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This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.
bA500G10.4; FLJ11864; Glrx3; GLRX4; glutaredoxin 3; glutaredoxin 4; glutaredoxin-3; GRX3; GRX4; HUSSY-22; Picot; PKC interacting cousin of thioredoxin; PKC-interacting cousin of thioredoxin; PKCq-interacting protein; PKC-theta-interacting protein; testicular tissue protein Li 75; thioredoxin-like 2; thioredoxin-like protein 2; TXNL2; TXNL3
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