Product References
Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.
Journal of biomedical science
Li P,Zhou D,Chen D,Cheng Y,Chen Y,Lin Z,Zhang X,Huang Z,Cai J,Huang W,Lin Y,Ke H,Long J,Zou Y,Ye S,Lan P
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Jun 28 00:00:00 EDT 2023
Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma.
International journal of molecular sciences
Sieow JL,Penny HL,Gun SY,Tan LQ,Duan K,Yeong JPS,Pang A,Lim D,Toh HC,Lim TKH,Engleman E,Rotzschke O,Ng LG,Chen J,Tan SM,Wong SC
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.
iScience
Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A
17-7321-82 was used in Flow cytometry/Cell sorting to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.
Fri Oct 20 00:00:00 EDT 2023
Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom.
International journal of molecular sciences
Lima C,Andrade-Barros AI,Carvalho FF,Falcão MAP,Lopes-Ferreira M
17-7321-82 was used in Flow cytometry/Cell sorting to demonstrate in mouse paws injected with the venom the installation of γH2AX/p16Ink4a-dependent senescence with persistent neutrophilic inflammation in the proliferation and remodeling phases.
Mon May 08 00:00:00 EDT 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
17-7321-82 was used in Flow Cytometry to show that lipopolysaccharide from KLPJ could bind with caspase-11 to induce mature IL18 in mouse and human colon organoids.
Thu Feb 23 00:00:00 EST 2023
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Oct 10 00:00:00 EDT 2022
Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung.
Nature communications
Horn KJ,Schopper MA,Drigot ZG,Clark SE
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Jun 09 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes.
Nature communications
Tan TCJ,Kelly V,Zou X,Wright D,Ly T,Zamoyska R
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Sat Dec 17 00:00:00 EST 2022
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation.
JCI insight
Linnerbauer M,Lößlein L,Vandrey O,Tsaktanis T,Beer A,Naumann UJ,Panier F,Beyer T,Nirschl L,Kuramatsu JB,Winkler J,Quintana FJ,Rothhammer V
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Interleukin-37 protects against acinar cell pyroptosis in acute pancreatitis.
JCI insight
Ma N,Yuan C,Shi J,Zhu Q,Liu Y,Ma X,Li B,Gong W,Xue J,Lu G,Li W,Li J
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Nov 08 00:00:00 EST 2022
Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies.
Theranostics
Li H,Peng K,Yang K,Ma W,Qi S,Yu X,He J,Lin X,Yu G
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Sep 29 00:00:00 EDT 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Oct 31 00:00:00 EDT 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
17-7321-82 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 EDT 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
17-7321-82 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 EDT 2022
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao Y,Ma C,Chen C,Li S,Wang Y,Yang T,Stetler RA,Bennett MVL,Dixon CE,Chen J,Shi Y
17-7321-82 was used in Flow cytometry/Cell sorting to show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising therapeutic target for TBI.
Wed Sep 28 00:00:00 EDT 2022
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Nature
Zheng J,Wong LR,Li K,Verma AK,Ortiz ME,Wohlford-Lenane C,Leidinger MR,Knudson CM,Meyerholz DK,McCray PB,Perlman S
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions.
Cell
Huang H,Zhou P,Wei J,Long L,Shi H,Dhungana Y,Chapman NM,Fu G,Saravia J,Raynor JL,Liu S,Palacios G,Wang YD,Qian C,Yu J,Chi H
17-7321-82 was used in Flow Cytometry to establish that nutrient uptake and signaling are key determinants of T cell fate and shape the quantity and quality of TMEM responses.
Thu Mar 04 00:00:00 EST 2021
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
Nature immunology
Zhou J,Kryczek I,Li S,Li X,Aguilar A,Wei S,Grove S,Vatan L,Yu J,Yan Y,Liao P,Lin H,Li J,Li G,Du W,Wang W,Lang X,Wang W,Wang S,Zou W
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
Molecular therapy : the journal of the American Society of Gene Therapy
Teng Y,Xu F,Zhang X,Mu J,Sayed M,Hu X,Lei C,Sriwastva M,Kumar A,Sundaram K,Zhang L,Park JW,Chen SY,Zhang S,Yan J,Merchant ML,Zhang X,McClain CJ,Wolfe JK,Adcock RS,Chung D,Palmer KE,Zhang HG
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Aug 04 00:00:00 EDT 2021
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Harmand TJ,Rothlauf PW,Praest P,Alexander RK,van den Doel R,Liebeskind MJ,Vakaki MA,McCaul N,Wijne C,Verhaar E,Pinney W,Heston H,Bloyet LM,Pontelli MC,Ilagan MXG,Jan Lebbink R,Buchser WJ,Wiertz EJHJ,Whelan SPJ,Ploegh HL
17-7321-82 was used in Flow cytometry/Cell sorting to report the development of a candidate SARS-CoV-2 vaccine that is purely protein based and directly targets antigen-presenting cells.
