Product References
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets.
NPJ vaccines
Cheung M,Chang C,Rathnasinghe R,Rossignol E,Zhang Y,Ferrari A,Patel H,Huang Y,Sanchez Guillen M,Scalzo T,Lee C,Otten GR,Settembre EC,Music N,Palladino G,Wen Y
12-7133-82 was used in Flow Cytometry to demonstrate that next-generation bicistronic sa-mRNA vaccines expressing HA and NA induce potent antibodies against both viral coat proteins, as well as vaccine-specific cell-mediated immunity.
Wed Oct 04 00:00:00 EDT 2023
Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets.
NPJ vaccines
Cheung M,Chang C,Rathnasinghe R,Rossignol E,Zhang Y,Ferrari A,Patel H,Huang Y,Sanchez Guillen M,Scalzo T,Lee C,Otten GR,Settembre EC,Music N,Palladino G,Wen Y
12-7133-82 was used in Flow Cytometry to demonstrate that next-generation bicistronic sa-mRNA vaccines expressing HA and NA induce potent antibodies against both viral coat proteins, as well as vaccine-specific cell-mediated immunity.
Wed Oct 04 00:00:00 EDT 2023
Monitoring Group 2 Innate Lymphoid Cell Biology in Models of Lung Inflammation.
Bio-protocol
Badrani JH,Strohm AN,Haung YA,Doherty TA
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Thu Jul 20 00:00:00 EDT 2023
Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.
Nature communications
Cheong LY,Wang B,Wang Q,Jin L,Kwok KHM,Wu X,Shu L,Lin H,Chung SK,Cheng KKY,Hoo RLC,Xu A
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Fri Mar 03 00:00:00 EST 2023
Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion.
Cell reports
Chen F,El-Naccache DW,Ponessa JJ,Lemenze A,Espinosa V,Wu W,Lothstein K,Jin L,Antao O,Weinstein JS,Damani-Yokota P,Khanna K,Murray PJ,Rivera A,Siracusa MC,Gause WC
12-7133-82 was used in Flow Cytometry to indicate that recruited monocytes are selectively programmed in the pulmonary environment to express AM markers and an anti-helminth phenotype.
Tue Jan 11 00:00:00 EST 2022
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
The Journal of experimental medicine
Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y
12-7133-82 was used in Flow cytometry/Cell sorting to identify a distinct phenotype of the pathogenic T cell population in the lung and skin, and ACC1 was shown to be an essential regulator controlling the pathogenic function of these populations to promote type 2 inflammation.
Mon Dec 06 00:00:00 EST 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Thu Jul 22 00:00:00 EDT 2021
Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza.
iScience
Shibuya M,Tamiya S,Kawai A,Hirai T,Cragg MS,Yoshioka Y
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Fri Oct 22 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling.
Frontiers in immunology
Deng F,Hu JJ,Yang X,Sun QS,Lin ZB,Zhao BC,Yao ZW,Luo SD,Chen ZL,Liu Y,Yan ZZ,Li C,Liu WF,Liu KX
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Dec 21 00:00:00 EST 2021
6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.
eLife
Daneshmandi S,Cassel T,Higashi RM,Fan TW,Seth P
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Thu Oct 28 00:00:00 EDT 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
Science immunology
Castellanos CA,Ren X,Gonzalez SL,Li HK,Schroeder AW,Liang HE,Laidlaw BJ,Hu D,Mak ACY,Eng C,Rodríguez-Santana JR,LeNoir M,Yan Q,Celedón JC,Burchard EG,Zamvil SS,Ishido S,Locksley RM,Cyster JG,Huang X,Shin JS
12-7133-82 was used in Flow cytometry/Cell sorting to suggest that TH2 cell development depends on ubiquitin-mediated clearance of antigen-presenting and costimulatory molecules by LN-resident DCs and consequent control of TCR signaling.
