Invitrogen

CD105 Monoclonal Antibody (SN6), PE

5 Published Figures

16 References

View all (127) CD105 (Endoglin) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (5)

FIGURE: 1 / 6

CD105 Antibody (MHCD10504) in Flow

Antigen Specificity: According to the literature this antibody recognizes the CD105 antigen. Also known as endoglin, this antigen is expressed on endothelial cells, some bone marrow cells and activated macrophages.

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Product Details

MHCD10504

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-Dependent

View 14 publications 14 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SN6

Immunogen

Human CD105 (Endoglin)

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Purification

purified

Storage buffer

PBS with sucrose, BSA

Contains

0.1% sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10392382

Product Specific Information

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

Analyte Specific Reagent

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury.

Stem cell research & therapy

Vaka R,Khan S,Ye B,Risha Y,Parent S,Courtman D,Stewart DJ,Davis DR

MHCD10504 was used in Flow Cytometry to assess the impact of inflammatory cytokines on the viability, and paracrine profile (extracellular vesicles) of bone marrow-derived mesenchymal stromal cells, heart-derived cells, and umbilical cord-derived mesenchymal stromal cells.

Sat Jan 15 00:00:00 EST 2022

A bone-based 3D scaffold as an in-vitro model of microenvironment-DLBCL lymphoma cell interaction.

Frontiers in oncology

Ceccato J,Piazza M,Pizzi M,Manni S,Piazza F,Caputo I,Cinetto F,Pisoni L,Trojan D,Scarpa R,Zambello R,Tos APD,Trentin L,Semenzato G,Vianello F

MHCD10504 was used in Flow cytometry/Cell sorting to study the role of mesenchymal stromal cells (MSC) and the extracellular matrix (ECM) in the adaptation, growth, and drug resistance of DLBCL lymphoma cells in a developed 3D in-vitro model which was from human decellularized femoral bone fragments.

Sat Nov 05 00:00:00 EDT 2022

Effects of triptolide on bone marrow-derived mesenchymal stem cells from patients with multiple myeloma.

Experimental and therapeutic medicine

Wu H,Wu Y,Ren L,Zhai W,Jiang Y,Guo S,Tao D,Su C,Chen Z,Jiang H

MHCD10504 was used in Flow cytometry/Cell sorting to suggest that TPL inhibited BMMSC growth and improved the bone marrow hematopoietic microenvironment by decreasing IL-6, IL-1Β and SCF mRNA expression, subsequently inhibiting the proliferation of MM cells.

Wed May 01 00:00:00 EDT 2019

Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models.

Blood

Dourado KMC,Baik J,Oliveira VKP,Beltrame M,Yamamoto A,Theuer CP,Figueiredo CAV,Verneris MR,Perlingeiro RCR

MHCD10504 was used in flow cytometry to explore the contribution of CD105 to leukemogenesis

Thu May 04 00:00:00 EDT 2017

Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering.

PloS one

Monsuur HN,Weijers EM,Niessen FB,Gefen A,Koolwijk P,Gibbs S,van den Broek LJ

MHCD10504 was used in Flow cytometry/Cell sorting to characterise endothelial cells from adipose tissue and compare them with endothelial cells from dermis.

Mon Sep 18 00:00:00 EDT 2017

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.

Nature genetics

Maass PG,Aydin A,Luft FC,Schächterle C,Weise A,Stricker S,Lindschau C,Vaegler M,Qadri F,Toka HR,Schulz H,Krawitz PM,Parkhomchuk D,Hecht J,Hollfinger I,Wefeld-Neuenfeld Y,Bartels-Klein E,Mühl A,Kann M,Schuster H,Chitayat D,Bialer MG,Wienker TF,Ott J,Rittscher K,Liehr T,Jordan J,Plessis G,Tank J,Mai K,Naraghi R,Hodge R,Hopp M,Hattenbach LO,Busjahn A,Rauch A,Vandeput F,Gong M,Rüschendorf F,Hübner N,Haller H,Mundlos S,Bilginturan N,Movsesian MA,Klussmann E,Toka O,Bähring S

MHCD10504 was used in flow cytometry to discuss the contribution of missense mutations in PDE3A to hypertension.

Mon Jun 01 00:00:00 EDT 2015

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Stem cell reports

Cai J,Orlova VV,Cai X,Eekhoff EMW,Zhang K,Pei D,Pan G,Mummery CL,Ten Dijke P

Published figure using CD105 monoclonal antibody (Product # MHCD10504) in Flow Cytometry

Tue Dec 08 00:00:00 EST 2015

Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.

