Product References
Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation.
Journal of innate immunity
Leong E,Pang Z,Stadnyk AW,Lin TJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Jul 07 00:00:00 EDT 2022
Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution.
Scientific reports
Rossi G,Giger S,Hübscher T,Lutolf MP
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Aug 04 00:00:00 EDT 2022
Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression.
International journal of biological sciences
Li J,Li X,Sun W,Zhang J,Yan Q,Wu J,Jin J,Lu R,Miao D
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Apr 15 00:00:00 EDT 2022
Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos.
Nature communications
Li CC,Zhang G,Du J,Liu D,Li Z,Ni Y,Zhou J,Li Y,Hou S,Zheng X,Lan Y,Liu B,He A
14-1171-82 was used in Flow Cytometry to provide a framework to decipher how temporal epigenomic configurations fulfill cell lineage specification during development.
Mon Jan 17 00:00:00 EST 2022
Preventive Effects of a Human Hematopoietic Mesenchymal Stem Cell (hHMSC) Therapy in Ovalbumin-Induced Food Allergy.
Biomedicines
Lee DG,Lee YJ,Park SH,Park HR,Kang H,Kim JE
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Feb 21 00:00:00 EST 2022
Bone marrow-derived myeloid progenitors in the leptomeninges of adult mice.
Stem cells (Dayton, Ohio)
Koeniger T,Bell L,Mifka A,Enders M,Hautmann V,Mekala SR,Kirchner P,Ekici AB,Schulz C,Wörsdörfer P,Mencl S,Kleinschnitz C,Ergün S,Kuerten S
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunocytochemistry
Mon Feb 01 00:00:00 EST 2021
Inaccessible LCG Promoters Act as Safeguards to Restrict T Cell Development to Appropriate Notch Signaling Environments.
Stem cell reports
Furuyama S,Wu QV,Varnum-Finney B,Sandstrom R,Meuleman W,Stamatoyannopoulos JA,Bernstein ID
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Jul 22 00:00:00 EDT 2021
SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis.
The Journal of biological chemistry
Cardenas RA,Gonzalez R,Sanchez E,Ramos MA,Cardenas EI,Rodarte AI,Alcazar-Felix RJ,Isaza A,Burns AR,Heidelberger R,Adachi R
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain.
Frontiers in pain research (Lausanne, Switzerland)
Pattabiraman G,Liu Z,Paul M,Schaeffer AJ,Thumbikat P
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Oct 20 00:00:00 EDT 2023
Analysis of Radiation-Induced Changes in Cell Cycle and DNA Damage of Murine Hematopoietic Stem Cells by Multi-Color Flow Cytometry.
Current protocols
Majumdar D,Pietras EM,Pawar SA
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-1171-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Hsu J,Huang HT,Lee CT,Choudhuri A,Wilson NK,Abraham BJ,Moignard V,Kucinski I,Yu S,Hyde RK,Tober J,Cai X,Li Y,Guo Y,Yang S,Superdock M,Trompouki E,Calero-Nieto FJ,Ghamari A,Jiang J,Gao P,Gao L,Nguyen V,Robertson AL,Durand EM,Kathrein KL,Aifantis I,Gerber SA,Tong W,Tan K,Cantor AB,Zhou Y,Liu PP,Young RA,Göttgens B,Speck NA,Zon LI
14-1171-81 was used in Immunohistochemistry (PFA fixed) to determine that CHD7 and Runx1 are used as a braking mechanism for hematopoietic differentiation.
Tue Sep 22 00:00:00 EDT 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
14-1171-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
14-1171 was used in Flow cytometry/Cell sorting to demonstrate how heme oxygenase 1 (HO-1) extrinsic activity prevents hematopoietic stem cells (HSCs) from premature exhaustion and may restore their function when aged.
Wed Feb 05 00:00:00 EST 2020
Diverse epithelial cell populations contribute to the regeneration of secretory units in injured salivary glands.
Development (Cambridge, England)
Ninche N,Kwak M,Ghazizadeh S
14-1171-82 was used in Immunohistochemistry (Paraffin) to show that de novo formation of acini involves induction of cellular plasticity in multiple non-acinar cell populations.
Fri Oct 09 00:00:00 EDT 2020
XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling.