Fri Oct 15 00:00:00 EDT 2021
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
International journal of molecular sciences
Hering L,Katkeviciute E,Schwarzfischer M,Niechcial A,Riggs JB,Wawrzyniak M,Atrott K,van de Sande M,Lang S,Becher B,Rogler G,Scharl M,Spalinger MR
12-7133-82 was used in Flow cytometry/Cell sorting to investigate the dendritic cells-specific role of PTPN2 in the intestine during colitis development.
Fri Jun 25 00:00:00 EDT 2021
A helminth-derived suppressor of ST2 blocks allergic responses.
eLife
Vacca F,Chauché C,Jamwal A,Hinchy EC,Heieis G,Webster H,Ogunkanbi A,Sekne Z,Gregory WF,Wear M,Perona-Wright G,Higgins MK,Nys JA,Cohen ES,McSorley HJ
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice.
Nature communications
Wang G,Xu J,Zhao J,Yin W,Liu D,Chen W,Hou SX
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
12-7133-82 was used in Flow Cytometry to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.
Tue Jul 16 00:00:00 EDT 2019
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
Immunity
Wallrapp A,Burkett PR,Riesenfeld SJ,Kim SJ,Christian E,Abdulnour RE,Thakore PI,Schnell A,Lambden C,Herbst RH,Khan P,Tsujikawa K,Xavier RJ,Chiu IM,Levy BD,Regev A,Kuchroo VK
12-7133-82 was used in Flow Cytometry to show that ILC2s expressed both the neuropeptide calcitonin gene-related peptide and its receptor.
Tue Oct 15 00:00:00 EDT 2019
GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses.
Cancer immunology research
Kim IK,Koh CH,Jeon I,Shin KS,Kang TS,Bae EA,Seo H,Ko HJ,Kim BS,Chung Y,Kang CY
12-7133-82 was used in Flow Cytometry to demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing Th (Th9) cells.
Fri Mar 01 00:00:00 EST 2019
Ovalbumin induces natural killer cells to secrete Th2 cytokines IL‑5 and IL‑13 in a mouse model of asthma.
Molecular medicine reports
Chen Z,Wang L
12-7133-82 was used in Flow cytometry/Cell sorting to analyse the dynamic changes of NK cells and their subsets during the development of the ovalbumin (OVA)‚induced allergic airway response.
Mon Apr 01 00:00:00 EDT 2019
Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.
Nature communications
Galle-Treger L,Sankaranarayanan I,Hurrell BP,Howard E,Lo R,Maazi H,Lewis G,Banie H,Epstein AL,Hu P,Rehan VK,Gilliland FD,Allayee H,Soroosh P,Sharpe AH,Akbari O
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Feb 12 00:00:00 EST 2019
TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity.
Cell reports
Hurrell BP,Galle-Treger L,Jahani PS,Howard E,Helou DG,Banie H,Soroosh P,Akbari O
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Dec 24 00:00:00 EST 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity
Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells.
Arthritis research & therapy
Saigusa R,Asano Y,Taniguchi T,Hirabayashi M,Nakamura K,Miura S,Yamashita T,Takahashi T,Ichimura Y,Toyama T,Yoshizaki A,Trojanowska M,Sato S
12-7133 was used in Flow cytometry/Cell sorting to investigate the role of Fli1 deficiency in dermal fibroblast-mediated transdifferentiation of Tregs in mice.
Wed Feb 07 00:00:00 EST 2018
Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung.
Frontiers in immunology
Yasuda K,Adachi T,Koida A,Nakanishi K
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that Strongyloides venezuelensis-experienced mice become significantly resistant against infection by Nippostrongylus brasiliensis.
Mon Sep 30 00:00:00 EDT 2019
Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung.
Frontiers in immunology
Yasuda K,Adachi T,Koida A,Nakanishi K
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that Strongyloides venezuelensis-experienced mice become significantly resistant against infection by Nippostrongylus brasiliensis.
