Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
1300019I03Rik; dual specificity phosphatase 6; dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; Dusp6; DUSP6-ALT; HH19; MAP kinase phosphatase 3; mitogen-activated protein kinase phosphatase 3; Mkp3; MKP-3; PYST1; serine/threonine specific protein phosphatase
100 µL
100 µg
100 µL
400 µL
100 µL
100 µL
100 µg
400 µL
100 µL
100 µg
200 µL
50 µg
100 µg
100 µL
100 µL
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk to a specialist nowIf an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support