PloS one

Tasev D,van Wijhe MH,Weijers EM,van Hinsbergh VW,Koolwijk P

Published figure using CD105 monoclonal antibody (Product # MHCD10504) in Flow Cytometry

Wed Mar 02 00:00:00 EST 2016

The isolation and culture of endothelial colony-forming cells from human and rat lungs.

Nature protocols

Alphonse RS,Vadivel A,Zhong S,McConaghy S,Ohls R,Yoder MC,Thébaud B

MHCD10504 was used in Immunohistochemistry to allow assessment of the functional state of these cells in experimental and human lung diseases, providing newer insights into their pathophysiological mechanisms.

Sun Nov 01 00:00:00 EDT 2015

Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.

Arteriosclerosis, thrombosis, and vascular biology

Orlova VV,Drabsch Y,Freund C,Petrus-Reurer S,van den Hil FE,Muenthaisong S,Dijke PT,Mummery CL

MHCD10504 was used in Flow cytometry/Cell sorting to demonstrate that vascular derivatives of hiPSC are fully functional and can be used to study defective endothelia-pericyte interactions in vitro.

Wed Jan 01 00:00:00 EST 2014

Characterization and functionality of proliferative human Sertoli cells.

Cell transplantation

Chui K,Trivedi A,Cheng CY,Cherbavaz DB,Dazin PF,Huynh AL,Mitchell JB,Rabinovich GA,Noble-Haeusslein LJ,John CM

Published figure using CD105 monoclonal antibody (Product # MHCD10504) in Flow Cytometry

Thu Feb 09 00:00:00 EST 2012

Promigratory activity of oxytocin on umbilical cord blood-derived mesenchymal stem cells.

Artificial organs

Kim YS,Kwon JS,Hong MH,Kim J,Song CH,Jeong MH,Cho JG,Park JC,Kang JC,Ahn Y

MHCD10504 was used in Flow cytometry/Cell sorting to evaluate the angiogenic potential and migration activity of oxytocin on mesenchymal stem cells.

Tue Jun 01 00:00:00 EDT 2010

Aging and replicative senescence have related effects on human stem and progenitor cells.

PloS one

Wagner W,Bork S,Horn P,Krunic D,Walenda T,Diehlmann A,Benes V,Blake J,Huber FX,Eckstein V,Boukamp P,Ho AD

MHCD10504 was used in Flow cytometry/Cell sorting to analyse the effect of aging on the gene expression profiles of human mesenchymal stromal cells and human haematopoietic progenitor cells.

Tue Jun 09 00:00:00 EDT 2009

Replicative senescence of mesenchymal stem cells: a continuous and organized process.

PloS one

Wagner W,Horn P,Castoldi M,Diehlmann A,Bork S,Saffrich R,Benes V,Blake J,Pfister S,Eckstein V,Ho AD

MHCD10504 was used in Flow cytometry/Cell sorting to study the impact of replicative senescence on human mesenchymal stem cells preparations.

Wed May 21 00:00:00 EDT 2008

Mesenchymal stem cell features of Ewing tumors.

Cancer cell

Tirode F,Laud-Duval K,Prieur A,Delorme B,Charbord P,Delattre O

MHCD10504 was used in Flow Cytometry to characterise the mesenchymal stem cell features of Ewing tumours.

Tue May 01 00:00:00 EDT 2007

Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers.

Stem cells (Dayton, Ohio)

Mitchell JB,McIntosh K,Zvonic S,Garrett S,Floyd ZE,Kloster A,Di Halvorsen Y,Storms RW,Goh B,Kilroy G,Wu X,Gimble JM

MHCD10504 was used in Flow cytometry/Cell sorting to compare the immunophenotype of freshly isolated human adipose tissue-derived stromal vascular fraction cells relative to serial-passaged adipose-derived stem cells.

Wed Feb 01 00:00:00 EST 2006

Bioinformatics

Protein Aliases: CD105; CD105 antigen; Endoglin; ORW

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Gene Aliases: END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022

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Function(s)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transmembrane signal receptor

Process(es)

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

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CD105 Monoclonal Antibody (SN6), PE

CD105 Antibody (MHCD10504) in Flow

Product Details

MHCD10504

Immunohistochemistry (IHC)

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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