Product References
Analyzing trogocytosis of T lymphocytes by flow cytometry and confocal microscopy.
STAR protocols
Zink A,Zenke S,Wiese T,Beyersdorf N,Lämmermann T,Rohr JC
17-0081-82 was used in Flow cytometry/Cell sorting to describe the steps needed from T lymphocyte isolation, via co-culture with cells expressing the ligand of interest, to cell harvest and subsequent staining for flow cytometry and confocal microscopy.
Fri Mar 17 00:00:00 EDT 2023
Analyzing trogocytosis of T lymphocytes by flow cytometry and confocal microscopy.
STAR protocols
Zink A,Zenke S,Wiese T,Beyersdorf N,Lämmermann T,Rohr JC
17-0081-82 was used in Flow cytometry/Cell sorting to describe the steps needed from T lymphocyte isolation, via co-culture with cells expressing the ligand of interest, to cell harvest and subsequent staining for flow cytometry and confocal microscopy.
Fri Mar 17 00:00:00 EDT 2023
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
Nature immunology
Gressier E,Schulte-Schrepping J,Petrov L,Brumhard S,Stubbemann P,Hiller A,Obermayer B,Spitzer J,Kostevc T,Whitney PG,Bachem A,Odainic A,van de Sandt C,Nguyen THO,Ashhurst T,Wilson K,Oates CVL,Gearing LJ,Meischel T,Hochheiser K,Greyer M,Clarke M,Kreutzenbeck M,Gabriel SS,Kastenmüller W,Kurts C,Londrigan SL,Kallies A,Kedzierska K,Hertzog PJ,Latz E,Chen YE,Radford KJ,Chopin M,Schroeder J,Kurth F,Gebhardt T,Sander LE,Sawitzki B,Schultze JL,Schmidt SV,Bedoui S
17-0081-82 was used in Flow cytometry/Cell sorting to describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4+ T cell-mediated CD40 stimulation.
Thu Jun 01 00:00:00 EDT 2023
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Cancer immunology, immunotherapy : CII
Symonds ALJ,Miao T,Busharat Z,Li S,Wang P
17-0081-82 was used in Flow cytometry/Cell sorting to conclude that Egr2 and 3 are important for maintaining anti-tumour responses of exhausted CD8 + TILs.
Mon May 01 00:00:00 EDT 2023
IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis.
Aging and disease
Chen H,Wang Q,Li J,Li Y,Chen A,Zhou J,Zhao J,Mao Z,Zhou Z,Zhang J,Wang Y,Wang R,Li Q,Zhang Y,Jiang R,Miao D,Jin J
17-0081-82 was used in Flow Cytometry to find that physiological aging increased pulmonary CD4+ TEM cells, IFNγ was produced mainly by CD4+ TEM cells, and pulmonary cells had increased responsiveness to IFNγ signaling.
Fri Dec 01 00:00:00 EST 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
17-0081-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 EDT 2023
Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.
Cell research
Zhou C,Ma L,Xu H,Huo Y,Luo J
17-0081-82 was used in Flow Cytometry to suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity, and highlight the potential of VEGF-C mRNA for brain tumor therapy.
Wed Jun 01 00:00:00 EDT 2022
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate.
Molecular cell
Liedmann S,Liu X,Guy CS,Crawford JC,Rodriguez DA,Kuzuoğlu-Öztürk D,Guo A,Verbist KC,Temirov J,Chen MJ,Ruggero D,Zhang H,Thomas PG,Green DR
17-0081-82 was used in flow cytometry to provide mechanistic insights as to how distinct T cell fate trajectories can be established during the first division.
Thu Jul 07 00:00:00 EDT 2022
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Vesin B,Lopez J,Noirat A,Authié P,Fert I,Le Chevalier F,Moncoq F,Nemirov K,Blanc C,Planchais C,Mouquet H,Guinet F,Hardy D,Vives FL,Gerke C,Anna F,Bourgine M,Majlessi L,Charneau P
17-0081-82 was used in Flow cytometry/Cell sorting to demonstrate the suitability of the LV::SBeta-2P vaccine candidate as an intranasal booster against COVID-19. LV::SBeta-2P vaccination was also fully protective against Omicron infection of the lungs and central nervous system, in the highly susceptible B6.K18-hACE2IP-THV transgenic mice.
Wed Sep 07 00:00:00 EDT 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
17-0081-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
Wed Feb 16 00:00:00 EST 2022
A mouse model of vitiligo based on endogenous auto-reactive CD8 + T cell targeting skin melanocyte.
Cell regeneration (London, England)
Chen D,Xu Z,Cui J,Chen T
17-0081-82 was used in Flow cytometry/Cell sorting to describe a vitiligo mouse model which recapitulates key clinical features of vitiligo, including epidermis depigmentation, CD8 + T cell infiltration in skin, and melanocyte loss.
Sun Oct 02 00:00:00 EDT 2022
Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation.
Nature communications
Zenke S,Sica MP,Steinberg F,Braun J,Zink A,Gavrilov A,Hilger A,Arra A,Brunner-Weinzierl M,Elling R,Beyersdorf N,Lämmermann T,Smulski CR,Rohr JC
17-0081-82 was used in Flow cytometry/Cell sorting to find that T cells utilize trogocytosis by competing antagonistic receptors to differentially control the abundance of immunoregulatory ligands.
Sat Oct 29 00:00:00 EDT 2022
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.
Frontiers in immunology
Schall N,Talamini L,Wilhelm M,Jouvin-Marche E,Muller S
17-0081-82 was used in Flow cytometry/Cell sorting to suggest that P140 belongs to a new family of non-immunosuppressive immunoregulators that do not correct T and B cell abnormalities but rather contribute to the clearance of deleterious T and B cells.
Tue Jun 21 00:00:00 EDT 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
17-0081-82 was used in Flow cytometry/Cell sorting to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
Nose-Only Exposure to Cherry- and Tobacco-Flavored E-Cigarettes Induced Lung Inflammation in Mice in a Sex-Dependent Manner.
Toxics
Lamb T,Muthumalage T,Meehan-Atrash J,Rahman I
17-0081-82 was used in Flow cytometry/Cell sorting to reveal flavor- and sex-based e-cigarette effects in female mice exposed to cherry-flavored e-liquids and male mice exposed to tobacco-flavored e-liquids, namely, increased lung inflammation.
Sat Aug 13 00:00:00 EDT 2022
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Cancer discovery
Wei SC,Meijers WC,Axelrod ML,Anang NAS,Screever EM,Wescott EC,Johnson DB,Whitley E,Lehmann L,Courand PY,Mancuso JJ,Himmel LE,Lebrun-Vignes B,Wleklinski MJ,Knollmann BC,Srinivasan J,Li Y,Atolagbe OT,Rao X,Zhao Y,Wang J,Ehrlich LIR,Sharma P,Salem JE,Balko JM,Moslehi JJ,Allison JP
17-0081 was used in Flow cytometry/Cell sorting to report a robust preclinical mouse model ofiImmune checkpoint inhibitors-associated myocarditis in which mono-allelic loss of Ctla4 in the context of complete genetic absence of Pdcd1 leads to premature death in approximately half of mice.
Mon Mar 01 00:00:00 EST 2021
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
17-0081 was used in Flow cytometry/Cell sorting to reveal that the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.
Tue Jun 01 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0081-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.
