Product References
Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.
Stem cell research & therapy
Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Oct 02 00:00:00 EDT 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Aug 06 00:00:00 EDT 2021
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.
The Journal of biological chemistry
Tsai SJ,Atai NA,Cacciottolo M,Nice J,Salehi A,Guo C,Sedgwick A,Kanagavelu S,Gould SJ
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration.
iScience
Makino A,Shibata T,Nagayasu M,Hosoya I,Nishimura T,Nakano C,Nagata K,Ito T,Takahashi Y,Nakamura S
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Oct 22 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
12-7041-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
12-7041-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.
International journal of biological sciences
Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X
12-7041 was used in Flow cytometry/Cell sorting to indicate that G-MDSC elevation plays a crucial role in asthmatic mice.
Fri Nov 12 00:00:00 EST 2021
Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation.
Cell reports
Jaeger N,McDonough RT,Rosen AL,Hernandez-Leyva A,Wilson NG,Lint MA,Russler-Germain EV,Chai JN,Bacharier LB,Hsieh CS,Kau AL
12-7041 was used in Flow cytometry/Cell sorting to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI).
Tue Nov 03 00:00:00 EST 2020
Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis.
Theranostics
Wu J,Wei Z,Cheng P,Qian C,Xu F,Yang Y,Wang A,Chen W,Sun Z,Lu Y
12-7041 was used in Flow cytometry/Cell sorting to investigate the effect of rhein on colitis and studied its possible mechanisms.
Mon May 31 00:00:00 EDT 2021
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
12-7041 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature immunology
Gabryšová L,Alvarez-Martinez M,Luisier R,Cox LS,Sodenkamp J,Hosking C,Pérez-Mazliah D,Whicher C,Kannan Y,Potempa K,Wu X,Bhaw L,Wende H,Sieweke MH,Elgar G,Wilson M,Briscoe J,Metzis V,Langhorne J,Luscombe NM,O'Garra A
12-7041 was used in Flow cytometry/Cell sorting to study the role of c-Maf as a regulator of the expression of cytokine-encoding genes.
Tue May 01 00:00:00 EDT 2018
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
12-7041 was used in Flow cytometry/Cell sorting to study the origin and functional specialisation of dermal macrophages in cutaneous infections.
Tue Jan 02 00:00:00 EST 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
12-7041 was used in Flow cytometry/Cell sorting to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus infection.
Thu Oct 01 00:00:00 EDT 2020
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Genome medicine
Pramanik J,Chen X,Kar G,Henriksson J,Gomes T,Park JE,Natarajan K,Meyer KB,Miao Z,McKenzie ANJ,Mahata B,Teichmann SA
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Wed Oct 24 00:00:00 EDT 2018
Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.
Cell host & microbe
Entwistle LJ,Pelly VS,Coomes SM,Kannan Y,Perez-Lloret J,Czieso S,Silva Dos Santos M,MacRae JI,Collinson L,Sesay A,Nikolov N,Metidji A,Helmby H,Hui DY,Wilson MS
12-7041 was used in Flow cytometry/Cell sorting to uncover epithelial-cell-derived Pla2g1b as an essential mediator of helminth killing.
Wed Oct 11 00:00:00 EDT 2017
Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis.
The Journal of allergy and clinical immunology
Chen PC,Hsieh MH,Kuo WS,Kao HF,Hsu CL,Wang JY
12-7041 was used in Flow cytometry/Cell sorting to evaluate the effect of extensive water-soluble chitosan in allergic rhinitis.
Sun Oct 01 00:00:00 EDT 2017
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology
Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
Mucosal immunology
Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS
12-7041 was used in Flow cytometry/Cell sorting to identify that pathogenic Th2 cells are an important direct target of IL-10 and an insight into IL-10 mediated regualation of allergic airway inflammation.
Sun Jan 01 00:00:00 EST 2017
The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus.
Epilepsia
Benson MJ,Manzanero S,Borges K
12-7041 was used in Flow cytometry/Cell sorting to show that C5aR1 is an inflammatory mediator and may play a role in epileptogenesis.
Sat Apr 01 00:00:00 EDT 2017
Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells.
Journal of immunology (Baltimore, Md. : 1950)
Xue D,Kaufman GN,Dembele M,Beland M,Massoud AH,Mindt BC,Fiter R,Fixman ED,Martin JG,Friedel RH,Divangahi M,Fritz JH,Mazer BD
12-7041 was used in Flow cytometry/Cell sorting to demonstrate that Sema4C is critical for optimal regulatory cytokine production in CD138+ B cells.
Sun Jan 01 00:00:00 EST 2017
Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells.
Stem cell research & therapy
Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ
12-7041 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which adipose tissue stem cells (ASCs) reduce allergic symptoms and eosinophilic inflammation following injection, showing that culture supernatant of ASCs also reduced allergic airway inflammation.
Mon Jan 23 00:00:00 EST 2017
Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses.
