Product References
Preventive Effects of a Human Hematopoietic Mesenchymal Stem Cell (hHMSC) Therapy in Ovalbumin-Induced Food Allergy.
Biomedicines
Lee DG,Lee YJ,Park SH,Park HR,Kang H,Kim JE
12-5898-82 was used in Flow Cytometry to investigate the preventive effects of human hematopoietic mesenchymal stem cells in mice with ovalbumin-induced food allergy.
Mon Feb 21 00:00:00 EST 2022
Low-affinity but high-avidity interactions may offer an explanation for IgE-mediated allergen cross-reactivity.
Allergy
Chang X,Zha L,Wallimann A,Mohsen MO,Krenger P,Liu X,Vogel M,Bachmann MF
12-5898-82 was used in Flow Cytometry to suggest that the underlying mechanism of allergen cross-reactivity may be low-affinity but high-avidity binding between IgE antibodies and cross-reactive allergen.
Sun Aug 01 00:00:00 EDT 2021
NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis.
Frontiers in immunology
Guo X,Xu X,Li T,Yu Q,Wang J,Chen Y,Ding S,Zhu L,Zou G,Zhang X
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Tue Jan 18 00:00:00 EST 2022
SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
The Journal of biological chemistry
Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2 Impairs Mast Cell Maturation and Functions.
Cells
Taketomi Y,Endo Y,Higashi T,Murase R,Ono T,Taya C,Kobayashi T,Murakami M
12-5898-82 was used in Flow Cytometry to investigate the role of sPLA2-III in mast cells (MC) using a newly generated MC-specific Pla2g3-deficient mouse strain.
Sun Jul 04 00:00:00 EDT 2021
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
12-5898 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
Mutant Huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells.
Journal of neuroinflammation
Pérez-Rodríguez MJ,Ibarra-Sánchez A,Román-Figueroa A,Pérez-Severiano F,González-Espinosa C
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Fri Mar 27 00:00:00 EDT 2020
Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Journal of translational medicine
Yang R,Wang G,Li L,He H,Zheng M,Lu L,Wu S
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Mon Nov 23 00:00:00 EST 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
12-5898 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Immune synapses between mast cells and γδ T cells limit viral infection.
The Journal of clinical investigation
Mantri CK,St John AL
12-5898 was used in Flow cytometry/Cell sorting to show that immune synapse formation between MCs and γδ T cells is a novel mechanism to induce specific and protective immunity at sites of viral infection.
Fri Mar 01 00:00:00 EST 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
12-5898 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis.
PLoS biology
Kobayashi T,Shimabukuro-Demoto S,Tsutsui H,Toyama-Sorimachi N
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2019
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.
Immunology and cell biology
McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC
12-5898-82 was used in Flow Cytometry to show that bone marrow-derived mast cells produce IL-13, IL-6, TNF, GM-CSF, CCL3 and CCL4 in response to IL-33 stimulation.
Tue Jan 01 00:00:00 EST 2019
GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms.
Molecular and cellular biology
Ohmori S,Ishijima Y,Numata S,Takahashi M,Sekita M,Sato T,Chugun K,Yamamoto M,Ohneda K
12-5898 was used in Western Blotting to show the formation of active chromatin structure and the expression of the mouse Ms4a2 relies on ETS factor PU.1 and chromatin looping factor LDB1.
Fri Nov 15 00:00:00 EST 2019
Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.
Frontiers in immunology
Potuckova L,Draberova L,Halova I,Paulenda T,Draber P
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Mon Oct 07 00:00:00 EDT 2019
IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.
Scientific reports
Ball DH,Al-Riyami L,Harnett W,Harnett MM
12-5898 was used in Flow cytometry/Cell sorting to investigate whether ES62 targets the MyD88-IL-33 signalling network by subverting ST2-signalling to exhibit therapeutic potential in allergy.
