Product References
CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
The Journal of clinical investigation
Sato Y,Oguchi A,Fukushima Y,Masuda K,Toriu N,Taniguchi K,Yoshikawa T,Cui X,Kondo M,Hosoi T,Komidori S,Shimizu Y,Fujita H,Jiang L,Kong Y,Yamanashi T,Seita J,Yamamoto T,Toyokuni S,Hamazaki Y,Hattori M,Yoshikai Y,Boor P,Floege J,Kawamoto H,Murakawa Y,Minato N,Yanagita M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 18 00:00:00 EST 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy.
Journal for immunotherapy of cancer
Hu J,He J,Wang Y,Zhao Y,Fang K,Dong Y,Chen Y,Zhang Y,Zhang C,Wang H,Tan J,Wang J,Zi R,Liu C,Liang H,Guo Y,Ou J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Nature immunology
Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
The role of dendritic cells for therapy of B-cell lymphoma with immune checkpoint inhibitors.
Cancer immunology, immunotherapy : CII
Scheuerpflug A,Ahmetlić F,Bauer V,Riedel T,Röcken M,Mocikat R
14-9985 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells (DCs) for the therapeutic effect of ICB in a λ-MYC-transgenic mouse model of endogenously arising B-cell lymphoma.
Sat May 01 00:00:00 EDT 2021
Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Man K,Chen Z
14-9985-82 was used in Flow Cytometry to evaluate the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T cell responses in the immune-competent murine mesothelioma model.
Fri Mar 26 00:00:00 EDT 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Thu Dec 02 00:00:00 EST 2021
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.
JCI insight
Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Jan 25 00:00:00 EST 2021
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Thu Aug 26 00:00:00 EDT 2021
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.
Cell reports
Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 05 00:00:00 EST 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.
The Journal of experimental medicine
Fumagalli V,Di Lucia P,Venzin V,Bono EB,Jordan R,Frey CR,Delaney W,Chisari FV,Guidotti LG,Iannacone M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Nov 02 00:00:00 EST 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
14-9985-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.
Mon Feb 03 00:00:00 EST 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
14-9985-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.
Mon Feb 03 00:00:00 EST 2020
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion.
Oncology letters
Shang K,Wang Z,Hu Y,Huang Y,Yuan K,Yu Y
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.
Frontiers in immunology
Ebelt ND,Zuniga E,Johnson BL,Diamond DJ,Manuel ER
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.
Antioxidants (Basel, Switzerland)
Lee HJ,Park JS,Yoo HJ,Lee HM,Lee BC,Kim JH
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Oct 20 00:00:00 EDT 2020
Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z
14-9985-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.
Fri Mar 27 00:00:00 EDT 2020
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.
Oncoimmunology
Ye X,Waite JC,Dhanik A,Gupta N,Zhong M,Adler C,Malahias E,Ni M,Wei Y,Gurer C,Zhang W,Macdonald LE,Murphy AJ,Sleeman MA,Skokos D
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Wed May 13 00:00:00 EDT 2020
CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses.
Vaccines
Lewis PE,Poteet EC,Liu D,Chen C,LaBranche CC,Stanfield-Oakley SA,Montefiori DC,Ferrari G,Yao Q
14-9985-82 was used in Flow Cytometry to show that CTLA-4 blockade can increase the levels of HIV antigen-specific B-cell and antigen-specific Tfh cell activity and impact humoral immune responses when combined with a clinically relevant HIV VLP-based vaccine.
Sat Jun 06 00:00:00 EDT 2020
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-9985 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases.
OncoTargets and therapy
Zhang J,Pang Y,Xie T,Zhu L
14-9985-82 was used in Flow Cytometry to provide preclinical evidence that AMD3465 treatment in combination with IDO1 inhibition may be a promising therapeutic regimen for refractory metastasized breast cancers.
Sat Apr 09 00:00:00 EDT 2022
Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.
Cell reports
Burrack AL,Spartz EJ,Raynor JF,Wang I,Olson M,Stromnes IM
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Aug 20 00:00:00 EDT 2019
Acetate Promotes T Cell Effector Function during Glucose Restriction.