Scientific reports
Hu X,Li X,Hu C,Qin L,He R,Luo L,Tang W,Feng J
12-7041 was used in Flow cytometry/Cell sorting to indicate that respiratory syncytial virus infection can increase C5a and C5aR expression in the pathogenesis of infected, asthmatic mice.
Thu Nov 09 00:00:00 EST 2017
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Frontiers in cellular and infection microbiology
Bock CN,Babu S,Breloer M,Rajamanickam A,Boothra Y,Brunn ML,Kühl AA,Merle R,Löhning M,Hartmann S,Rausch S
12-7041 was used in Flow cytometry/Cell sorting to assess the T helper cell phenotypes in threadworm-infected patients and experimental murine infections with focus on CD4+ T cells co-expressing markers of Th2 and Th1 differentiation.
Mon Feb 26 00:00:00 EST 2018
IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages.
The American journal of pathology
Gabunia K,Ellison S,Kelemen S,Kako F,Cornwell WD,Rogers TJ,Datta PK,Ouimet M,Moore KJ,Autieri MV
12-7041 was used in Flow cytometry/Cell sorting to investigate how IL-19 can halt progression of atherosclerotic plaques by regulating macrophage inflammation and cholesterol homeostasis.
Sun May 01 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
12-7041 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.
Tue Mar 01 00:00:00 EST 2016
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Gene therapy
Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H
12-7041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.
Fri Apr 01 00:00:00 EDT 2016
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Gene therapy
Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H
12-7041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.
Fri Apr 01 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
12-7041 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.
PLoS pathogens
Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS
12-7041 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.
Wed Jul 01 00:00:00 EDT 2015
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.
Journal of immunology (Baltimore, Md. : 1950)
Siggs OM,Miosge LA,Daley SR,Asquith K,Foster PS,Liston A,Goodnow CC
12-7041 was used in Flow cytometry/Cell sorting to investigate whether outcomes of null mutations of SLP-76 are due to biochemical uncoupling of tolerogenic signaling, showing that reduction of SLP-76 unbalances immunity and immune regulation.
Sun Mar 15 00:00:00 EDT 2015
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
12-7041 was used in Flow cytometry/Cell sorting to study how the activities of APCs were significantly lower in mice immunised with HBsAg vaccine, resulting in an inferior activation of HBsAg-specific Th cells.
Tue Apr 19 00:00:00 EDT 2016
Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Cui Y,Dahlin JS,Feinstein R,Bankova LG,Xing W,Shin K,Gurish MF,Hallgren J
12-7041 was used in Flow cytometry/Cell sorting to compare the immune responses of BALB/c mice to mMCP-6(-/-) and mMCP-6(-/-)/H-2bc mice in a mouse model of experimental asthma.
Sat Nov 15 00:00:00 EST 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-7041 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity.
Mediators of inflammation
Monk JM,Turk HF,Fan YY,Callaway E,Weeks B,Yang P,McMurray DN,Chapkin RS
12-7041 was used in Flow cytometry/Cell sorting to investigate the relationship between PGE2 levels and Th17 cells in regard to disease outcomes in a mouse model of colitis.
Wed Apr 08 00:00:00 EDT 2015
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain.
Journal of pain & relief
Draleau K,Maddula S,Slaiby A,Nutile-McMenemy N,De Leo J,Cao L
12-7041 was used in Flow cytometry/Cell sorting to investigate the phenotype of spinal cord-infiltrating CD4+ T lymphocytes involved in the maintenance of neuropathic pain in a murine model.
Sun Jun 01 00:00:00 EDT 2014
T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.
eLife
Burger ML,Leung KK,Bennett MJ,Winoto A
12-7041 was used in Flow cytometry/Cell sorting to show that T cell-specific expression of a Bcl2 BH3 mutant transgene results in enhanced rescue of thymocytes from negative selection.
Tue Sep 02 00:00:00 EDT 2014
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
12-7041 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
12-7041 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.
Sat Jun 15 00:00:00 EDT 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using IL-4 monoclonal antibody (Product # 12-7041-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
12-7041 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications
Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S
12-7041 was used in Flow cytometry/Cell sorting to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Tue Oct 22 00:00:00 EDT 2013
Type II NKT cells facilitate Alum-sensing and humoral immunity.
Journal of leukocyte biology
Shah HB,Devera TS,Rampuria P,Lang GA,Lang ML
12-7041 was used in Flow cytometry/Cell sorting to show that type II NKT cells function as part of the Alum-sensing apparatus and in a CD1d-dependent manner, facilitate T(H)2-driven humoral immunity.
Mon Oct 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
12-7041 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Mizutani N,Goshima H,Nabe T,Yoshino S
12-7041 was used in Flow cytometry/Cell sorting to investigate the relationship between IL-17 and IgE-mediated asthmatic responses.
Fri Jun 01 00:00:00 EDT 2012
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
International immunology
Iseki M,Omori-Miyake M,Xu W,Sun X,Takaki S,Rawlings DJ,Ziegler SF
12-7041 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity.
