Protein Degradation Resource Center

Protein degradation has recently emerged as a selective and potentially effective approach to identify new drug targets, by reducing specific cellular proteins—using targeted protein degradation. Understanding the mechanism by which proteins are degraded and identifying the tools available to target individual proteins will allow for the development and advancement of treatments for various diseases and disorders.

The Protein Degradation Resource Center includes the latest information and research tools to assist you in evaluating protein degradation by providing product offerings and solutions to your everyday protein degradation questions.

Foundations of protein degradation

Schematic of protein degradation using lysosomes to induce the lysosomal proteolysis pathway

Mechanisms of protein degradation

Learn about the different mechanisms of protein degradation including cellular functions each pathway mediates and which assays can be used to evaluate protein degradation.

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Schematic of the ubiquitin-proteosome pathway

Protein degradation using the ubiquitin-proteasome pathway

Learn about protein degradation through the ubiquitin-proteasome pathway (UPP) and tools to assess if your protein of interest is undergoing degradation.

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Targeted protein degradation using proteolysis-targeted chimeras

Learn about targeted protein degradation using proteolysis-targeted chimeras, and tools used for targeted protein degradation (TPD).

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Solutions for your protein degradation questions

Answer your protein degradation questions with our protein analysis products. Thermo Fisher Scientific offers high-quality reagents, assays, and instruments for experimental needs.

Complex formation

Does my probe target my protein of interest and E3 ligase to properly form a ternary complex?

A chimera or small molecule probe must have available binding sites for both the E3 ligase and protein of interest. Determine if the ternary complex is formed and initiated targeted protein degradation of the protein of interest.

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Polyubiquitination

Is our protein of interest being polyubiquitinated?

Polyubiquitination tags the protein of interest for degradation by the proteasome. Determine the state of ubiquitin modification of the protein of interest in cell or tissue lysates and confirm the protein has been tagged for degradation.

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Protein degradation

Was my protein of interest degraded?

As an alternative to gene deletion methods, use targeted protein degradation to modulate expression of the protein of interest. Determine if the protein of interest was targeted for degradation.

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Biological assessment

How is targeted protein degradation affecting my host cells?

Evaluate any off-target effects of protein degradation. Host cells can be biologically assessed to determine the impact on cell viability and function.

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