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Product Details
PA5-21570
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 129 and 381 of MKP-3 (Uniprot ID#Q16828)
Conjugate
Form
Liquid
Concentration
0.91 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_11152544
Product Specific Information
Recommended positive controls: A549.
Predicted reactivity: Mouse (98%), Rat (99%), Zebrafish (92%), Xenopus laevis (96%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUSP6-ALT; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; serine/threonine specific protein phosphatase
Gene Aliases: DUSP6; HH19; MKP3; PYST1
UniProt ID: (Human) Q16828
Entrez Gene ID: (Human) 1848
MAPK cascade
activation of MAPK activity
inactivation of MAPK activity
dorsal/ventral pattern formation
response to organic cyclic compound
cell differentiation
peptidyl-tyrosine dephosphorylation
regulation of fibroblast growth factor receptor signaling pathway
response to drug
regulation of endodermal cell fate specification
positive regulation of apoptotic process
response to nitrosative stress
regulation of heart growth
negative regulation of ERK1 and ERK2 cascade
response to growth factor
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