Wed Mar 14 00:00:00 EDT 2018
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nature communications
Asada S,Goyama S,Inoue D,Shikata S,Takeda R,Fukushima T,Yonezawa T,Fujino T,Hayashi Y,Kawabata KC,Fukuyama T,Tanaka Y,Yokoyama A,Yamazaki S,Kozuka-Hata H,Oyama M,Kojima S,Kawazu M,Mano H,Kitamura T
12-5898 was used in Flow cytometry/Cell sorting to examine the mechanism by which mutant ASXenopus laevis1 promotes myeloid leukaemogenesis.
Mon Jul 16 00:00:00 EDT 2018
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
12589882 was used in flow cytometry to demonstrate that SAMHD1 reduces nucleoside analog cytarabine cytotoxicity in acute myeloid leukemia cells
Wed Feb 01 00:00:00 EST 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
12-5898 was used in Flow cytometry/Cell sorting to study the effects of combined Hoxa9/Meis1 over-expression on intracellular signalling, and whether cells transformed by Hoxa9 and Meis1 become addicted to targetable signalling processes.
Mon Apr 10 00:00:00 EDT 2017
Transcriptional Heterogeneity of Mast Cells and Basophils upon Activation.
Journal of immunology (Baltimore, Md. : 1950)
Chhiba KD,Hsu CL,Berdnikovs S,Bryce PJ
12-5898 was used in Flow cytometry/Cell sorting to demonstrate that mast cells and basophils have cell- and activation-specific transcriptional responses and suggest that context specific gene networks and pathways may shape how the immune system responds to allergens and innate cytokines.
Thu Jun 15 00:00:00 EDT 2017
Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.
JCI insight
Ikutani M,Tsuneyama K,Kawaguchi M,Fukuoka J,Kudo F,Nakae S,Arita M,Nagai Y,Takaki S,Takatsu K
12-5898 was used in Flow cytometry/Cell sorting to demonstrate a previously unrecognized mechanism in the development of pulmonary arterial hypertrophy and the causative roles of ILC2 in the process.
Thu Apr 06 00:00:00 EDT 2017
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nature communications
Bohnacker T,Prota AE,Beaufils F,Burke JE,Melone A,Inglis AJ,Rageot D,Sele AM,Cmiljanovic V,Cmiljanovic N,Bargsten K,Aher A,Akhmanova A,Díaz JF,Fabbro D,Zvelebil M,Williams RL,Steinmetz MO,Wymann MP
12-5898 was used in Flow cytometry/Cell sorting to elucidate the mechanism of action of Buparlisib, demonstrating that the dual activity can be separated into discrete phosphoinositide 3-kinase and tubulin inhibitors.
Thu Mar 09 00:00:00 EST 2017
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.
The Journal of clinical investigation
Marichal T,Gaudenzio N,El Abbas S,Sibilano R,Zurek O,Starkl P,Reber LL,Pirottin D,Kim J,Chambon P,Roers A,Antoine N,Kawakami Y,Kawakami T,Bureau F,Tam SY,Tsai M,Galli SJ
12589882 was used in flow cytometry to show that deletion of the gene encoding RAB guanine nucleotide exchange factor 1 in keratinocytes severely impairs epidermal barrier function in mice
Thu Dec 01 00:00:00 EST 2016
Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.
Mucosal immunology
Patel KR,Aven L,Shao F,Krishnamoorthy N,Duvall MG,Levy BD,Ai X
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2016
New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling.
Molecular and cellular biology
Bambouskova M,Polakovicova I,Halova I,Goel G,Draberova L,Bugajev V,Doan A,Utekal P,Gardet A,Xavier RJ,Draber P
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice.
PloS one
Meurer SK,Neß M,Weiskirchen S,Kim P,Tag CG,Kauffmann M,Huber M,Weiskirchen R
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Mon Jul 24 00:00:00 EDT 2017
Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.
PloS one
Kim DK,Beaven MA,Kulinski JM,Desai A,Bandara G,Bai Y,Prussin C,Schwartz LB,Komarow H,Metcalfe DD,Olivera A
12-5898 was used in Flow cytometry/Cell sorting to propose consideration of IL-6 blockade as a potential adjunctive therapy in the treatment of patients with advanced mastocytosis.
Fri Aug 04 00:00:00 EDT 2017
iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation.
