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Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate.
6720461J18Rik; A830014I19; Arhgap29; AU040217; B130017I01Rik; C76601; Parg1; PTPL1-associated RhoGAP 1; PTPL1-associated RhoGAP 1 (PARG1); PTPL1-associated RhoGAP protein 1; RGD1306185; Rho GTPase activating protein 29; rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29; RP11-255E17.1
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