Tue Nov 02 00:00:00 EDT 2021
TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Oxidative medicine and cellular longevity
Luo Y,Guo J,Jia W,Wu M,Yin F,Niu G,Shih DQ,Targan SR,Zhang X
17-7321-82 was used in Flow cytometry/Cell sorting to investigate the role of TNF-like ligand 1 aberrance (TL1A) in nonalcoholic steatohepatitis (NASH).
Fri Mar 04 00:00:00 EST 2022
TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Oxidative medicine and cellular longevity
Luo Y,Guo J,Jia W,Wu M,Yin F,Niu G,Shih DQ,Targan SR,Zhang X
17-7321-82 was used in Flow cytometry/Cell sorting to investigate the role of TNF-like ligand 1 aberrance (TL1A) in nonalcoholic steatohepatitis (NASH).
Fri Mar 04 00:00:00 EST 2022
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2023
M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway.
Cell death discovery
Pu J,Xu Z,Nian J,Fang Q,Yang M,Huang Y,Li W,Ge B,Wang J,Wei H
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Dec 22 00:00:00 EST 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Aug 11 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Nature communications
Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon May 17 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon May 17 00:00:00 EDT 2021
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.
Cell death & disease
Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Dec 16 00:00:00 EST 2021
Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.
Pathogens (Basel, Switzerland)
Medina-Buelvas DM,Rodríguez-Sosa M,Vega L
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Sat Nov 06 00:00:00 EDT 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
17-7321-82 was used in Flow Cytometry to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.
Mon Dec 13 00:00:00 EST 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
17-7321-82 was used in Flow Cytometry to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.
Mon Dec 13 00:00:00 EST 2021
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
17-7321 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation.
Cell host & microbe
Liu X,Boyer MA,Holmgren AM,Shin S
17-7321-82 was used in Flow Cytometry to reveal that alveolar macrophages engage alveolar epithelial signals to metabolically reprogram monocytes for antibacterial inflammation.
Wed Nov 11 00:00:00 EST 2020
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Nature immunology
Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A
17-7321 was used in Flow cytometry/Cell sorting to help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
Sat Feb 01 00:00:00 EST 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950)
Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y
17-7321 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.
Sun Mar 15 00:00:00 EDT 2020
The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation.
Journal of cell science
Galeano Niño JL,Tay SS,Tearle JLE,Xie J,Govendir MA,Kempe D,Mazalo J,Drew AP,Colakoglu F,Kummerfeld SK,Proud CG,Biro M
17-7321 was used in Flow cytometry/Cell sorting to show that T cells exhibit a gain in fluorescence intensity following engagement of cognate tumour target cells.
Thu Mar 05 00:00:00 EST 2020
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
17-7321 was used in Flow cytometry/Cell sorting to conclude that administration of Fluvastatin to donor mice showed protective effects against recipient aGVHD when compared to untreated mice due to the retention of effector T cells in lymphoid organs accompanying with reduction of nonlymphatic infiltration and related inflammatory cytokines.
Fri Sep 10 00:00:00 EDT 2021
Fluvastatin-Pretreated Donor Cells Attenuated Murine aGVHD by Balancing Effector T Cell Distribution and Function under the Regulation of KLF2.
BioMed research international
Zhao K,Tian Y,Wang J,Chen C,Pan B,Yan Z,Zhu S,Xu K
17-7321 was used in Flow cytometry/Cell sorting to conclude that administration of Fluvastatin to donor mice showed protective effects against recipient aGVHD when compared to untreated mice due to the retention of effector T cells in lymphoid organs accompanying with reduction of nonlymphatic infiltration and related inflammatory cytokines.
Fri Sep 10 00:00:00 EDT 2021
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jul 24 00:00:00 EDT 2020
CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection.
Cell reports
Wen J,Wang YT,Valentine KM,Dos Santos Alves RP,Xu Z,Regla-Nava JA,Ngono AE,Young MP,Ferreira LCS,Shresta S
17-7321 was used in Flow cytometry/Cell sorting to examine the ability of DENV/ZIKV-cross-reactive CD4+ T cells to protect against versus exacerbate ZIKV infection.
Tue Apr 28 00:00:00 EDT 2020
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
17-7321-82 was used in Flow Cytometry to investigate the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss.