Cell communication and signaling : CCS
Zheng Y,Wang N,Wang S,Yang B,Situ H,Zhong L,Lin Y,Wang Z
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Mar 26 00:00:00 EDT 2020
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.
Cell reports
van den Berk P,Lancini C,Company C,Serresi M,Sanchez-Bailon MP,Hulsman D,Pritchard C,Song JY,Schmitt MJ,Tanger E,Popp O,Mertins P,Huijbers IJ,Jacobs H,van Lohuizen M,Gargiulo G,Citterio E
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2020
Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System.
Biomedicines
Hong Y,Singh N,Bamopoulos S,Gjerga E,Schmalbrock LK,Balabanian K,Schick M,Keller U,Wirth M
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed Dec 09 00:00:00 EST 2020
Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death.
International journal of molecular sciences
Darzianiazizi M,Mehrani Y,Chan L,Mould RC,Kulkarni RR,Sharif S,Bridle BW,Karimi K
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Nov 27 00:00:00 EST 2020
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
14-1171-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Cell stem cell
Ho YH,Del Toro R,Rivera-Torres J,Rak J,Korn C,García-García A,Macías D,González-Gómez C,Del Monte A,Wittner M,Waller AK,Foster HR,López-Otín C,Johnson RS,Nerlov C,Ghevaert C,Vainchenker W,Louache F,Andrés V,Méndez-Ferrer S
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Sep 05 00:00:00 EDT 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-1171 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
The Journal of experimental medicine
Malara A,Gruppi C,Abbonante V,Cattaneo D,De Marco L,Massa M,Iurlo A,Gianelli U,Balduini CL,Tira ME,Muro AF,Chauhan AK,Rosti V,Barosi G,Balduini A
14-1171 was used in Flow cytometry/Cell sorting to find that the EDA FN is increased in plasma and BM biopsies of PMF patients as compared with healthy controls, correlating with fibrotic phase.
Mon Mar 04 00:00:00 EST 2019
Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality.
Journal of gastroenterology
Wang H,Jing R,Trexler C,Li Y,Tang H,Pan Z,Zhu S,Zhao B,Fang X,Liu J,Chen J,Ouyang K
14-1171-82 was used in Immunohistochemistry to investigate the physiological function of IP3R1 in the gastrointestinal tract using genetically engineered IP3R1 knockout mice.
Wed May 01 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-1171 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Defective germline reprogramming rewires the spermatogonial transcriptome.
Nature structural & molecular biology
Vasiliauskaitė L,Berrens RV,Ivanova I,Carrieri C,Reik W,Enright AJ,O'Carroll D
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
Ca2+-mitochondria axis drives cell division in hematopoietic stem cells.
The Journal of experimental medicine
Umemoto T,Hashimoto M,Matsumura T,Nakamura-Ishizu A,Suda T
14-1171-82 was used in Flow Cytometry to indicate that the Ca2+ mitochondrial pathway induces hematopoietic stem cell division critically to determine HSC cell fate.
Mon Aug 06 00:00:00 EDT 2018
Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.
The Journal of experimental medicine
Koga S,Hozumi K,Hirano KI,Yazawa M,Terooatea T,Minoda A,Nagasawa T,Koyasu S,Moro K
14-1171 was used in Flow cytometry/Cell sorting to suggest that early differentiation of ILC2 occurs in the fetal liver via IL-7 and Notch signaling, whereas final differentiation occurs in the periphery with the aid of PDGFRα+gp38+ cells.
Mon Jun 04 00:00:00 EDT 2018
JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias.
Genes & development
Kim SK,Knight DA,Jones LR,Vervoort S,Ng AP,Seymour JF,Bradner JE,Waibel M,Kats L,Johnstone RW
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Experimental hematology
Serrano-Lopez J,Nattamai K,Pease NA,Shephard MS,Wellendorf AM,Sertorio M,Smith EA,Geiger H,Wells SI,Cancelas JA,Privette Vinnedge LM
14-1171 was used in Flow cytometry/Cell sorting to investigate the role of DEK in normal hematopoiesis and response to DNA damaging agents in vivo.