International journal of molecular sciences
Parigger T,Gassner FJ,Scherhäufl C,Bakar AA,Höpner JP,Hödlmoser A,Steiner M,Catakovic K,Geisberger R,Greil R,Zaborsky N
17-0081-82 was used in Flow cytometry/Cell sorting to indicate that in the CLL mouse model, a substantial fraction of non-CLL specific T cells becomes exhausted during disease progression in a bystander effect.
Tue Jun 22 00:00:00 EDT 2021
A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.
Science advances
Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC
17-0081-82 was used in Flow Cytometry to evaluate an Amphiphile (AMP) vaccine adjuvant, AMP-CpG, composed of diacyl lipid-modified CpG, admixed with the SARS-CoV-2 Spike-2 receptor binding domain protein as a candidate vaccine (ELI-005) in mice.
Mon Feb 01 00:00:00 EST 2021
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Cancer immunology research
De Martino M,Daviaud C,Diamond JM,Kraynak J,Alard A,Formenti SC,Miller LD,Demaria S,Vanpouille-Box C
17-0081-82 was used in Flow Cytometry to shed light on an immune escape mechanism driven by activin A and suggest that dual targeting of activin A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer.
Fri Jan 01 00:00:00 EST 2021
Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications.
STAR protocols
Hearnden R,Sandhar B,Vyas V,Longhi MP
17-0081-82 was used in flow cytometry to investigate isolation of stroll vascular fraction cells.
Fri Jun 18 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
17-0081 was used in Flow cytometry/Cell sorting to identify the critical contribution of TLR4-mediated macrophage activation in disease course and provided strong evidence to support TLR4 as a useful drug target for treating inflammatory autoimmune neuropathy.
Mon Mar 22 00:00:00 EDT 2021
Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.
International journal of molecular sciences
Stofkova A,Zloh M,Andreanska D,Fiserova I,Kubovciak J,Hejda J,Kutilek P,Murakami M
17-0081-82 was used in Flow cytometry/Cell sorting to hypothesize that rod photoreceptor dysfunction causes remodeling of retinal neural activity, which influences the blood-retinal barrier and the development of retinal inflammation.
Fri Dec 31 00:00:00 EST 2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy.
Nature communications
Koerner J,Horvath D,Herrmann VL,MacKerracher A,Gander B,Yagita H,Rohayem J,Groettrup M
17-0081 was used in Flow cytometry/Cell sorting to demonstrate the supreme adjuvant effect of the recently developed and pharmaceutically defined double-stranded (ds)RNA adjuvant Riboxxim especially when incorporated into PLGA particles.
Tue May 18 00:00:00 EDT 2021
Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection.
Cell host & microbe
Woo V,Eshleman EM,Hashimoto-Hill S,Whitt J,Wu SE,Engleman L,Rice T,Karns R,Qualls JE,Haslam DB,Vallance BA,Alenghat T
17-0081-82 was used in Flow cytometry/Cell sorting to reveal retinoic acid (RA) as an unexpected microbiota-derived metabolite that primes innate defense and suggests that pre- and probiotic approaches to elevate RA could prevent or combat infections.
Wed Dec 08 00:00:00 EST 2021
Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with GMCSF+IFN α Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.
Biomedicines
Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R
17-0081-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.
Thu Nov 25 00:00:00 EST 2021
Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression.
Immunity
Fasolino M,Goldman N,Wang W,Cattau B,Zhou Y,Petrovic J,Link VM,Cote A,Chandra A,Silverman M,Joyce EF,Little SC,Kaestner KH,Naji A,Raj A,Henao-Mejia J,Faryabi RB,Vahedi G
17-0081 was used in Flow cytometry/Cell sorting to determine that genetic variation alters 3D chromatin architecture and associated changes in gene expression which may underlie autoimmune pathology in a model of type 1 diabetes.
Tue Feb 18 00:00:00 EST 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
17-0081 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-0081-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.
Cancer cell
Yu X,Chan HTC,Fisher H,Penfold CA,Kim J,Inzhelevskaya T,Mockridge CI,French RR,Duriez PJ,Douglas LR,English V,Verbeek JS,White AL,Tews I,Glennie MJ,Cragg MS
17-0081 was used in Flow cytometry/Cell sorting to show that clinically relevant antagonists used for treating autoimmune conditions can be converted into potent FcγR-independent agonists with remarkable antitumor activity by isotype switching to hIgG2.
Mon Jun 08 00:00:00 EDT 2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V
17-0081-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.
Thu Jun 04 00:00:00 EDT 2020
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.
Cell stem cell
Liang R,Arif T,Kalmykova S,Kasianov A,Lin M,Menon V,Qiu J,Bernitz JM,Moore K,Lin F,Benson DL,Tzavaras N,Mahajan M,Papatsenko D,Ghaffari S
17-0081-82 was used in Flow Cytometry to investigate the overall metabolic properties of hematopoietic stem cells.
Thu Mar 05 00:00:00 EST 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
17-0081 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
17-0081-82 was used in Flow Cytometry to demonstrate that if in human colorectal cancer tumor samples expressing high levels of DKK2, DKK2 blockade cause stronger activation of tumor infiltrating CD8+ T cells in ex vivo culture.
Wed Jul 01 00:00:00 EDT 2020
Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.
Journal of cell science
Salz A,Gurniak C,Jönsson F,Witke W
17-0081 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.
Fri Mar 06 00:00:00 EST 2020
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.
Journal of Cancer
Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z
17-0081 was used in Flow cytometry/Cell sorting to improve the specific cytotoxic activity, proliferation and secretion of CD8+ TILs and reduced the production of tumor-promoting cytokines.
Wed Sep 30 00:00:00 EDT 2020
Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
eLife
Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL
17-0081 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.
Wed Oct 14 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0081-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-0081 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
The Effect of Different Immunization Cycles of a Recombinant Mucin1-Maltose-Binding Protein Vaccine on T Cell Responses to B16-MUC1 Melanoma in Mice.
International journal of molecular sciences
Zhou H,Zhang Z,Liu G,Jiang M,Wang J,Liu Y,Tai G
17-0081 was used in Flow cytometry/Cell sorting to provide an experimental foundation for the clinical application of a recombinant MUC1-MBP vaccine.
Thu Aug 13 00:00:00 EDT 2020
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Cancers
Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G
17-0081 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.
Sat Apr 11 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
17-0081 was used in Flow cytometry/Cell sorting to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.
Thu Aug 20 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
17-0081 was used in Flow cytometry/Cell sorting to show that cell-free mitochondrial DNA (cf-mt-DNA) released by senescent cells accumulates with aging and augments immunogenicity.
Thu Aug 27 00:00:00 EDT 2020
E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.
Respiratory research
Wang Q,Sundar IK,Li D,Lucas JH,Muthumalage T,McDonough SR,Rahman I
17-0081 was used in Flow cytometry/Cell sorting to investigate if sub-chronic e-cig exposure induces inflammatory response and dysregulated repair/extracellular matrix (ECM) remodeling, through the α7 nicotinic acetylcholine receptor (nAChRα7).
Thu Jun 18 00:00:00 EDT 2020
E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation.
Research square
Wang Q,Sundar I,Li D,Lucas J,Muthumalage T,McDonough S,Rahman I
17-0081 was used in Flow cytometry/Cell sorting to demostarte that sub-chronic e-cig exposure with or without nicotine affect lung inflammation and repair responses/ECM remodeling, which are mediated by nAChR α7 in a sex-dependent manner.
Mon May 18 00:00:00 EDT 2020
PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation.
