Product References
Overproduction of IFNγ by Cbl-b-Deficient CD8+ T Cells Provides Resistance against Regulatory T Cells and Induces Potent Antitumor Immunity.
Cancer immunology research
Han S,Liu ZQ,Chung DC,Paul MS,Garcia-Batres CR,Sayad A,Elford AR,Gold MJ,Grimshaw N,Ohashi PS
16-7311-81 was used in Treg suppression assay to demonstrate that the hypersecretion of IFNγ serves as a key mechanism by which Cbl-b-deficient CD8+ T cells are rendered resistant to Tregs.
Fri Apr 01 00:00:00 EDT 2022
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
16-7311-81 was used in Cell Culture to investigate the molecular basis for Siglec-1 binding to regulatory T cells using in vitro-induced cells as a model system.
Tue Mar 01 00:00:00 EST 2022
Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Qiu R,Yu X,Wang L,Han Z,Yao C,Cui Y,Hou G,Dai D,Jin W,Shen N
16-7311-81 was used in Functional assay to investigate if CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes compared with homeostatic intestinal TH17 cells.
Mon Jun 15 00:00:00 EDT 2020
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
16-7311-81 was used in T-Cell Activation to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms.
Tue Sep 01 00:00:00 EDT 2020
The MicroRNA miR-22 Represses Th17 Cell Pathogenicity by Targeting PTEN-Regulated Pathways.
ImmunoHorizons
Wang L,Qiu R,Zhang Z,Han Z,Yao C,Hou G,Dai D,Jin W,Tang Y,Yu X,Shen N
16-7311-81 was used in In vitro Assay to identify that Th17 cell-intrinsic miR-22 could protect mice from autoimmunity by targeting PTEN-regulated pathways.
Tue Jun 09 00:00:00 EDT 2020
CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection.
Cell reports
Wen J,Wang YT,Valentine KM,Dos Santos Alves RP,Xu Z,Regla-Nava JA,Ngono AE,Young MP,Ferreira LCS,Shresta S
16-7311 was used in Flow cytometry/Cell sorting to examine the ability of DENV/ZIKV-cross-reactive CD4+ T cells to protect against versus exacerbate ZIKV infection.
Tue Apr 28 00:00:00 EDT 2020
Proteomic Profiling of Mouse Helper T Cell Differentiation.
Proteomics
van den Ham HJ,Binai NA,Zaaraoui-Boutahar F,Heck AJR,Andeweg AC
16-7311-81 was used in In vitro Assay to support the design of prophylactic and therapeutic intervention strategies for (infectious) diseases.
Mon Apr 01 00:00:00 EDT 2019
Interleukin‑12 exacerbates Sjögren's syndrome through induction of myeloid‑derived suppressor cells.
Molecular medicine reports
Qi J,Li D,Shi G,Zhang X,Pan Y,Dou H,Wang T,Yao G,Hou Y
16-7311-81 was used in Flow Cytometry to suggest that aggravation of SS‚like symptoms by IL‚12 in NOD mice may be attributed to its promotion of MDSC development.
Thu Aug 01 00:00:00 EDT 2019
Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Wildes TJ,Grippin A,Dyson KA,Wummer BM,Damiani DJ,Abraham RS,Flores CT,Mitchell DA
16-7311 was used in a Functional assay to demonstrate that cellular interactions between adoptively transferred tumour-reactive T cells and bone marrow-derived haematopoietic stem and progenitor cells lead to the generation of potent intratumoural dendritic cells within the CNS compartment.
Wed Aug 15 00:00:00 EDT 2018
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Nature
Xu T,Stewart KM,Wang X,Liu K,Xie M,Ryu JK,Li K,Ma T,Wang H,Ni L,Zhu S,Cao N,Zhu D,Zhang Y,Akassoglou K,Dong C,Driggers EM,Ding S
16-7311-81 was used in Immunohistochemistry, Functional Assay, Neutralization to investigate T helper 17 cell differentiation and fate.
Thu Aug 10 00:00:00 EDT 2017
Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E2 axis.
Scientific reports
Yu M,Guo G,Zhang X,Li L,Yang W,Bollag R,Cui Y
16-7311 was used in Flow cytometry/Cell sorting to identify an intrinsic mechanism of fibroblastic reticular cells shared between mice and humans for suppressing T cell sensitivity to activation via PGE2.
