Invitrogen

CD105 Monoclonal Antibody (MEM-226), FITC

5 Published Figures

7 References

View all (127) CD105 (Endoglin) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (5)

FIGURE: 1 / 6

CD105 Antibody (MA1-19594) in Flow

Separation of HUVEC cells stained using anti-human CD105 (MEM-226) FITC Monoclonal antibody (Product # MA1-19594), 20 µL reagent per million cells in 100 µL of cell suspension (red-filled) from unstained HUVEC cells (black-dashed) in flow cytometry analysis (surface staining) of HUVEC cells.

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Product Details

MA1-19594

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

20 µL/1x10^6 cells

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

MEM-226

Immunogen

Recombinant vaccinia virus containing the human CD105 cDNA.

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1071125

Product Specific Information

This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Therapeutic role of adipose-derived mesenchymal stem cells-derived extracellular vesicles in rats with obstructive sleep apnea hypopnea syndrome.

Regenerative therapy

Xu L,Zhang L,Xiang Y,Zhang X

Published figure using CD105 monoclonal antibody (Product # MA1-19594) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Therapeutic role of adipose-derived mesenchymal stem cells-derived extracellular vesicles in rats with obstructive sleep apnea hypopnea syndrome.

Regenerative therapy

Xu L,Zhang L,Xiang Y,Zhang X

Published figure using CD105 monoclonal antibody (Product # MA1-19594) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway.

Experimental and therapeutic medicine

Liu Y,Zhang X,Hu Y,Kang M,Wu Y,Wang Y,Deng C

Published figure using CD105 monoclonal antibody (Product # MA1-19594) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2022

Transplanted allogeneic cardiac progenitor cells secrete GDF-15 and stimulate an active immune remodeling process in the ischemic myocardium.

Journal of translational medicine

Mishra R,Saha P,Datla SR,Mellacheruvu P,Gunasekaran M,Guru SA,Fu X,Chen L,Bolli R,Sharma S,Kaushal S

MA1-19594 was used in Flow cytometry/Cell sorting to investigate if transplanted allogenic rat cardiac progenitor cells (rCPCs) augment T-regulatory cells which ultimately promote proliferation of M2 like macrophages by an as-yet undefined mechanism.

Thu Jul 21 00:00:00 EDT 2022

The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject's Individual Age, Sex, Body Mass Index and Ethnicity.

Cells

Schmitz C,Alt C,Azares AR,Pearce DA,Facile TR,Furia JP,Maffulli N,Huang C,Alt EU

MA1-19594 was used in Flow cytometry/Cell sorting to show that key characteristics of unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) can be independent of the subject's age, sex, BMI and ethnicity.

Wed Dec 21 00:00:00 EST 2022

VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway.

Bioengineered

Jiang W,Zhang J,Zhang X,Fan C,Huang J

Published figure using CD105 monoclonal antibody (Product # MA1-19594) in Flow Cytometry

Wed Dec 01 00:00:00 EST 2021

Bcl-xL mutant promotes cartilage differentiation of BMSCs by upregulating TGF-β/BMP expression levels.

Experimental and therapeutic medicine

Xiao K,Yang L,Xie W,Gao X,Huang R,Xie M

MA1-19594 was used in Flow Cytometry to investigate the impact of this Bcl-xL mutant on cartilage differentiation and the expression levels of TGF-β and bone morphogenetic protein (BMP).

Thu Jul 01 00:00:00 EDT 2021

Bcl-xL mutant promotes cartilage differentiation of BMSCs by upregulating TGF-β/BMP expression levels.

Experimental and therapeutic medicine

Xiao K,Yang L,Xie W,Gao X,Huang R,Xie M

MA1-19594 was used in Flow Cytometry to investigate the impact of this Bcl-xL mutant on cartilage differentiation and the expression levels of TGF-β and bone morphogenetic protein (BMP).

Thu Jul 01 00:00:00 EDT 2021

Sodium Selenite Improves The Therapeutic Effect Of BMSCs Via Promoting The Proliferation And Differentiation, Thereby Promoting The Hematopoietic Factors.

OncoTargets and therapy

Yan D,Tang B,Yan L,Zhang L,Miao M,Chen X,Sui G,Zhang Q,Liu D,Wang H

Published figure using CD105 monoclonal antibody (Product # MA1-19594) in Flow Cytometry

Tue Apr 12 00:00:00 EDT 2022

Bioinformatics

Protein Aliases: CD105; CD105 antigen; Endoglin; ORW

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Gene Aliases: END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022, (Rat) 497010

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Function(s)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transforming growth factor beta-activated receptor activity transmembrane signal receptor

Process(es)

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of transcription from RNA polymerase II promoter angiogenesis response to hypoxia negative regulation of endothelial cell proliferation positive regulation of systemic arterial blood pressure transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway heart development positive regulation of gene expression cell migration extracellular matrix disassembly response to corticosteroid positive regulation of collagen biosynthetic process intracellular signal transduction response to statin wound healing cell motility negative regulation of nitric-oxide synthase activity cell chemotaxis bone development negative regulation of pathway-restricted SMAD protein phosphorylation extracellular matrix constituent secretion detection of hypoxia cellular response to mechanical stimulus response to transforming growth factor beta

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CD105 Monoclonal Antibody (MEM-226), FITC

CD105 Antibody (MA1-19594) in Flow

Product Details

MA1-19594

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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