Product References
Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self.
Cell reports
Geiger KM,Manoharan M,Coombs R,Arana K,Park CS,Lee AY,Shastri N,Robey EA,Coscoy L
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Tue Apr 25 00:00:00 EDT 2023
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Fri Dec 09 00:00:00 EST 2022
CD8 memory precursor cell generation is a continuous process.
iScience
Todorov H,Prieux M,Laubreton D,Bouvier M,Wang S,de Bernard S,Arpin C,Cannoodt R,Saelens W,Bonnaffoux A,Gandrillon O,Crauste F,Saeys Y,Marvel J
11-5893-82 was used in flow cytometry to study the generation of memory precursor cells following an acute infection by analyzing single-cell RNA-seq data that contained CD8 T cells collected during the postinfection expansion phase.
Fri Sep 16 00:00:00 EDT 2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Science immunology
Christian DA,Adams TA,Shallberg LA,Phan AT,Smith TE,Abraha M,Perry J,Ruthel G,Clark JT,Pritchard GH,Aronson LR,Gossa S,McGavern DB,Kedl RM,Hunter CA
11-5893-82 was used in Flow Cytometry to investigate how conventional type 1 dendritic cells (cDC1s) in the peritoneal cavity's omentum coordinate innate responses to microbial challenge and provide secondary signals required for CD8+ T cell expansion and memory formation, particularly after intraperitoneal immunization with Toxoplasma gondii.
Fri Sep 30 00:00:00 EDT 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Tue Jun 15 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance.
Nature communications
Wagle MV,Vervoort SJ,Kelly MJ,Van Der Byl W,Peters TJ,Martin BP,Martelotto LG,Nüssing S,Ramsbottom KM,Torpy JR,Knight D,Reading S,Thia K,Miosge LA,Howard DR,Gloury R,Gabriel SS,Utzschneider DT,Oliaro J,Powell JD,Luciani F,Trapani JA,Johnstone RW,Kallies A,Goodnow CC,Parish IA
11-5893-82 was used in Flow cytometry/Cell sorting to show that persistent antigen recognition drives higher EGR2 expression within exhausted versus effector CD8+T cells.
Thu May 13 00:00:00 EDT 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
11-5893-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.
Nature immunology
Abdelsamed HA,Zebley CC,Nguyen H,Rutishauser RL,Fan Y,Ghoneim HE,Crawford JC,Alfei F,Alli S,Ribeiro SP,Castellaw AH,McGargill MA,Jin H,Boi SK,Speake C,Serti E,Turka LA,Busch ME,Stone M,Deeks SG,Sekaly RP,Zehn D,James EA,Nepom GT,Youngblood B
11-5893 was used in Flow cytometry/Cell sorting to investigate the long-lived nature of these cells, we established a DNA methylation-based T cell 'multipotency index' and found that beta cell-specific CD8+ T cells retained a stem-like epigenetic multipotency score.
Fri May 01 00:00:00 EDT 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Cancer cells educate natural killer cells to a metastasis-promoting cell state.
The Journal of cell biology
Chan IS,Knútsdóttir H,Ramakrishnan G,Padmanaban V,Warrier M,Ramirez JC,Dunworth M,Zhang H,Jaffee EM,Bader JS,Ewald AJ
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Functional Assay
Mon Sep 07 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Cell metabolism
Hall JA,Ramachandran D,Roh HC,DiSpirito JR,Belchior T,Zushin PH,Palmer C,Hong S,Mina AI,Liu B,Deng Z,Aryal P,Jacobs C,Tenen D,Brown CW,Charles JF,Shulman GI,Kahn BB,Tsai LTY,Rosen ED,Spiegelman BM,Banks AS
11-5893-82 was used in Flow cytometry/Cell sorting to highlight the diabetogenic role of PPARγ S273 phosphorylation and focus attention on a putative target, Gdf3.
Tue Oct 06 00:00:00 EDT 2020
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses.
Communications biology
Benitez AA,Khalil-Agüero S,Nandakumar A,Gupta NT,Zhang W,Atwal GS,Murphy AJ,Sleeman MA,Haxhinasto S
11-5893 was used in Flow cytometry/Cell sorting to show that tumor rejection induced by immune checkpoint blockade is significantly enhanced in Aire-deficient mice, the epitome of central tolerance breakdown.
Wed Jul 08 00:00:00 EDT 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
11-5893 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
CXCR3 chemokine receptor guides Trypanosoma cruzi-specific T-cells triggered by DNA/adenovirus ASP2 vaccine to heart tissue after challenge.