Tue Jun 13 00:00:00 EDT 2017
PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas.
Scientific reports
Navarro J,Gozalbo-López B,Méndez AC,Dantzer F,Schreiber V,Martínez C,Arana DM,Farrés J,Revilla-Nuin B,Bueno MF,Ampurdanés C,Galindo-Campos MA,Knobel PA,Segura-Bayona S,Martin-Caballero J,Stracker TH,Aparicio P,Del Val M,Yélamos J
16-7311 was used in Flow cytometry/Cell sorting to establish a coordinated role of PARP-1 and PARP-2 in T-cell homeostasis that might impact on the development of PARP-centred therapies.
Thu Feb 09 00:00:00 EST 2017
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.
Mucosal immunology
Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA
16-7311 was used in Flow cytometry/Cell sorting to show that macrophages are required for the maintenance of type 2 immunity within affected tissues but not within secondary lymphoid organs.
Fri Jan 01 00:00:00 EST 2016
Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells.
Mediators of inflammation
Huang P,Zhou Y,Liu Z,Zhang P
16-7311 was used in Functional assays to investigate the interaction effects of ANXA1 and GATA-3 to influence T cell differentiation in CD4(+) T cells.
Fri May 19 00:00:00 EDT 2017
Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models.
Scientific reports
Yang L,Cai C,Feng Q,Shi Y,Zuo Q,Yang H,Jing H,Wei C,Zhuang Y,Zou Q,Zeng H
16-7311 was used in Neutralization experiments to design a novel chimeric vaccine for S. aureus infection.
Thu Feb 11 00:00:00 EST 2016
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one
Fontana MF,Baccarella A,Craft JF,Boyle MJ,McIntyre TI,Wood MD,Thorn KS,Anidi C,Bayat A,Chung MR,Hamburger R,Kim CY,Pearman E,Pham J,Tang JJ,Boon L,Kamya MR,Dorsey G,Feeney ME,Kim CC
16-7311 was used in Flow cytometry/Cell sorting to investigate aspects of the human immune response to asymptomatic persistent Plasmodium infection using a novel animal model.
Wed Aug 02 00:00:00 EDT 2017
Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage.
PLoS neglected tropical diseases
Martínez Gómez JM,Ong LC,Lam JH,Binte Aman SA,Libau EA,Lee PX,St John AL,Alonso S
16-7311 was used in Neutralization experiments to report an antibody mediated disease enhancement model that is mediated by maternal antibodies in type I IFN receptor-deficient A129 mice.
Tue Mar 01 00:00:00 EST 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
16-7311 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 EDT 2016
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses.
Scientific reports
Li Y,Wang H,Zhou X,Xie X,Chen X,Jie Z,Zou Q,Hu H,Zhu L,Cheng X,Brightbill HD,Wu LC,Wang L,Sun SC
16-7311 was used in Flow cytometry/Cell sorting to demonstrate a role for NF-κB inducing kinase in regulating the homeostasis and function of peripheral T cells.
Thu Feb 25 00:00:00 EST 2016
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.
Oncoimmunology
Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB
16-7311 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.
Tue Jan 12 00:00:00 EST 2021
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
16-7311 was used in Flow cytometry/Cell sorting to exhibit a preclinical strategy for the identification and development of highly effective antitumour combination immunotherapies.
Fri Aug 25 00:00:00 EDT 2017
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice.
Frontiers in immunology
Shen W,Hixon JA,McLean MH,Li WQ,Durum SK
16-7311 was used in Flow cytometry/Cell sorting to identify and explore the function, plasticity, pathogenicity and location of IL-22-expressing lymphocytes in reporter mice.
Tue Feb 02 00:00:00 EST 2016
Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription.
European journal of immunology
Sercan Alp Ö,Durlanik S,Schulz D,McGrath M,Grün JR,Bardua M,Ikuta K,Sgouroudis E,Riedel R,Zehentmeier S,Hauser AE,Tsuneto M,Melchers F,Tokoyoda K,Chang HD,Thiel A,Radbruch A
16-7311 was used in Flow cytometry/Cell sorting to suggest that CD8+ memory T cells are maintained in the bone marrow, conditional on IL-7 receptor signaling.
