Product References
Immunostimulatory effects of a subcritical water extract of Ganoderma.
Biomedical reports
Hattori K,Takagi H,Ogata Y,Yamada T,Horiba H,Fukata K,Sakaida T,Yashiro Y,Hasegawa S,Tanaka H
17-1171-82 was used in Flow cytometry/Cell sorting to demonstrate that Ganoderma (SWEG) increased hematopoietic precursor cells, immature B cells, and NK cells in the bone marrow, and T cells in the thymus.
Sun Jan 01 00:00:00 EST 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
17-1171-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
The Journal of clinical investigation
Han X,Mei Y,Mishra RK,Bi H,Jain AD,Schiltz GE,Zhao B,Sukhanova M,Wang P,Grigorescu AA,Weber PC,Piwinski JJ,Prado MA,Paulo JA,Stephens L,Anderson KE,Abrams CS,Yang J,Ji P
17-1171-82 was used in Flow cytometry/Cell sorting to reveal a Plek2-Akt complex that drives cell proliferation and can be targeted by a new class of anti-proliferative compounds for MPN therapy.
Wed Mar 15 00:00:00 EDT 2023
The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing.
Frontiers in immunology
Harnett MM,Doonan J,Lumb FE,Crowe J,Damink RO,Buitrago G,Duncombe-Moore J,Wilkinson DI,Suckling CJ,Selman C,Harnett W
17-1171-82 was used in Flow cytometry/Cell sorting to report the ability of small drug-like molecule analogues of ES-62 to mimic some of its key actions, particularly in strongly protecting trabecular bone structure, highlighting the translational potential of these studies.
Fri Sep 16 00:00:00 EDT 2022
Targeted deletion of Interleukin-3 results in asthma exacerbations.
iScience
Kölle J,Zimmermann T,Kiefer A,Rieker RJ,Xepapadaki P,Zundler S,Papadopoulos NG,Finotto S
17-1171-82 was used in Flow cytometry/Cell sorting to demonstrate that IL-3 downregulation was found associated with more severe allergic asthma in pre-school children.
Fri Jun 17 00:00:00 EDT 2022
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Cancer cell
Ueda K,Kumari R,Schwenger E,Wheat JC,Bohorquez O,Narayanagari SR,Taylor SJ,Carvajal LA,Pradhan K,Bartholdy B,Todorova TI,Goto H,Sun D,Chen J,Shan J,Song Y,Montagna C,Xiong S,Lozano G,Pellagatti A,Boultwood J,Verma A,Steidl U
17-1171-82 was used in Flow cytometry/Cell sorting to identify MDMX overexpression as a pervasive preleukemic-to-AML transition mechanism in different genetically driven disease subtypes, and reveal Wnt/β-Catenin as a non-canonical MDMX-driven pathway with therapeutic potential for progression prevention and cancer interception.
Mon Apr 12 00:00:00 EDT 2021
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
17-1171-82 was used in Flow Cytometry to show that Runx1 and GATA3 work stage specifically through an intronic silencing element in mouse Spi1 to control strength and maintenance of Spi1 repression during T lineage commitment.
Mon Aug 02 00:00:00 EDT 2021
Effects of signaling pathway inhibitors on hematopoietic stem cells.
Molecular medicine reports
Jiang Y,Xu Z,Ma N,Yin L,Hao C,Li J
17-1171 was used in Flow cytometry/Cell sorting to determine the effect of HDACs, mTOR, GSK‚3β and p38MAPK inhibitor combinations on the efficient expansion of HSCs using flow cytometry.
Fri Jan 01 00:00:00 EST 2021
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Nature communications
Lei H,Xu HZ,Shan HZ,Liu M,Lu Y,Fang ZX,Jin J,Jing B,Xiao XH,Gao SM,Gao FH,Xia L,Yang L,Liu LG,Wang WW,Liu CX,Tong Y,Wu YZ,Zheng JK,Chen GQ,Zhou L,Wu YL
17-1171-82 was used in Flow cytometry/Cell sorting to conclude that targeting USP47 is a promising strategy to overcome TKI resistance and eradicate leukemia stem/progenitor cells in CML.
Mon Jan 04 00:00:00 EST 2021
Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells.
Nature communications
Freter R,Falletta P,Omrani O,Rasa M,Herbert K,Annunziata F,Minetti A,Krepelova A,Adam L,Käppel S,Rüdiger T,Wang ZQ,Goding CR,Neri F
17-1171-82 was used in Magnetic cell separation to identify a dormant OSCARhigh cell population in the small intestine.
Thu Jun 03 00:00:00 EDT 2021
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.