PLoS neglected tropical diseases
Pontes Ferreira C,Cariste LM,Ferri Moraschi B,Ferrarini Zanetti B,Won Han S,Araki Ribeiro D,Vieira Machado A,Lannes-Vieira J,Gazzinelli RT,Vasconcelos JRC
11-5893 was used in Flow cytometry/Cell sorting to study how CXCR3 and its ligands drive Trypanosoma cruzi-specific effector CD8+ T-cells into infected heart tissue.
Mon Jul 01 00:00:00 EDT 2019
A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression.
Nature communications
Myers LM,Tal MC,Torrez Dulgeroff LB,Carmody AB,Messer RJ,Gulati G,Yiu YY,Staron MM,Angel CL,Sinha R,Markovic M,Pham EA,Fram B,Ahmed A,Newman AM,Glenn JS,Davis MM,Kaech SM,Weissman IL,Hasenkrug KJ
11-5893-82 was used in Flow Cytometry to demonstrate that even during exhaustion there is a subset of functional CD8+ T cells defined by surface expression of SIRPα.
Fri Feb 15 00:00:00 EST 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
11-5893 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Mon Sep 30 00:00:00 EDT 2019
Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells.
Cell death and differentiation
Patel R,Kim K,Shutinoski B,Wachholz K,Krishnan L,Sad S
11-5893 was used in Flow cytometry/Cell sorting to evaluate the impact of premature cell death of antigen-presenting cells by Caspase-1- and RipK3-signalling pathways on CD8+ T-cell priming during infection of mice with Salmonella typhimurium.
Wed Nov 01 00:00:00 EDT 2017
LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection.
Frontiers in immunology
Ferreira CP,Cariste LM,Santos Virgílio FD,Moraschi BF,Monteiro CB,Vieira Machado AM,Gazzinelli RT,Bruna-Romero O,Menin Ruiz PL,Ribeiro DA,Lannes-Vieira J,Lopes MF,Rodrigues MM,de Vasconcelos JRC
11-5893 was used in Flow cytometry/Cell sorting to explore the roles of LFA-1 and VLA-4 in the migration of specific CD8+ T cells generated by heterologous prime-boost immunisation during experimental infection with Trypanosoma cruzi.
Wed Nov 20 00:00:00 EST 2019
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
11-5893 was used in Flow cytometry/Cell sorting to provide a basis for combinatorial checkpoint blockade in clinical intervention for ovarian cancer.
Tue Jan 12 00:00:00 EST 2021
Understanding CD8+ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.
Clinical & translational immunology
Nguyen TH,Tan AC,Xiang SD,Goubier A,Harland KL,Clemens EB,Plebanski M,Kedzierska K
11-5893-82 was used in Flow cytometry/Cell sorting to investigate HLA in Wilms' tumour 1 antigen.
Wed Mar 01 00:00:00 EST 2017
A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells.
PLoS pathogens
Ersching J,Basso AS,Kalich VL,Bortoluci KR,Rodrigues MM
11-5893 was used in Flow cytometry/Cell sorting to demonstrate a newly described mechanism of CD8+ T cell priming by CD4+ Foxp3+ T cells during Trypanosoma cruzi infection.
Wed Jun 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
11-5893 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Römer C,Engel O,Winek K,Hochmeister S,Zhang T,Royl G,Klehmet J,Dirnagl U,Meisel C,Meisel A
11-5893 was used in Flow cytometry/Cell sorting to show that inhibiting stroke-induced immunodepression by pharmacological blockade of body's stress axes increases autoreactive CNS antigen-specific T-cell responses in the brain.
Wed May 20 00:00:00 EDT 2015
Diverse roles for T-bet in the effector responses required for resistance to infection.
Journal of immunology (Baltimore, Md. : 1950)
Harms Pritchard G,Hall AO,Christian DA,Wagage S,Fang Q,Muallem G,John B,Glatman Zaretsky A,Dunn WG,Perrigoue J,Reiner SL,Hunter CA
11-5893 was used in Flow cytometry/Cell sorting to highlight T-bet-independent pathways to IFN-γ production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control infection in peripheral tissues.
Sun Feb 01 00:00:00 EST 2015
Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.
mBio
Jensen KD,Camejo A,Melo MB,Cordeiro C,Julien L,Grotenbreg GM,Frickel EM,Ploegh HL,Young L,Saeij JP
11-5893 was used in Flow cytometry/Cell sorting to investigate the interaction between infected host and Toxoplasma gondii strains in endemic regions, showing that secondary infection correlates with the ROP5/ROP18 allele combinations.
Tue Feb 24 00:00:00 EST 2015
MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.
Nature communications
Kieckbusch J,Gaynor LM,Moffett A,Colucci F
Published figure using KLRG1 monoclonal antibody (Product # 11-5893-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
11-5893 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