Wed Apr 01 00:00:00 EDT 2015
Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)
Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S
16-7311 was used in Flow cytometry/Cell sorting to study the factors in the tissue microenvironment and signalling networks critical for programming dendritic cells to control chronic inflammation and promote tolerance, showing that Th1/Th17 responses are regulated by canonical Wnt signalling in dendritic cells and suppresses autoimmune neuroinflammation.
Wed Apr 01 00:00:00 EDT 2015
Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.
Journal of immunology (Baltimore, Md. : 1950)
Evonuk KS,Baker BJ,Doyle RE,Moseley CE,Sestero CM,Johnston BP,De Sarno P,Tang A,Gembitsky I,Hewett SJ,Weaver CT,Raman C,DeSilva TM
16-7311 was used in Flow cytometry/Cell sorting to investigate the link between inflammation and glutamate dysregulation in EAE, showing that inhibition of system Xc(-) transporter attenuates autoimmune inflammatory demyelination.
Wed Jul 15 00:00:00 EDT 2015
Skeletal muscle interleukin 15 promotes CD8(+) T-cell function and autoimmune myositis.
Skeletal muscle
Huang PL,Hou MS,Wang SW,Chang CL,Liou YH,Liao NS
16-7311 was used in Flow cytometry/Cell sorting to highlight a new level of complexity in TRAIL signalling and point to an improved therapeutic rationale in view of hitherto disappointing results.
Tue Sep 29 00:00:00 EDT 2015
Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.
Vaccine
Arnold IC,Hutchings C,Kondova I,Hey A,Powrie F,Beverley P,Tchilian E
16-7311 was used in Flow cytometry/Cell sorting to show that alteration of the intestinal microbiota can profoundly influence protection induced by a TB subunit vaccine via an IL10-dependent mechanism.
Wed Apr 08 00:00:00 EDT 2015
Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome.
Infection and immunity
Zhang ZQ,Wang J,Hoy Z,Keegan A,Bhagwat S,Gigliotti F,Wright TW
16-7311 was used in Flow cytometry/Cell sorting to demonstrate that restricting the ability of macrophages to polarize in response to Th1 or Th2 cytokines does not impair Pneumocystis clearance.
Tue Dec 01 00:00:00 EST 2015
Prevention of Tumor Formation by Latent Gammaherpesvirus Infection.
PloS one
Raffegerst S,Steer B,Hohloch M,Adler H
16-7311 was used in Functional assays to demonstrate that under certain circumstances, chronic herpesvirus infection may prevent the development of tumors.
Mon Jul 04 00:00:00 EDT 2016
Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice.
PloS one
Kornete M,Mason ES,Girouard J,Lafferty EI,Qureshi S,Piccirillo CA
16-7311 was used in Flow cytometry/Cell sorting to reveal that CXCR3-mediated trafficking of Tregs could represent a mechanism of homeostatic immunoregulation during diabetogenesis.
Mon Apr 25 00:00:00 EDT 2016
Ginseng Berry Extract Promotes Maturation of Mouse Dendritic Cells.
PloS one
Zhang W,Cho SY,Xiang G,Min KJ,Yu Q,Jin JO
16-7311 was used in Flow cytometry/Cell sorting to demonstrate the potential for ginseng extract as a novel therapeutic tumour vaccine adjuvant.
Wed Apr 13 00:00:00 EDT 2016
Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.
Scientific reports
Casiraghi C,Márquez AC,Shanina I,Horwitz MS
16-7311 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.
Thu Sep 10 00:00:00 EDT 2015
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.
The Journal of experimental medicine
Farin HF,Karthaus WR,Kujala P,Rakhshandehroo M,Schwank G,Vries RG,Kalkhoven E,Nieuwenhuis EE,Clevers H
16-7311 was used in Functional assays to study the control of paneth cell degranulation in primary epithelial organoids in culture, showing that it is directly controlled by immune cell-derived IFN-γ.
Mon Jun 30 00:00:00 EDT 2014
Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.
