Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: SGSSTTRLTQ GIGRSQRTLR QLTANTGHTI HVHYPGNRQP NPPLILQRLL GPSAAADILQ LSSSLPLQSR GRARLLVGND DVHIIARSDD ELLDDFFHDQ STATSQAGTL SSIPTALTRW TEECKVLDAE SMHDCVSVVK VSIVNHLE
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 86%.
SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).
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Protein Aliases: ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin-protein ligase HUWE1; HECT domain protein LASU1; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; RP3-339A18.4; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1
Gene Aliases: ARF-BP1; HECTH9; HSPC272; HUWE1; Ib772; KIAA0312; KIAA1578; LASU1; MULE; URE-B1; UREB1
UniProt ID: (Human) Q7Z6Z7
Entrez Gene ID: (Human) 10075
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