Thu Mar 01 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem cell reports
Hamanaka S,Umino A,Sato H,Hayama T,Yanagida A,Mizuno N,Kobayashi T,Kasai M,Suchy FP,Yamazaki S,Masaki H,Yamaguchi T,Nakauchi H
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Oct 09 00:00:00 EDT 2018
Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.
eLife
Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Mar 20 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.
Frontiers in immunology
Potuckova L,Draberova L,Halova I,Paulenda T,Draber P
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Oct 07 00:00:00 EDT 2019
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-1171 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation.
PloS one
Meroni E,Stakenborg N,Gomez-Pinilla PJ,De Hertogh G,Goverse G,Matteoli G,Verheijden S,Boeckxstaens GE
14-1171 was used in Flow cytometry/Cell sorting to characterise the immune response in oxazolone-induced colitis and study the therapeutic effect of vagus nerve stimulation.
Tue Nov 27 00:00:00 EST 2018
c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells.
Scientific reports
Kwak M,Ninche N,Klein S,Saur D,Ghazizadeh S
14-1171 was used in Immunohistochemistry-immunofluorescence to study whether c-Kit is a reliable marker for salivary gland stem cells.
Fri Sep 21 00:00:00 EDT 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Apr 06 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-1171 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 EST 2017
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.
EMBO molecular medicine
Lopes N,Vachon H,Marie J,Irla M
14-1171 was used in Flow cytometry/Cell sorting to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration.
Thu Jun 01 00:00:00 EDT 2017
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.
Developmental cell
Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2017
Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling.
Scientific reports
Kasaai B,Caolo V,Peacock HM,Lehoux S,Gomez-Perdiguero E,Luttun A,Jones EA
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunofluorescence
Wed Mar 08 00:00:00 EST 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b.
Scientific reports
Niu R,Xiao X,Liu B,Li Y,Zhong Y,Ma L
14-1171 was used in Flow cytometry/Cell sorting to study the role of miR-33b in asthma and mast cell biology and identifies novel mechanisms that may contribute to mast cell-related pathological conditions in airway inflammation.
Mon Aug 07 00:00:00 EDT 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-1171 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-1171-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
Developmental mechanisms of stripe patterns in rodents.
Nature
Mallarino R,Henegar C,Mirasierra M,Manceau M,Schradin C,Vallejo M,Beronja S,Barsh GS,Hoekstra HE
Thu Nov 24 00:00:00 EST 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-1171 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 EDT 2016
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
Nucleic acids research
Yang Y,Poe JC,Yang L,Fedoriw A,Desai S,Magnuson T,Li Z,Fedoriw Y,Araki K,Gao Y,Tateishi S,Sarantopoulos S,Vaziri C
14-1171-82 was used in Flow Cytometry to investigate the physiological roles of Rad18 in DNA damage tolerance and carcinogenesis.
Thu May 19 00:00:00 EDT 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
14-1171 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.
Tue Feb 09 00:00:00 EST 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-1171 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration.
American journal of physiology. Heart and circulatory physiology
Bellio MA,Rodrigues CO,Landin AM,Hatzistergos KE,Kuznetsov J,Florea V,Valasaki K,Khan A,Hare JM,Schulman IH
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.
Molecular and cellular biology
Thoms JA,Knezevic K,Liu JJ,Glaros EN,Thai T,Qiao Q,Campbell H,Packham D,Huang Y,Papathanasiou P,Tunningley R,Whittle B,Yeung AW,Chandrakanthan V,Hesson L,Chen V,Wong JW,Purton LE,Ward RL,Thomas SR,Pimanda JE
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2016
New Regulatory Roles of Galectin-3 in High-Affinity IgE Receptor Signaling.
Molecular and cellular biology
Bambouskova M,Polakovicova I,Halova I,Goel G,Draberova L,Bugajev V,Doan A,Utekal P,Gardet A,Xavier RJ,Draber P
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.
Leukemia research
Mian YA,Zeleznik-Le NJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.
Stem cell reports
Crisan M,Solaimani Kartalaei P,Neagu A,Karkanpouna S,Yamada-Inagawa T,Purini C,Vink CS,van der Linden R,van Ijcken W,Chuva de Sousa Lopes SM,Monteiro R,Mummery C,Dzierzak E
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Mar 08 00:00:00 EST 2016
LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.
