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This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis.
9030625A04Rik; C12H13orf31; C13orf31; FAMIN; Fatty acid metabolism-immunity nexus; LACC1; laccase (multicopper oxidoreductase) domain containing 1; laccase domain containing 1; laccase domain-containing protein 1; purine nucleoside phosphorylase LACC1; laccase domain-containing protein 1; RGD1310185; si:ch211-187f22.1
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