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Immunogen sequence: FGLKLNSQKN CHQTLLKTLN AVQYHHAAKA KFLCIMCCSN ISYERDGEQD NCEIETSNGL SALLEEFEIV SCPSMAATLY TIKQKIDEKN LSSIKVI
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 59%.
This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adenosine deaminase LACC1; Fatty acid metabolism-immunity nexus; Guanosine phosphorylase LACC1; laccase (multicopper oxidoreductase) domain containing 1; Laccase domain-containing protein 1; Purine nucleoside phosphorylase LACC1; S-methyl-5'-thioadenosine phosphorylase LACC1
Gene Aliases: C13orf31; FAMIN; LACC1
UniProt ID: (Human) Q8IV20
Entrez Gene ID: (Human) 144811
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