Product References
Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.
Neural regeneration research
Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2024
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.
Molecular pain
Lenert ME,Szabo-Pardi TA,Burton MD
12-7101-82 was used in Flow cytometry/Cell sorting to provide novel evidence that downregulation of regulatory T-cells play a role in chronic muscle pain pathology in the acidic saline model of FM and that IL-5 signaling is a promising target for future development of therapeutics.
Mon Feb 13 00:00:00 EST 2023
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.
EMBO reports
Zhu K,Wang Y,Sarlus H,Geng K,Nutma E,Sun J,Kung SY,Bay C,Han J,Min JH,Benito-Cuesta I,Lund H,Amor S,Wang J,Zhang XM,Kutter C,Guerreiro-Cacais AO,Högberg B,Harris RA
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Tue Jul 05 00:00:00 EDT 2022
RORγt phosphorylation protects against T cell-mediated inflammation.
Cell reports
Ma S,Patel SA,Abe Y,Chen N,Patel PR,Cho BS,Abbasi N,Zeng S,Schnabl B,Chang JT,Huang WJM
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Tue Mar 15 00:00:00 EDT 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
12-7101-82 was used in Flow cytometry/Cell sorting to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program.
Cell reports
Damasceno LEA,Cebinelli GCM,Fernandes MF,Nascimento DC,Públio GA,Vinolo MAR,Oliveira SC,Sparwasser T,Cunha TM,Cunha FQ,Alves-Filho JC
12-7101-82 was used in flow cytometry to describe an intrinsic role of STING in limiting the TH17 cell pathogenic program and reveal a regulatory function of STING in the TH17 cell activation program, proposing it as a valuable target to limit TH17-cell-mediated inflammation.
Tue May 24 00:00:00 EDT 2022
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes.
The Journal of experimental medicine
Lin CH,Chen MC,Lin LL,Christian DA,Min B,Hunter CA,Lu LF
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
12-7101-82 was used in Flow Cytometry to reveal that mEVs alleviate colitis by regulating intestinal immune homeostasis via inhibiting TLR4-NF-κB and NLRP3 signaling pathways, restoring Treg/Th17 cell balance, and reshaping the gut microbiota.
Fri Jan 28 00:00:00 EST 2022
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
12-7101-82 was used in Flow Cytometry to reveal that mEVs alleviate colitis by regulating intestinal immune homeostasis via inhibiting TLR4-NF-κB and NLRP3 signaling pathways, restoring Treg/Th17 cell balance, and reshaping the gut microbiota.
Fri Jan 28 00:00:00 EST 2022
Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.
Pathogens (Basel, Switzerland)
Medina-Buelvas DM,Rodríguez-Sosa M,Vega L
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Sat Nov 06 00:00:00 EDT 2021
Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L infantum infection.
Parasite immunology
Carvalho LM,de Brito RCF,Gusmão MR,de Oliveira Aguiar-Soares RD,Reis AB,Roatt BM
12-7101-82 was used in flow cytometry to propose the validation of some important commercially anti-mouse mAbs (CD4, TNF-α, IFN-γ and IL-10) and how this could be useful to evaluate a specific cellular immune response in Leishmania-infected hamster using flow cytometry experiments.
Thu Apr 01 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
12-7101 was used in Flow cytometry/Cell sorting to study the origin and functional specialisation of dermal macrophages in cutaneous infections.
Tue Jan 02 00:00:00 EST 2018
ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection.
Frontiers in immunology
Lee S,Kim GL,Kim NY,Kim SJ,Ghosh P,Rhee DK
Wed Sep 18 00:00:00 EDT 2019
Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model.
Allergy
Shin JU,Kim SH,Noh JY,Kim JH,Kim HR,Jeong KY,Park KH,Lee J,Chu H,Lee JH,Yong TS,Park JW,Lee KH
12-7101-82 was used in flow cytometry to suggest an SIT model is a useful tool to investigate mechanism of action of SIT and to validate the efficacy of new SIT modalities for the treatment of AD.
Sat Sep 01 00:00:00 EDT 2018
Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.
International journal of nanomedicine
Tomić S,Ilić N,Kokol V,Gruden-Movsesijan A,Mihajlović D,Bekić M,Sofronić-Milosavljević L,Čolić M,Vučević D
12-7101 was used in Flow cytometry/Cell sorting to investigate how differentially functionalised cellulose nanofibrils affect dendritic cell properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response.
Mon Dec 31 00:00:00 EST 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
12-7101 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells.
Stem cell research & therapy
Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ
12-7101 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which adipose tissue stem cells (ASCs) reduce allergic symptoms and eosinophilic inflammation following injection, showing that culture supernatant of ASCs also reduced allergic airway inflammation.
Mon Jan 23 00:00:00 EST 2017
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
12-7101 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 EDT 2016
HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).