Mon Sep 30 00:00:00 EDT 2019
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Genome medicine
Pramanik J,Chen X,Kar G,Henriksson J,Gomes T,Park JE,Natarajan K,Meyer KB,Miao Z,McKenzie ANJ,Mahata B,Teichmann SA
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Wed Oct 24 00:00:00 EDT 2018
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that T-bet+ Treg cells have an essential immunosuppressive function.
Thu Jun 15 00:00:00 EDT 2017
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
Tue Oct 17 00:00:00 EDT 2017
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
Tue Oct 17 00:00:00 EDT 2017
HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.
Immunity
Osbourn M,Soares DC,Vacca F,Cohen ES,Scott IC,Gregory WF,Smyth DJ,Toivakka M,Kemter AM,le Bihan T,Wear M,Hoving D,Filbey KJ,Hewitson JP,Henderson H,Gonzàlez-Cìscar A,Errington C,Vermeren S,Astier AL,Wallace WA,Schwarze J,Ivens AC,Maizels RM,McSorley HJ
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
A type 2 cytokine axis for thymus emigration.
The Journal of experimental medicine
White AJ,Baik S,Parnell SM,Holland AM,Brombacher F,Jenkinson WE,Anderson G
12-7133 was used in Flow cytometry/Cell sorting to show the thymic microenvironment expresses the type 2 IL-4R complex and is functionally responsive to its known ligands, IL-4 and IL-13.
Mon Aug 07 00:00:00 EDT 2017
Water-soluble chitosan inhibits nerve growth factor and attenuates allergic inflammation in mite allergen-induced allergic rhinitis.
The Journal of allergy and clinical immunology
Chen PC,Hsieh MH,Kuo WS,Kao HF,Hsu CL,Wang JY
12-7133 was used in Flow cytometry/Cell sorting to evaluate the effect of extensive water-soluble chitosan in allergic rhinitis.
Sun Oct 01 00:00:00 EDT 2017
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.
Journal of immunology (Baltimore, Md. : 1950)
Braune J,Weyer U,Hobusch C,Mauer J,Brüning JC,Bechmann I,Gericke M
12-7133 was used in Flow cytometry/Cell sorting to study how IL-6 acts as a Th2 cytokine in obesity by stimulating M2 polarisation and local adipose tissue macrophages proliferation.
Sat Apr 01 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Respiratory syncytial virus infection of newborn CX3CR1-deficient mice induces a pathogenic pulmonary innate immune response.
JCI insight
Das S,Raundhal M,Chen J,Oriss TB,Huff R,Williams JV,Ray A,Ray P
12-7133 was used in Flow cytometry/Cell sorting to propose that, in infants harbouring mutant CX3CR1, targeting the IL-17R may minimize respiratory syncytial virus severity and hospitalization in early life.
Thu Sep 07 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
12-7133 was used in Flow cytometry/Cell sorting to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
Lack of autophagy induces steroid-resistant airway inflammation.
The Journal of allergy and clinical immunology
Suzuki Y,Maazi H,Sankaranarayanan I,Lam J,Khoo B,Soroosh P,Barbers RG,James Ou JH,Jung JU,Akbari O
12-7133 was used in Flow cytometry/Cell sorting to examine the role of autophagy in lung inflammation and the pathogenesis of corticosteroid-resistant neutrophilic asthma.
Sun May 01 00:00:00 EDT 2016
Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region.
PloS one
Kim K,Kim N,Lee GR
12-7133 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms behind Th2 cytokine gene regulation.
Thu Jul 07 00:00:00 EDT 2016
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Nature communications
Schedel M,Jia Y,Michel S,Takeda K,Domenico J,Joetham A,Ning F,Strand M,Han J,Wang M,Lucas JJ,Vogelberg C,Kabesch M,O'Connor BP,Gelfand EW
12-7133 was used in Flow cytometry/Cell sorting to investigate the underlying regulatory mechanisms of the conversion of Tc1 to Tc2 effector T cells in the presence of IL-4.
