Product References
Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self.
Cell reports
Geiger KM,Manoharan M,Coombs R,Arana K,Park CS,Lee AY,Shastri N,Robey EA,Coscoy L
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Apr 25 00:00:00 EDT 2023
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Fri Dec 09 00:00:00 EST 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.
Oncoimmunology
Tata A,Dodard G,Fugère C,Leget C,Ors M,Rossi B,Vivier E,Brossay L
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Jun 15 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
16-5893-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
16-5893-82 was used in Flow Cytometry to report a feature of skin Treg cells expanded by ultraviolet B (UVB) exposure.
Tue Aug 25 00:00:00 EDT 2020
Cancer cells educate natural killer cells to a metastasis-promoting cell state.
The Journal of cell biology
Chan IS,Knútsdóttir H,Ramakrishnan G,Padmanaban V,Warrier M,Ramirez JC,Dunworth M,Zhang H,Jaffee EM,Bader JS,Ewald AJ
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Functional Assay
Mon Sep 07 00:00:00 EDT 2020
Cancer cells educate natural killer cells to a metastasis-promoting cell state.
The Journal of cell biology
Chan IS,Knútsdóttir H,Ramakrishnan G,Padmanaban V,Warrier M,Ramirez JC,Dunworth M,Zhang H,Jaffee EM,Bader JS,Ewald AJ
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Functional Assay
Mon Sep 07 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.
The Journal of experimental medicine
Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S
16-5893 was used in Flow cytometry/Cell sorting to solve a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I-restricted Ly49 receptors.
Mon Aug 05 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
16-5893-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Yasuda K,Kitagawa Y,Kawakami R,Isaka Y,Watanabe H,Kondoh G,Kohwi-Shigematsu T,Sakaguchi S,Hirota K
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Fri Feb 01 00:00:00 EST 2019
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.
ImmunoHorizons
Poholek CH,Dulson SJ,Zajac AJ,Harrington LE
16-5893 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.
Tue Jun 04 00:00:00 EDT 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
16-5893 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.
The Journal of experimental medicine
Delpoux A,Michelini RH,Verma S,Lai CY,Omilusik KD,Utzschneider DT,Redwood AJ,Goldrath AW,Benedict CA,Hedrick SM
16-5893 was used in Flow cytometry/Cell sorting to show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells.
Mon Feb 05 00:00:00 EST 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Mon Sep 30 00:00:00 EDT 2019
PD-1 regulates KLRG1+ group 2 innate lymphoid cells.
The Journal of experimental medicine
Taylor S,Huang Y,Mallett G,Stathopoulou C,Felizardo TC,Sun MA,Martin EL,Zhu N,Woodward EL,Elias MS,Scott J,Reynolds NJ,Paul WE,Fowler DH,Amarnath S
16-5893 was used in Flow cytometry/Cell sorting to report that PD-1 is required for maintaining the number, and hence function, of KLRG1+ Group 2 innate lymphoid cells.
Mon Jun 05 00:00:00 EDT 2017
NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.
Proceedings of the National Academy of Sciences of the United States of America
Knudson KM,Pritzl CJ,Saxena V,Altman A,Daniels MA,Teixeiro E
16-5893 was used in Flow cytometry/Cell sorting to show that TCR/antigenic signals regulate the induction of a NFκB/Pim-1 feedback loop that controls expression of Eomes and thereby long-term maintenance of the memory pool.
Tue Feb 28 00:00:00 EST 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
16-5893-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
The Journal of clinical investigation
Doorduijn EM,Sluijter M,Querido BJ,Oliveira CC,Achour A,Ossendorp F,van der Burg SH,van Hall T
16-5893 was used in Flow cytometry/Cell sorting to analyse thymus selection and peripheral behaviour of T cells with specificity for the self-antigen known as T cell epitopes associated with impaired peptide processing (TEIPP).
Mon Feb 01 00:00:00 EST 2016
TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.
The Journal of clinical investigation
Lewis GM,Wehrens EJ,Labarta-Bajo L,Streeck H,Zuniga EI
16-5893 was used in Flow cytometry/Cell sorting to uncover an eomesodermin-driven CD4 T cell program that is continuously suppressed by TGF-β signalling.
Mon Oct 03 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.