Nature communications
Shi Y,Wu W,Chai Q,Li Q,Hou Y,Xia H,Ren B,Xu H,Guo X,Jin C,Lv M,Wang Z,Fu YX,Zhu M
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Aug 05 00:00:00 EDT 2016
Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Nature communications
Li Z,Hodgkinson T,Gothard EJ,Boroumand S,Lamb R,Cummins I,Narang P,Sawtell A,Coles J,Leonov G,Reboldi A,Buckley CD,Cupedo T,Siebel C,Bayat A,Coles MC,Ambler CA
14-1171 was used in Immunohistochemistry to invesitgate whether Notch directs non-cell-autonomous signalling in adult tissues, showing that it recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Thu Apr 21 00:00:00 EDT 2016
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Nature
Acar M,Kocherlakota KS,Murphy MM,Peyer JG,Oguro H,Inra CN,Jaiyeola C,Zhao Z,Luby-Phelps K,Morrison SJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2015
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Nature
Acar M,Kocherlakota KS,Murphy MM,Peyer JG,Oguro H,Inra CN,Jaiyeola C,Zhao Z,Luby-Phelps K,Morrison SJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2015
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cancer cell
Cole A,Wang Z,Coyaud E,Voisin V,Gronda M,Jitkova Y,Mattson R,Hurren R,Babovic S,Maclean N,Restall I,Wang X,Jeyaraju DV,Sukhai MA,Prabha S,Bashir S,Ramakrishnan A,Leung E,Qia YH,Zhang N,Combes KR,Ketela T,Lin F,Houry WA,Aman A,Al-Awar R,Zheng W,Wienholds E,Xu CJ,Dick J,Wang JC,Moffat J,Minden MD,Eaves CJ,Bader GD,Hao Z,Kornblau SM,Raught B,Schimmer AD
14-1171-82 was used in Flow Cytometry to study the inhibition of ClpP as a therapeutic strategy for human Acute Myeloid Leukaemia.
Mon Jun 08 00:00:00 EDT 2015
Mast cells mediate malignant pleural effusion formation.
The Journal of clinical investigation
Giannou AD,Marazioti A,Spella M,Kanellakis NI,Apostolopoulou H,Psallidas I,Prijovich ZM,Vreka M,Zazara DE,Lilis I,Papaleonidopoulos V,Kairi CA,Patmanidi AL,Giopanou I,Spiropoulou N,Harokopos V,Aidinis V,Spyratos D,Teliousi S,Papadaki H,Taraviras S,Snyder LA,Eickelberg O,Kardamakis D,Iwakura Y,Feyerabend TB,Rodewald HR,Kalomenidis I,Blackwell TS,Agalioti T,Stathopoulos GT
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunocytochemistry
Mon Jun 01 00:00:00 EDT 2015
Mast cells mediate malignant pleural effusion formation.
The Journal of clinical investigation
Giannou AD,Marazioti A,Spella M,Kanellakis NI,Apostolopoulou H,Psallidas I,Prijovich ZM,Vreka M,Zazara DE,Lilis I,Papaleonidopoulos V,Kairi CA,Patmanidi AL,Giopanou I,Spiropoulou N,Harokopos V,Aidinis V,Spyratos D,Teliousi S,Papadaki H,Taraviras S,Snyder LA,Eickelberg O,Kardamakis D,Iwakura Y,Feyerabend TB,Rodewald HR,Kalomenidis I,Blackwell TS,Agalioti T,Stathopoulos GT
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunocytochemistry
Mon Jun 01 00:00:00 EDT 2015
F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.
The Journal of clinical investigation
Yumimoto K,Akiyoshi S,Ueo H,Sagara Y,Onoyama I,Ueo H,Ohno S,Mori M,Mimori K,Nakayama KI
14-1171 was used in Immunofluorescence on frozen tissues to investigate the role of FBXW7 in suppression of cancer metastasis, showing that it suppresses metastasis in a non-cell-autonomous manner.
Sun Feb 01 00:00:00 EST 2015
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Science advances
Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation.
Stem cells (Dayton, Ohio)
Salabei JK,Lorkiewicz PK,Holden CR,Li Q,Hong KU,Bolli R,Bhatnagar A,Hill BG
14-1171 was used in Flow cytometry/Cell sorting to investigate how Gln, by enhancing mitochondrial function and stimulating mTORC1, increases CPC proliferation, and that interventions to increase Gln uptake or oxidation may improve CPC therapy.
