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The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; PRO1280; RP11-47A8.1; Su(fu); Sufu; SUFU negative regulator of hedgehog signaling; SUFUH; SUFUXL; suppressor of fused homolog; suppressor of fused homolog (Drosophila); UNQ650/PRO1280
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