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OGFOD1, a member of the 2-OG-Fe(II) dioxygenase family, plays an important role in ischemic survival and stress. It is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. An OGFOD1 iron binding residue is required for ATPAF1 gene expression. As a novel stress granule component, OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.
2-oxoglutarate and iron dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; 4930415J21Rik; AA387199; AA939912; AW061076; Kiaa1612; mKIAA1612; OGFOD1; Prolyl 3-hydroxylase OGFOD1; RGD1308848; Termination and polyadenylation 1 homolog; TPA1; TPA1, termination and polyadenylation 1, homolog; uS12 prolyl 3-hydroxylase
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