PLoS pathogens
Yasuma K,Yasunaga J,Takemoto K,Sugata K,Mitobe Y,Takenouchi N,Nakagawa M,Suzuki Y,Matsuoka M
12-7101 was used in Flow cytometry/Cell sorting to show that HTLV-1 bZIP factor-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favourable to HTLV-1 in vitro.
Fri Jan 01 00:00:00 EST 2016
Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes.
Infection and immunity
Maaz D,Rausch S,Richter D,Krücken J,Kühl AA,Demeler J,Blümke J,Matuschka FR,von Samson-Himmelstjerna G,Hartmann S
12-7101 was used in Flow cytometry/Cell sorting to analyse the immunological impact of the nematode/tick coinfection, showing that susceptibility to ticks and Lyme disease is not affected by coinfection.
Sun May 01 00:00:00 EDT 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Tue Jul 19 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Wed May 25 00:00:00 EDT 2016
High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance.
PloS one
Pizzolla A,Oh DY,Luong S,Prickett SR,Henstridge DC,Febbraio MA,O'Hehir RE,Rolland JM,Hardy CL
12-7101 was used in Flow cytometry/Cell sorting to study the relationship between a high fat diet and allergic asthma using an induced-respiratory tolerance model in mice.
Wed Jul 26 00:00:00 EDT 2017
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
PloS one
Watanabe N,Kaminuma O,Kitamura N,Hiroi T
12-7101 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.
Mon Aug 01 00:00:00 EDT 2016
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Biomaterials
Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP
Tue Dec 01 00:00:00 EST 2015
Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner.
Cancer research
Kratochvill F,Gratz N,Qualls JE,Van De Velde LA,Chi H,Kovarik P,Murray PJ
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Manlove LS,Berquam-Vrieze KE,Pauken KE,Williams RT,Jenkins MK,Farrar MA
12710182 was used in flow cytometry to determine the mechanism by which BCR-ABL positive leukemia escapes immune surveillance
Thu Oct 15 00:00:00 EDT 2015
Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant.
International journal of molecular medicine
Song N,Gao L,Qiu H,Huang C,Cheng H,Zhou H,Lv S,Chen L,Wang J
12-7101 was used in Flow cytometry/Cell sorting to determine that MSCs may be safe and effective when used in allogeneic BMT for the treatment of haemotological malignancies.
Wed Jul 01 00:00:00 EDT 2015
Toxoplasma gondii Infection Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice.
Allergy, asthma & immunology research
Jeong YI,Hong SH,Cho SH,Lee WJ,Lee SE
12-7101 was used in Flow cytometry/Cell sorting to partly explain the mechanisms of how parasite infection prevents the development of allergic disorder.
Sun Nov 01 00:00:00 EDT 2015
Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli.
PloS one
Holm JB,Sorobetea D,Kiilerich P,Ramayo-Caldas Y,Estellé J,Ma T,Madsen L,Kristiansen K,Svensson-Frej M
12-7101 was used in Flow cytometry/Cell sorting to study the influence of chronic parasite infection on the intestinal microbiota and the adaptive immune system.
Wed Feb 03 00:00:00 EST 2016
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Schedel M,Takeda K,Jia Y,Ashino S,Dakhama A,Lluis A,Okamoto M,Gelfand EW
12-7101 was used in Flow cytometry/Cell sorting to study the mechanism by which GITR stimulation of naturally occurring regulatory T cells triggers the loss of regulatory function while concomitantly gaining pathogenic CD4(+) effector function.
Mon Sep 01 00:00:00 EDT 2014
A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.
Journal of immunology (Baltimore, Md. : 1950)
Kaku H,Cheng KF,Al-Abed Y,Rothstein TL
12-7101 was used in Flow cytometry/Cell sorting to identify a novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.
Mon Dec 15 00:00:00 EST 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-7101 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
12-7101 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IL-10 monoclonal antibody (Product # 12-7101-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
12-7101 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
12-7101 was used in Flow cytometry/Cell sorting to show that macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentum.
Tue Jan 01 00:00:00 EST 2013
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Zhang W,Usherwood EJ
12-7101 was used in Flow cytometry/Cell sorting to investigate the generation, phenotype and function of IL-10 producing CD8+ T cells during persistent virus infection.
Mon Jul 01 00:00:00 EDT 2013
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.
PLoS pathogens
Owens BM,Beattie L,Moore JW,Brown N,Mann JL,Dalton JE,Maroof A,Kaye PM
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that only CD11c(hi) dendritic cells that produce both IL-10 and IL-27 are capable of inducing IL-10-producing Th1 cells in vivo.
Tue Jan 29 00:00:00 EST 2013
Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu JQ,Liu Z,Zhang X,Shi Y,Talebian F,Carl JW,Yu C,Shi FD,Whitacre CC,Trgovcich J,Bai XF
12-7101 was used in Flow cytometry/Cell sorting to evaluate the development of experimental autoimmune encephalomyelitis in EBV-induced gene 3-deficient mice that lack both IL-27 and IL-35.