Cell reports
Frohner IE,Mudrak I,Schüchner S,Anrather D,Hartl M,Sontag JM,Sontag E,Wadzinski BE,Preglej T,Ellmeier W,Ogris E
17-0081 was used in Flow cytometry/Cell sorting to show that the most cited pTyr307 monoclonal antibodies, E155 and F-8, are not specific for phosphorylated Tyr307 but instead are hampered by PP2AC methylation at leucine 309 or phosphorylation at threonine 304.
Tue Mar 03 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
17-0081 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.
Cell
Davies AJ,Kim HW,Gonzalez-Cano R,Choi J,Back SK,Roh SE,Johnson E,Gabriac M,Kim MS,Lee J,Lee JE,Kim YS,Bae YC,Kim SJ,Lee KM,Na HS,Riva P,Latremoliere A,Rinaldi S,Ugolini S,Costigan M,Oh SB
17-0081 was used in Flow cytometry/Cell sorting to suggest the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves.
Thu Feb 07 00:00:00 EST 2019
Salmonella infection leads to severe intestinal inflammation and increased CD4+FoxP3+ Treg cells in streptozotocin‑induced hyperglycemic mice.
Molecular medicine reports
Zhang S,Wang M,Wang X,Li H,Tang H,Li X
17-0081-82 was used in Flow Cytometry to use streptozotocin‚induced hyperglycemic mice to model T1DM and induced a Salmonella infection in the mouse model, leading to aggravated inflammation, which resulted in an elevated proportion of CD103+CD11b+ DCs and a significantly elevated proportion of CD4+FoxP3+ Tregs in the intestinal lamina propria.
Sat Jun 01 00:00:00 EDT 2019
Preproinsulin Designer Antigens Excluded from Endoplasmic Reticulum Suppressed Diabetes Development in NOD Mice by DNA Vaccination.
Molecular therapy. Methods & clinical development
Stifter K,Schuster C,Krieger J,Spyrantis A,Boehm BO,Schirmbeck R
17-0081-82 was used in Flow Cytometry to analyse whether structural properties of preproinsulin variants and/or subcellular targetting of ppins designer antigens influence the priming of effector CD8+ T cell responses by DNA immunisation.
Fri Mar 15 00:00:00 EDT 2019
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma.
Oncotarget
Takahashi Y,Yasui T,Minami K,Tamari K,Hayashi K,Otani K,Seo Y,Isohashi F,Koizumi M,Ogawa K
17-0081 was used in Flow cytometry/Cell sorting to understand the efficacy of combining carbon ion irradiation and dual immune checkpoint blockade therapy to treat local and distant sites in osteosarcoma in mice.
Fri Jan 18 00:00:00 EST 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
17-0081-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
17-0081 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
17-0081 was used in Flow cytometry/Cell sorting to investigate the underlying sex differences that may contribute to differential footpad delayed-type hypersensitivity responses using wildtype and four core genotypes mice and popliteal lymphnode cellularity and gene expression.
Wed Jan 30 00:00:00 EST 2019
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
17-0081-82 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.
Thu Sep 26 00:00:00 EDT 2019
Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.
Molecular medicine reports
Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H
17-0081-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.
Fri Mar 01 00:00:00 EST 2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
17-0081-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.
Nature medicine
Xiao Q,Wu J,Wang WJ,Chen S,Zheng Y,Yu X,Meeth K,Sahraei M,Bothwell ALM,Chen L,Bosenberg M,Chen J,Sexl V,Sun L,Li L,Tang W,Wu D
Thu Mar 01 00:00:00 EST 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Thu Jun 28 00:00:00 EDT 2018
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.
Nature immunology
Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F
17-0081-82 was used in Flow cytometry/Cell sorting to provide a mechanistic explanation for these similarities by showing that TCF-1 and HEB share ~7,000 DNA-binding sites genome wide and promote chromatin accessibility.
Sat Dec 01 00:00:00 EST 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
17-0081 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Frontiers in immunology
Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K
17-0081 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.
Tue Jun 25 00:00:00 EDT 2019
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
17-0081 was used in Flow cytometry/Cell sorting to indicate that BIM regulates B cell homeostasis predominantly by limiting the life span of non-activated mature B cells.
Wed May 01 00:00:00 EDT 2019
SunRiSE - measuring translation elongation at single-cell resolution by means of flow cytometry.
Journal of cell science
Argüello RJ,Reverendo M,Mendes A,Camosseto V,Torres AG,Ribas de Pouplana L,van de Pavert SA,Gatti E,Pierre P
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that, in mouse embryonic fibroblasts, eEF2 phosphorylation by eEF2 kinase (eEF2K) mostly affects translation engagement, but has a surprisingly small effect on elongation, except after proteotoxic stress induction.
Thu May 31 00:00:00 EDT 2018
PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.
Journal of Cancer
Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z
17-0081 was used in Flow cytometry/Cell sorting to investigate whether PD-L1 mediated adaptive resistance could occur in treatment with Anchored-GM-CSF vaccine and whether PD-1 blockade combined with Anchored-GM-CSF vaccine could induce a greater anti-tumour immune response than either immunotherapy alone.
Thu Oct 01 00:00:00 EDT 2020
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
17-0081 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
Scientific reports
Beesetty P,Wieczerzak KB,Gibson JN,Kaitsuka T,Luu CT,Matsushita M,Kozak JA
17-0081 was used in Flow cytometry/Cell sorting to study the role of TRPM7 channel kinase as a novel modulator of blastogenesis, proliferation and store-operated calcium entry.
Wed Feb 14 00:00:00 EST 2018
Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant.
Frontiers in cellular neuroscience
Cardona SM,Kim SV,Church KA,Torres VO,Cleary IA,Mendiola AS,Saville SP,Watowich SS,Parker-Thornburg J,Soto-Ospina A,Araque P,Ransohoff RM,Cardona AE
Thu Oct 01 00:00:00 EDT 2020
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
Tue Sep 11 00:00:00 EDT 2018
Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.
Frontiers in immunology
Pigni M,Ashok D,Stevanin M,Acha-Orbea H
17-0081 was used in Flow cytometry/Cell sorting to show that our new cell line, that we named CD4- MutuDC2 line, represents a valuable model for the CD4- cDC2 subset.
Thu Sep 19 00:00:00 EDT 2019
Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype.
Oncoimmunology
Borgoni S,Iannello A,Cutrupi S,Allavena P,D'Incalci M,Novelli F,Cappello P
17-0081 was used in Flow cytometry/Cell sorting to analyse whether the functional and epigenetic profile of T cells that infiltrate pancreatic ductal adenocarcinoma is modulated by the microenvironment, and in particular by tumour-associated macrophages.
Tue Jan 12 00:00:00 EST 2021
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
17-0081 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin.
PloS one
Carlow DA,Tra MC,Ziltener HJ
17-0081 was used in Flow cytometry to examine P-selectin ligand expression on activated CD8+ T cells in murine adoptive transfer models.
Tue Mar 26 00:00:00 EDT 2019
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Nature communications
Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C
17-0081 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.
Thu Apr 12 00:00:00 EDT 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
17-0081 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Immunity
Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S
17-0081-82 was used in Flow Cytometry to characterise the population and single cell transcriptomes, as well as enhancer and promoter landscapes of the murine monocyte compartment.
Tue May 16 00:00:00 EDT 2017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism
Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW
17-0081 was used in Flow cytometry/Cell sorting to develop a predictive model for selective targeting of the Warburg effect.
Tue Oct 03 00:00:00 EDT 2017
Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria.
