Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-142997
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-PSNQNVYQVDSLQST.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933637
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_001937.2; NP_073143.2).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6-ALT; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; serine/threonine specific protein phosphatase
Gene Aliases: 1300019I03Rik; DUSP6; HH19; MKP-3; MKP3; PYST1
UniProt ID: (Human) Q16828, (Rat) Q64346, (Mouse) Q9DBB1
Entrez Gene ID: (Human) 1848, (Pig) 100622968, (Rat) 116663, (Mouse) 67603
MAPK cascade
activation of MAPK activity
inactivation of MAPK activity
dorsal/ventral pattern formation
response to organic cyclic compound
cell differentiation
peptidyl-tyrosine dephosphorylation
regulation of fibroblast growth factor receptor signaling pathway
response to drug
regulation of endodermal cell fate specification
positive regulation of apoptotic process
response to nitrosative stress
regulation of heart growth
negative regulation of ERK1 and ERK2 cascade
response to growth factor
negative regulation of protein phosphorylation
protein dephosphorylation
response to organic substance
positive regulation of cell death
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support