Product References
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction.
Frontiers in endocrinology
Hueso L,Marques P,Morant B,Gonzalez-Navarro H,Ortega J,Real JT,Sanz MJ,Piqueras L
B35130 was used in Immunohistochemistry-immunofluorescence to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity.
Tue May 02 00:00:00 EDT 2023
The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.
BMC cancer
Mandic R,Marquardt A,Terhorst P,Ali U,Nowak-Rossmann A,Cai C,Rodepeter FR,Stiewe T,Wezorke B,Wanzel M,Neff A,Stuck BA,Bette M
B35130 was used in Flow cytometry/Cell sorting to investigate the role of the importin beta superfamily member Ran GTP-binding protein (RanBP) 17.
Mon Jul 18 00:00:00 EDT 2022
Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome.
International journal of molecular sciences
Mao X,Xiong ZM,Xue H,Brown MA,Gete YG,Yu R,Sun L,Cao K
B35130 was used in Flow Cytometry to bring new insight into the molecular basis and therapeutic application for the skin abnormalities in HGPS.
Sat May 14 00:00:00 EDT 2022
Early growth response 2 (EGR2) is a novel regulator of the senescence programme.
Aging cell
Tyler EJ,Gutierrez Del Arroyo A,Hughes BK,Wallis R,Garbe JC,Stampfer MR,Koh J,Lowe R,Philpott MP,Bishop CL
B35130 was used in Immunocytochemistry to identify key regulators of p16 and ARF transcription in senescent human mammary epithelial cells and fibroblasts.
Mon Mar 01 00:00:00 EST 2021
ZNF768 links oncogenic RAS to cellular senescence.
Nature communications
Villot R,Poirier A,Bakan I,Boulay K,Fernández E,Devillers R,Gama-Braga L,Tribouillard L,Gagné A,Duchesne É,Caron D,Bérubé JS,Bérubé JC,Coulombe Y,Orain M,Gélinas Y,Gobeil S,Bossé Y,Masson JY,Elowe S,Bilodeau S,Manem V,Joubert P,Mallette FA,Laplante M
B35130 was used in Immunocytochemistry to identify ZNF768 as a protein linking oncogenic signaling to the control of cell fate decision and proliferation.
Tue Aug 17 00:00:00 EDT 2021
Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota.
Cell reports
Travier L,Alonso M,Andronico A,Hafner L,Disson O,Lledo PM,Cauchemez S,Lecuit M
B35130 was used in Immunohistochemistry to show that the immaturity of the neonatal intestinal microbiota leads to low resistance to GBS intestinal colonization and permissiveness of the gut-vascular barrier.
Tue Jun 29 00:00:00 EDT 2021
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
American journal of human genetics
Rodger C,Flex E,Allison RJ,Sanchis-Juan A,Hasenahuer MA,Cecchetti S,French CE,Edgar JR,Carpentieri G,Ciolfi A,Pantaleoni F,Bruselles A,Onesimo R,Zampino G,Marcon F,Siniscalchi E,Lees M,Krishnakumar D,McCann E,Yosifova D,Jarvis J,Kruer MC,Marks W,Campbell J,Allen LE,Gustincich S,Raymond FL,Tartaglia M,Reid E
B35130 was used in Immunocytochemistry to characterize a distinct multisystem disorder caused by mutations affecting VPS4A and demonstrate that its normal function is required for multiple human developmental and cellular processes.
Thu Dec 03 00:00:00 EST 2020
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
American journal of human genetics
Rodger C,Flex E,Allison RJ,Sanchis-Juan A,Hasenahuer MA,Cecchetti S,French CE,Edgar JR,Carpentieri G,Ciolfi A,Pantaleoni F,Bruselles A,Onesimo R,Zampino G,Marcon F,Siniscalchi E,Lees M,Krishnakumar D,McCann E,Yosifova D,Jarvis J,Kruer MC,Marks W,Campbell J,Allen LE,Gustincich S,Raymond FL,Tartaglia M,Reid E
B35130 was used in Immunocytochemistry to characterize a distinct multisystem disorder caused by mutations affecting VPS4A and demonstrate that its normal function is required for multiple human developmental and cellular processes.
Thu Dec 03 00:00:00 EST 2020
Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
Bone
Socorro M,Shinde A,Yamazaki H,Khalid S,Monier D,Beniash E,Napierala D
B35130 was used in Cell Culture to establish, if SerpinB2 is involved in function of cells producing mineralized ECM and to determine the interplay between Pi signaling and Trps1 in the regulation of SerpinB2 expression specifically in cells producing mineralized ECM.