Cell host & microbe
Jiang TT,Shao TY,Ang WXG,Kinder JM,Turner LH,Pham G,Whitt J,Alenghat T,Way SS
17-0081 was used in Flow cytometry/Cell sorting to show that commensal fungi can functionally replace intestinal bacteria by conferring protection against injury to mucosal tissues and positively calibrating the responsiveness of circulating immune cells.
Wed Dec 13 00:00:00 EST 2017
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
17-0081 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
17-0081-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect.
Sat Jul 15 00:00:00 EDT 2017
Modulation of Endoplasmic Reticulum Stress Controls CD4+ T-cell Activation and Antitumor Function.
Cancer immunology research
Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z
17-0081 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.
Tue Aug 01 00:00:00 EDT 2017
PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.
Cancer immunology research
Foubert P,Kaneda MM,Varner JA
17-0081 was used in Flow cytometry/Cell sorting to highlight PI3Kγ and integrin α4 as targets for the design of cancer therapeutics.
Wed Nov 01 00:00:00 EDT 2017
An engineered S1P chaperone attenuates hypertension and ischemic injury.
Science signaling
Swendeman SL,Xiong Y,Cantalupo A,Yuan H,Burg N,Hisano Y,Cartier A,Liu CH,Engelbrecht E,Blaho V,Zhang Y,Yanagida K,Galvani S,Obinata H,Salmon JE,Sanchez T,Di Lorenzo A,Hla T
17-0081 was used in Flow cytometry/Cell sorting to show development of a soluble carrier for S1P, ApoM-Fc, which activates S1P receptors and promotes endothelial function.
Tue Aug 15 00:00:00 EDT 2017
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
17-0081 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 EDT 2017
CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.
Journal of leukocyte biology
Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK
17-0081 was used in Flow cytometry/Cell sorting to show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans.
Sun Jan 01 00:00:00 EST 2017
The inflammatory phase of fracture healing is influenced by oestrogen status in mice.
European journal of medical research
Haffner-Luntzer M,Fischer V,Prystaz K,Liedert A,Ignatius A
17-0081 was used in Immunohistochemistry to indicate that oestrogen-deficiency influences the early inflammatory phase after fracture.
Thu Jul 06 00:00:00 EDT 2017
Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland.
Journal of mammary gland biology and neoplasia
Dill R,Walker AM
17-0081 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in immune cell recruitment.
Wed Mar 01 00:00:00 EST 2017
Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.
Cell reports
Platteel ACM,Liepe J,Textoris-Taube K,Keller C,Henklein P,Schalkwijk HH,Cardoso R,Kloetzel PM,Mishto M,Sijts AJAM
Tue Aug 01 00:00:00 EDT 2017
Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma.
PloS one
Takahashi Y,Yasui T,Tamari K,Minami K,Otani K,Isohashi F,Seo Y,Kambe R,Koizumi M,Ogawa K
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that radiation therapy enhances the efficacy of immune checkpoint blockade therapy, thus providing a promising therapeutic option for osteosarcoma.
Mon Jan 08 00:00:00 EST 2018
Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.
Frontiers in microbiology
Lai CY,Strange DP,Wong TAS,Lehrer AT,Verma S
17-0081 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo.
Tue Sep 29 00:00:00 EDT 2020
Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia.
JCI insight
Shivakumar P,Mizuochi T,Mourya R,Gutta S,Yang L,Luo Z,Bezerra JA
17-0081 was used in Flow cytometry/Cell sorting to determine factors regulating the pathogenic mechanisms of biliary atresia.
Thu Mar 09 00:00:00 EST 2017
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response.
Cell death & disease
He K,Liu P,Xu LX
17-0081 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced.
Thu Mar 23 00:00:00 EDT 2017
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Cell
Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K
17-0081 was used in Flow cytometry/Cell sorting to suggest that HSCs accumulate discrete memory stages over their divisional history and identify cellular memory in HSC aging.
Thu Nov 17 00:00:00 EST 2016
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
17-0081 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
17-0081 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
NLRP2 controls age-associated maternal fertility.
The Journal of experimental medicine
Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M
17-0081 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.
Mon Dec 12 00:00:00 EST 2016
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.
The Journal of experimental medicine
Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D
17-0081 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.
Mon Sep 19 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
17-0081 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.
Frontiers in immunology
Schmitt ME,Sitte S,Voehringer D
17-0081 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.
Wed Nov 20 00:00:00 EST 2019
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
17-0081 was used in Magnetic cell separation to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
17-0081 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hilpert C,Sitte S,Matthies A,Voehringer D
17-0081 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.
Sat Oct 01 00:00:00 EDT 2016
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
17-0081 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
17-0081 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.
Mon Feb 01 00:00:00 EST 2016
A Toll-like receptor 2 agonist-fused antigen enhanced antitumor immunity by increasing antigen presentation and the CD8 memory T cells population.
Oncotarget
Wu CC,Liu SJ,Chen HW,Shen KY,Leng CH
17-0081 was used in Flow cytometry/Cell sorting to explore the use of TLR2 agonist-fused antigens for efficient cancer therapy.
Tue May 24 00:00:00 EDT 2016
Immunogenic Human Papillomavirus Pseudovirus-Mediated Suicide-Gene Therapy for Bladder Cancer.
International journal of molecular sciences
Hojeij R,Domingos-Pereira S,Nkosi M,Gharbi D,Derré L,Schiller JT,Jichlinski P,Nardelli-Haefliger D
17-0081 was used in Flow cytometry/Cell sorting to show that IVES human papillomavirus non-replicative pseudovirions can pseudoinfect tumors with a ten-fold higher efficacy than normal bladders.
Thu Jul 14 00:00:00 EDT 2016
Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis.
PloS one
Alves da Costa T,Di Gangi R,Thomé R,Barreto Felisbino M,Pires Bonfanti A,Lumi Watanabe Ishikawa L,Sartori A,Burger E,Verinaud L
17-0081 was used in Flow cytometry/Cell sorting to develop a new experimental model where Pb yeast cells are injected through the intraperitoneal route and mice are evaluated over 120 days of infection.
Mon May 22 00:00:00 EDT 2017
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.
PloS one
Put K,Brisse E,Avau A,Imbrechts M,Mitera T,Janssens R,Proost P,Fallarino F,Wouters CH,Matthys P
17-0081 was used in Flow cytometry/Cell sorting to unravel the role of IDO1, an immune-modulatory enzyme, in the pathogenesis of certain inflammatory diseases.
Mon Aug 08 00:00:00 EDT 2016
Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.
JCI insight
Collins SL,Chan-Li Y,Oh M,Vigeland CL,Limjunyawong N,Mitzner W,Powell JD,Horton MR
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that lung-directed immunotherapy induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis.
Thu Apr 07 00:00:00 EDT 2016
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-0081 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.
Journal for immunotherapy of cancer
Andersen BM,Xia J,Epstein AL,Ohlfest JR,Chen W,Blazar BR,Pennell CA,Olin MR
17-0081 was used in Flow cytometry/Cell sorting to study the effect of ANXA2m on CD80 and CD86 expression, antigen cross-presentation, and the secretion of various cytokines.
Wed Feb 17 00:00:00 EST 2016
Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis.
Parasites & vectors
de Mendonça LZ,Resende LA,Lanna MF,Aguiar-Soares RD,Roatt BM,Castro RA,Batista MA,Silveira-Lemos D,Gomes Jde A,Fujiwara RT,Rezende SA,Martins-Filho OA,Corrêa-Oliveira R,Dutra WO,Reis AB,Giunchetti RC
17-0081 was used in Flow cytometry/Cell sorting to compare the effects of the multicomponent LBSap vaccine with those of Leish-Tec® and Leishmune®.
