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The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
dilated pupils 1; Dilp1; GENA 269; LOW QUALITY PROTEIN: paired mesoderm homeobox protein 2B; NBLST2; NBPhox; neuroblastoma paired-type homeobox protein; neuroblastoma Phox; paired like homeobox 2B; paired mesoderm homeobox 2b; paired mesoderm homeobox protein 2B; Paired-like homeobox 2B; PHOX2B; PHOX2B homeodomain protein; Pmx2b
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