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Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
C79654; fug1; KIAA1835; MGC20266; mKIAA1835; RAN GTPase activating protein 1; RAN GTPase activating protein 1 a; Ran GTPase activating protein 1 b; Ran GTPase activating protein 1 L homeolog; Ran GTPase activating protein 1 S homeolog; ran GTPase-activating protein 1; RANGAP; RanGAP1; rangap1.L; rangap1.S; rangap1a; rangap1-a; rangap1b; rangap1-b; rna1p; SD; segregation distorter homolog; segregation distortion; XELAEV_18023679mg; XELAEV_18025680mg
100 µg
100 µL
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100 µL
100 µL
150 µL
100 µg
100 µL
100 µL
100 µg
150 µL
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50 µg
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10 µL
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