Cell reports
Qiu J,Villa M,Sanin DE,Buck MD,O'Sullivan D,Ching R,Matsushita M,Grzes KM,Winkler F,Chang CH,Curtis JD,Kyle RL,Van Teijlingen Bakker N,Corrado M,Haessler F,Alfei F,Edwards-Hicks J,Maggi LB,Zehn D,Egawa T,Bengsch B,Klein Geltink RI,Jenuwein T,Pearce EJ,Pearce EL
14-9985-82 was used in Flow Cytometry to show that acetate rescues effector function in glucose-restricted CD8+ T cells.
Tue May 14 00:00:00 EDT 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-9985 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division.
The Journal of experimental medicine
Bohineust A,Garcia Z,Beuneu H,Lemaître F,Bousso P
14-9985 was used in Flow cytometry/Cell sorting to propose that transient unresponsiveness represents an essential phase of T cell priming that promotes T cell disengagement from APCs and favors effective clonal expansion.
Mon May 07 00:00:00 EDT 2018
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ferdinand JR,Richard AC,Meylan F,Al-Shamkhani A,Siegel RM
14-9985 was used in Flow cytometry/Cell sorting to suggest differential roles for membrane and soluble TL1A on adaptive and innate immune cells and have implications for the consequences of blocking these two forms of TL1A.
Thu Feb 15 00:00:00 EST 2018
PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.
Journal of Cancer
Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2020
PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.
Journal of Cancer
Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2020
Reactive glia promote development of CD103+ CD69+ CD8+ T-cells through programmed cell death-ligand 1 (PD-L1).
Immunity, inflammation and disease
Prasad S,Hu S,Sheng WS,Chauhan P,Lokensgard JR
14-9985 was used in Flow cytometry/Cell sorting to demonstrate a role for activated glia in promoting development of bTRM through the PD-1: PD-L1 pathway.
Fri Jun 01 00:00:00 EDT 2018
Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function.
eLife
Bettonville M,d'Aria S,Weatherly K,Porporato PE,Zhang J,Bousbata S,Sonveaux P,Braun MY
14-9985 was used in Flow cytometry/Cell sorting to examine how persistent antigenic stimulation affects T cell metabolism.
Mon Jun 18 00:00:00 EDT 2018
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.
The Journal of experimental medicine
Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z
14-9985-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.
Wed Feb 01 00:00:00 EST 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Sat Jul 15 00:00:00 EDT 2017
NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.
European journal of immunology
Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S
14-9985 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.
Fri Sep 01 00:00:00 EDT 2017
Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.
Oncotarget
Peer S,Baier G,Gruber T
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jun 27 00:00:00 EDT 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.
The Journal of clinical investigation
Patterson SJ,Pesenacker AM,Wang AY,Gillies J,Mojibian M,Morishita K,Tan R,Kieffer TJ,Verchere CB,Panagiotopoulos C,Levings MK
14-9985-82 was used in Flow Cytometry to investigate how Treg-to-target proximity is controlled.
Tue Mar 01 00:00:00 EST 2016
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination.
Scientific reports
Knowlden ZA,Sant AJ
14-9985 was used in Flow cytometry/Cell sorting to study the effect of peptide specificity on the clonal expansion of follicular helper T cell (Tfh) and NonTfh cell populations in response to influenza.
Wed Jun 22 00:00:00 EDT 2016
Attenuation of the programmed cell death-1 pathway increases the M1 polarization of macrophages induced by zymosan.
Cell death & disease
Chen W,Wang J,Jia L,Liu J,Tian Y
14-9985 was used in Flow cytometry/Cell sorting to find that PD-1 engagement followed by zymosan stimulation might primarily attenuate the phosphorylation of tyrosine residue in PD-1 receptor/ligand and the recruitment of SHP-2 to PD-1 receptor/ligand.
Thu Feb 25 00:00:00 EST 2016
PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Immunoendocrinology (Houston, Tex.)
Martinov T,Spanier JA,Pauken KE,Fife BT
14-9985 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.
Wed Mar 30 00:00:00 EDT 2022
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Nature immunology
Choi YS,Gullicksrud JA,Xing S,Zeng Z,Shan Q,Li F,Love PE,Peng W,Xue HH,Crotty S
14-9985 was used in Flow cytometry/Cell sorting to report that selective loss of Lef1 or Tcf7 results in T(FH) cell defects.