Sat Aug 01 00:00:00 EDT 2015
Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
Platelets
Ramsey H,Zhang Q,Wu MX
14-1171 was used in Flow cytometry/Cell sorting to investigate whether increased ROS production in myelodysplastic syndromes is an instigator or a byproduct of the disease.
Tue Mar 08 00:00:00 EST 2016
Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.
PloS one
Zoch A,Mayerl S,Schulz A,Greither T,Frappart L,Rübsam J,Heuer H,Giovannini M,Morrison H
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon May 23 00:00:00 EDT 2016
Notch signal strength controls cell fate in the haemogenic endothelium.
Nature communications
Gama-Norton L,Ferrando E,Ruiz-Herguido C,Liu Z,Guiu J,Islam AB,Lee SU,Yan M,Guidos CJ,López-Bigas N,Maeda T,Espinosa L,Kopan R,Bigas A
Wed Oct 14 00:00:00 EDT 2015
Notch signal strength controls cell fate in the haemogenic endothelium.
Nature communications
Gama-Norton L,Ferrando E,Ruiz-Herguido C,Liu Z,Guiu J,Islam AB,Lee SU,Yan M,Guidos CJ,López-Bigas N,Maeda T,Espinosa L,Kopan R,Bigas A
Wed Oct 14 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-1171 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways.
PloS one
Vajravelu BN,Hong KU,Al-Maqtari T,Cao P,Keith MC,Wysoczynski M,Zhao J,Moore JB,Bolli R
14-1171 was used in Flow cytometry/Cell sorting to imply that the efficiency of CPC homing to the injury site as well as their survival after transplantation may be improved by modulating the activity of c-kit.
Fri Jun 10 00:00:00 EDT 2016
Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.
eLife
Yzaguirre AD,Padmanabhan A,de Groh ED,Engleka KA,Li J,Speck NA,Epstein JA
14-1171-82 was used in Immunohistochemistry to characterise previously unappreciated phenotypes in Nf1-/- embryos.
Tue Oct 13 00:00:00 EDT 2015
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-1171 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
Circulation research
Hodgkinson CP,Gomez JA,Payne AJ,Zhang L,Wang X,Dal-Pra S,Pratt RE,Dzau VJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Dec 05 00:00:00 EST 2014
Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
Circulation research
Hodgkinson CP,Gomez JA,Payne AJ,Zhang L,Wang X,Dal-Pra S,Pratt RE,Dzau VJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Dec 05 00:00:00 EST 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-1171 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-1171 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 EDT 2014
Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody.
Bioscience trends
Ohshima S,Mori S,Shigenari A,Miyamoto A,Takasu M,Imaeda N,Nunomura S,Okayama Y,Tanaka M,Kitagawa H,Kulski JK,Inoko H,Ando A,Kametani Y
14-1171 was used in Flow cytometry/Cell sorting to reveal that the swine BM CD117+ cells possess hematopoietic stem/progenitor activity.
Mon Dec 01 00:00:00 EST 2014
Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus.
The Journal of investigative dermatology
Lin Q,Wesson RN,Maeda H,Wang Y,Cui Z,Liu JO,Cameron AM,Gao B,Montgomery RA,Williams GM,Sun Z
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Sep 01 00:00:00 EDT 2014
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.
Development (Cambridge, England)
Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sun Jun 01 00:00:00 EDT 2014
Murine mast cells secrete and respond to interleukin-33.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Tung HY,Plunkett B,Huang SK,Zhou Y
14-1171 was used in Flow cytometry/Cell sorting to elucidate the cellular source and regulatory mechanisms of IL-33.
Sat Mar 01 00:00:00 EST 2014
Identification of hematopoietic-specific regulatory elements from the CD45 gene and use for lentiviral tracking of transplanted cells.
Experimental hematology
Duong KL,Das S,Yu S,Barr JY,Jena S,Kim E,Zavazava N,Colgan JD,Xue HH,Levasseur DN
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Sep 01 00:00:00 EDT 2014
F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
Molecular & cellular proteomics : MCP
Honarpour N,Rose CM,Brumbaugh J,Anderson J,Graham RL,Sweredoski MJ,Hess S,Coon JJ,Deshaies RJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation.