Mon Jan 11 00:00:00 EST 2016
Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.
Nature communications
Kuwahara M,Ise W,Ochi M,Suzuki J,Kometani K,Maruyama S,Izumoto M,Matsumoto A,Takemori N,Takemori A,Shinoda K,Nakayama T,Ohara O,Yasukawa M,Sawasaki T,Kurosaki T,Yamashita M
12-7133 was used in Flow cytometry/Cell sorting to suggest that IL-4 and Batf form a positive feedback amplification loop to induce Th2 cell differentiation and the subsequent Th2-type immune response.
Thu Sep 01 00:00:00 EDT 2016
High IFN-γ and low SLPI mark severe asthma in mice and humans.
The Journal of clinical investigation
Raundhal M,Morse C,Khare A,Oriss TB,Milosevic J,Trudeau J,Huff R,Pilewski J,Holguin F,Kolls J,Wenzel S,Ray P,Ray A
12-7133 was used in Flow cytometry/Cell sorting to identify a distinct immune response in SA characterized by a dysregulated IFN-γ/SLPI axis that affects lung function.
Mon Aug 03 00:00:00 EDT 2015
Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.
The Journal of allergy and clinical immunology
Christianson CA,Goplen NP,Zafar I,Irvin C,Good JT,Rollins DR,Gorentla B,Liu W,Gorska MM,Chu H,Martin RJ,Alam R
12-7133 was used in Flow cytometry/Cell sorting to present a critical network of feedback and feed-forward interactions between epithelial cells and ILC2s involved in maintaining chronic asthma.
Wed Jul 01 00:00:00 EDT 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
12-7133 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.
Mon Jun 15 00:00:00 EDT 2015
Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses.
Toxicological sciences : an official journal of the Society of Toxicology
Marshall NB,Lukomska E,Long CM,Kashon ML,Sharpnack DD,Nayak AP,Anderson KL,Jean Meade B,Anderson SE
12-7133 was used in Flow cytometry/Cell sorting to examine the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses.
Tue Sep 01 00:00:00 EDT 2015
The Effects of Antigen-Specific IgG1 Antibody for the Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in Mice Exposed to Antigen and Fine Particles from Air Pollution.
PloS one
Park SH,Chen WC,Durmus N,Bleck B,Reibman J,Riemekasten G,Grunig G
12-7133 was used in Flow cytometry/Cell sorting to identify B cells and antigen specific IgG1 as potential therapeutical targets for pulmonary hypertension.
Mon Apr 25 00:00:00 EDT 2016
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.
Nature immunology
Simpson LJ,Patel S,Bhakta NR,Choy DF,Brightbill HD,Ren X,Wang Y,Pua HH,Baumjohann D,Montoya MM,Panduro M,Remedios KA,Huang X,Fahy JV,Arron JR,Woodruff PG,Ansel KM
12-7133 was used in Flow cytometry/Cell sorting to study how upregulation of miR-19a in asthma may be an indicator and a cause of increased TH2 cytokine production in the airways.
Mon Dec 01 00:00:00 EST 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
12-7133 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.
The Journal of allergy and clinical immunology
Farhadi N,Lambert L,Triulzi C,Openshaw PJ,Guerra N,Culley FJ
12-7133 was used in Flow cytometry/Cell sorting to investigate the importance of natural killer cells in house dust mite-triggered allergic response.
Sat Mar 01 00:00:00 EST 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-7133 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
Infection and immunity
Angkasekwinai P,Sringkarin N,Supasorn O,Fungkrajai M,Wang YH,Chayakulkeeree M,Ngamskulrungroj P,Angkasekwinai N,Pattanapanyasat K
12-7133 was used in Flow cytometry/Cell sorting to investigate the impact of C. gattii infection on the development of the adaptive T helper cell immune response.