EMBO molecular medicine
Diana J,Lehuen A
16-7311 was used in Flow cytometry/Cell sorting to determine the cellular and molecular mechanisms leading to the recruitment of neutrophils in the pancreatic islets of non-obese diabetic mice.
Fri Aug 01 00:00:00 EDT 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
16-7311 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 EDT 2014
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Proceedings of the National Academy of Sciences of the United States of America
Limon JJ,So L,Jellbauer S,Chiu H,Corado J,Sykes SM,Raffatellu M,Fruman DA
16-7311 was used in in vitro experiments to further elucidate the complexity of mTOR signalling in B cells.
Tue Nov 25 00:00:00 EST 2014
Rapid generation of a mouse model for Middle East respiratory syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Zhao J,Li K,Wohlford-Lenane C,Agnihothram SS,Fett C,Zhao J,Gale MJ,Baric RS,Enjuanes L,Gallagher T,McCray PB,Perlman S
16-7311 was used in Immunohistochemistry to demonstrate that this system will be useful for MERS-CoV studies and for the rapid development of relevant animal models for emerging respiratory viral infections.
Tue Apr 01 00:00:00 EDT 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
16-7311 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
16-7311 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
16-7311 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Cancer immunology research
Ohkuri T,Ghosh A,Kosaka A,Zhu J,Ikeura M,David M,Watkins SC,Sarkar SN,Okada H
16-7311 was used in Flow cytometry/Cell sorting to display a potential use of STING agonists for the development of effective immunotherapy.
Mon Dec 01 00:00:00 EST 2014
IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.
Mucosal immunology
Webster KE,Kim HO,Kyparissoudis K,Corpuz TM,Pinget GV,Uldrich AP,Brink R,Belz GT,Cho JH,Godfrey DI,Sprent J
16-7311 was used in Flow cytometry/Cell sorting to elucidate the factors that maintain the natural killer T cell population in the periphery.
Mon Sep 01 00:00:00 EDT 2014
γδ T cells restrain extrathymic development of Foxp3+-inducible regulatory T cells via IFN-γ.
European journal of immunology
Visperas A,Shen B,Min B
16-7311 was used in Flow cytometry/Cell sorting to reveal a novel function of γδ T cells in limiting the generation of iTreg cells, potentially balancing immunity and tolerance.
Fri Aug 01 00:00:00 EDT 2014
Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection.
Journal of virology
Channappanavar R,Fett C,Zhao J,Meyerholz DK,Perlman S
16-7311 was used in Flow cytometry/Cell sorting to determine the factors governing a successful immune response to lethal SARS-CoV challenge.
Wed Oct 01 00:00:00 EDT 2014
Autocrine interleukin-6 drives skin-derived mesenchymal stem cell trafficking via regulating voltage-gated Ca(2+) channels.
Stem cells (Dayton, Ohio)
Ke F,Zhang L,Liu Z,Liu J,Yan S,Xu Z,Bai J,Zhu H,Lou F,Wang H,Shi Y,Jiang Y,Su B,Wang H
16-7311 was used in Functional assays to identify that skin-derived mesenchymal stem cells secrete high levels of interleukin-6 in inflammatory conditions.
Wed Oct 01 00:00:00 EDT 2014
IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection.
Journal of immunology (Baltimore, Md. : 1950)
Ahlfors H,Morrison PJ,Duarte JH,Li Y,Biro J,Tolaini M,Di Meglio P,Potocnik AJ,Stockinger B
16-7311 was used in Flow cytometry/Cell sorting to identify, trace and investigate IL-22-producing cells in vivo.
Sat Nov 01 00:00:00 EDT 2014
Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection.
Infection and immunity
Jeong YH,Jeon BY,Gu SH,Cho SN,Shin SJ,Chang J,Ha SJ
16-7311 was used in Flow cytometry/Cell sorting to investigate the phenotype and function of different antigen-specific T cells during Mycobacterium tuberculosis infection.
Wed Jan 01 00:00:00 EST 2014
CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response.
Journal of the American Heart Association
Kasahara K,Sasaki N,Yamashita T,Kita T,Yodoi K,Sasaki Y,Takeda M,Hirata K
16-7311 was used in Flow cytometry/Cell sorting to investigate the inhibition of atherosclerosis by a CD3 antibody and IL-2 complex combination.