PloS one
Gomez-Pinilla PJ,Farro G,Di Giovangiulio M,Stakenborg N,Némethova A,de Vries A,Liston A,Feyerabend TB,Rodewald HR,Boeckxstaens GE,Matteoli G
14-1171 was used in Immunohistochemistry on frozen tissues to investigate the role of mast cells in the development of postoperative ileus, showing that they play no role in the pathogenesis.
Tue Sep 02 00:00:00 EDT 2014
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
Immunity
Cheng LE,Hartmann K,Roers A,Krummel MF,Locksley RM
14-1171 was used in Flow cytometry/Cell sorting to investigate the mechanism by which perivascular mast cells acquire IgE from the blood.
Thu Jan 24 00:00:00 EST 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The expression of Sox17 identifies and regulates haemogenic endothelium.
Nature cell biology
Clarke RL,Yzaguirre AD,Yashiro-Ohtani Y,Bondue A,Blanpain C,Pear WS,Speck NA,Keller G
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke.
Circulation research
Ludewig P,Sedlacik J,Gelderblom M,Bernreuther C,Korkusuz Y,Wagener C,Gerloff C,Fiehler J,Magnus T,Horst AK
14-1171 was used in Flow cytometry/Cell sorting to identify and characterise the relevance of CEACAM1-expressing inflammatory cells in blood-brain-barrier breakdown.
Fri Sep 27 00:00:00 EDT 2013
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke.
Circulation research
Ludewig P,Sedlacik J,Gelderblom M,Bernreuther C,Korkusuz Y,Wagener C,Gerloff C,Fiehler J,Magnus T,Horst AK
14-1171 was used in Flow cytometry/Cell sorting to identify and characterise the relevance of CEACAM1-expressing inflammatory cells in blood-brain-barrier breakdown.
Fri Sep 27 00:00:00 EDT 2013
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.
The Journal of experimental medicine
Jutzi JS,Bogeska R,Nikoloski G,Schmid CA,Seeger TS,Stegelmann F,Schwemmers S,Gründer A,Peeken JC,Gothwal M,Wehrle J,Aumann K,Hamdi K,Dierks C,Kamar Wang W,Döhner K,Jansen JH,Pahl HL
14-1171 was used in Flow cytometry/Cell sorting to report the presence of acquired insertion and deletion mutations in the NF-E2 gene in myeloproliferative neoplasm patients.
Mon May 06 00:00:00 EDT 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-1171 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
14-1171 was used in Immunohistochemistry-wholemount to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal.
Stem cells (Dayton, Ohio)
Jeannet R,Cai Q,Liu H,Vu H,Kuo YH
14-1171 was used in Flow cytometry/Cell sorting to investigate the role of activated leukocyte cell adhesion molecule in hematopoietic stem cell differentiation and self-renewal using an Alcam-null mouse model.
Fri Mar 01 00:00:00 EST 2013
Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice.
The American journal of pathology
Moniaga CS,Jeong SK,Egawa G,Nakajima S,Hara-Chikuma M,Jeon JE,Lee SH,Hibino T,Miyachi Y,Kabashima K
14-1171 was used in Flow cytometry/Cell sorting to study the interplay between cellular protease activity and filaggrin deficiency in epidermal barrier abnormality as a predisposing factor in atopic dermatitis.
Fri Mar 01 00:00:00 EST 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-1171 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 EDT 2013
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
The Journal of experimental medicine
Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL
14-1171 was used in Flow cytometry/Cell sorting to investigate the molecular pathophysiology of myeloproliferative neoplasms.
Mon Jan 16 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-1171 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
The EMBO journal
Gu P,Min JN,Wang Y,Huang C,Peng T,Chai W,Chang S
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed May 16 00:00:00 EDT 2012
Temporal control of neural crest lineage generation by Wnt/β-catenin signaling.
Development (Cambridge, England)
Hari L,Miescher I,Shakhova O,Suter U,Chin L,Taketo M,Richardson WD,Kessaris N,Sommer L
14-1171 was used in Immunohistochemistry on frozen tissues to examine how Wnt/β-catenin signalling regulates the formation of distinct lineages from the neural crest.