Tue Aug 30 00:00:00 EDT 2016
Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection.
Cell death & disease
Cabral-Piccin MP,Guillermo LV,Vellozo NS,Filardy AA,Pereira-Marques ST,Rigoni TS,Pereira-Manfro WF,DosReis GA,Lopes MF
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that disposal of apoptotic CD8 T cells increases M2-macrophage differentiation and contributes to parasite persistence.
Thu May 19 00:00:00 EDT 2016
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
PloS one
Lakshminarayanan V,Supekar NT,Wei J,McCurry DB,Dueck AC,Kosiorek HE,Trivedi PP,Bradley JM,Madsen CS,Pathangey LB,Hoelzinger DB,Wolfert MA,Boons GJ,Cohen PA,Gendler SJ
17-0081 was used in Flow cytometry/Cell sorting to investigate vaccines against MUC1.
Fri Jul 29 00:00:00 EDT 2016
ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.
PloS one
Yabas M,Jing W,Shafik S,Bröer S,Enders A
17-0081 was used in Flow cytometry/Cell sorting to identify the P4-type ATPase ATP11C as a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine to the inner leaflet of the plasma membrane in immune cells.
Mon Jul 25 00:00:00 EDT 2016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW
17-0081 was used in Flow cytometry/Cell sorting to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.
Fri Jul 31 00:00:00 EDT 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
17-0081 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response.
EMBO molecular medicine
Sartorius R,D'Apice L,Trovato M,Cuccaro F,Costa V,De Leo MG,Marzullo VM,Biondo C,D'Auria S,De Matteis MA,Ciccodicola A,De Berardinis P
17-0081 was used in Flow cytometry/Cell sorting to reveal the fd bacteriophage as a valuable tool for immunization without administering exogenous adjuvants.
Wed Jul 01 00:00:00 EDT 2015
Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Katakam AK,Brightbill H,Franci C,Kung C,Nunez V,Jones C,Peng I,Jeet S,Wu LC,Mellman I,Delamarre L,Austin CD
17-0081 was used in Flow cytometry/Cell sorting to assess the role of NIK within dendritic cells on antigen presentation and cross priming of CD8 T Cells.
Tue Nov 24 00:00:00 EST 2015
Early virus-host interactions dictate the course of a persistent infection.
PLoS pathogens
Sullivan BM,Teijaro JR,de la Torre JC,Oldstone MB
17-0081 was used in Flow cytometry/Cell sorting to investigate the very early host-virus interactions that determine the establishment of viral persistence.
Thu Jan 01 00:00:00 EST 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
17-0081 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform.
Journal of virology
Malczyk AH,Kupke A,Prüfer S,Scheuplein VA,Hutzler S,Kreuz D,Beissert T,Bauer S,Hubich-Rau S,Tondera C,Eldin HS,Schmidt J,Vergara-Alert J,Süzer Y,Seifried J,Hanschmann KM,Kalinke U,Herold S,Sahin U,Cichutek K,Waibler Z,Eickmann M,Becker S,Mühlebach MD
17-0081 was used in Flow cytometry/Cell sorting to generate measles virus expressing the spike glycoprotein of MERS-CoV in its full-length.
Sun Nov 01 00:00:00 EDT 2015
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Journal of leukocyte biology
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W
17-0081 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.
Wed Apr 01 00:00:00 EDT 2015
The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.
Journal of immunology (Baltimore, Md. : 1950)
Buerger S,Herrmann VL,Mundt S,Trautwein N,Groettrup M,Basler M
17-0081 was used in Flow cytometry/Cell sorting to assess the role of FAT10 in modification of thymic Ag presentation and epitope-dependent elimination of self-reactive T cells.
Sun Nov 01 00:00:00 EDT 2015
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
17-0081 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 EDT 2015
Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen.
Immunity, inflammation and disease
Kristensen MB,Metzdorff SB,Bergström A,Damlund DS,Fink LN,Licht TR,Frøkiær H
17-0081 was used in Flow cytometry/Cell sorting to assess the microbial influence on postnatal haematopoiesis.
Tue Sep 01 00:00:00 EDT 2015
Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.
Nature communications
Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN
17-0081 was used in Flow cytometry/Cell sorting to suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone loss following ART initiation.
Tue Sep 22 00:00:00 EDT 2015
Immune Reactions against Gene Gun Vaccines Are Differentially Modulated by Distinct Dendritic Cell Subsets in the Skin.
PloS one
Weber CS,Hainz K,Deressa T,Strandt H,Florindo Pinheiro D,Mittermair R,Pizarro Pesado J,Thalhamer J,Hammerl P,Stoecklinger A
17-0081 was used in Flow cytometry/Cell sorting to investigate how skin-borne protein antigens may be differentially handled by distinct DC subsets, and, in this way, intrinsic features of the antigen can participate in immune modulation.
Wed Apr 06 00:00:00 EDT 2016
Loss of Gadkin Affects Dendritic Cell Migration In Vitro.
PloS one
Schachtner H,Weimershaus M,Stache V,Plewa N,Legler DF,Höpken UE,Maritzen T
17-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which Gadkin and ARP2/3 regulate dendritic cell motility and migration.
Mon Jun 20 00:00:00 EDT 2016
Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.
mBio
Jensen KD,Camejo A,Melo MB,Cordeiro C,Julien L,Grotenbreg GM,Frickel EM,Ploegh HL,Young L,Saeij JP
17-0081 was used in Flow cytometry/Cell sorting to investigate the interaction between infected host and Toxoplasma gondii strains in endemic regions, showing that secondary infection correlates with the ROP5/ROP18 allele combinations.
Tue Feb 24 00:00:00 EST 2015
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.
Cell death & disease
Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D
17-0081 was used in Flow cytometry/Cell sorting to define the clearance of infected neutrophils by dendritic cells as central to the early immune evasion strategies of L. major.
Thu Dec 10 00:00:00 EST 2015
Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.
Oncoimmunology
Domingos-Pereira S,Hojeij R,Reggi E,Derré L,Chevalier MF,Romero P,Jichlinski P,Nardelli-Haefliger D
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that combining vaccination with local immunostimulation may be an effective treatment strategy for different types of cancer.
Wed Jul 01 00:00:00 EDT 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
17-0081 was used in Flow cytometry/Cell sorting to study the aetiology of human hypertension, showing that GATA5, an endothelial transcription factor, regulates blood pressure, allowing the development of a new animal model of hypertension for further studies.
Mon Nov 30 00:00:00 EST 2015
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
17-0081 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines.
Scientific reports
Szeto GL,Van Egeren D,Worku H,Sharei A,Alejandro B,Park C,Frew K,Brefo M,Mao S,Heimann M,Langer R,Jensen K,Irvine DJ
17-0081 was used in Flow cytometry/Cell sorting to demonstrate proof-of-concept for mechano-poration as an enabling technology for loading B-cells with antigens to prime specific CD8(+)T-cells.
Fri May 22 00:00:00 EDT 2015
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
17-0081 was used in Immunofluorescence to show that a subset of alveolar macrophages (AMs) attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.
Thu Feb 27 00:00:00 EST 2014
A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.
Cancer discovery
Donohoe DR,Holley D,Collins LB,Montgomery SA,Whitmore AC,Hillhouse A,Curry KP,Renner SW,Greenwalt A,Ryan EP,Godfrey V,Heise MT,Threadgill DS,Han A,Swenberg JA,Threadgill DW,Bultman SJ
17-0081 was used in Flow cytometry/Cell sorting to assess whether dietary fiber is protective in colorectal cancer.
