program provides up to $10,000 USD of Thermo Fisher Scientific products to qualifying doctoral or post-doctoral students who are using or plan to use cryo-EM to advance their research.
The Thermo Fisher Scientific Grant Program will award three eligible doctoral or post-doctoral students with reagent awards to be used for the 2024 academic year. Entries will be accepted from January 2, 2024, through March 31, 2024. See official rules for detailed eligibility requirements. Applicants are asked to send in research proposals that demonstrate how they will use cryo-electron microscopy to answer their research questions. Applicants will be judged based on their connection with their proposed biological samples and access to cryo-TEM instrumentation. Recipients will be selected by a panel of judges and recognized at the 74th ACA Annual Meeting in Denver, CO, from July 7 to 12. Proposals will be judged on innovative and impactful intended use of reagents and by scientific merit, significance of use, approach, and instrumentation.
The top three submissions will win:
Cryo-EM Grant Program submission requirements:
Winners can choose from a wide range of sample preparation products, reagents, and cryo-EM accessories.
*Cryo-EM reagents and accessories should make up 50% of the award value. Quality limits may apply for certain products.
Penn State University- College of Medicine
Research proposal: Visual proteomics of neuronal growth cones using cryoET and deep learning segmentation
Jessica Heebner is a sixth year PhD candidate working in the Swulius Lab at Penn State College of Medicine studying neuron development with cryo-electron tomography. She is working towards a degree in Biomedical Science and Clinical and Translational Science. During her studies, Jess has developed a passion for image analysis and deep learning. She has developed an efficient workflow for training neural networks to segment everything from FIB-SEM to microCT to cryo-electron tomography data. Now in the final year of her program, Jess is working towards creating a whole growth cone protein atlas using a combination of montage tomography and deep learning segmentation. In her free time, Jess enjoys spending time with her pets and family and catering to the whims of a two-year-old. After graduation, she hopes to continue to develop her career in deep learning image analysis.
University of California, San Diego, HHMI
Research proposal: In situ structure of WT and PD mutant LRRK2 on cellular membranes
Siyu Chen is a postdoctoral fellow in the laboratory of Dr. Elizabeth Villa at UCSD, HHMI. He received his PhD in biophysics in 2022 at Northwestern University in the interdisciplinary biological sciences (IBiS) program, where he worked with Dr. Yuan He, using the cutting-edge technique of single particle cryo-EM to study the assembly and dynamics of large protein-DNA complexes and their functions in the process of DNA repair and transcription initiation. Siyu’s PhD training was sponsored by the Rappaport award from the department and the Molecular Biophysics training grant from NIH.
With a solid training in the field of structural biology on single-particle cryo-EM, Siyu aims to extend his research interests into in situ structural biology during his postdoctoral tenure, obtaining high-resolution maps of molecular assemblies when they function in their native environment. In Dr. Elizabeth Villa’s biophysics and cellular biology laboratory, he will utilize the state-of-the-art techniques of cryo-electron tomography with focused ion-beam milling (cryo-FIB-ET) to study the molecular mechanism of LRRK2 function at lysosomes and Golgi networks, as well as how mutant LRRK2 is related to Parkinson’s disease. With his background and enthusiasm, as well as the leading-edge technologies being developed in close collaboration with Thermo Fisher Scientific, Siyu will devote himself to help advance the understanding of molecular mechanisms of PD and contribute to our fight against this disease.
Scripps Research Institute
Research proposal: Uncovering the molecular mechanisms of mitochondrial proteostasis
Dr. Eshun-Wilson is currently a National Science Foundation Postdoctoral Fellow (NSF-PRFB) in the laboratory of Dr. Gabriel Lander at the Scripps Research Institute in La Jolla. She completed her PhD in the laboratory of Dr. Eva Nogales at UC Berkeley as a recipient of the National Science Foundation Graduate Research Fellowship Program (NSF-GRFP) and Ford Foundation Fellowship. She also received the 2020 Cris Alvaro PhD Commencement Prize for excellence in research and community service. Currently, she uses the most powerful microscopes on the planet, transmission electron microscopes, to visualize the ways molecular machines can be harnessed to fight disease, with an emphasis on mitochondrial quality control proteases—or, in other words, vital stress sensors of the cell. She aims to characterize how these biological motors communicate within the body, providing avenues for therapeutic intervention in cancer, heart disease, and neurodegeneration.
University of Wisconsin-Madison
Research Proposal: Elucidating the G-quadruplex binding mechanism of the Bloom Syndrome Helicase
University of Bern, Institute of Anatomy
Research Proposal: Structural analysis of synapse impairment in ALS patients with C9ORF72 mutation using cryo-electron tomography
Lund University
Research Proposal: Polymorphism of amyloid fibrils: New diagnostic tools in the era of single particle Cryo-EM
Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Research Proposal: Mechanism of transmembrane signaling by EGFR in development and cancer
ITQB-NOVA
Research Proposal: Unveiling the function of PolyP granules in metal homeostasis and stress response mechanisms
Stockholm University
Research Proposal: Structural and functional characterization of the membrane proteins DctA (Rv2443), nanT (Rv1902c) and SppA (Rv0724) from Mycobacterium tuberculosis
University of Massachusetts Chan Medical School
Research Proposal: Characterizing influenza virus entry using cryo-electron tomography and convolutional neural networks
Utrecht University
Research Proposal: Revolutionize the isolation and characterization of antigen-targeting antibodies
For Research Use Only. Not for use in diagnostic procedures.