PloS one
Park HJ,Lee SW,Park SH,Hong S
12-5898 was used in Flow cytometry/Cell sorting to demonstrate that γPGA-induced iNKT cell polarization toward the Th1 phenotype induces apoptotic basophil depletion, leading to the suppression of Th2 immune responses.
Mon Aug 22 00:00:00 EDT 2016
Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment.
Cancer immunology research
Danelli L,Frossi B,Gri G,Mion F,Guarnotta C,Bongiovanni L,Tripodo C,Mariuzzi L,Marzinotto S,Rigoni A,Blank U,Colombo MP,Pucillo CE
12-5898 was used in Flow cytometry/Cell sorting to examine the interactions between myeloid-derived suppressor cells and mast cells in the mucosa of patients with colon carcinoma.
Thu Jan 01 00:00:00 EST 2015
Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice.
Journal of immunology (Baltimore, Md. : 1950)
Evans H,Killoran KE,Mitre BK,Morris CP,Kim SY,Mitre E
12-5898 was used in Flow cytometry/Cell sorting to demonstrate that chronic filarial infection suppresses eosinophilic responses to antibody-mediated activation.
Thu Oct 01 00:00:00 EDT 2015
Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells.
Cellular immunology
Rodriguez AR,Plascencia-Villa G,Witt CM,Yu JJ,José-Yacamán M,Chambers JP,Perry G,Guentzel MN,Arulanandam BP
12-5898 was used in Flow cytometry/Cell sorting to reveal the negative effect of C. pneumoniae on mast cells, and the consequential impact on pancreatic beta cell function and viability.
Mon Jun 01 00:00:00 EDT 2015
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
PloS one
Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S
12-5898 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.
Mon Apr 11 00:00:00 EDT 2016
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
Nature medicine
Schönhuber N,Seidler B,Schuck K,Veltkamp C,Schachtler C,Zukowska M,Eser S,Feyerabend TB,Paul MC,Eser P,Klein S,Lowy AM,Banerjee R,Yang F,Lee CL,Moding EJ,Kirsch DG,Scheideler A,Alessi DR,Varela I,Bradley A,Kind A,Schnieke AE,Rodewald HR,Rad R,Schmid RM,Schneider G,Saur D
12-5898 was used in Immunofluorescence in immunohistochemistry on frozen tissues to develop an inducible dual-recombinase system engineered mouse model of pancreatic cancer to further investigate carcinogenesis complexity.
Sat Nov 01 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
12-5898 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism.
Parasite (Paris, France)
Lee YA,Nam YH,Min A,Kim KA,Nozaki T,Saito-Nakano Y,Mirelman D,Shin MH
12-5898 was used in Flow cytometry/Cell sorting to examine whether Entamoeba histolytica-derived secretory proteins induce mast cell activation.
Tue Jan 20 00:00:00 EST 2015
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
Nature immunology
Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF
12-5898 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.
Mon Apr 01 00:00:00 EDT 2013
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.
Journal of leukocyte biology
Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ
12-5898 was used in Flow cytometry/Cell sorting to develop a novel murine strain to allow a better definition of the role of eosinophils in health and disease.
Mon Jul 01 00:00:00 EDT 2013
Fasciola hepatica tegumental coat impairs mast cells' ability to drive Th1 immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Vukman KV,Adams PN,Metz M,Maurer M,O'Neill SM
12-5898 was used in Flow cytometry/Cell sorting to investigate the mechanism by which Fasciola hepatica impairs mast cells' ability to induce Th1 immune responses.
Fri Mar 15 00:00:00 EDT 2013
Calcitonin gene-related peptide and cyclic adenosine 5'-monophosphate/protein kinase A pathway promote IL-9 production in Th9 differentiation process.
Journal of immunology (Baltimore, Md. : 1950)
Mikami N,Miyagi Y,Sueda K,Takatsuji M,Fukada S,Yamamoto H,Tsujikawa K
12-5898 was used in Flow cytometry/Cell sorting to reveal a novel regulatory mechanism comprising G protein-coupled receptor ligands and nervous system-derived substances in Th9 cell differentiation and type I hypersensitivity.