Nature communications
Wang Q,Hernández-Ochoa EO,Viswanathan MC,Blum ID,Do DC,Granger JM,Murphy KR,Wei AC,Aja S,Liu N,Antonescu CM,Florea LD,Talbot CC,Mohr D,Wagner KR,Regot S,Lovering RM,Gao P,Bianchet MA,Wu MN,Cammarato A,Schneider MF,Bever GS,Anderson ME
17-1171-82 was used in Flow Cytometry to examine CaMKII and find that its activation by reactive oxygen species (ROS) was acquired more than half-a-billion years ago along the vertebrate stem lineage.
Wed May 26 00:00:00 EDT 2021
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
17-1171-82 was used in Flow Cytometry to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
17-1171-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B,Harbeson DJ,Shannon CP,Cai B,He D,Ben-Othman R,Francis F,Huang J,Varankovich N,Liu A,Bao W,Bjerregaard-Andersen M,Schaltz-Buchholzer F,Sanca L,Golding CN,Larsen KL,Levy O,Kampmann B,Tan R,Charles A,Wynn JL,Shann F,Aaby P,Benn CS,Tebbutt SJ,Kollmann TR,Amenyogbe N
17-1171 was used in Flow cytometry/Cell sorting to show that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration.
Wed May 06 00:00:00 EDT 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
17-1171 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.
Arteriosclerosis, thrombosis, and vascular biology
Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that IgE deficiency reduced atherosclerosis lesion burden, lesion lipid deposition, smooth muscle cell and endothelial cell contents, chemokine MCP (monocyte chemoattractant protein)-1 expression and macrophage accumulation.
Sun Mar 01 00:00:00 EST 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
17-1171 was used in Flow cytometry/Cell sorting to define a distinct mechanism of Notch signal response that distinguishes the initial stages of murine T cell development.
Mon Oct 05 00:00:00 EDT 2020
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
17-1171 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP
17-1171 was used in Flow cytometry/Cell sorting to support a direct role of IgE in abdominal aortic aneurysm by promoting lesion chemokine expression, inflammatory cell accumulation, MAPK signalling and cytokine expression in mice.
Sat Feb 01 00:00:00 EST 2020
Osteoclasts Derive Predominantly from Bone Marrow-Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair.
Journal of immunology (Baltimore, Md. : 1950)
Novak S,Roeder E,Kalinowski J,Jastrzebski S,Aguila HL,Lee SK,Kalajzic I,Lorenzo JA
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that OCP, but not mature OC, express CX3CR1 during both homeostasis and fracture repair.
Sat Feb 15 00:00:00 EST 2020
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
World journal of stem cells
Lei JH,Yan W,Luo CH,Guo YM,Zhang YY,Wang XH,Su XJ
17-1171 was used in Flow cytometry/Cell sorting to investigate the cytotoxic effect of NP on SSCs via the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway.
Fri Jun 26 00:00:00 EDT 2020
Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo.
Anatomical record (Hoboken, N.J. : 2007)
Goncalves S,Goldstein BJ
17-1171-83 was used in immunomagnetic selection to identify new treatment strategies for preventing degeneration of olfactory neurones.
Sun Mar 01 00:00:00 EST 2020
Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models.
Frontiers in genetics
Sun G,Liang X,Qin K,Qin Y,Shi X,Cong P,Mo D,Liu X,Chen Y,He Z
17-1171-82 was used in Flow Cytometry to create two mouse models, KIT D17/+ to mimic the splice mutation, and KIT Dup/+ to partially mimic the duplication mutation of KIT gene in dominant white pigs using CRISPR/Cas9 technology.
Mon Sep 28 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-1171 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
17-1171 was used in Flow cytometry/Cell sorting to provide additional evidence for an interaction between MYSM1 and key DNA replication and repair factors, and indicate a potential function of 2A-DUB/MYSM1 in DNA repair processes.
Tue May 26 00:00:00 EDT 2020
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Nature communications
Giannini S,Lee-Sundlov MM,Rivadeneyra L,Di Buduo CA,Burns R,Lau JT,Falet H,Balduini A,Hoffmeister KM
17-1171 was used in Flow cytometry/Cell sorting to identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in megakaryocytes.
Fri Jan 17 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
17-1171 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
17-1171-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
17-1171 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Blood
Esnault C,Rahmé R,Rice KL,Berthier C,Gaillard C,Quentin S,Maubert AL,Kogan S,de Thé H
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that FLT3-ITD severely blunts ATRA response.
Thu Mar 28 00:00:00 EDT 2019
Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.
The Journal of clinical investigation
Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH
17-1171 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.
Fri Mar 01 00:00:00 EST 2019
Immune synapses between mast cells and γδ T cells limit viral infection.
The Journal of clinical investigation
Mantri CK,St John AL
17-1171 was used in Flow cytometry/Cell sorting to show that immune synapse formation between MCs and γδ T cells is a novel mechanism to induce specific and protective immunity at sites of viral infection.
