Product References
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease.
JCI insight
Little AJ,Chen PM,Vesely MD,Khan RN,Fiedler J,Garritano J,Maisha FI,McNiff JM,Craft J
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate in human CLE tissue that the T cell-rich inflammatory infiltrate exhibited increased amounts of HIF-1 and a cytotoxic signature.
Tue Aug 22 00:00:00 EDT 2023
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair.
Gut microbes
Wu WH,Kim M,Chang LC,Assie A,Saldana-Morales FB,Zegarra-Ruiz DF,Norwood K,Samuel BS,Diehl GE
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate an unexpected role for commensal bacteria in promoting IL-1β secretion to support intestinal barrier repair.
Thu Feb 24 00:00:00 EST 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
12-6981-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.
Scientific reports
Rivet-Noor CR,Merchak AR,Li S,Beiter RM,Lee S,Thomas JA,Fernández-Castañeda A,Shin JB,Gaultier A
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate that neither CD4 specific Ahr nor Rorc are necessary for the development of stress-induced anxiety- or depressive-like behaviors.
Sat May 21 00:00:00 EDT 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Cell
Leonardi I,Gao IH,Lin WY,Allen M,Li XV,Fiers WD,De Celie MB,Putzel GG,Yantiss RK,Johncilla M,Colak D,Iliev ID
12-6981-82 was used in Flow cytometry/Cell sorting to characterize the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
Thu Mar 03 00:00:00 EST 2022
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Immunity
Bhattacharjee A,Burr AHP,Overacre-Delgoffe AE,Tometich JT,Yang D,Huckestein BR,Linehan JL,Spencer SP,Hall JA,Harrison OJ,Morais da Fonseca D,Norton EB,Belkaid Y,Hand TW
12-6981-82 was used in Flow Cytometry to provide insight into the poor efficacy of oral vaccines in EED and highlight how RORγT+FOXP3+ Treg cells can regulate intestinal immunity while leaving systemic responses intact.
Tue Aug 10 00:00:00 EDT 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 EST 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
12-6981-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation.
Nature communications
Minns D,Smith KJ,Alessandrini V,Hardisty G,Melrose L,Jackson-Jones L,MacDonald AS,Davidson DJ,Gwyer Findlay E
12-6981-82 was used in Flow cytometry to investigate if cathelicidin is a powerful Th17 potentiator which enhances aryl hydrocarbon receptor (AHR) and RORγt expression, in a TGF-β1-dependent manner.
Wed Feb 24 00:00:00 EST 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
12-6981-82 was used in Flow cytometry/Cell sorting to demonstrate a critical role for antigen-presenting ILC3s in orchestrating immune tolerance in the airway by restricting pro-inflammatory T cell responses to both allergens and microbes.
Tue Nov 23 00:00:00 EST 2021
LmjF.36.3850, a novel hypothetical Leishmania major protein, contributes to the infection.
Immunology
Zutshi S,Sarode AY,Ghosh SK,Jha MK,Sudan R,Kumar S,Sadhale LP,Roy S,Saha B
12-6981-82 was used in Flow cytometry/Cell sorting to indicate that LmjF.36.3850 is a plausible virulence factor that enhances disease-promoting response, possibly by interfering with PKC activation and by eliciting disease-promoting T cells.
Sun Aug 01 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
12-6981 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Cell
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
12-6981-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Immunity
Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA
12-6981-82 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.
Tue Dec 15 00:00:00 EST 2020
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Girnary M,Wang L,Jiao Y,Zeng E,Mercer K,Zhang J,Marchesan JT,Yu N,Moss K,Lei YL,Offenbacher S,Zhang S
12-6981 was used in Flow cytometry/Cell sorting to determine the effects of IL-10 on IL-17-mediated periodontitis-associated inflammatory networks.
Wed Apr 15 00:00:00 EDT 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
12-6981-82 was used in Flow Cytometry to find that cell migration-inducing protein (Cemip) is the major inducible gene responsible for hyaluronan catabolism in mice.
Tue Jan 07 00:00:00 EST 2020
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.
Nature medicine
Qi X,Yun C,Sun L,Xia J,Wu Q,Wang Y,Wang L,Zhang Y,Liang X,Wang L,Gonzalez FJ,Patterson AD,Liu H,Mu L,Zhou Z,Zhao Y,Li R,Liu P,Zhong C,Pang Y,Jiang C,Qiao J
12-6981 was used in Flow cytometry/Cell sorting to investigate the impact of the gut microbiota and its metabolites on the regulation of PCOS-associated ovarian dysfunction and insulin resistance.
Thu Aug 01 00:00:00 EDT 2019
Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Immunity
Chun E,Lavoie S,Fonseca-Pereira D,Bae S,Michaud M,Hoveyda HR,Fraser GL,Gallini Comeau CA,Glickman JN,Fuller MH,Layden BT,Garrett WS
12-6981 was used in Flow cytometry/Cell sorting to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.
Tue Nov 19 00:00:00 EST 2019
TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells.
Journal of biomedical science
Yang FC,Chiu PY,Chen Y,Mak TW,Chen NJ
Wed Jun 12 00:00:00 EDT 2019
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
12-6981 was used in Flow cytometry/Cell sorting to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 EST 2018
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Immunity
Kim M,Galan C,Hill AA,Wu WJ,Fehlner-Peach H,Song HW,Schady D,Bettini ML,Simpson KW,Longman RS,Littman DR,Diehl GE
12-6981 was used in Flow cytometry/Cell sorting to identify a cellular mechanism by which the microbiota limits intestinal inflammation and promotes tissue homeostasis.