Tue Sep 01 00:00:00 EDT 2015
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Lobo PI,Schlegel KH,Bajwa A,Huang L,Kurmaeva E,Wang B,Ye H,Tedder TF,Kinsey GR,Okusa MD
14-9985 was used in Flow cytometry/Cell sorting to investigate how natural IgM anti-leukocyte Abs can switch BMDC to a regulatory phenotype despite the presence of LPS that ordinarily induces BMDC maturation.
Tue Dec 01 00:00:00 EST 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-9985 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-9985 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 EST 2015
PD-L1hi B cells are critical regulators of humoral immunity.
Nature communications
Khan AR,Hams E,Floudas A,Sparwasser T,Weaver CT,Fallon PG
14-9985 was used in Functional assays to demonstrate that elevated PD-L1 expression on B cells is an important regulator of T follicular helper-cell activity, downstream antibody responses and autoimmune disease.
Thu Jan 22 00:00:00 EST 2015
Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hongo D,Tang X,Baker J,Engleman EG,Strober S
14-9985 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms required for suitable immune tolerance for combined bone marrow and heart transplant acceptance in mice.
Sat Nov 01 00:00:00 EDT 2014
Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.
The Journal of infectious diseases
Vogelzang A,Perdomo C,Zedler U,Kuhlmann S,Hurwitz R,Gengenbacher M,Kaufmann SH
14-9985 was used in Flow cytometry/Cell sorting to investigate the T-cell population required for recombinant Bacillus Calmette-Guérin δureC::hly vaccine's enhanced protection against tuberculosis.
Mon Dec 15 00:00:00 EST 2014
Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.
Journal of innate immunity
Ayala A,Elphick GF,Kim YS,Huang X,Carreira-Rosario A,Santos SC,Shubin NJ,Chen Y,Reichner J,Chung CS
14-9985 was used in Flow cytometry/Cell sorting to investigate the effect of programmed cell death receptor-1 in mediating aspects of innate macrophage immune dysfunction during sepsis.
Mon May 11 00:00:00 EDT 2015
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
14-9985-82 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 EDT 2014
B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.
Journal of immunology (Baltimore, Md. : 1950)
Weinstein JS,Bertino SA,Hernandez SG,Poholek AC,Teplitzky TB,Nowyhed HN,Craft J
14-9985 was used in Flow cytometry/Cell sorting to study the role of B cells in the development of Tfh cells and germinal centres.
Tue Apr 01 00:00:00 EDT 2014
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using CD279 (PD-1) monoclonal antibody (Product # 14-9985-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.
PLoS biology
Peine M,Rausch S,Helmstetter C,Fröhlich A,Hegazy AN,Kühl AA,Grevelding CG,Höfer T,Hartmann S,Löhning M
14-9985 was used in Flow cytometry/Cell sorting to characterise Th1/Th2 hybrid cells and assess their role in inflammation.
Thu Mar 06 00:00:00 EST 2014
Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Ma Y,Dawicki W,Zhang X,Gordon JR
14-9985 was used in Flow cytometry/Cell sorting to compare abilities of nTreg and iTreg cells to mediate tolerance in OVA-asthmatic C57BL/6 mice.
Thu Aug 01 00:00:00 EDT 2013
Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.
Journal of immunology (Baltimore, Md. : 1950)
Koni PA,Bolduc A,Takezaki M,Ametani Y,Huang L,Lee JR,Nutt SL,Kamanaka M,Flavell RA,Mellor AL,Tsubata T,Shimoda M
14-9985 was used in Flow cytometry/Cell sorting to investigate the role of constitutively CD40-activated B cells in the CD8 T cell inflammatory response.
Mon Apr 01 00:00:00 EDT 2013
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.
Infection and immunity
Bhadra R,Cobb DA,Khan IA
14-9985 was used in Flow cytometry/Cell sorting to determine if treatment with exogenous CD8+ T cells can rescue the endogenous population during Toxoplasma gondii infection.
Sun Sep 01 00:00:00 EDT 2013
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.
The Journal of biological chemistry
Zhong MC,Veillette A
14-9985 was used in Flow cytometry/Cell sorting to investigate how SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types.