Mon Apr 15 00:00:00 EDT 2013
Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis.
Journal of immunology (Baltimore, Md. : 1950)
Shiraishi Y,Jia Y,Domenico J,Joetham A,Karasuyama H,Takeda K,Gelfand EW
12-5898 was used in Flow cytometry/Cell sorting to demonstrate how the development of allergic rhinitis has two distinct stages: histamine release from FcεRI-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity.
Tue Jan 15 00:00:00 EST 2013
Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice.
FEBS open bio
Ishijima Y,Ohmori S,Ohneda K
12-5898 was used in Flow cytometry/Cell sorting to suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions.
Mon Dec 09 00:00:00 EST 2013
Transcription factor E3, a major regulator of mast cell-mediated allergic response.
The Journal of allergy and clinical immunology
Yagil Z,Hadad Erlich T,Ofir-Birin Y,Tshori S,Kay G,Yekhtin Z,Fisher DE,Cheng C,Wong WS,Hartmann K,Razin E,Nechushtan H
12-5898 was used in Flow cytometry/Cell sorting to explore the role played by TFE3 in mast cell function.
Tue May 01 00:00:00 EDT 2012
CD11c+ cells are required for antigen-induced increase of mast cells in the lung.
Journal of immunology (Baltimore, Md. : 1950)
Dahlin JS,Feinstein R,Cui Y,Heyman B,Hallgren J
12-5898 was used in Flow cytometry/Cell sorting to determine the contribution of Ag-stimulated CD11c(+) cells to the allergic response in asthmatics.
Mon Oct 15 00:00:00 EDT 2012
Regulation of GATA factor expression is distinct between erythroid and mast cell lineages.
Molecular and cellular biology
Ohmori S,Takai J,Ishijima Y,Suzuki M,Moriguchi T,Philipsen S,Yamamoto M,Ohneda K
12-5898 was used in Flow cytometry/Cell sorting to characterise the differences in the regulation of GATA factor expression between mast cells and erythroid cells.
Sat Dec 01 00:00:00 EST 2012
Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy.
Immunology letters
Diesner SC,Olivera A,Dillahunt S,Schultz C,Watzlawek T,Förster-Waldl E,Pollak A,Jensen-Jarolim E,Untersmayr E,Rivera J
12-5898 was used in Flow cytometry/Cell sorting to reveal the reduced proportion of CD4(+) effector T-cells in SphK deficient animals and reduced accumulation of mast cells in gastric mucosa.
Mon Jan 30 00:00:00 EST 2012
NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Nishikado H,Mukai K,Kawano Y,Minegishi Y,Karasuyama H
12-5898 was used in Functional assays to demonstrate that anti-asialo GM1 (ASGM1) antibodies deplete basophils in mice and may contribute to phenotypes previously attributed to NK cell depletion.
Sun May 15 00:00:00 EDT 2011
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nel HJ,Hams E,Saunders SP,Mangan NE,Smith P,Atzberger A,Flavell RA,Akira S,McKenzie AN,Fallon PG
12-5898 was used in Flow cytometry/Cell sorting to investigate the age-dependence of helminth-induced type 2 immune responses in adult and juvenile mice.
Fri Apr 15 00:00:00 EDT 2011
Genetic variation determines mast cell functions in experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M
12-5898 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.
Wed Jun 15 00:00:00 EDT 2011
Non-FcεR bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages.
Cytokine
Thathiah P,Sanapala S,Rodriguez AR,Yu JJ,Murthy AK,Guentzel MN,Forsthuber TG,Chambers JP,Arulanandam BP
12-5898 was used in Flow cytometry/Cell sorting to suggest that primary mast cells and P815 mast cells secrete IL-4 to control Francisella tularensis replication within macrophages.
Mon Aug 01 00:00:00 EDT 2011
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Parasite immunology
Svensson M,Bell L,Little MC,DeSchoolmeester M,Locksley RM,Else KJ
12-5898 was used in Flow cytometry/Cell sorting to study the accumulation of eosinophils in intestine-draining mesenteric lymph nodes following Trichuris muris infection.