Tue Apr 22 00:00:00 EDT 2014
Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.
Cell reports
Mahata B,Zhang X,Kolodziejczyk AA,Proserpio V,Haim-Vilmovsky L,Taylor AE,Hebenstreit D,Dingler FA,Moignard V,Göttgens B,Arlt W,McKenzie AN,Teichmann SA
16-7311 was used in Functional assays to demonstrate the production of the steroid pregnenolone by Th2 cells in vitro and in vivo in a helminth infection model.
Thu May 22 00:00:00 EDT 2014
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
16-7311 was used in Flow cytometry/Cell sorting to explore the proneurogenic potential of interleukin 17-producing T helper (Th17) cells.
Fri Mar 06 00:00:00 EST 2020
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
eLife
Sojka DK,Plougastel-Douglas B,Yang L,Pak-Wittel MA,Artyomov MN,Ivanova Y,Zhong C,Chase JM,Rothman PB,Yu J,Riley JK,Zhu J,Tian Z,Yokoyama WM
16-7311 was used in Flow cytometry/Cell sorting to investigate whether tissue-resident and cells resembling conventional splenic natural killer cells natural killer cells are derived from the same lineage, showing that there are at least four distinct lineages.
Wed Jan 01 00:00:00 EST 2014
Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation.
Marine drugs
Zhang W,Du JY,Jiang Z,Okimura T,Oda T,Yu Q,Jin JO
16-7311 was used in an ELISA assay to demonstrate that marine-derived ascophyllan induces DC maturation, and consequently enhances Th1 and Tc1 responses in vivo.
Mon Jul 14 00:00:00 EDT 2014
Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation.
Marine drugs
Zhang W,Du JY,Jiang Z,Okimura T,Oda T,Yu Q,Jin JO
16-7311 was used in an ELISA assay to demonstrate that marine-derived ascophyllan induces DC maturation, and consequently enhances Th1 and Tc1 responses in vivo.
Mon Jul 14 00:00:00 EDT 2014
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
16-7311 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Nature
Kleinewietfeld M,Manzel A,Titze J,Kvakan H,Yosef N,Linker RA,Muller DN,Hafler DA
16-7311 was used in Flow cytometry/Cell sorting to investigate the environmental factors that influence TH17 cells, showing that sodium chloride induces TH17 cells and drives autoimmune disease.
Thu Apr 25 00:00:00 EDT 2013
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nature immunology
Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ
16-7311 was used in Flow cytometry/Cell sorting to provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.
Wed May 01 00:00:00 EDT 2013
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Nature immunology
Garris CS,Wu L,Acharya S,Arac A,Blaho VA,Huang Y,Moon BS,Axtell RC,Ho PP,Steinberg GK,Lewis DB,Sobel RA,Han DK,Steinman L,Snyder MP,Hla T,Han MH
16-7311 was used in Flow cytometry/Cell sorting to identify the non-functioning S1P1 gene as a key factor contributing to the development of severe experimental autoimmune encephalomyelitis.
Fri Nov 01 00:00:00 EDT 2013
Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection.
Proceedings of the National Academy of Sciences of the United States of America
Tregoning JS,Wang BL,McDonald JU,Yamaguchi Y,Harker JA,Goritzka M,Johansson C,Bukreyev A,Collins PL,Openshaw PJ
16-7311 was used in Inhibition experiments to examine the role of interferon-γ in inhibiting the antibody response to respiratory syncytial virus infection after neonatal infection.
Tue Apr 02 00:00:00 EDT 2013
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
PLoS pathogens
Villegas-Mendez A,de Souza JB,Lavelle SW,Gwyer Findlay E,Shaw TN,van Rooijen N,Saris CJ,Hunter CA,Riley EM,Couper KN
16-7311 was used in Flow cytometry/Cell sorting to investigate the molecular basis of IL-27 receptor/ WSX-1-mediated regulation of Th1 responses in vivo during malaria infection.
Fri Jan 10 00:00:00 EST 2014
Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production.