Thu Mar 01 00:00:00 EST 2012
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.
Cell & bioscience
Qu Z,Fu J,Ma H,Zhou J,Jin M,Mapara MY,Grusby MJ,Xiao G
12-7041 was used in Flow cytometry/Cell sorting to investigate PDLIM2 as a key modulator of T-cell-mediated immune responses and its role in preventing autoimmune disease.
Mon Jun 25 00:00:00 EDT 2012
Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
International immunology
Nakahira M,Nakanishi K
12-7041 was used in Functional assays to elucidate the molecular mechanism by which gene expression pattern is altered in T(h)1 cells in response to IL-18, showing that Gata3 is required for this altered gene expression.
Thu Dec 01 00:00:00 EST 2011
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
PloS one
Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T
12-7041 was used in Flow cytometry/Cell sorting to suggest that overexpressing a minimal domain of calpastatin could coordinately suppress proinflammatory activities of Th cells and synovial fibroblasts.
Mon Mar 26 00:00:00 EDT 2012
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Immunity
Staudt V,Bothur E,Klein M,Lingnau K,Reuter S,Grebe N,Gerlitzki B,Hoffmann M,Ulges A,Taube C,Dehzad N,Becker M,Stassen M,Steinborn A,Lohoff M,Schild H,Schmitt E,Bopp T
12-7041 was used in Affinity chromatography to demonstrate the immunological effects of interferon-regulatory factor 4 (IRF4) deficiency on CD4(+) T cell polarsiation.
Fri Aug 27 00:00:00 EDT 2010
ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.
Journal of autoimmunity
Hondowicz BD,Batheja AO,Metzgar MH,Caton AJ,Erikson J
12-7041 was used in Flow cytometry/Cell sorting to study the effect of elevated effector T-cell ICOS levels on immunity and immune cells.
Tue Jun 01 00:00:00 EDT 2010
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Journal of biomedicine & biotechnology
Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C
12-7041 was used in Flow cytometry/Cell sorting to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.
Thu Apr 01 00:00:00 EDT 2010
Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor.
The Journal of infectious diseases
Khounlotham M,Subbian S,Smith R,Cirillo SL,Cirillo JD
12-7041 was used in Flow cytometry/Cell sorting to suggest that induction of the erythropoietin-producing hepatoma (Eph) receptor, ephA2, is important for the survival of M. tuberculosis during latency.
Mon Jun 15 00:00:00 EDT 2009
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
Journal of leukocyte biology
Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D
12-7041 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..
Tue Sep 01 00:00:00 EDT 2009
Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin.
Vaccine
Cheng C,Bettahi I,Cruz-Fisher MI,Pal S,Jain P,Jia Z,Holmgren J,Harandi AM,de la Maza LM
12-7041 was used in Flow cytometry/Cell sorting to test the efficacy of immunisation with the nMOMP of Chlamydia trachomatis mouse pneumonitis serovar in combination with CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin to elicit a protective immune response to C. trachomatis.
Mon Oct 19 00:00:00 EDT 2009
Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice.
Infection and immunity
Ing R,Stevenson MM
12-7041 was used in Immunofluorescence to elucidate the signalling mechanisms underlying interferon-γ-dependent immunity to malaria.
Sun Feb 01 00:00:00 EST 2009
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-7041 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.
Journal of autoimmunity
Hondowicz BD,Fields ML,Nish SA,Larkin J,Caton AJ,Erikson J
12-7041 was used in Flow cytometry/Cell sorting to show that Treg cells block lpr/lpr gld/gld Th cells from providing help to anti-chromatin B cells in an in vivo transfer system.
Mon Sep 01 00:00:00 EDT 2008
T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
European journal of immunology
Heckman KL,Radhakrishnan S,Peikert T,Iijima K,McGregor HC,Bell MP,Kita H,Pease LR
12-7041 was used in Flow cytometry/Cell sorting to investigate the critical mediators controlling the ability of DC to modify the responses of previously activated T cells.
Mon Sep 01 00:00:00 EDT 2008
Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma.
Cancer immunology, immunotherapy : CII
Ciesielski MJ,Kozbor D,Castanaro CA,Barone TA,Fenstermaker RA
12-7041 was used in Flow cytometry/Cell sorting to identify survivin epitopes that might serve as targets for CTL-mediated, anti-tumour responses.
Mon Dec 01 00:00:00 EST 2008
Deletion of both ICAM-1 and C3 enhances severity of experimental autoimmune encephalomyelitis compared to C3-deficient mice.
Neuroscience letters
Smith SS,Ludwig M,Wohler JE,Bullard DC,Szalai AJ,Barnum SR
12-7041 was used in Flow cytometry/Cell sorting to examine experimental autoimmune encephalitis in ICAM-1 x C3 double knockout mice.
Fri Sep 12 00:00:00 EDT 2008
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The Journal of experimental medicine
Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF
12-7041 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.
Mon Aug 15 00:00:00 EDT 2005