Wed May 13 00:00:00 EDT 2020
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
17-7321-82 was used in Flow Cytometry to investigate the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss.
Wed May 13 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
17-7321 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.
Molecular therapy oncolytics
Zhu Y,Hu X,Feng L,Yang Z,Zhou L,Duan X,Cheng S,Zhang W,Liu B,Zhang K
17-7321-82 was used in Flow Cytometry to develop a novel oncolytic herpes simplex virus 2 (HSV2) encoding an anti-human programmed cell death 1 (PD-1) monoclonal antibody (oHSV2-aPD1) and demostrate its therapeutic efficacy.
Fri Dec 20 00:00:00 EST 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.
JCI insight
Cai W,Dai X,Chen J,Zhao J,Xu M,Zhang L,Yang B,Zhang W,Rocha M,Nakao T,Kofler J,Shi Y,Stetler RA,Hu X,Chen J
17-7321-82 was used in Flow Cytometry to suggest that efferocytosis via STAT6/Arg1 modulates microglia/macrophage phenotype, accelerates inflammation resolution, and improves stroke outcomes.
Thu Oct 17 00:00:00 EDT 2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology
Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE
17-7321-82 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.
Wed Sep 09 00:00:00 EDT 2020
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
17-7321-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.
American journal of physiology. Renal physiology
Privratsky JR,Zhang J,Lu X,Rudemiller N,Wei Q,Yu YR,Gunn MD,Crowley SD
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Molecular pain
Lee S,Shi XQ,Fan A,West B,Zhang J
17-7321 was used in Flow cytometry/Cell sorting to investigate whether blocking macrophage-colony stimulating factor/colony stimulating factor 1 receptor signalling can be effective in relieving neuropathic pain.
Mon Oct 22 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites.
JCI insight
Wasnik S,Rundle CH,Baylink DJ,Yazdi MS,Carreon EE,Xu Y,Qin X,Lau KW,Tang X
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.
Scientific reports
Leroux LP,Nasr M,Valanparambil R,Tam M,Rosa BA,Siciliani E,Hill DE,Zarlenga DS,Jaramillo M,Weinstock JV,Geary TG,Stevenson MM,Urban JF,Mitreva M,Jardim A
17-7321 was used in Flow cytometry/Cell sorting to analyse the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties.
Mon Oct 29 00:00:00 EDT 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
17-7321 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
17-7321 was used in Flow cytometry/Cell sorting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Cell metabolism
Thwe PM,Pelgrom LR,Cooper R,Beauchamp S,Reisz JA,D'Alessandro A,Everts B,Amiel E
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Sep 05 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
17-7321 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
17732182 was used in flow cytometry to investigate the use of red blood cells expressing disease-associated autoantigenas a means of inducing antigen-specific tolerance
Tue Mar 21 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
17-7321 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
Oncotarget
Cho JH,Lee HJ,Ko HJ,Yoon BI,Choe J,Kim KC,Hahn TW,Han JA,Choi SS,Jung YM,Lee KH,Lee YS,Jung YJ
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Apr 11 00:00:00 EDT 2017
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.
JCI insight
Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
C3d regulates immune checkpoint blockade and enhances antitumor immunity.
JCI insight
Platt JL,Silva I,Balin SJ,Lefferts AR,Farkash E,Ross TM,Carroll MC,Cascalho M
17-7321 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which tumours engage T cell checkpoint regulators and expanding Tregs, showing that C3d regulates immune checkpoint blockade and enhances antitumor immunity.
Thu May 04 00:00:00 EDT 2017
Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells.
Nature microbiology
Wen J,Tang WW,Sheets N,Ellison J,Sette A,Kim K,Shresta S
17-7321 was used in Flow cytometry/Cell sorting to demonstrate both an altered immunodominance pattern in the DENV-immune setting relative to naive, as well as a protective role for epitope-specific CD8+ T cells against ZIKV.
Mon Mar 13 00:00:00 EDT 2017
Exploiting a host-commensal interaction to promote intestinal barrier function and enteric pathogen tolerance.
Science immunology
Pedicord VA,Lockhart AAK,Rangan KJ,Craig JW,Loschko J,Rogoz A,Hang HC,Mucida D
17-7321 was used in Flow cytometry/Cell sorting to demonstrate that specific factors from commensal bacteria can improve host barrier function and limit the pathogenesis of distinct enteric infections.
Thu Sep 01 00:00:00 EDT 2016
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
The Journal of experimental medicine
Hu Y,Kim JH,He K,Wan Q,Kim J,Flach M,Kirchhausen T,Vortkamp A,Winau F
Mon Nov 14 00:00:00 EST 2016
Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9.