Sat Jan 01 00:00:00 EST 2011
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
PloS one
Reichel CA,Lerchenberger M,Uhl B,Rehberg M,Berberich N,Zahler S,Wymann MP,Krombach F
12-5898 was used in Flow cytometry/Cell sorting to study the mechanisms behind the prevention of ischemia-reperfusion (I/R) injury using the broad-spectrum serine protease inhibitor, aprotinin.
Tue Feb 22 00:00:00 EST 2011
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PloS one
Ohno T,Oboki K,Morita H,Kajiwara N,Arae K,Tanaka S,Ikeda M,Iikura M,Akiyama T,Inoue J,Matsumoto K,Sudo K,Azuma M,Okumura K,Kamradt T,Saito H,Nakae S
12-5898 was used in Flow cytometry/Cell sorting to show that exogenous IL-33 potentiates LPS-mediated cytokine production by macrophages.
Mon Apr 11 00:00:00 EDT 2011
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
The Journal of clinical investigation
Wada T,Ishiwata K,Koseki H,Ishikura T,Ugajin T,Ohnuma N,Obata K,Ishikawa R,Yoshikawa S,Mukai K,Kawano Y,Minegishi Y,Yokozeki H,Watanabe N,Karasuyama H
12-5898 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms underlying acquired resistance to Haemaphysalis longicornis ticks in mice.
Sun Aug 01 00:00:00 EDT 2010
Human basophils express amphiregulin in response to T cell-derived IL-3.
The Journal of allergy and clinical immunology
Qi Y,Operario DJ,Oberholzer CM,Kobie JJ,Looney RJ,Georas SN,Mosmann TR
12-5898 was used in Flow cytometry/Cell sorting to identify the human peripheral blood cell population expressing amphiregulin, showing that human basophils express amphiregulin in response to T cell-derived IL-3.
Wed Dec 01 00:00:00 EST 2010
Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils.
The Journal of allergy and clinical immunology
Song Y,Qu C,Srivastava K,Yang N,Busse P,Zhao W,Li XM
12-5898 was used in Flow cytometry/Cell sorting to show that food allergy herbal formula 2 reduction of basophils and mast cell numbers as well as suppression of IgE-mediated mast cell activation may contribute to FAHF-2''s persistent protection against peanut anaphylaxis.
Wed Dec 01 00:00:00 EST 2010
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology
Perrigoue JG,Saenz SA,Siracusa MC,Allenspach EJ,Taylor BC,Giacomin PR,Nair MG,Du Y,Zaph C,van Rooijen N,Comeau MR,Pearce EJ,Laufer TM,Artis D
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2009
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology
Perrigoue JG,Saenz SA,Siracusa MC,Allenspach EJ,Taylor BC,Giacomin PR,Nair MG,Du Y,Zaph C,van Rooijen N,Comeau MR,Pearce EJ,Laufer TM,Artis D
Published figure using FceR1 alpha monoclonal antibody (Product # 12-5898-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2009
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
The Journal of clinical investigation
Jin H,Oyoshi MK,Le Y,Bianchi T,Koduru S,Mathias CB,Kumar L,Le Bras S,Young D,Collins M,Grusby MJ,Wenzel J,Bieber T,Boes M,Silberstein LE,Oettgen HC,Geha RS
12-5898 was used in Flow cytometry/Cell sorting to suggest an important role for IL-21R in the mobilization of skin DCs to DLNs and the subsequent allergic response.
Thu Jan 01 00:00:00 EST 2009
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
The Journal of clinical investigation
Jin H,Oyoshi MK,Le Y,Bianchi T,Koduru S,Mathias CB,Kumar L,Le Bras S,Young D,Collins M,Grusby MJ,Wenzel J,Bieber T,Boes M,Silberstein LE,Oettgen HC,Geha RS
12-5898 was used in Flow cytometry/Cell sorting to suggest an important role for IL-21R in the mobilization of skin DCs to DLNs and the subsequent allergic response.
Thu Jan 01 00:00:00 EST 2009
Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells.