Mon Sep 01 00:00:00 EDT 2014
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.
Nature communications
Kuwahara M,Suzuki J,Tofukuji S,Yamada T,Kanoh M,Matsumoto A,Maruyama S,Kometani K,Kurosaki T,Ohara O,Nakayama T,Yamashita M
12-7133 was used in Flow cytometry/Cell sorting to show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype after antigenic stimulation and dysregulated cytokine production.
Wed Apr 02 00:00:00 EDT 2014
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nature
Nussbaum JC,Van Dyken SJ,von Moltke J,Cheng LE,Mohapatra A,Molofsky AB,Thornton EE,Krummel MF,Chawla A,Liang HE,Locksley RM
Published figure using IL-13 monoclonal antibody (Product # 12-7133-82) in Flow Cytometry
Thu Oct 10 00:00:00 EDT 2013
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Immunity
McHedlidze T,Waldner M,Zopf S,Walker J,Rankin AL,Schuchmann M,Voehringer D,McKenzie AN,Neurath MF,Pflanz S,Wirtz S
12-7133 was used in Flow cytometry/Cell sorting to investigate the role of inflammatory networks in liver fibrosis, showing that it is mediated by interleukin-33-dependent innate lymphoid cells.
Thu Aug 22 00:00:00 EDT 2013
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of experimental medicine
Bronevetsky Y,Villarino AV,Eisley CJ,Barbeau R,Barczak AJ,Heinz GA,Kremmer E,Heissmeyer V,McManus MT,Erle DJ,Rao A,Ansel KM
12-7133 was used in Flow cytometry/Cell sorting to reveal T cell activation induces global post-transcriptional miRNA down-regulation, promoting acquisition of helper T cell effector functions.
Mon Feb 11 00:00:00 EST 2013
Diesel exhaust particle induction of IL-17A contributes to severe asthma.
The Journal of allergy and clinical immunology
Brandt EB,Kovacic MB,Lee GB,Gibson AM,Acciani TH,Le Cras TD,Ryan PH,Budelsky AL,Khurana Hershey GK
12-7133 was used in Flow cytometry/Cell sorting to determine the mechanism by which diesel exhaust particles affect asthma severity, showing that diesel exhaust particles increase airway responsiveness to house dust mite extract due to increased levels of IL-17A, suggesting neutralisation of IL-17A could be used as a future therapy.
Fri Nov 01 00:00:00 EDT 2013
Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease.
Proceedings of the National Academy of Sciences of the United States of America
Jia Y,Domenico J,Takeda K,Han J,Wang M,Armstrong M,Reisdorph N,O'Connor BP,Lucas JJ,Gelfand EW
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that Cyp11a1 controls the phenotypic conversion of CD8+ T-cells from IFN-γ to IL-13 production.
Tue May 14 00:00:00 EDT 2013
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.
Journal of virology
Durant LR,Makris S,Voorburg CM,Loebbermann J,Johansson C,Openshaw PJ
12-7133 was used in Flow cytometry/Cell sorting to provide evidence that dysregulation of normal immune responses to viral infection may contribute to severe respiratory viral disease.
Tue Oct 01 00:00:00 EDT 2013
Stepwise epigenetic and phenotypic alterations poise CD8+ T cells to mediate airway hyperresponsiveness and inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Jia Y,Takeda K,Han J,Joetham A,Marcus RA,Lucas JJ,O'Connor BP,Gelfand EW
12-7133 was used in Flow cytometry/Cell sorting to show that an atopic, IL-4 rich environment predisposes CD8 T cells to allergen-mediated pathogenic conversion to IL-13 production.
Mon Apr 15 00:00:00 EDT 2013
Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene.
PloS one
Park SH,Chen WC,Hoffman C,Marsh LM,West J,Grunig G
12-7133 was used in Flow cytometry/Cell sorting to test the idea that Th2 responses to a mild antigen, together with the expression of a hypomorphic BMPR2 gene, would trigger pulmonary hypertension.
