Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: KKRRPCLEGM QQQGLGGVPA RVRAVTYHLE DLRRRQSIIN ELKKAQWGSS GAASEPVVLG EEGCGFPSTN EYPD
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 68%.
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inhibitor of CDK interacting with cyclin A1; Protein INCA1
Gene Aliases: HSD45; INCA1
UniProt ID: (Human) Q0VD86
Entrez Gene ID: (Human) 388324
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