Mon Dec 01 00:00:00 EST 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
17-0081 was used in in vivo experiments to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 EST 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
17-0081 was used in in vivo experiments to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 EST 2014
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
The EMBO journal
Jurkin J,Henkel T,Nielsen AF,Minnich M,Popow J,Kaufmann T,Heindl K,Hoffmann T,Busslinger M,Martinez J
17-0081 was used in Flow cytometry/Cell sorting to investigate the mammalian ligase required for cleavage of XBP1, showing that tRNA ligase complex mediates splicing of XBP1 mRNA.
Wed Dec 17 00:00:00 EST 2014
IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum.
Clinical immunology (Orlando, Fla.)
Darling AR,Freyschmidt EJ,Burton OT,Koleoglou KJ,Oyoshi MK,Oettgen HC
17-0081 was used in Flow cytometry/Cell sorting to demonstrate the role of IL-10 in limiting IL-17-mediated skin inflammation and reducing the systemic burden of vaccinia virus.
Sat Feb 01 00:00:00 EST 2014
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.
Molecular metabolism
Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN
17-0081 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.
Mon Sep 01 00:00:00 EDT 2014
Apoptotic cell administration is detrimental in murine renal ischaemia reperfusion injury.
Journal of inflammation (London, England)
Hesketh EE,Kluth DC,Hughes J
17-0081 was used in Flow cytometry/Cell sorting to study tissue damage and immune responses following renal ischaemia reperfusion injury and assess whether administration of apoptotic cells represents a novel line of therapy.
Wed Oct 15 00:00:00 EDT 2014
Administration of anti-CD20 mAb is highly effective in preventing but ineffective in treating chronic graft-versus-host disease while preserving strong graft-versus-leukemia effects.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Johnston HF,Xu Y,Racine JJ,Cassady K,Ni X,Wu T,Chan A,Forman S,Zeng D
17-0081 was used in Flow cytometry/Cell sorting to indicate that administration of anti-CD20 mAb before signs of cGVHD can prevent induction of autoimmune-like cGVHD while preserving a GVL effect.
Fri Aug 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
17-0081 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
17-0081 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950)
Bökers S,Urbat A,Daniel C,Amann K,Smith KG,Espéli M,Nitschke L
17-0081 was used in Flow cytometry/Cell sorting to study how loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis.
Tue Apr 01 00:00:00 EDT 2014
Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice.
Human vaccines & immunotherapeutics
Xiao L,Wang D,Sun C,Li P,Jin Y,Feng L,Chen L
17-0081 was used in Flow cytometry/Cell sorting to study whether co-administration of sPD-1 and sTim-3 with an adenovirus vectored SIV vaccine (rAd5-SIV) can enhance cell mediated immune responses.
Mon Mar 30 00:00:00 EDT 2015
Immune selection of tumor cells in TCR β-chain transgenic mice.
Journal of immunotoxicology
Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB
17-0081 was used in Flow cytometry/Cell sorting to compare the ability of WT and transgenic, immune-compromised mice to reject EL4 thymoma cells.
Wed Oct 01 00:00:00 EDT 2014
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
17-0081 was used in Flow cytometry/Cell sorting to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.
Journal of inflammation research
Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC
17-0081 was used in Flow cytometry/Cell sorting to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.
Thu Mar 27 00:00:00 EDT 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
17-0081 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages.
PloS one
Škrnjug I,Rueckert C,Libanova R,Lienenklaus S,Weiss S,Guzmán CA
17-0081 was used in Flow cytometry/Cell sorting to assess changes in cell surface marker expression of dendritic cells and macrophages in response to c-di-AMP.
Wed Jan 14 00:00:00 EST 2015
Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes.
Vaccines
Becker PD,Nörder M,Weissmann S,Ljapoci R,Erfle V,Drexler I,Guzmán CA
17-0081 was used in Flow cytometry/Cell sorting to evaluate the effect of overexpressing recombinant Ag using modified vaccinia virus early/late promoter H5 (mPH5), showing that overexpression enhances antibody responses and increases vaccination efficiency.
Tue Jul 22 00:00:00 EDT 2014
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
17-0081 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
17-0081 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 EST 2013
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
The EMBO journal
Petersen B,Wolf M,Austermann J,van Lent P,Foell D,Ahlmann M,Kupas V,Loser K,Sorg C,Roth J,Vogl T
17-0081 was used in Magnetic cell separation to study the role of TLR-4 ligand Mrp8/14 in inflammation and adaptive immunity.
Wed Jan 09 00:00:00 EST 2013
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
17-0081 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 EDT 2013
Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.
Mucosal immunology
Domingos-Pereira S,Decrausaz L,Derré L,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D
17-0081 was used in Flow cytometry/Cell sorting to study the immune effects of the instillation of Toll-like receptor agonists after subcutaneous E7 vaccination.
Fri Mar 01 00:00:00 EST 2013
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kipari T,Hadoke PW,Iqbal J,Man TY,Miller E,Coutinho AE,Zhang Z,Sullivan KM,Mitic T,Livingstone DE,Schrecker C,Samuel K,White CI,Bouhlel MA,Chinetti-Gbaguidi G,Staels B,Andrew R,Walker BR,Savill JS,Chapman KE,Seckl JR
17-0081 was used in Flow cytometry/Cell sorting to determine the effects of 11Β-Hydroxysteroid dehydrogenase type-1 deficiency on atherosclerosis and its inflammation.
Mon Apr 01 00:00:00 EDT 2013
Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.
Journal of immunology (Baltimore, Md. : 1950)
Hogan T,Shuvaev A,Commenges D,Yates A,Callard R,Thiebaut R,Seddon B
17-0081 was used in Flow cytometry/Cell sorting to analyse the heterogenous proliferative response of T cell clones to lymphopenia using in vivo and mathematical models.
Mon Apr 15 00:00:00 EDT 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
17-0081 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
17-0081 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
17-0081 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.
Sat Jun 15 00:00:00 EDT 2013
Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses.
Gene therapy
Chervin AS,Stone JD,Soto CM,Engels B,Schreiber H,Roy EJ,Kranz DM
17-0081 was used in Flow cytometry/Cell sorting to show that the TCR library strategy enables rapid assessment of TCR-binding properties that promote peripheral T-cell survival and tumor elimination.
Sat Jun 01 00:00:00 EDT 2013
The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis.
Immunobiology
Rouse M,Nagarkatti M,Nagarkatti PS
17-0081 was used in Flow cytometry/Cell sorting to investigate the effect of administration of IL-2 on the development of EAE, showing that pre-treatment causes significant amelioration of EAE.
Mon Apr 01 00:00:00 EDT 2013
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
17-0081 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
17-0081 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
17-0081 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.
Annals of surgery
Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A
17-0081 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.
Sun Jan 01 00:00:00 EST 2012
An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma.
Molecular therapy : the journal of the American Society of Gene Therapy
Spies E,Reichardt W,Alvarez G,Groettrup M,Ohlschläger P
17-0081 was used in Flow cytometry/Cell sorting to develop prostate cancer immunotherapies.
Thu Mar 01 00:00:00 EST 2012
Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection.
European journal of immunology
Pearl JE,Torrado E,Tighe M,Fountain JJ,Solache A,Strutt T,Swain S,Appelberg R,Cooper AM
17-0081 was used in Immunohistochemistry to support the hypothesis that effector T cells in mycobacterial granulomata are not a uniform effector population but exist in distinct subsets with differential susceptibility to the regulatory effects of nitric oxide.
