Infographic: Homologous Recombination Repair Deficiency in Cancer

Homologous recombination repair (HRR) is a DNA repair mechanism that enables template-dependent, high-fidelity repair of complex DNA damages, including DNA double-strand breaks, and it has an important role in maintaining stability of the genome and tumor suppression. [1]

The inability of the cell to effectively employ the HRR mechanism of DNA damage is termed homologous recombination repair deficiency (HRD). In contrast, tumors can also display homologous recombination proficiency (HRP) if they do not have HRD. [1]

HRD is often observed in cancer in the form of genomic instability, and it can be the driver of tumorigenesis and represents one of the hallmarks of cancer. [2]

Download this educational infographic to learn more.

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References

1. Stewart MD, Merino Vega D, Arend RC, et al. Homologous Recombination Deficiency: Concepts, Definitions, and Assays. Oncologist. 2022;27(3):167-174. doi:10.1093/oncolo/oyab053

2. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12(1):31-46. doi:10.1158/2159-8290.CD-21-1059