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CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1, 278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
1500004I01Rik; 6430511D02Rik; AA930218; AU022376; CYFIP1; cyfip2; cytoplasmic FMR1 interacting protein 1; cytoplasmic FMR1 interacting protein 2; cytoplasmic FMR1-interacting protein 1; Cytoplasmic FMR1-interacting protein 2; cytoplasmic FMRP interacting protein 1; E030028J09Rik; Kiaa0068; Kiaa1168; l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; mKIAA1168; P140sra1; P140SRA-1; p53-inducible protein 121; Pir121; pl-1; selective hybridizing clone; SHYC; Specifically Rac1-associated protein 1; Sra1; SRA-1
150 µL
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