Sat Dec 01 00:00:00 EST 2012
Requirement of CD4 help for induction of CD8 T cell response specific for virally derived h60.
Immune network
Ryu SJ,Kang B,Kim SH,Kim TW,Chang J,Choi EY
17-0081 was used in Flow cytometry/Cell sorting to provide insights into the characterization of the CD8 T cell response specifically for antigens originating from cellular sources compared to viral sources.
Fri Jun 01 00:00:00 EDT 2012
Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Gupta A,Probst HC,Vuong V,Landshammer A,Muth S,Yagita H,Schwendener R,Pruschy M,Knuth A,van den Broek M
17-0081 was used in Flow cytometry/Cell sorting to investigate the role of immune cells on efficacy of radiotherapy.
Sun Jul 15 00:00:00 EDT 2012
Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Journal of immunology (Baltimore, Md. : 1950)
Notake T,Horisawa S,Sanjo H,Miyagawa S,Hida S,Taki S
17-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind the generation and function of NKR(+) T cells.
Tue May 15 00:00:00 EDT 2012
A critical role for Rictor in T lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P
17-0081 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.
Wed Aug 15 00:00:00 EDT 2012
Cutting edge: intravascular staining redefines lung CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Anderson KG,Sung H,Skon CN,Lefrancois L,Deisinger A,Vezys V,Masopust D
17-0081 was used in Immunofluorescence to elucidate T cell trafficking and differentiation within the lung after systemic infection.
Sat Sep 15 00:00:00 EDT 2012
Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.
Molecular pharmaceutics
Zhan X,Tran KK,Shen H
17-0081 was used in Flow cytometry/Cell sorting to study the effect of PEGylation on the lymphatic trafficking and accumulation of particles in draining lymph nodes.
Mon Dec 03 00:00:00 EST 2012
A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment.
Molecules and cells
Ryu SJ,Jeon JY,Chang J,Sproule TJ,Roopenian DC,Choi EY
17-0081 was used in Flow cytometry/Cell sorting to study the CD8 T-cell response to the the variant of the H60 minor histocompatibility antigen, H60H.
Sun Apr 01 00:00:00 EDT 2012
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
17-0081 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
17-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 EDT 2011
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia.
Blood
Sokalski KM,Li SK,Welch I,Cadieux-Pitre HA,Gruca MR,DeKoter RP
17-0081 was used in Flow cytometry/Cell sorting to investigate the impairment of differentiation of B cells and induction of pre-B cell acute lymphoblastic leukemia through the deletion of genes encoding PU.1 and Spi-1 in B cells.
Thu Sep 08 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
17-0081 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen.
Immune network
Jeon JY,Jung KM,Chang J,Choi EY
17-0081 was used in Flow cytometry/Cell sorting to show that Zbtb20 regulates astrocyte specification in the mouse neocortex.
Fri Apr 01 00:00:00 EDT 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
17-0081 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 EDT 2011
Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.
Infection and immunity
Hsieh SH,Lin JS,Huang JH,Wu SY,Chu CL,Kung JT,Wu-Hsieh BA
17-0081 was used in Flow cytometry/Cell sorting to investigate the effect of immunisation with apoptotic phagocytes containing heat-killed Histoplasma, showing that it activates functional CD8(+) T cells to protect against histoplasmosis.
Tue Nov 01 00:00:00 EDT 2011
CD4+ T cells modulate expansion and survival but not functional properties of effector and memory CD8+ T cells induced by malaria sporozoites.
PloS one
Overstreet MG,Chen YC,Cockburn IA,Tse SW,Zavala F
17-0081 was used in Flow cytometry/Cell sorting to investigate CD4+ T cells modulation of effector and memory CD8+ T cells, induced by malaria sporozoites.
Tue Jan 04 00:00:00 EST 2011
Visualization of immune response kinetics in full allogeneic chimeras.
American journal of blood research
Elkin G,Prigozhina TB,Slavin S,Gurevitch O,Khitrin S,Resnick IB
17-0081 was used in Flow cytometry/Cell sorting to visualise the changes in full chimera immune response kinetics after co-transplantation of donor and host hematopoietic cells together.
Thu Aug 23 00:00:00 EDT 2012
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.
Immunity
Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S
17-0081 was used in Flow cytometry/Cell sorting to explore the regulatory processes maintaining a tolerogenic attitude towards enteric commensal bacteria.
Wed Nov 24 00:00:00 EST 2010
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Blood
Huber S,Hoffmann R,Muskens F,Voehringer D
17-0081 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.
Thu Oct 28 00:00:00 EDT 2010
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Cancer research
Shah MY,Vasanthakumar A,Barnes NY,Figueroa ME,Kamp A,Hendrick C,Ostler KR,Davis EM,Lin S,Anastasi J,Le Beau MM,Moskowitz IP,Melnick A,Pytel P,Godley LA
17-0081 was used in Flow cytometry/Cell sorting to examine the role of truncated DNMT3B isoforms in the redistribution of DNA methylation in human tumours.
Thu Jul 15 00:00:00 EDT 2010
Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.
Proceedings of the National Academy of Sciences of the United States of America
Menzel U,Ktistaki E,Tolaini M,Veiga-Fernandes H,Kioussis D
17-0081 was used in Flow cytometry/Cell sorting to explore the effect of a locus control region on a developmentally regulated locus in the mouse CD8 gene complex.
Tue Sep 28 00:00:00 EDT 2010
Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S
17-0081 was used in Flow cytometry/Cell sorting to assess the role of MCP-1 in immunity to acute pneumonia caused by gram-negative bacteria.
Mon Feb 01 00:00:00 EST 2010
Resistance to dengue virus infection in mice is potentiated by CXCL10 and is independent of CXCL10-mediated leukocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Ip PP,Liao F
17-0081 was used in Flow cytometry/Cell sorting to study how CXCL10(-/-) mice are more susceptible than wild-type mice to dengue virus infection.
Sat May 15 00:00:00 EDT 2010
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Freyschmidt EJ,Mathias CB,Diaz N,MacArthur DH,Laouar A,Manjunath N,Hofer MD,Wurbel MA,Campbell JJ,Chatila TA,Oettgen HC
17-0081 was used in Flow cytometry/Cell sorting to investigate whether Treg deficiency predisposes to eczema vaccinatum.
Thu Jul 15 00:00:00 EDT 2010
The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.
Journal of immunology (Baltimore, Md. : 1950)
Boucheron N,Sharif O,Schebesta A,Croxford A,Raberger J,Schmidt U,Vigl B,Bauer J,Bankoti R,Lassmann H,Epstein MM,Knapp S,Waisman A,Ellmeier W
17-0081 was used in Flow cytometry/Cell sorting to study a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations.
Mon Nov 01 00:00:00 EDT 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
17-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
Quantitative and qualitative features of heterologous virus-vector-induced antigen-specific CD8+ T cells against Trypanosoma cruzi infection.
International journal for parasitology
Takayama E,Ono T,Carnero E,Umemoto S,Yamaguchi Y,Kanayama A,Oguma T,Takashima Y,Tadakuma T,García-Sastre A,Miyahira Y
17-0081 was used in Flow cytometry/Cell sorting to investigate the quantitative and qualitative features of heterologous recombinant virus-vector-induced, antigen-specific CD8(+) T cells against Trypanosoma cruzi.
Mon Nov 01 00:00:00 EDT 2010
Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.