Journal of leukocyte biology
Ugajin T,Kojima T,Mukai K,Obata K,Kawano Y,Minegishi Y,Eishi Y,Yokozeki H,Karasuyama H
12-5898 was used in Western Blotting to reveal mouse basophils rather than mast cells are the major source of mMCP-11, a trypsin-like protease.
Tue Dec 01 00:00:00 EST 2009
Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Lisboa FA,Peng Z,Combs CA,Beaven MA
12-5898 was used in Flow cytometry/Cell sorting to suggest that phospholipase D catalytic product phosphatidic acid promotes IgE-dependent signaling events within lipid microdomains in mast cells.
Thu Oct 15 00:00:00 EDT 2009
Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.
Journal of immunology (Baltimore, Md. : 1950)
Ota T,Aoki-Ota M,Duong BH,Nemazee D
12-5898 was used in Flow cytometry/Cell sorting to reveal implications for the optimal design of safe and effective anti-IgE therapies and suggest that the IgE memory B cells may be targeted by such genetic Ab therapies.
Mon Jun 15 00:00:00 EDT 2009
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.
Immunity
Gri G,Piconese S,Frossi B,Manfroi V,Merluzzi S,Tripodo C,Viola A,Odom S,Rivera J,Colombo MP,Pucillo CE
12-5898 was used in Flow cytometry/Cell sorting to explore whether Treg cells influence the immediate hypersensitivity response of mast cells.
Fri Nov 14 00:00:00 EST 2008
Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis.
Immunity
Tsujimura Y,Obata K,Mukai K,Shindou H,Yoshida M,Nishikado H,Kawano Y,Minegishi Y,Shimizu T,Karasuyama H
12-5898 was used in Flow cytometry/Cell sorting to highlight a pivotal role for basophils in vivo and contrast two major, distinct pathways leading to allergen-induced systemic anaphylaxis.
Tue Apr 01 00:00:00 EDT 2008
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
12-5898 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.
Fri Aug 01 00:00:00 EDT 2008
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3.
Nature immunology
Taghon T,Yui MA,Rothenberg EV
12-5898 was used in Flow cytometry/Cell sorting to assess both Notch-dependent and Notch-independent roles of GATA-3 in monolayer culture systems with OP9 stromal cells.
Wed Aug 01 00:00:00 EDT 2007
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
Journal of leukocyte biology
Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S
12-5898 was used in Flow cytometry/Cell sorting to reveal potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders.
Sat Dec 01 00:00:00 EST 2007
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.
Proceedings of the National Academy of Sciences of the United States of America
Kalesnikoff J,Rios EJ,Chen CC,Nakae S,Zabel BA,Butcher EC,Tsai M,Tam SY,Galli SJ
12-5898 was used in Flow cytometry/Cell sorting to investigate how RabGEF1 can regulate signaling events and biological responses in mast cells.
Tue Feb 21 00:00:00 EST 2006
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.
Immunity
Mukai K,Matsuoka K,Taya C,Suzuki H,Yokozeki H,Nishioka K,Hirokawa K,Etori M,Yamashita M,Kubota T,Minegishi Y,Yonekawa H,Karasuyama H
12-5898 was used in Flow cytometry/Cell sorting to reveal a novel basophil-induced mechanism of development of chronic allergic inflammation.
Mon Aug 01 00:00:00 EDT 2005
Identification of mast cell progenitors in adult mice.
Proceedings of the National Academy of Sciences of the United States of America
Chen CC,Grimbaldeston MA,Tsai M,Weissman IL,Galli SJ
12-5898 was used in Flow cytometry/Cell sorting to identify mast cell progenitors in mice and investigate their timeline of commitment to the mast cell lineage.
Tue Aug 09 00:00:00 EDT 2005
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite.
The Journal of experimental medicine
Min B,Prout M,Hu-Li J,Zhu J,Jankovic D,Morgan ES,Urban JF,Dvorak AM,Finkelman FD,LeGros G,Paul WE
12-5898 was used in Flow cytometry/Cell sorting to examine the production of interleukin-4 during infection by the intestinal nematode Nippostrongylus brasiliensis using green fluorescent protein-expressing mice.
Mon Aug 16 00:00:00 EDT 2004
