Product References
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
14-5934-82 was used in Flow cytometry/Cell sorting to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
14-5934-82 was used in Flow cytometry/Cell sorting to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.
eLife
Fujimori S,Ohigashi I,Abe H,Matsushita Y,Katagiri T,Taketo MM,Takahama Y,Takada S
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in Immunohistochemistry
Wed Jan 19 00:00:00 EST 2022
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.
The Journal of experimental medicine
Goldfarb Y,Givony T,Kadouri N,Dobeš J,Peligero-Cruz C,Zalayat I,Damari G,Dassa B,Ben-Dor S,Gruper Y,Oftedal BE,Bratland E,Erichsen MM,Berger A,Avin A,Nevo S,Haljasorg U,Kuperman Y,Ulman A,Haffner-Krausz R,Porat Z,Atasoy U,Leshkowitz D,Husebye ES,Abramson J
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to elucidate why some autoimmune regulator (AIRE) mutations are recessive while others dominant and identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
Mon Nov 01 00:00:00 EDT 2021
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.
The Journal of experimental medicine
Goldfarb Y,Givony T,Kadouri N,Dobeš J,Peligero-Cruz C,Zalayat I,Damari G,Dassa B,Ben-Dor S,Gruper Y,Oftedal BE,Bratland E,Erichsen MM,Berger A,Avin A,Nevo S,Haljasorg U,Kuperman Y,Ulman A,Haffner-Krausz R,Porat Z,Atasoy U,Leshkowitz D,Husebye ES,Abramson J
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to elucidate why some autoimmune regulator (AIRE) mutations are recessive while others dominant and identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
Mon Nov 01 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in Flow Cytometry
Wed Apr 21 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that involution of dystrophic thymus exacerbates muscular dystrophy by altering central immune tolerance.
Thu Apr 08 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that involution of dystrophic thymus exacerbates muscular dystrophy by altering central immune tolerance.
Thu Apr 08 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that involution of dystrophic thymus exacerbates muscular dystrophy by altering central immune tolerance.
Thu Apr 08 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
14-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot to indicate that involution of dystrophic thymus exacerbates muscular dystrophy by altering central immune tolerance.
Thu Apr 08 00:00:00 EDT 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Retracing the evolutionary emergence of thymopoiesis.
Science advances
Swann JB,Nusser A,Morimoto R,Nagakubo D,Boehm T
14-5934 was used in Immunohistochemistry to retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the Foxn1/4 transcription factor gene family, which direct the differentiation of the thymic microenvironment.
Sun Nov 01 00:00:00 EDT 2020
Retracing the evolutionary emergence of thymopoiesis.
Science advances
Swann JB,Nusser A,Morimoto R,Nagakubo D,Boehm T
14-5934 was used in Immunohistochemistry to retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the Foxn1/4 transcription factor gene family, which direct the differentiation of the thymic microenvironment.
Sun Nov 01 00:00:00 EDT 2020
Rapid chromatin repression by Aire provides precise control of immune tolerance.
Nature immunology
Koh AS,Miller EL,Buenrostro JD,Moskowitz DM,Wang J,Greenleaf WJ,Chang HY,Crabtree GR
14-5934 was used in Flow cytometry/Cell sorting to demonstrate that Brg1 and Aire fine-tune the expression of tissue-specific genes at levels that prevent toxicity yet promote immune tolerance.
Thu Feb 01 00:00:00 EST 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in ChIP assay
Wed Mar 01 00:00:00 EST 2017
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in ChIP assay
Wed Mar 01 00:00:00 EST 2017
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in ChIP assay
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
14593482 was used in immunohistochemistry to explore the contribution of epithelial cells to systemic sclerosis pathogenesis
Mon Apr 03 00:00:00 EDT 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
14593482 was used in immunohistochemistry to explore the contribution of epithelial cells to systemic sclerosis pathogenesis
Mon Apr 03 00:00:00 EDT 2017
Essential role of CCL21 in establishment of central self-tolerance in T cells.
The Journal of experimental medicine
Kozai M,Kubo Y,Katakai T,Kondo H,Kiyonari H,Schaeuble K,Luther SA,Ishimaru N,Ohigashi I,Takahama Y
14-5934 was used in Flow cytometry/Cell sorting to produce evidence that within the thymic medulla, self-tolerance in T cells is established by CCL21.
Mon Jul 03 00:00:00 EDT 2017
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.
EMBO molecular medicine
Lopes N,Vachon H,Marie J,Irla M
14-5934 was used in Flow cytometry/Cell sorting to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration.
Thu Jun 01 00:00:00 EDT 2017
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.
European journal of immunology
Mayer CE,Žuklys S,Zhanybekova S,Ohigashi I,Teh HY,Sansom SN,Shikama-Dorn N,Hafen K,Macaulay IC,Deadman ME,Ponting CP,Takahama Y,Holländer GA
14-5934 was used in Flow cytometry/Cell sorting to reveal the spatio-temporal dynamics that control the growth of the thymic medulla.
Fri Apr 01 00:00:00 EDT 2016
The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse.
PloS one
Engelmann R,Biemelt A,Cordshagen A,Johl A,Kuthning D,Müller-Hilke B
14-5934 was used in Immunofluorescence on frozen tissues to investigate the expression of peptidylarginine deiminases in murine medullary thymic epithelial cells.
Mon Jul 24 00:00:00 EDT 2017
Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Coder BD,Wang H,Ruan L,Su DM
Published figure using AIRE monoclonal antibody (Product # 14-5934-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
14-5934 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms Aire uses to target loci encoding tissue-specific antigens.
Sat Mar 01 00:00:00 EST 2014
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
14-5934 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms Aire uses to target loci encoding tissue-specific antigens.
Sat Mar 01 00:00:00 EST 2014
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
14-5934 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms Aire uses to target loci encoding tissue-specific antigens.
Sat Mar 01 00:00:00 EST 2014
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
14-5934 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms Aire uses to target loci encoding tissue-specific antigens.
Sat Mar 01 00:00:00 EST 2014