Acta pharmacologica Sinica
Kong FY,Chen W,He SJ,Lin ZM,Li X,Zhang XH,Yang XQ,Zhu FH,Tong XK,Zhou Y,Tang W,Duan WH,Zuo JP
16-7311 was used in Flow cytometry/Cell sorting to investigate the interaction between the mycophenolic acid derivative, 118, and the immune environment in a murine allogeneic skin graft model.
Mon Jul 01 00:00:00 EDT 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
16-7311 was used in Immunofluorescence to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 EST 2013
ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Zumwalde NA,Domae E,Mescher MF,Shimizu Y
16-7311 was used in Flow cytometry/Cell sorting to demonstrate that during CD8 T cell activation, the T cell clustering mechanism allows for continued proliferation of T cells, and regulates CD8 T cell effector function and differentiation.
Tue Oct 01 00:00:00 EDT 2013
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.
Journal of immunology (Baltimore, Md. : 1950)
Baird JR,Byrne KT,Lizotte PH,Toraya-Brown S,Scarlett UK,Alexander MP,Sheen MR,Fox BA,Bzik DJ,Bosenberg M,Mullins DW,Turk MJ,Fiering S
16-7311 was used in Flow cytometry/Cell sorting to show that intratumoral administration of a highly immunogenic but attenuated parasite could induce rejection of an established, poorly immunogenic melanoma.
Tue Jan 01 00:00:00 EST 2013
Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.
Vaccine
Beverley P,Ronan E,Lee L,Arnold I,Bolinger B,Powrie F,Tchilian E
16-7311 was used in Flow cytometry/Cell sorting to show that exposure to environmental microorganisms can alter the protective immune response to a parenterally administered subunit vaccine.
Mon Feb 04 00:00:00 EST 2013
IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke.
Metabolic brain disease
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
16-7311 was used in Flow cytometry/Cell sorting to determine whether the IL-10-producing regulatory B-cell subset can limit CNS inflammation and reduce infarct volume following ischemic stroke in B-cell deficient mice.
Sun Sep 01 00:00:00 EDT 2013
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
PloS one
Barron L,Smith AM,El Kasmi KC,Qualls JE,Huang X,Cheever A,Borthwick LA,Wilson MS,Murray PJ,Wynn TA
16-7311 was used in Flow cytometry/Cell sorting to investigate the contribution of arginase 1 to asthma pathogenesis.
Mon Dec 09 00:00:00 EST 2013
Ulmus davidiana var. japonica Nakai upregulates eosinophils and suppresses Th1 and Th17 cells in the small intestine.
PloS one
Lee HS,Jang MS,Kim JH,Hong CP,Lee EJ,Jeun EJ,Kim C,Kim EK,Ahn KS,Yang BG,Ahn KS,Jang YP,Ahn KS,Kim YM,Jang MH
16-7311 was used in Flow cytometry/Cell sorting to investigate the frequency and cytokine profile of the major immune cells in mice treated orally with UDE.
Sat Aug 02 00:00:00 EDT 2014
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
16-7311 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
16-7311 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
16-7311 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion.
PloS one
Shugart JA,Bambina S,Alice AF,Montler R,Bahjat KS
16-7311 was used in Flow cytometry/Cell sorting to demonstrate that vaccination regimens differ in their dependence on CD40L-expressing CD8+ T cells for secondary expansion.
Tue Jan 07 00:00:00 EST 2014
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
16-7311 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens
Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R
16-7311 was used in Flow cytometry/Cell sorting to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.
Mon Jul 09 00:00:00 EDT 2012
TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines.
Cancer immunology, immunotherapy : CII
Jordan KR,Buhrman JD,Sprague J,Moore BL,Gao D,Kappler JW,Slansky JE
16-7311 was used in Flow cytometry/Cell sorting to demonstrate that peptide vaccines can expand T-cells that naturally respond to tumor antigens, improving antitumor immunity.
Mon Oct 01 00:00:00 EDT 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
16-7311 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 EST 2012
Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling.
PloS one
Rowse AL,Naves R,Cashman KS,McGuire DJ,Mbana T,Raman C,De Sarno P
16-7311 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism of GSK3 inhibitors as therapeutic agents in autoimmune neuroinflammation.
Thu Jun 27 00:00:00 EDT 2013
Th17 cells mediate clade-specific, serotype-independent mucosal immunity.
