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This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
4933411J24Rik; C330016J05; RB binding protein 5, histone lysine methyltransferase complex subunit; RBBP 5; Rbbp5; RBBP-5; RBQ 3; RBQ3; retinoblastoma binding protein 5; retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog
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