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TFAP2E is the sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 epsilon may play a role in the development of the CNS and in cartilage differentiation.
activating enhancer-binding protein 2 epsilon; activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit; AI505200; AP2E; AP-2e; AP-2-epsilon; AP2-epsilon; hypothetical protein MGC65882; LOW QUALITY PROTEIN: transcription factor AP-2-epsilon; MGC49007; RGD1563297; Tcfap2e; Tfap2e; transcription factor AP-2 epsilon; transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon); transcription factor AP-2, epsilon; transcription factor AP-2-epsilon; zgc:65882; zgc:65882 protein; zgc:77338
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