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SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).
5430439H10Rik; ARF-binding protein 1; ARF-BP1; AU041296; BJ-HCC-24 tumor antigen; C430014N20Rik; C80292; E3 ubiquitin-protein ligase HUWE1; E3Histone; Gm1718; HECT domain protein LASU1; HECT, UBA and WWE domain containing 1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; HECT, UBA and WWE domain-containing protein 1; HectH9; HECT-type E3 ubiquitin transferase HUWE1; Homologous to E6AP carboxyl terminus homologous protein 9; HSPC272; HUWE1; Ib772; Kiaa0312; KIAA1578; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase; Mcl-1 ubiquitin ligase E3; Mule; RP3-339A18.4; upstream regulatory element binding protein 1; upstream regulatory element-binding protein 1; Ureb1; URE-B1; URE-binding protein 1
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100 µg
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