Tue Dec 01 00:00:00 EST 2020
Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease.
Stem cells and development
Ali G,Elsayed AK,Nandakumar M,Bashir M,Younis I,Abu Aqel Y,Memon B,Temanni R,Abubaker F,Taheri S,Abdelalim EM
B35130 was used in Flow cytometry/Cell sorting to study patient-specific induced pluripotent stem cells and identify the role of abnormal keratinocytes in psoriasis development.
Wed Apr 01 00:00:00 EDT 2020
Keratinocytes Derived from Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Genetic Signature of Psoriasis Disease.
Stem cells and development
Ali G,Elsayed AK,Nandakumar M,Bashir M,Younis I,Abu Aqel Y,Memon B,Temanni R,Abubaker F,Taheri S,Abdelalim EM
B35130 was used in Flow cytometry/Cell sorting to study patient-specific induced pluripotent stem cells and identify the role of abnormal keratinocytes in psoriasis development.
Wed Apr 01 00:00:00 EDT 2020
Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods.
Journal of pharmacological and toxicological methods
Schmid C,Wohnhaas CT,Hildebrandt T,Baum P,Rast G
B35130 was used in Immunocytochemistry to investigate the composition of the commercially available iCell cardiomyocyte (Fuijifilm Cellular Dynamics) cultures and the transcriptomic phenotype of individual cells.
Mon Aug 23 00:00:00 EDT 2021
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress.
Cell reports
Murai J,Zhang H,Pongor L,Tang SW,Jo U,Moribe F,Ma Y,Tomita M,Pommier Y
B35130 was used in Immunocytochemistry-immunoflourescence to understand how Schlafen 11 acts as a cellular restriction factor against replication stress by causing genome-wide chromatin remodelling and immediate early gene activation.
Tue Mar 24 00:00:00 EDT 2020
Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors.
Molecular oncology
Dias MH,Fonseca CS,Zeidler JD,Albuquerque LL,da Silva MS,Cararo-Lopes E,Reis MS,Noël V,Dos Santos EO,Prior IA,Armelin HA
B35130 was used in Flow Cytometry to study the effect of fibroblast growth factor 2 on the sensitisation of cancer cells to stress targeted therapeutic inhibitors.
Fri Feb 01 00:00:00 EST 2019
TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions.
Molecular cancer research : MCR
Nepon-Sixt BS,Alexandrow MG
B35130 was used in Immunoprecipitation to demonstrate that the MCM assembly process is a pivotal target of TGFβ1 in eliciting cell cycle arrest, and provide evidence for a novel oncogenic role for CDT1 in abrogating TGFβ1 inhibition of MCM assembly.
Tue Jan 01 00:00:00 EST 2019
Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
eLife
Bigot N,Day M,Baldock RA,Watts FZ,Oliver AW,Pearl LH
B35130 was used in Immunocytochemistry to show that the DNA damage checkpoint regulating S-phase entry is controlled by a phosphorylation-dependent interaction of 53BP1 and TOPBP1.
Tue May 28 00:00:00 EDT 2019
Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45).
The Journal of biological chemistry
Perl AL,O'Connor CM,Fa P,Mayca Pozo F,Zhang J,Zhang Y,Narla G
B35130 was used in Flow cytometry/Cell sorting to show protein phosphatase 2A can interact with CDC45 causing an interruption in DNA replication and prolonging of S phase.
Fri Nov 08 00:00:00 EST 2019
Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms.
Frontiers in pharmacology
Li Y,Ruan X,Xu X,Li C,Qiang T,Zhou H,Gao J,Wang X
B35130 was used in Immunohistochemistry to study the effects of Shengmai injection on energy metabolism and its suppression of cardiomyocyte hypertrophy and apoptosis.
Wed Sep 30 00:00:00 EDT 2020
Targeting loss of the Hippo signaling pathway in NF2-deficient papillary kidney cancers.
Oncotarget
Sourbier C,Liao PJ,Ricketts CJ,Wei D,Yang Y,Baranes SM,Gibbs BK,Ohanjanian L,Spencer Krane L,Scroggins BT,Keith Killian J,Wei MH,Kijima T,Meltzer PS,Citrin DE,Neckers L,Vocke CD,Marston Linehan W
Published figure using BrdU monoclonal antibody (Product # B35130) in Flow Cytometry
Tue Feb 13 00:00:00 EST 2018
Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients.