Immunity
Chen K,McAleer JP,Lin Y,Paterson DL,Zheng M,Alcorn JF,Weaver CT,Kolls JK
16-7311 was used in Flow cytometry/Cell sorting to demonstrate the Th17 cell lineage confers a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibody.
Fri Dec 23 00:00:00 EST 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
16-7311 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.
The Journal of clinical investigation
Zhao J,Zhao J,Legge K,Perlman S
16-7311 was used in Flow cytometry/Cell sorting to study the effect of increased PGD(2) expression on the viral immune response.
Thu Dec 01 00:00:00 EST 2011
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.
Proceedings of the National Academy of Sciences of the United States of America
Sauer JD,Pereyre S,Archer KA,Burke TP,Hanson B,Lauer P,Portnoy DA
16-7311 was used in Flow cytometry/Cell sorting to determine the consequences of inflammasome activation during infection and in the development of long-term immunity.
Tue Jul 26 00:00:00 EDT 2011
IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.
European journal of immunology
Yang Q,Li G,Zhu Y,Liu L,Chen E,Turnquist H,Zhang X,Finn OJ,Chen X,Lu B
16-7311 was used in Flow cytometry/Cell sorting to study expression of the IL-33 receptor ST2 by type 1 cytotoxic T cells.
Tue Nov 01 00:00:00 EDT 2011
The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.
European journal of immunology
van de Veerdonk FL,Joosten LA,Shaw PJ,Smeekens SP,Malireddi RK,van der Meer JW,Kullberg BJ,Netea MG,Kanneganti TD
16-7311 was used in Flow cytometry to demonstrate an essential protective role for caspase-1 and ASC in disseminated candidiasis through the regulation of antifungal Th1 and Th17 responses.
Mon Aug 01 00:00:00 EDT 2011
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Rudolph M,Hebel K,Miyamura Y,Maverakis E,Brunner-Weinzierl MC
16-7311 was used in Flow cytometry/Cell sorting to investigate the role of CTLA-4 on memory formation of adaptive immune responses using anti-CTLA-4 mAb treatment in mice.
Sun May 15 00:00:00 EDT 2011
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Visperas A,Dong C,Baldwin WM,Min B
16-7311 was used in Flow cytometry/Cell sorting to elucidate a cellular mechanism by which colitogenic Th17 immunity arises in vivo.
Fri Apr 15 00:00:00 EDT 2011
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Weiss KA,Christiaansen AF,Fulton RB,Meyerholz DK,Varga SM
16-7311 was used in Flow cytometry/Cell sorting to evaluate the role of IL-10 in the modulation of the respiratory syncytial virus-specific immune response.
Thu Sep 15 00:00:00 EDT 2011
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
PloS one
Kar UK,Srivastava MK,Andersson A,Baratelli F,Huang M,Kickhoefer VA,Dubinett SM,Rome LH,Sharma S
16-7311 was used in Western Blotting to demonstrate that the vault nanocapsule can efficiently deliver CCL21 to recruit antitumour effectors, sustain antitumour activity and inhibit tumour growth.
Tue May 03 00:00:00 EDT 2011
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
PloS one
Kar UK,Srivastava MK,Andersson A,Baratelli F,Huang M,Kickhoefer VA,Dubinett SM,Rome LH,Sharma S
16-7311 was used in Western Blotting to demonstrate that the vault nanocapsule can efficiently deliver CCL21 to recruit antitumour effectors, sustain antitumour activity and inhibit tumour growth.
Tue May 03 00:00:00 EDT 2011
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
16-7311 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
Blood
Coghill JM,Carlson MJ,Panoskaltsis-Mortari A,West ML,Burgents JE,Blazar BR,Serody JS
16-7311 was used in Flow cytometry/Cell sorting to investigate the role of MHC disparity between donor and recipient, in the attenuated graft-versus-host disease responses of murine T cells lacking CCR7.
Thu Jun 10 00:00:00 EDT 2010
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
16-7311 was used in Flow cytometry/Cell sorting to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
The proteasome inhibitor bortezomib inhibits T cell-dependent inflammatory responses.