Proceedings of the National Academy of Sciences of the United States of America
Newman ZR,Young JM,Ingolia NT,Barton GM
17-7321-82 was used in Flow Cytometry to propose that suboptimal codon bias, which correlates with low guanine-cytosine content, limits transcription of certain genes.
Tue Mar 08 00:00:00 EST 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Dec 23 00:00:00 EST 2016
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
Cell
Parnas O,Jovanovic M,Eisenhaure TM,Herbst RH,Dixit A,Ye CJ,Przybylski D,Platt RJ,Tirosh I,Sanjana NE,Shalem O,Satija R,Raychowdhury R,Mertins P,Carr SA,Zhang F,Hacohen N,Regev A
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Whibley N,Jaycox JR,Reid D,Garg AV,Taylor JA,Clancy CJ,Nguyen MH,Biswas PS,McGeachy MJ,Brown GD,Gaffen SL
17-7321 was used in Flow cytometry/Cell sorting to demonstrate that protection against systemic Candida tropicalis infection requires CARD9 and TNF-α, but not IL-17, signaling.
Thu Oct 15 00:00:00 EDT 2015
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
17-7321 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
17-7321 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
UNC93B1 mediates differential trafficking of endosomal TLRs.
eLife
Lee BL,Moon JE,Shu JH,Yuan L,Newman ZR,Schekman R,Barton GM
17-7321 was used in Flow cytometry/Cell sorting to describe the mechanisms by which UNC93B1 regulates multiple aspects of Toll-like receptor trafficking, showing that post-Golgi trafficking of TLR7 and TLR9 are distinct.
Tue Feb 19 00:00:00 EST 2013
T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes.
European journal of immunology
Baker RL,Mallevaey T,Gapin L,Haskins K
17-7321 was used in Flow cytometry/Cell sorting to investigate how CD40 may be an important signalling molecule on autoreactive CD4+ T cells and contribute to their pathogenic effector function.
Thu Mar 01 00:00:00 EST 2012
Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-α production.
International immunology
Takahara K,Tokieda S,Nagaoka K,Inaba K
17-7321 was used in Flow cytometry/Cell sorting to suggest that SIGNR1 recognising microbes participates in the enhanced tumour necrosis factor-α production by Mϕ in cooperation with toll-like receptor 2.
Wed Feb 01 00:00:00 EST 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using TNF alpha monoclonal antibody (Product # 17-7321-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Li Z,Zhang C,Zhou Z,Zhang J,Zhang J,Tian Z
17-7321 was used in Flow cytometry/Cell sorting to investigate the role of intestinal intraepithelial lymphocytes in responding to oral infection, showing that they express CD8 and T cell receptor γδ for bacterial clearance.
Wed Feb 01 00:00:00 EST 2012
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters.
PloS one
Shoji M,Yoshizaki S,Mizuguchi H,Okuda K,Shimada M
17-7321 was used in Flow cytometry/Cell sorting to explore transgene protein expression and its immunogenicity using optimized codon usage, promoters and adaptors.
Mon Jun 04 00:00:00 EDT 2012
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Harty JT
17-7321 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.
Fri Apr 01 00:00:00 EDT 2011
Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.
PloS one
Yabas M,Godfrey DI,Goodnow CC,Hoyne GF
17-7321 was used in Flow cytometry/Cell sorting to investigate the effect of mutations in heterogeneous ribonucleoprotein L-like protein on NKT and T cells.
Mon Mar 26 00:00:00 EDT 2012
Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure.
Journal of immunology (Baltimore, Md. : 1950)
Zou Y,Chen T,Han M,Wang H,Yan W,Song G,Wu Z,Wang X,Zhu C,Luo X,Ning Q
17-7321 was used in Immunocytochemistry to reveal a pivotal role for liver natural killer cells in the pathogenesis of virus-induced fulminant hepatic failure and acute-on-chronic liver failure.
Fri Jan 01 00:00:00 EST 2010
Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
The Journal of infectious diseases
Beaumier CM,Mathew A,Bashyam HS,Rothman AL
17-7321 was used in Flow cytometry/Cell sorting to demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection.
Fri Feb 15 00:00:00 EST 2008
Vaginal protection and immunity after oral immunization of mice with a novel vaccine strain of Listeria monocytogenes expressing human immunodeficiency virus type 1 gag.
Journal of virology
Zhao X,Zhang M,Li Z,Frankel FR
17-7321 was used in Flow cytometry/Cell sorting to demonstrate that a Listeria monocytogenes-based vaccine expressing the HIV gag gene induces strong protective immune responses.
Fri Sep 01 00:00:00 EDT 2006