Oncogene
Tsoi H,Lam KC,Dong Y,Zhang X,Lee CK,Zhang J,Ng SC,Ng SSM,Zheng S,Chen Y,Fang J,Yu J
B35130 was used in Immunocytochemistry to identify a novel mechanism in colorectal cancer (CRC) pathogenesis mediated by precursor 45s ribosomal RNA (pre-45s rRNA) and a prognostic factor of pre-45s rRNA in CRC patients.
Thu Nov 02 00:00:00 EDT 2017
Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276).
Genes, chromosomes & cancer
Yang Y,Vocke CD,Ricketts CJ,Wei D,Padilla-Nash HM,Lang M,Sourbier C,Killian JK,Boyle SL,Worrell R,Meltzer PS,Ried T,Merino MJ,Metwalli AR,Linehan WM
B35130 was used in Flow cytometry/Cell sorting to demonstrate that UOK276 represents a novel cell line model for aggressive, sarcomatoid-differentiated, TP53 mutant chromophobe renal cell carcinoma.
Sun Oct 01 00:00:00 EDT 2017
Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression.
Scientific reports
Morita Y,Ohno M,Nishi K,Hiraoka Y,Saijo S,Matsuda S,Kita T,Kimura T,Nishi E
Published figure using BrdU monoclonal antibody (Product # B35130) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.
Cell stem cell
Otani T,Marchetto MC,Gage FH,Simons BD,Livesey FJ
B35130 was used in Flow cytometry/Cell sorting to compare cortical progenitor cell output in humans and three nonhuman primates.
Thu Apr 07 00:00:00 EDT 2016
Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice.
Reproduction (Cambridge, England)
Busada JT,Velte EK,Serra N,Cook K,Niedenberger BA,Willis WD,Goulding EH,Eddy EM,Geyer CB
B35130 was used in immunohistochemistry to use knockout mice to determine if RHOX13 contributes to male germ cell differentiation
Tue Nov 01 00:00:00 EDT 2016
LOX is a novel mitotic spindle-associated protein essential for mitosis.
Oncotarget
Boufraqech M,Wei D,Weyemi U,Zhang L,Quezado M,Kalab P,Kebebew E
B35130 was used in flow cytometry to explore the function of LOX in mitosis
Tue May 17 00:00:00 EDT 2016
BRD4 is a novel therapeutic target for liver fibrosis.
Proceedings of the National Academy of Sciences of the United States of America
Ding N,Hah N,Yu RT,Sherman MH,Benner C,Leblanc M,He M,Liddle C,Downes M,Evans RM
B35130 was used in Immunocytochemistry-immunoflourescence to suggest bromodomain-containing protein 4 as a potential therapeutic target for patients with fibrotic liver complications.
Tue Dec 22 00:00:00 EST 2015
DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.
Arteriosclerosis, thrombosis, and vascular biology
Rostama B,Turner JE,Seavey GT,Norton CR,Gridley T,Vary CP,Liaw L
B35130 was used in Immunocytochemistry-immunoflourescence to examine the role of delta-like 4 (DLL4)/Notch signalling in human endothelial cell quiescence.
Tue Dec 01 00:00:00 EST 2015
The spatial and temporal organization of origin firing during the S-phase of fission yeast.
Genome research
Kaykov A,Nurse P
Published figure using BrdU monoclonal antibody (Product # B35130) in Immunofluorescence
Sun Mar 01 00:00:00 EST 2015
FANCD2 influences replication fork processes and genome stability in response to clustered DSBs.
Cell cycle (Georgetown, Tex.)
Zhu J,Su F,Mukherjee S,Mori E,Hu B,Asaithamby A
B35130 was used in flow cytometry to show that FANCD2 is needed for genome stability maintenance in response to high-linear energy transfer radiation
Tue Apr 19 00:00:00 EDT 2016
Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases.
PloS one
Tapia O,Fong LG,Huber MD,Young SG,Gerace L
B35130 was used in immunohistochemistry - frozen section to characterize mice harboring a disrupted allele for the Lem2 gene
Fri Apr 29 00:00:00 EDT 2016
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.