Fri Jun 01 00:00:00 EDT 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Courtial N,Smink JJ,Kuvardina ON,Leutz A,Göthert JR,Lausen J
14-1171 was used in Flow cytometry/Cell sorting to show that Tal1 is expressed in osteoclasts and that loss of Tal1 in osteoclast progenitors leads to altered expression of >1200 genes.
Wed Feb 01 00:00:00 EST 2012
Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation.
Tissue engineering. Part A
Agrawal V,Siu BF,Chao H,Hirschi KK,Raborn E,Johnson SA,Tottey S,Hurley KB,Medberry CJ,Badylak SF
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sun Jul 01 00:00:00 EDT 2012
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Nature
Zuber J,Shi J,Wang E,Rappaport AR,Herrmann H,Sison EA,Magoon D,Qi J,Blatt K,Wunderlich M,Taylor MJ,Johns C,Chicas A,Mulloy JC,Kogan SC,Brown P,Valent P,Bradner JE,Lowe SW,Vakoc CR
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Wed Aug 03 00:00:00 EDT 2011
Essential roles for Pot1b in HSC self-renewal and survival.
Blood
Wang Y,Shen MF,Chang S
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
Blood
Cook BD,Liu S,Evans T
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Jun 16 00:00:00 EDT 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-1171 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
14-1171 was used in Flow cytometry/Cell sorting to study the relationship between gene dosage and FLT3 production.
Thu Sep 29 00:00:00 EDT 2011
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.
Blood
Wilhelm BT,Briau M,Austin P,Faubert A,Boucher G,Chagnon P,Hope K,Girard S,Mayotte N,Landry JR,Hébert J,Sauvageau G
14-1171 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms regulating self-renewal of leukemia stem cells.
Thu Jan 13 00:00:00 EST 2011
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.
The Journal of experimental medicine
Christopher MJ,Rao M,Liu F,Woloszynek JR,Link DC
14-1171 was used in Flow cytometry/Cell sorting to suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance.
Mon Feb 14 00:00:00 EST 2011
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation.
The Journal of experimental medicine
Takizawa H,Regoes RR,Boddupalli CS,Bonhoeffer S,Manz MG
14-1171 was used in Flow cytometry/Cell sorting to investigate how often mouse hematopoietic stem cells (HSCs) divide and whether each HSC contributes simultaneously, sequentially, or repetitively to hematopoiesis, showing that entry into and exit out of the cell cycle is dynamic varies due to demand.
Mon Feb 14 00:00:00 EST 2011
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A
14-1171 was used in Flow cytometry/Cell sorting to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.
Tue Mar 01 00:00:00 EST 2011
Intramuscular VEGF activates an SDF1-dependent progenitor cell cascade and an SDF1-independent muscle paracrine cascade for cardiac repair.
American journal of physiology. Heart and circulatory physiology
Zisa D,Shabbir A,Mastri M,Taylor T,Aleksic I,McDaniel M,Suzuki G,Lee T
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice.
Endocrinology
Laronda MM,Jameson JL
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2011
Contribution of IL-13 to early exocrinopathy in Id3-/- mice.
Molecular immunology
Mahlios J,Zhuang Y
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunofluorescence
Sat Oct 01 00:00:00 EDT 2011
A high omega-3 fatty acid diet has different effects on early and late stage myeloid progenitors.
Lipids
Varney ME,Buchanan JT,Dementieva Y,Hardman WE,Sollars VE
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2011
Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation.
Blood
Fewkes NM,Krauss AC,Guimond M,Meadors JL,Dobre S,Mackall CL
14-1171 was used in Flow cytometry/Cell sorting to study the effects of the multityrosine kinase inhibitor, sunitinib, on hematopoietic stem cell engraftment following bone marrow transplantation.
Thu May 20 00:00:00 EDT 2010
Food allergy herbal formula 2 protection against peanut anaphylactic reaction is via inhibition of mast cells and basophils.
The Journal of allergy and clinical immunology
Song Y,Qu C,Srivastava K,Yang N,Busse P,Zhao W,Li XM
14-1171 was used in Flow cytometry/Cell sorting to show that food allergy herbal formula 2 reduction of basophils and mast cell numbers as well as suppression of IgE-mediated mast cell activation may contribute to FAHF-2''s persistent protection against peanut anaphylaxis.
