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CD90 Monoclonal Antibody (5a-8), Biotin

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Antibody Testing Data (2)

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CD90 Antibody (MA5-17745) in Flow

Flow cytometric analysis of Balb/c mouse thymocytes stained using a CD90/Thy-1 monoclonal antibody (Product # MA5-17745) (filled histogram) or mouse IgG2b isotype control (open histogram).

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Product Details

MA5-17745

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

Flow Cytometry (Flow)

1.0 µg/1x10^6 cells

Miscellaneous PubMed (Misc)

View 8 publications 8 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

5a-8

Immunogen

CBA/J

View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS with 4-5mg/mL BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2539133

Target Information

CD90 (Thy 1) antigen is a GPI linked glycoprotein member of the Immunoglobulin super family. CD90 is expressed in murine T cells, thymocytes, neural cells, Kupffer's cells and fibroblasts. CD90 may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. CD90 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of CD90 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to the first biochemical description and characterization of a vertebrate GPI anchor. Diseases associated with CD90 dysfunction include nasopharyngeal carcinoma and thymoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus.

Journal of immunology (Baltimore, Md. : 1950)

García-Ojeda ME,Dejbakhsh-Jones S,Chatterjea-Matthes D,Mukhopadhyay A,BitMansour A,Weissman IL,Brown JM,Strober S

MA5-17745 was used to conclude that bone marrow committed T cell progenitors can generate functional T cells via an extrathymic pathway

Sat Oct 01 00:00:00 EDT 2005

Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice.

Journal of immunology (Baltimore, Md. : 1950)

Chatterjea-Matthes D,García-Ojeda ME,Dejbakhsh-Jones S,Jerabek L,Manz MG,Weissman IL,Strober S

MA5-17745 was used in flow cytometry to examine early T cell progenitor development in the nu/nu bone marrow.

Fri Aug 01 00:00:00 EDT 2003

Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation.

The Journal of experimental medicine

Hoffmann P,Ermann J,Edinger M,Fathman CG,Strober S

MA5-17745 was used in flow cytometry to report that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells determines the outcome of acute graft-versus-host disease.

Mon Aug 05 00:00:00 EDT 2002

Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-alphabeta.

Blood

Lan F,Zeng D,Huie P,Higgins JP,Strober S

MA5-17745 was used in flow cytometry to test if specific subsets of cells in allogeneic bone marrow transplants can treat the BCL(1) B-cell lymphoma without inducing graft verses host disease.

Fri Jun 01 00:00:00 EDT 2001

Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.

Proceedings of the National Academy of Sciences of the United States of America

Dejbakhsh-Jones S,Garcia-Ojeda ME,Chatterjea-Matthes D,Zeng D,Strober S

MA5-17745 was used in flow cytometry to identify progenitors that can result in T cells via an extrathymic pathway.

Tue Jun 19 00:00:00 EDT 2001

Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells.

Journal of immunology (Baltimore, Md. : 1950)

Lan F,Zeng D,Higuchi M,Huie P,Higgins JP,Strober S

MA5-17745 was used in flow cytometry to develop a nonmyeloablative host conditioning regimen for transplantation.

Wed Aug 15 00:00:00 EDT 2001

Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.

Proceedings of the National Academy of Sciences of the United States of America

Dejbakhsh-Jones S,Strober S

MA5-17745 was used in flow cytometry to identify a rare population of cells in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells.

Tue Dec 07 00:00:00 EST 1999

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

Journal of immunology (Baltimore, Md. : 1950)

Rathmell JC,Goodnow CC

MA5-17745 was used in flow cytometry to investigate the fate of autoreactive B cells in lpr/lpr mice.

Thu Sep 15 00:00:00 EDT 1994

Bioinformatics

Protein Aliases: CD90; FLJ33325; Thy 1.2; Thy-1 antigen; Thy-1 membrane glycoprotein

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Gene Aliases: CD90; T25; Thy-1; Thy-1.2; Thy1; Thy1.1; Thy1.2

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UniProt ID: (Mouse) P01831

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Entrez Gene ID: (Mouse) 21838

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Function(s)

GTPase activator activity integrin binding enzyme binding protein kinase binding GPI anchor binding cell adhesion molecule

Process(es)

angiogenesis negative regulation of protein kinase activity cytoskeleton organization single organismal cell-cell adhesion negative regulation of cell migration positive regulation of GTPase activity retinal cone cell development protein autophosphorylation focal adhesion assembly negative regulation of axonogenesis T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of release of sequestered calcium ion into cytosol

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CD90 Monoclonal Antibody (5a-8), Biotin

CD90 Antibody (MA5-17745) in Flow

Product Details

MA5-17745

Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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