Genome biology
Lowe R,Overhoff MG,Ramagopalan SV,Garbe JC,Koh J,Stampfer MR,Beach DH,Rakyan VK,Bishop CL
Published figure using BrdU monoclonal antibody (Product # B35130) in Immunofluorescence
Thu Sep 17 00:00:00 EDT 2015
Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling.
Biochimica et biophysica acta
Vinué Á,Andrés-Blasco I,Herrero-Cervera A,Piqueras L,Andrés V,Burks DJ,Sanz MJ,González-Navarro H
B35130 was used in Immunocytochemistry-immunoflourescence to demonstrate that increased Ink4/Arf locus expression ameliorates hepatic steatosis, inflammation and insulin resistance in mice with impaired IRS2-dependent signalling.
Tue Sep 01 00:00:00 EDT 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
B35130 was used in Immunocytochemistry-immunoflourescence to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint.
Molecular cell
Dimitrova N,Zamudio JR,Jong RM,Soukup D,Resnick R,Sarma K,Ward AJ,Raj A,Lee JT,Sharp PA,Jacks T
Published figure using BrdU monoclonal antibody (Product # B35130) in Flow Cytometry
Thu Jun 05 00:00:00 EDT 2014
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America
Yu H,Pak H,Hammond-Martel I,Ghram M,Rodrigue A,Daou S,Barbour H,Corbeil L,Hébert J,Drobetsky E,Masson JY,Di Noia JM,Affar el B
B35130 was used in flow cytometry to determine deubiquitinases required to assemble homologous recombination factors BRCA1 and RAD51
Tue Jan 07 00:00:00 EST 2014
RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression.
Molecular and cellular biology
Ram RR,Mendiratta S,Bodemann BO,Torres MJ,Eskiocak U,White MA
B35130 was used in immunocytochemistry to study the involvement of RASSF1A inactivation in carcinogenesis
Sun Jun 01 00:00:00 EDT 2014
Thermally targeted p21 peptide enhances bortezomib cytotoxicity in androgen-independent prostate cancer cell lines.
Anti-cancer drugs
Mikecin AM,Walker LR,Kuna M,Raucher D
B35130 was used in flow cytometry to examine the combination treatment of prostate cancer cells with bortezomib and the C-terminal part of the p21(WAF1/CIP1) protein bound to the Elastin-like polypeptide carrier.
Sat Feb 01 00:00:00 EST 2014
Cell-cycle analyses using thymidine analogues in fission yeast.
PloS one
Anda S,Boye E,Grallert B
B35130 was used in immunocytochemistry to evaluate the effectiveness of thymidine analogues for cell cycle studies in fission yeast
Tue Oct 14 00:00:00 EDT 2014
Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts.
Cell cycle (Georgetown, Tex.)
Smith-Roe SL,Patel SS,Zhou Y,Simpson DA,Rao S,Ibrahim JG,Cordeiro-Stone M,Kaufmann WK
B35130 was used in Flow cytometry/Cell sorting to reveal a complex and coordinated program of genome maintenance enforced by proteins known for their intra-S checkpoint function.
Tue Jan 15 00:00:00 EST 2013
CDC42 is required for structural patterning of the lung during development.
Developmental biology
Wan H,Liu C,Wert SE,Xu W,Liao Y,Zheng Y,Whitsett JA
Published figure using BrdU monoclonal antibody (Product # B35130) in Immunohistochemistry
Fri Feb 01 00:00:00 EST 2013
Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Z,Walters BJ,Owen T,Brimble MA,Steigelman KA,Zhang L,Mellado Lagarde MM,Valentine MB,Yu Y,Cox BC,Zuo J
B35130 was used in immunohistochemistry to investigate the role of Sox2 in postmitotic cells.
Wed Aug 01 00:00:00 EDT 2012
Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Z,Walters BJ,Owen T,Brimble MA,Steigelman KA,Zhang L,Mellado Lagarde MM,Valentine MB,Yu Y,Cox BC,Zuo J
B35130 was used in immunohistochemistry to investigate the role of Sox2 in postmitotic cells.
Wed Aug 01 00:00:00 EDT 2012
The rostral migratory stream plays a key role in intranasal delivery of drugs into the CNS.
PloS one
Scranton RA,Fletcher L,Sprague S,Jimenez DF,Digicaylioglu M
B35130 was used in immunohistochemistry to discuss the anatomical structures involved in the transport of intranasally administered drugs into the central nervous system.
Wed Apr 13 00:00:00 EDT 2011
