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This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.
ARCL2B; ARCL3B; P5C; P5C reductase 1; P5CR; P5CR 1; PIG45; PP222; PRO3; proliferation-inducing protein 45; PYCR; Pycr1; pyrroline-5-carboxylate reductase 1; pyrroline-5-carboxylate reductase 1, mitochondrial
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