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Search Thermo Fisher Scientific
Immunogen sequence: YGQAPDAAA AFPHLAGDPY GGLAPLAQPQ PPQAAWAAPR AAARAHEEPP GLLAPPARAL GLDPRRDYAT AVPRLLHGLA DGAHGLADAP LGLPGLAAAP GLEDLQAMDE PGMSLLDQSV IKKVPIPSKA SSLSALSLAK DSLVGGITNP GEVFCSVPGR LSL (58-219 aa encoded by BC041175)
TFAP2E is the sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 epsilon may play a role in the development of the CNS and in cartilage differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activating enhancer-binding protein 2 epsilon; Activating enhancer-binding protein 2-epsilon; adaptor-related protein complex 2, epsilon subunit; AP2-epsilon; MGC49007; TFAP2E; transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon); Transcription factor AP-2-epsilon
Gene Aliases: AI505200; AP-2e; AP2E; RGD1563297; Tcfap2e; TFAP2E
UniProt ID: (Human) Q6VUC0, (Mouse) Q6VUP9
Entrez Gene ID: (Human) 339488, (Mouse) 332937, (Rat) 313596
Molecular Function:
general transcription factor
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