Sun Apr 01 00:00:00 EDT 2012
Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.
Journal of immunology (Baltimore, Md. : 1950)
Iwata Y,Boström EA,Menke J,Rabacal WA,Morel L,Wada T,Kelley VR
12-7101 was used in Flow cytometry/Cell sorting to elucidate the macrophage-associated effects of CSF-1 expression by tubular epithelial cells during kidney inflammation.
Tue May 01 00:00:00 EDT 2012
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that soluble divalent MHC class II molecules can abrogate pathogenic T cells in experimental autoimmune encephalomyelitis.
Fri Jul 19 00:00:00 EDT 2013
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Okamoto M,Takeda K,Schedel M,Ohnishi H,Dakhama A,Gelfand EW
12-7101 was used in Flow cytometry/Cell sorting to identify the critical role of CD8-T regulatory cell interactions in regulating the suppressive phenotype of nTregs through control of IL-6 production.
Sat Jan 01 00:00:00 EST 2011
IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.
PloS one
Ganesh BB,Bhattacharya P,Gopisetty A,Sheng J,Vasu C,Prabhakar BS
12-7101 was used in an ELISA assay to investigate the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells, showing that IL-1β promotes TGF-β1- and IL-2-dependent Foxp3 expression in Tregs.
Tue Nov 15 00:00:00 EST 2011
Antigen-specific dependence of Tr1-cell therapy in preclinical models of islet transplant.
Diabetes
Gagliani N,Jofra T,Stabilini A,Valle A,Atkinson M,Roncarolo MG,Battaglia M
12-7101 was used in Flow cytometry to define the efficacy of T inducible regulatory type 1-cell therapy in preclinical models of islet transplant.
Mon Feb 01 00:00:00 EST 2010
Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
The American journal of pathology
Wondimu Z,Santodomingo-Garzon T,Le T,Swain MG
12-7101 was used in Flow cytometry/Cell sorting to determine the role played by IL-17 in hepatic inflammation.
Mon Nov 01 00:00:00 EDT 2010
Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.
Journal of immunology (Baltimore, Md. : 1950)
Haas KM,Watanabe R,Matsushita T,Nakashima H,Ishiura N,Okochi H,Fujimoto M,Tedder TF
12-7101 was used in Flow cytometry/Cell sorting to compare systemic mature B cell depletion with depletion of circulating and marginal zone B cells in a systemic lupus erythematosus model.
Sat May 01 00:00:00 EDT 2010
Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Journal of immunology (Baltimore, Md. : 1950)
Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH
12-7101 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.
Sat Aug 01 00:00:00 EDT 2009
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Journal of immunology (Baltimore, Md. : 1950)
Pierau M,Engelmann S,Reinhold D,Lapp T,Schraven B,Bommhardt UH
12-7101 was used in Flow cytometry/Cell sorting to indicate an important role of PKB signals on control of TGF-beta1-mediated T cell responses and, thereby, on tolerizing and inflammatory immune processes.
Sun Nov 15 00:00:00 EST 2009
The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals.
Journal of immunology (Baltimore, Md. : 1950)
Yanaba K,Bouaziz JD,Matsushita T,Tsubata T,Tedder TF
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production.
Mon Jun 15 00:00:00 EDT 2009
Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice.
Infection and immunity
Vargas-Inchaustegui DA,Tai W,Xin L,Hogg AE,Corry DB,Soong L
12-7101 was used in Flow cytometry/Cell sorting to investigate whether TLRs are involved in L. braziliensis-mediated dendritic cell activation, showing distinct roles for MyD88 and TLR2 in infection.
Wed Jul 01 00:00:00 EDT 2009
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
12-7101 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Vargas-Inchaustegui DA,Xin L,Soong L
12-7101 was used in Flow cytometry/Cell sorting to investigate whether Leishmania braziliensis infection efficiently triggers innate responses in dendritic cells and the subsequent adaptive immune responses for parasite clearance.
Sun Jun 01 00:00:00 EDT 2008
Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.
International journal for parasitology
Wanasen N,Xin L,Soong L
12-7101 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.
Sat Mar 01 00:00:00 EST 2008
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Proceedings of the National Academy of Sciences of the United States of America
Joetham A,Takeda K,Miyahara N,Matsubara S,Ohnishi H,Koya T,Dakhama A,Gelfand EW
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that functional activation of nTregs requires the interaction between MHC I on CD4(+)CD25(+) T cells and CD8.
Tue Sep 18 00:00:00 EDT 2007
Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Luke PP,Deng JP,Lian D,O'Connell PJ,Garcia B,Jevnikar AM,Zhong R
12-7101 was used in Flow cytometry/Cell sorting to assess the importance of CD45RBhi T-cell depletion in murine cardiac allograft survival.
Fri Sep 01 00:00:00 EDT 2006
Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The Journal of experimental medicine
Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF
12-7101 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.
Mon Aug 15 00:00:00 EDT 2005