Journal of leukocyte biology
Yanaba K,Yoshizaki A,Muroi E,Hara T,Ogawa F,Shimizu K,Sato S
16-7311 was used in Immunofluorescence to determine that bortezomib treatment induces T cell death, thereby suppressing CHS responses by reducing IFN-gamma production.
Thu Jul 01 00:00:00 EDT 2010
Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation.
Journal of immunology (Baltimore, Md. : 1950)
Martin AJ,McCarthy D,Waltenbaugh C,Goings G,Luo X,Miller SD
16-7311 was used in an ELISA assay to investigate methods to protect against male graft transplant destruction by the female immune system.
Wed Sep 15 00:00:00 EDT 2010
Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Journal of immunology (Baltimore, Md. : 1950)
Kemp KL,Levin SD,Bryce PJ,Stein PL
16-7311 was used in Magnetic cell separation to imply that Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Thu Apr 15 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
16-7311 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950)
Findlay EG,Greig R,Stumhofer JS,Hafalla JC,de Souza JB,Saris CJ,Hunter CA,Riley EM,Couper KN
16-7311 was used in Flow cytometry/Cell sorting to demonstrate the essential role of IL-27R signalling in regulating effector T cell function during malaria infection.
Sun Aug 15 00:00:00 EDT 2010
Lack of interleukin-12 in p40-deficient mice leads to poor CD8+ T-cell immunity against Encephalitozoon cuniculi infection.
Infection and immunity
Moretto MM,Lawlor EM,Khan IA
16-7311 was used in Blocking experiments to demonstrate the important role of IL-12 in inducing an effective CD8+ T cell response against Encephalitozoon cuniculi Infection.
Tue Jun 01 00:00:00 EDT 2010
Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
Blood
Jin W,Zhou XF,Yu J,Cheng X,Sun SC
16-7311 was used in Blocking experiments to investigate the molecular mechanism underlying Th17 differentiation.
Thu Jun 25 00:00:00 EDT 2009
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood
Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ
16-7311 was used in Flow cytometry/Cell sorting to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.
Sat Mar 15 00:00:00 EDT 2008
Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection.
Journal of virology
Kemball CC,Harkins S,Whitton JL
16-7311 was used in Flow cytometry/Cell sorting to evaluate CVB3 epitope-specific CD8(+) and CD4(+) T-cell responses in the spleen, heart and pancreas of mice in vivo.
Thu May 01 00:00:00 EDT 2008
Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Xu G,Zhang L,Roberts AI,Shi Y
Tue Jul 01 00:00:00 EDT 2008
T cell acquisition of APC membrane can impact interpretation of adoptive transfer experiments using CD45 congenic mouse strains.
Journal of immunological methods
Cho KS,Hill AB
Thu Jan 31 00:00:00 EST 2008
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
Proceedings of the National Academy of Sciences of the United States of America
Kimura A,Naka T,Kishimoto T
Tue Jul 17 00:00:00 EDT 2007
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Immunity
Marie JC,Liggitt D,Rudensky AY
16-7311 was used in Immunocytochemistry to demonstrate that TGF-beta signalling in T cells is crucial to restrain fatal autoimmune processes.
Fri Sep 01 00:00:00 EDT 2006
CD137-mediated immunotherapy for allergic asthma.
The Journal of clinical investigation
Polte T,Foell J,Werner C,Hoymann HG,Braun A,Burdach S,Mittler RS,Hansen G
16-7311 was used in Functional assays to show that anti-CD137 mAb prevent the development of airway hyperreactivity, eosinophilic airway inflammation, excessive mucus production, and elevated IgE over 7 weeks, in a murine asthma model.
Sat Apr 01 00:00:00 EST 2006
ADAP is dispensable for NK cell development and function.
International immunology
Fostel LV,Dluzniewska J,Shimizu Y,Burbach BJ,Peterson EJ
16-7311 was used in an ELISA assay to show that whilst ADAP is required for efficient TCR signaling and T cell activation by NK cells, it is dispensable for other key NK functions.
Tue Aug 01 00:00:00 EDT 2006
IFN-gamma decreases CTL generation by limiting IL-2 production: A feedback loop controlling effector cell production.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hidalgo LG,Urmson J,Halloran PF
Fri Apr 01 00:00:00 EST 2005
