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Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth. [UniProt]
AI842396; HSD45; INCA1; Inhibitor of CDK interacting with cyclin A1; inhibitor of CDK, cyclin A1 interacting protein 1; protein INCA1; RGD1306656
100 µL
100 µL
100 µL
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