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SUFU Polyclonal Antibody

SUFU Antibody in Immunocytochemistry (ICC/IF)

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SUFU Antibody (26759-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using (Product # 26759-1-AP) (SUFU antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SUFU Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SUFU Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

26759-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SUFU Fusion Protein Ag25200 (185-454 aa encoded by BC013291)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQPVQTPFG VVTFLQIVGV CTEELHSAQQ WNGQGILELL RTVPIAGGPW LITDMRRGET IFEIDPHLQE RVDKGIETDG SNLSGVSAKC AWDDLSRPPE DDEDSRSICI GTQPRRLSGK DTEQIRETLR RGLEINSKPV LPPINPQRQN GLAHDRAPSR KDSLESDSST AIIPHELIRT RQLESVHLKF NQESGALIPL CLRGRLLHGR HFTYKSITGD MAITFVSTGV EGAFATEEHP YAAHGPWLQI LLTEEFVEKM LEDLEDLTSP E (185-454 aa encoded by BC013291)

Target Information

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sonic Hedgehog Signaling Is Essential for Pulmonary Ionocyte Specification in Human and Ferret Airway Epithelia.

American journal of respiratory cell and molecular biology

Cai Q,Luo M,Tang Y,Yu M,Yuan F,Gasser GN,Liu X,Engelhardt JF

Fri Sep 01 00:00:00 EDT 2023

Sonic Hedgehog Signaling Is Essential for Pulmonary Ionocyte Specification in Human and Ferret Airway Epithelia.

American journal of respiratory cell and molecular biology

Cai Q,Luo M,Tang Y,Yu M,Yuan F,Gasser GN,Liu X,Engelhardt JF

Fri Sep 01 00:00:00 EDT 2023

Sonic Hedgehog Signaling Is Essential for Pulmonary Ionocyte Specification in Human and Ferret Airway Epithelia.

American journal of respiratory cell and molecular biology

Cai Q,Luo M,Tang Y,Yu M,Yuan F,Gasser GN,Liu X,Engelhardt JF

Fri Sep 01 00:00:00 EDT 2023

Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.

Phytotherapy research : PTR

He CH,Lv JM,Khan GJ,Duan H,Wang W,Zhai KF,Zou GA,Aisa HA

Sat Jul 01 00:00:00 EDT 2023

WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.

Molecular medicine reports

Sola IM,Karin-Kujundzic V,Paic F,Lijovic L,Glibo M,Serman N,Duic T,Skrtic A,Kuna K,Vranic S,Serman L

Wed Feb 01 00:00:00 EST 2023

Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism.

Computational intelligence and neuroscience

Lyu X,Zhang X,Sun L,Wang J,Wang D

Thu May 19 00:00:00 EDT 2022

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Cell reports

Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T

Tue May 17 00:00:00 EDT 2022

Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade.

Phytotherapy research : PTR

Chen L,Liu M,Yang H,Ren S,Sun Q,Zhao H,Ming T,Tang S,Tao Q,Zeng S,Meng X,Xu H

Thu Sep 01 00:00:00 EDT 2022

Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade.

Theranostics

Zhang L,Yang Y,Liao Z,Liu Q,Lei X,Li M,Zhang Z,Hong D,Zhu M,Li B,Yang H,Chen J

Tue May 18 00:00:00 EDT 2021

Suppression of Hedgehog signaling is required for cementum apposition.

Scientific reports

Choi H,Liu Y,Yang L,Cho ES

Wed Apr 29 00:00:00 EDT 2020

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.

Journal of experimental & clinical cancer research : CR

Ding X,Fan K,Hu J,Zang Z,Zhang S,Zhang Y,Lin Z,Pei X,Zheng X,Zhu F,Yang H,Li S

Fri Sep 13 00:00:00 EDT 2019

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.

Journal of experimental & clinical cancer research : CR

Ding X,Fan K,Hu J,Zang Z,Zhang S,Zhang Y,Lin Z,Pei X,Zheng X,Zhu F,Yang H,Li S

Fri Sep 13 00:00:00 EDT 2019

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.

Journal of experimental & clinical cancer research : CR

Ding X,Fan K,Hu J,Zang Z,Zhang S,Zhang Y,Lin Z,Pei X,Zheng X,Zhu F,Yang H,Li S

Fri Sep 13 00:00:00 EDT 2019

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.

Journal of experimental & clinical cancer research : CR

Ding X,Fan K,Hu J,Zang Z,Zhang S,Zhang Y,Lin Z,Pei X,Zheng X,Zhu F,Yang H,Li S

Fri Sep 13 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; RP11-47A8.1; SUFUH; Suppressor of fused homolog

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Gene Aliases: PRO1280; Su(fu); SUFU; SUFUH; SUFUXL; UNQ650/PRO1280

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UniProt ID: (Human) Q9UMX1, (Mouse) Q9Z0P7

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Entrez Gene ID: (Human) 51684, (Rat) 361769, (Mouse) 24069

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Function(s)

transcription corepressor activity signal transducer activity protein binding beta-catenin binding transcription factor binding protein kinase binding molecular_function scaffold/adaptor protein

Process(es)

negative regulation of transcription from RNA polymerase II promoter skeletal system development neural tube closure heart looping ventricular septum development regulation of transcription, DNA-templated proteolysis signal transduction multicellular organism development smoothened signaling pathway involved in ventral spinal cord interneuron specification smoothened signaling pathway involved in spinal cord motor neuron cell fate specification aorta development negative regulation of transcription factor import into nucleus cytoplasmic sequestering of transcription factor negative regulation of sequence-specific DNA binding transcription factor activity skin development negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway coronary vasculature development negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process determination of left/right symmetry biological_process spinal cord dorsal/ventral patterning

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SUFU Polyclonal Antibody

SUFU Antibody (26759-1-AP) in ICC/IF

Product Details

26759-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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