Wed Dec 01 00:00:00 EST 2010
Cytokine-induced memory-like natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM
14-1171 was used in Flow cytometry/Cell sorting to identify an ability of innate immune cells to retain an intrinsic memory of prior activation.
Tue Feb 10 00:00:00 EST 2009
Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150.
Stem cells (Dayton, Ohio)
Papathanasiou P,Attema JL,Karsunky H,Xu J,Smale ST,Weissman IL
14-1171 was used in Flow cytometry/Cell sorting to identify cell surface markers that allow the isolation and characterisation of haematopoietic stem cells.
Thu Oct 01 00:00:00 EDT 2009
Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen.
American journal of physiology. Heart and circulatory physiology
Shabbir A,Zisa D,Suzuki G,Lee T
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2009
Chlamydia infection causes loss of pacemaker cells and inhibits oocyte transport in the mouse oviduct.
Biology of reproduction
Dixon RE,Hwang SJ,Hennig GW,Ramsey KH,Schripsema JH,Sanders KM,Ward SM
14-1171 was used in Western Blotting to find that electrical pacemaker activity is responsible for oviduct motility and egg transport, loss of which may cause tubal factor infertility.
Wed Apr 01 00:00:00 EDT 2009
Intramuscular VEGF repairs the failing heart: role of host-derived growth factors and mobilization of progenitor cells.
American journal of physiology. Regulatory, integrative and comparative physiology
Zisa D,Shabbir A,Mastri M,Suzuki G,Lee T
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Immunofluorescence
Sun Nov 01 00:00:00 EDT 2009
In vivo expression of signaling proteins in reconstituted NK cells.
Journal of immunological methods
Orr SJ,Quigley L,McVicar DW
14-1171 was used in Flow cytometry/Cell sorting to develop a novel technique to generate NK cells in vivo, all of which express a gene of interest.
Fri Jan 30 00:00:00 EST 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
14-1171 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 EST 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-1171-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-1171-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
Deciphering developmental stages of adult myelopoiesis.
Cell cycle (Georgetown, Tex.)
Pronk CJ,Attema J,Rossi DJ,Sigvardsson M,Bryder D
14-1171 was used in Flow cytometry/Cell sorting to provide additional characterization of these cellular subsets to further refine their developmental potential.
Sat Mar 15 00:00:00 EDT 2008
Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice.
Blood
Chappaz S,Flueck L,Farr AG,Rolink AG,Finke D
14-1171 was used in Flow cytometry/Cell sorting to investigate the role of TSLP in lymphopoiesis and immune cell development in IL-7-deficient mice.
Sat Dec 01 00:00:00 EST 2007
Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine.
American journal of physiology. Cell physiology
Chen H,Redelman D,Ro S,Ward SM,Ordög T,Sanders KM
14-1171 was used in Flow cytometry/Cell sorting to investigate different functional classes of interstitial cells of Cajal of human and murine small intestine.
Mon Jan 01 00:00:00 EST 2007
Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine.
American journal of physiology. Cell physiology
Chen H,Redelman D,Ro S,Ward SM,Ordög T,Sanders KM
14-1171 was used in Flow cytometry/Cell sorting to investigate different functional classes of interstitial cells of Cajal of human and murine small intestine.
Mon Jan 01 00:00:00 EST 2007
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature.
The Journal of clinical investigation
Jin H,Aiyer A,Su J,Borgstrom P,Stupack D,Friedlander M,Varner J
14-1171-82 was used in Flow Cytometry to show that integrin alpha4beta1 promotes the homing of circulating progenitor cells to the alpha4beta1 ligands VCAM and cellular fibronectin which are expressed on actively remodelling neovasculature.
Wed Mar 01 00:00:00 EST 2006
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD117 (c-Kit) monoclonal antibody (Product # 14-1171-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2006
A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision.
The Journal of experimental medicine
Benz C,Bleul CC
14-1171 was used in Flow cytometry/Cell sorting to identify a multipotent thymic precursor that maps to the branching point of the T versus B lineage decision.
Mon Jul 04 00:00:00 EDT 2005
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.jpg?time=20240507?time=20240507 "CD117 (c-Kit) Antibody (14-1171-82) in Flow")