Mon Jul 22 00:00:00 EDT 2013
A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus.
PloS one
Suzuki J,Kuwahara M,Tofukuji S,Imamura M,Kato F,Nakayama T,Ohara O,Yamashita M
12-7133 was used in Flow cytometry/Cell sorting to identify SH-2251 as a novel therapeutic candidate for allergic inflammation that selectively inhibits active histone marks at the Il5 gene locus.
Thu Nov 14 00:00:00 EST 2013
Virus-like particle-induced protection against MRSA pneumonia is dependent on IL-13 and enhancement of phagocyte function.
The American journal of pathology
Rynda-Apple A,Dobrinen E,McAlpine M,Read A,Harmsen A,Richert LE,Calverley M,Pallister K,Voyich J,Wiley JA,Johnson B,Young M,Douglas T,Harmsen AG
12-7133 was used in Flow cytometry/Cell sorting to investigate whether altering the lung environment in anticipation of insults provides a novel therapy for emerging infectious diseases.
Sun Jul 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
12-7133 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
12-7133 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
Blood
Milpied P,Massot B,Renand A,Diem S,Herbelin A,Leite-de-Moraes M,Rubio MT,Hermine O
12-7133 was used in Flow cytometry/Cell sorting to determine the function of recent thymic emigrant invariant natural killer (RTE TiNKT) cells in naive mice.
Thu Sep 15 00:00:00 EDT 2011
EpiChIP: gene-by-gene quantification of epigenetic modification levels.
Nucleic acids research
Hebenstreit D,Gu M,Haider S,Turner DJ,Liò P,Teichmann SA
12-7133 was used in Flow cytometry/Cell sorting to develop a software package that analyses ChIP-seq data in order to quantify epigenetic modification levels for individual genes.
Tue Mar 01 00:00:00 EST 2011
Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
International immunology
Nakahira M,Nakanishi K
12-7133 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanism by which gene expression pattern is altered in T(h)1 cells in response to IL-18, showing that Gata3 is required for this altered gene expression.
Thu Dec 01 00:00:00 EST 2011
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Journal of immunology (Baltimore, Md. : 1950)
Chen G,Wan H,Luo F,Zhang L,Xu Y,Lewkowich I,Wills-Karp M,Whitsett JA
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that selective expression of Foxa2 plays a key role in regulating Th2 cell-mediated pulmonary inflammation.
Tue Jun 01 00:00:00 EDT 2010
Antigen aggregation decides the fate of the allergic immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zaborsky N,Brunner M,Wallner M,Himly M,Karl T,Schwarzenbacher R,Ferreira F,Achatz G
12-7133 was used in Flow cytometry/Cell sorting to elucidate the molecular background of hypoallergenicity using Betula verrucosa.
Fri Jan 15 00:00:00 EST 2010
In vivo significance of ITK-SLP-76 interaction in cytokine production.
Molecular and cellular biology
Grasis JA,Guimond DM,Cam NR,Herman K,Magotti P,Lambris JD,Tsoukas CD
Thu Jul 01 00:00:00 EDT 2010
In vivo significance of ITK-SLP-76 interaction in cytokine production.
Molecular and cellular biology
Grasis JA,Guimond DM,Cam NR,Herman K,Magotti P,Lambris JD,Tsoukas CD
Thu Jul 01 00:00:00 EDT 2010
IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.
PLoS neglected tropical diseases
Dewals BG,Marillier RG,Hoving JC,Leeto M,Schwegmann A,Brombacher F
12-7133 was used in Flow cytometry/Cell sorting to demonstrate that IL-4Ralpha-responsive T cells are essential to drive alternative macrophage activation, and to control granulomatous inflammation in the liver.
Tue May 18 00:00:00 EDT 2010