Fri Nov 01 00:00:00 EDT 2013
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
The Journal of experimental medicine
Yokosuka T,Takamatsu M,Kobayashi-Imanishi W,Hashimoto-Tane A,Azuma M,Saito T
14-9985 was used in Western Blotting to investigate the molecular mechanisms of PD-1-mediated suppression of T cell activation, showing that it inhibits T cell receptor signalling via SHP2.
Mon Jun 04 00:00:00 EDT 2012
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Huang L,Jaworska K,Khutsishvili K,Becker DA,Ye H,Lobo PI,Okusa MD
14-9985 was used in Flow cytometry/Cell sorting to demonstrate that the simultaneous ability to generate and respond to adenosine is required for Tregs to suppress innate immune responses in IRI through a PD-1-dependent mechanism.
Sat Sep 01 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
14-9985 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells.
Diabetes
Krishnamurthy B,Chee J,Jhala G,Fynch S,Graham KL,Santamaria P,Morahan G,Allison J,Izon D,Thomas HE,Kay TW
14-9985 was used in Flow cytometry/Cell sorting to indicate that peripheral tolerance alone can protect NOD8.3 mice from autoimmune diabetes.
Wed Feb 01 00:00:00 EST 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
14-9985 was used in Blocking experiments to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 EDT 2012
Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation.
Frontiers in immunology
Bachem A,Hartung E,Güttler S,Mora A,Zhou X,Hegemann A,Plantinga M,Mazzini E,Stoitzner P,Gurka S,Henn V,Mages HW,Kroczek RA
14-9985 was used in Flow cytometry/Cell sorting to provide evidence that expression of XCR1 throughout the body defines the Batf3-dependent lineage of DCs with a special capacity to cross-present antigen.
Thu Aug 23 00:00:00 EDT 2012
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
Immunity
Choi YS,Kageyama R,Eto D,Escobar TC,Johnston RJ,Monticelli L,Lao C,Crotty S
14-9985 was used in Flow cytometry/Cell sorting to demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5, the canonical feature of Tfh cells.
Fri Jun 24 00:00:00 EDT 2011
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Journal of virology
Allen SJ,Hamrah P,Gate D,Mott KR,Mantopoulos D,Zheng L,Town T,Jones C,von Andrian UH,Freeman GJ,Sharpe AH,BenMohamed L,Ahmed R,Wechsler SL,Ghiasi H
14-9985 was used in Immunofluorescence to suggest that PD-1 and Tim-3 are facilitators of CD8(+) T cell exhaustion and dormancy in herpes simplex virus-1 infection.
Sun May 01 00:00:00 EDT 2011
B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.
Journal of immunology (Baltimore, Md. : 1950)
Salek-Ardakani S,Choi YS,Rafii-El-Idrissi Benhnia M,Flynn R,Arens R,Shoenberger S,Crotty S,Croft M,Salek-Ardakani S
14-9985 was used in Flow cytometry/Cell sorting to determine the effects of B7-1 and B7-2 interactions on follicular Th (T(FH)) cell function in response to vaccinia virus.
Sun May 01 00:00:00 EDT 2011
Plasma cells negatively regulate the follicular helper T cell program.
Nature immunology
Pelletier N,McHeyzer-Williams LJ,Wong KA,Urich E,Fazilleau N,McHeyzer-Williams MG
14-9985 was used in Flow cytometry/Cell sorting to study plasma cells, showing that they negatively regulate the follicular helper T cell program.
Wed Dec 01 00:00:00 EST 2010
Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells.
Investigative ophthalmology & visual science
Chen L,Sham CW,Chan AM,Francisco LM,Wu Y,Mareninov S,Sharpe AH,Freeman GJ,Yang XJ,Braun J,Gordon LK
14-9985-82 was used in Inhibition experiments to support a novel role for a PD-1-mediated signaling pathway in developmental programmed cell death during postnatal retinal ganglion cell maturation.
Thu Oct 01 00:00:00 EDT 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
14-9985-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 EDT 2009
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology
Wahl C,Bochtler P,Chen L,Schirmbeck R,Reimann J
14-9985 was used in Flow cytometry/Cell sorting to study the relationship between B7-H1 on hepatocytes and specific CD8 T cells.
Mon Sep 01 00:00:00 EDT 2008
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine
Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH
Mon Jul 07 00:00:00 EDT 2003
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.
The Journal of experimental medicine
Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH
Mon Jul 07 00:00:00 EDT 2003