PloS one
Nörder M,Becker PD,Drexler I,Link C,Erfle V,Guzmán CA
17-0081 was used in Flow cytometry/Cell sorting to assess the immune response to vaccine antigens co-administered or not co-administered with modified vaccinia virus Ankara.
Wed Jun 30 00:00:00 EDT 2010
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
The Journal of experimental medicine
Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A
17-0081 was used in Flow cytometry/Cell sorting to show that migrant and resident dendritic cells play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo.
Mon Feb 16 00:00:00 EST 2009
CD1d-based combination therapy eradicates established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Teng MW,Sharkey J,McLaughlin NM,Exley MA,Smyth MJ
17-0081 was used in Flow cytometry/Cell sorting to test an approach to directly activate/mature antigen presenting cells using anti-CD1d mAbs for the treatment of cancer.
Sat Aug 01 00:00:00 EDT 2009
The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.
Journal of immunology (Baltimore, Md. : 1950)
Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL
17-0081 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.
Sun Feb 01 00:00:00 EST 2009
Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin.
Journal of immunology (Baltimore, Md. : 1950)
French JD,Roark CL,Born WK,O'Brien RL
17-0081 was used in Flow cytometry/Cell sorting to investigate the role of β2-microglobulin in regulating gamma-delta T lymphocyte homeostasis.
Sun Feb 15 00:00:00 EST 2009
NKG2A inhibits invariant NKT cell activation in hepatic injury.
Journal of immunology (Baltimore, Md. : 1950)
Kawamura T,Takeda K,Kaneda H,Matsumoto H,Hayakawa Y,Raulet DH,Ikarashi Y,Kronenberg M,Yagita H,Kinoshita K,Abo T,Okumura K,Smyth MJ
17-0081 was used in Flow cytometry/Cell sorting to investigate the role of NK cell receptors in iNKT cell activation, showing that NKG2A-mediated signalling negatively regulated iNKT activation and hepatic injury.
Thu Jan 01 00:00:00 EST 2009
Nylon wool purification alters the activation of T cells.
Molecular immunology
Wohler JE,Barnum SR
17-0081 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.
Sun Feb 01 00:00:00 EST 2009
Deletion of both the C3a and C5a receptors fails to protect against experimental autoimmune encephalomyelitis.
Neuroscience letters
Ramos TN,Wohler JE,Barnum SR
17-0081 was used in Flow cytometry/Cell sorting to demonstrate the delayed onset of experimental autoimmune encephalomyelitis but no attenuation of disease severity in C3aR/C5aR double knockout mice.
Thu Dec 31 00:00:00 EST 2009
Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.
BMC microbiology
Petersen A,Heegaard PM,Pedersen AL,Andersen JB,Sørensen RB,Frøkiaer H,Lahtinen SJ,Ouwehand AC,Poulsen M,Licht TR
17-0081 was used in Flow cytometry/Cell sorting to examine whether Salmonella infection could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles.
Mon Nov 30 00:00:00 EST 2009
An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
Blood
Shigeta A,Matsumoto M,Tedder TF,Lowe JB,Miyasaka M,Hirata T
17-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms of L-selectin-mediated neutrophil recruitment.
Mon Dec 15 00:00:00 EST 2008
Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses.
Brain, behavior, and immunity
Ashcraft KA,Bonneau RH
17-0081 was used in Flow cytometry/Cell sorting to investigate the role that psychological stress, through its suppression of both innate and adaptive immune responses, plays in the ability of the body to control vaginal Herpes Simplex Virus type 1 infection.
Sat Nov 01 00:00:00 EDT 2008
Inhalation of Staphylococcus aureus enterotoxin A induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology in mice.
Journal of immunology (Baltimore, Md. : 1950)
Muralimohan G,Rossi RJ,Guernsey LA,Thrall RS,Vella AT
17-0081 was used in Flow cytometry/Cell sorting to investigate molecular mediators involved in bacterial superantigen-mediated pulmonary disease, showing that inhalation induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology.
Mon Sep 01 00:00:00 EDT 2008
Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Cook L,Miyahara N,Jin N,Wands JM,Taube C,Roark CL,Potter TA,Gelfand EW,O'Brien RL,Born WK
17-0081 was used in Flow cytometry/Cell sorting to study the mechanism by which dendritic cells enable the development of specific T cells that modulate airway hyperresponsiveness..
Tue Jul 01 00:00:00 EDT 2008
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.
Journal of immunology (Baltimore, Md. : 1950)
Lukens JR,Cruise MW,Lassen MG,Hahn YS
17-0081 was used in Flow cytometry/Cell sorting to study the blockade of PD-1/B7-H1 interaction to restore effector CD8+ T cell responses in a hepatitis C virus core murine model.
Tue Apr 01 00:00:00 EDT 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.
Psychoneuroendocrinology
Ashcraft KA,Hunzeker J,Bonneau RH
17-0081 was used in Flow cytometry/Cell sorting to determine how psychological stress and associated increases in corticosterone may increase susceptibility to herpes simplex virus encephalitis.
Fri Aug 01 00:00:00 EDT 2008
Trans-epithelial immune cell transfer during suckling modulates delayed-type hypersensitivity in recipients as a function of gender.
PloS one
Ma LJ,Walter B,Deguzman A,Muller HK,Walker AM
17-0081 was used in Immunohistochemistry to investigate the transfer of milk immune cells in mice pups during normal suckling and its subsequent effects on adult immunity.
Mon Feb 23 00:00:00 EST 2009
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood
Dorn T,Kuhn U,Bungartz G,Stiller S,Bauer M,Ellwart J,Peters T,Scharffetter-Kochanek K,Semmrich M,Laschinger M,Holzmann B,Klinkert WE,Straten PT,Køllgaard T,Sixt M,Brakebusch C
17-0081 was used in Flow cytometry/Cell sorting to investigate how RhoH is important for pre-TCR and TCR signaling because it allows the efficient interaction of ZAP70 with the LAT signalosome, thus regulating thymocyte development.
Thu Mar 15 00:00:00 EDT 2007
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
17-0081 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 EDT 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
17-0081-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
Disruption of the beta2-integrin CD11d (alphaDbeta2) gene fails to protect against experimental autoimmune encephalomyelitis.
Journal of neuroimmunology
Adams JE,Webb MS,Hu X,Staunton D,Barnum SR
17-0081 was used in Flow cytometry/Cell sorting to show that deletion of the β2-integrin CD11d has no effect on the development and progression of EAE.
Thu Mar 01 00:00:00 EST 2007
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.
The Journal of experimental medicine
Bogunovic M,Ginhoux F,Wagers A,Loubeau M,Isola LM,Lubrano L,Najfeld V,Phelps RG,Grosskreutz C,Scigliano E,Frenette PS,Merad M
17-0081 was used in Flow cytometry/Cell sorting to explore dermal DC homeostasis in mice and humans both in the steady state and after haematopoietic cell transplantation.
Mon Nov 27 00:00:00 EST 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
17-0081 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.
Immunity
Sato T,Ohno S,Hayashi T,Sato C,Kohu K,Satake M,Habu S
17-0081 was used in Flow cytometry/Cell sorting to investigate the involvement of Runx proteins in the lineage specification of CD8 T cells.
Tue Mar 01 00:00:00 EST 2005
Frizzled 9 knock-out mice have abnormal B-cell development.
Blood
Ranheim EA,Kwan HC,Reya T,Wang YK,Weissman IL,Francke U
17-0081 was used in Flow cytometry/Cell sorting to suggest a role for frizzled 9 signalling in lymphoid development.
Tue Mar 15 00:00:00 EST 2005