Scientific reports
Luu TT,Ganesan S,Wagner AK,Sarhan D,Meinke S,Garbi N,Hämmerling G,Alici E,Kärre K,Chambers BJ,Höglund P,Kadri N
16-5893 was used in Flow cytometry/Cell sorting to study the effect of DC depletion on resting NK cell function.
Thu Dec 01 00:00:00 EST 2016
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
16-5893 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 EST 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
16-5893 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Comparison of predicted and actual consequences of missense mutations.
Proceedings of the National Academy of Sciences of the United States of America
Miosge LA,Field MA,Sontani Y,Cho V,Johnson S,Palkova A,Balakishnan B,Liang R,Zhang Y,Lyon S,Beutler B,Whittle B,Bertram EM,Enders A,Goodnow CC,Andrews TD
16-5893 was used in Flow cytometry/Cell sorting to analyse the efficacy of computational inferences of the functional significance of missense mutations in mice.
Tue Sep 15 00:00:00 EDT 2015
Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis.
Journal of virology
Kenney LL,Cornberg M,Chen AT,Emonet S,de la Torre JC,Selin LK
16-5893 was used in Flow cytometry/Cell sorting to investigate how competition between immune responses to two viruses would influence the development of CD8 T cell memory and subsequent disease outcome.
Sun Nov 01 00:00:00 EDT 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
16-5893 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
DNAM-1 expression marks an alternative program of NK cell maturation.
Cell reports
Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ
16-5893 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Tue Apr 07 00:00:00 EDT 2015
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
16-5893 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
16-5893-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Boulet S,Daudelin JF,Labrecque N
16-5893 was used in Flow cytometry/Cell sorting to demonstrate that IL-2 induction of Blimp-1 expression is a key regulator of short-lived effector cell differentiation.
Fri Aug 15 00:00:00 EDT 2014
MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling.
Nature communications
Kieckbusch J,Gaynor LM,Moffett A,Colucci F
Published figure using KLRG1 monoclonal antibody (Product # 16-5893-82) in Flow Cytometry
Fri Feb 28 00:00:00 EST 2014
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
16-5893 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
16-5893 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
16-5893 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo.
European journal of immunology
Wiesel M,Crouse J,Bedenikovic G,Sutherland A,Joller N,Oxenius A
16-5893 was used in Flow cytometry/Cell sorting to study in vivo the role of type-I interferon in the differentiation of CD8+ T cells.
Wed Feb 01 00:00:00 EST 2012
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.
PloS one
van Helden MJ,Zaiss DM,Sijts AJ
16-5893 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.
Mon Jun 10 00:00:00 EDT 2013
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance.
Oncoimmunology
Mizutani T,Neugebauer N,Putz EM,Moritz N,Simma O,Zebedin-Brandl E,Gotthardt D,Warsch W,Eckelhart E,Kantner HP,Kalinke U,Lienenklaus S,Weiss S,Strobl B,Müller M,Sexl V,Stoiber D
16-5893 was used in Flow cytometry/Cell sorting to examine the role of Type 1 IFN signalling in the prevention of leukaemogenesis.
Mon Oct 01 00:00:00 EDT 2012
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
16-5893 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells.
Journal of immunology (Baltimore, Md. : 1950)
Fowler CC,Pao LI,Blattman JN,Greenberg PD
16-5893 was used in Flow cytometry/Cell sorting to investigate the role of SHP-1 in shaping responses of mature CD8 T cells in vivo.
Wed Sep 15 00:00:00 EDT 2010
CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.
PloS one
Yewdall AW,Drutman SB,Jinwala F,Bahjat KS,Bhardwaj N
16-5893 was used in Flow cytometry/Cell sorting to examine the fate and function of dendritic cell vaccines following their injection.
Wed Jun 16 00:00:00 EDT 2010
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling.
Blood
Banh C,Fugère C,Brossay L
16-5893 was used in Flow cytometry/Cell sorting to provide novel insight into KLRG1 and E-cadherin interaction are in differential regulation of KLRG1(+) cells and E-cadherin-expressing cells.
Thu Dec 17 00:00:00 EST 2009
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity.
The Journal of experimental medicine
Ito M,Maruyama T,Saito N,Koganei S,Yamamoto K,Matsumoto N
16-5893 was used in Functional assays to suggest that KLRG1 ligation by E-, N-, or R-cadherins may regulate the cytotoxicity of killer cells.
Mon Feb 20 00:00:00 EST 2006