Tue Jul 17 00:00:00 EDT 2018
Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22.
Cell death and differentiation
Hou Q,Ye L,Liu H,Huang L,Yang Q,Turner JR,Yu Q
12-6981 was used in Flow cytometry/Cell sorting to explore the protective effect of Lactobacillus reuteri D8 on integrity of intestinal mucosa.
Sat Sep 01 00:00:00 EDT 2018
Protective role of γδ T cells in cigarette smoke and influenza infection.
Mucosal immunology
Hong MJ,Gu BH,Madison MC,Landers C,Tung HY,Kim M,Yuan X,You R,Machado AA,Gilbert BE,Soroosh P,Elloso M,Song L,Chen M,Corry DB,Diehl G,Kheradmand F
12-6981 was used in Flow cytometry/Cell sorting to demonstrate that cigarette smoke induces IL-17A expression in the lungs and inhibits γδ T-cell-mediated protective anti-viral immune responses.
Tue May 01 00:00:00 EDT 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
12-6981 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Nature
Tang AT,Choi JP,Kotzin JJ,Yang Y,Hong CC,Hobson N,Girard R,Zeineddine HA,Lightle R,Moore T,Cao Y,Shenkar R,Chen M,Mericko P,Yang J,Li L,Tanes C,Kobuley D,Võsa U,Whitehead KJ,Li DY,Franke L,Hart B,Schwaninger M,Henao-Mejia J,Morrison L,Kim H,Awad IA,Zheng X,Kahn ML
12-6981 was used in Flow cytometry/Cell sorting to identify roles for the microbiome and innate immune signalling in the pathogenesis of a cerebrovascular disease.
Thu May 18 00:00:00 EDT 2017
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Gut microbes
Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J
12-6981 was used in Flow cytometry/Cell sorting to identify polymorphisms near C1galt1 and its molecular chaperone, Cosmc, were associated with altered composition of the colonic mucosal microbiota.
Mon Jan 02 00:00:00 EST 2017
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
PLoS pathogens
Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM
12-6981 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.
Sun Oct 01 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
Mon May 01 00:00:00 EDT 2017
Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection.
PLoS pathogens
Sia JK,Bizzell E,Madan-Lala R,Rengarajan J
12-6981 was used in Flow cytometry/Cell sorting to determine the mechanism by which dendritic cells generate antigen specific T helper cells in response to Mycobacterium tuberculosis infection.
Tue Aug 01 00:00:00 EDT 2017
The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
Immunology
Gonçalves AC,Ferreira LS,Manente FA,de Faria CMQG,Polesi MC,de Andrade CR,Zamboni DS,Carlos IZ
Thu Jun 01 00:00:00 EDT 2017
Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORγt+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia.
Journal of Cancer
Soutto M,Saleh M,Arredouani MS,Piazuelo B,Belkhiri A,El-Rifai W
12-6981 was used in Flow cytometry/Cell sorting to utilize the Tff1-KO mouse model to assess the impact of TFF1 loss on immune cells infiltration in the stomach.
Wed May 26 00:00:00 EDT 2021
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis.
PloS one
Pardo E,Cárcamo C,Uribe-San Martín R,Ciampi E,Segovia-Miranda F,Curkovic-Peña C,Montecino F,Holmes C,Tichauer JE,Acuña E,Osorio-Barrios F,Castro M,Cortes P,Oyanadel C,Valenzuela DM,Pacheco R,Naves R,Soza A,González A
12-6981 was used in Flow cytometry/Cell sorting to reveal that Gal-8 has an immunosuppressive protective role against autoimmune CNS inflammation, modulating the balance of Th17 and Th1 polarisation and their respective Tregs.
Wed Sep 20 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
12-6981 was used in Flow cytometry/Cell sorting to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
12-6981 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Mucosal immunology
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
12-6981 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
PloS one
Watanabe N,Kaminuma O,Kitamura N,Hiroi T
12-6981 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.
Mon Aug 01 00:00:00 EDT 2016
Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner.
Biology of sex differences
Elderman M,van Beek A,Brandsma E,de Haan B,Savelkoul H,de Vos P,Faas M
12-6981 was used in Flow cytometry/Cell sorting to study sex differences in the intestinal and peripheral immune cell populations of two mouse strains with different susceptibility for developing colitis.
Thu Apr 07 00:00:00 EDT 2016
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Rasouli J,Ciric B,Imitola J,Gonnella P,Hwang D,Mahajan K,Mari ER,Safavi F,Leist TP,Zhang GX,Rostami A
12-6981 was used in Flow cytometry/Cell sorting to characterise GM-CSF production by T cells of MS patients and to determine the effect of IFN-β therapy on its production.
Mon Jun 01 00:00:00 EDT 2015
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Pei B,Zhao M,Miller BC,Véla JL,Bruinsma MW,Virgin HW,Kronenberg M
12-6981 was used in Flow cytometry/Cell sorting to examine the effect of a disrupting autophagy on the differentiation of iNKT cells, showing that they require autophagy to coordinate proliferation and survival.
Mon Jun 15 00:00:00 EDT 2015
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
PloS one
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
12-6981 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
12-6981 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 EDT 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
12-6981 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