Fri Mar 01 00:00:00 EST 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
17-1171 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
Rats provide a superior model of human stress erythropoiesis.
Experimental hematology
Zhang J,Liu Y,Han X,Mei Y,Yang J,Zhang ZJ,Lu X,Ji P
17-1171 was used in Flow cytometry/Cell sorting to establish rat in vitro and in vivo erythropoiesis models that are more appropriate and superior for the study of human stress erythropoiesis than mouse models.
Tue Oct 01 00:00:00 EDT 2019
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
17-1171 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
Analysis of Hematopoietic Stem Progenitor Cell Metabolism.
Journal of visualized experiments : JoVE
Scapin G,Goulard MC,Dharampuriya PR,Cillis JL,Shah DI
17-1171 was used in Flow cytometry/Cell sorting to provide a set of clear, step-by-step instructions to measure metabolic respiration (oxygen consumption rate; OCR) and glycolysis (extracellular acidification rate; ECAR) of murine bone marrow-LineagenegSca1+c-Kit+ (LSK) HSPCs.
Sat Nov 09 00:00:00 EST 2019
Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.
Cell stem cell
Varum S,Baggiolini A,Zurkirchen L,Atak ZK,Cantù C,Marzorati E,Bossart R,Wouters J,Häusel J,Tuncer E,Zingg D,Veen D,John N,Balz M,Levesque MP,Basler K,Aerts S,Zamboni N,Dummer R,Sommer L
17-1171 was used in Flow cytometry/Cell sorting to identify the transcription factor, Yin Yang 1, as a neural crest stem cell regulator.
Thu Apr 04 00:00:00 EDT 2019
Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
Nature communications
Bae J,Choi SP,Isono K,Lee JY,Park SW,Choi CY,Han J,Kim SH,Lee HH,Park K,Jin HY,Lee SJ,Park CG,Koseki H,Lee YS,Chun T
17-1171-82 was used in Flow cytometry/Cell sorting to determine the role of PHc2 in controlling the mobilisation of hematopoietic stem and progenitor cells.
Fri Aug 02 00:00:00 EDT 2019
Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia.
Stem cell reports
Kurtenbach S,Goss GM,Goncalves S,Choi R,Hare JM,Chaudhari N,Goldstein BJ
17-1171 was used in Flow cytometry/Cell sorting to develop a mouse model of inducible hyposmia and demonstrate that purified tissue-specific stem cells delivered intranasally engraft to produce olfactory neurons, achieving recovery of function.
Tue Jun 11 00:00:00 EDT 2019
Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.
Cell reports
Chen C,Yu W,Tober J,Gao P,He B,Lee K,Trieu T,Blobel GA,Speck NA,Tan K
17-1171 was used in Flow cytometry/Cell sorting to find that chromosomal compartments and topologically associating domains (TADs) are largely conserved between fetal and adult HSCs.
Tue Dec 17 00:00:00 EST 2019
Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS.
PloS one
Rando A,de la Torre M,Martinez-Muriana A,Zaragoza P,Musaro A,Hernández S,Navarro X,Toivonen JM,Osta R
17-1171 was used in Flow cytometry/Cell sorting to study the effect of known stem cell mobilising agents and antimetabolite 5-fluorouracil in the SOD1G93A model of amyotrophic lateral sclerosis.
Fri Nov 01 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
17-1171 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
17-1171-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
17-1171 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
17-1171 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
17-1171 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
International journal of molecular medicine
Tsunoda T,Doi K,Ishikura S,Luo H,Nishi K,Matsuzaki H,Koyanagi M,Tanaka Y,Okamura T,Shirasawa S
17-1171-82 was used in Flow Cytometry to identify the expression and function of Zfat using ZsGreen signalling in the ZfatZsG/+ reporter mouse model.
Thu Nov 01 00:00:00 EDT 2018
Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.
Endocrinology
van der Spek AH,Surovtseva OV,Jim KK,van Oudenaren A,Brouwer MC,Vandenbroucke-Grauls CMJE,Leenen PJM,van de Beek D,Hernandez A,Fliers E,Boelen A
17-1171 was used in Flow cytometry/Cell sorting to study the role of optimal intracellular concentrations of the active thyroid hormone triiodothyronine in proinflammatory macrophage function.
Tue May 01 00:00:00 EDT 2018
The Thyroid Hormone Inactivating Type 3 Deiodinase Is Essential for Optimal Neutrophil Function: Observations From Three Species.
Endocrinology
van der Spek AH,Jim KK,Karaczyn A,van Beeren HC,Ackermans MT,Darras VM,Vandenbroucke-Grauls CMJE,Hernandez A,Brouwer MC,Fliers E,van de Beek D,Boelen A
17-1171 was used in Flow cytometry/Cell sorting to study whether type 3 deiodinase plays a role in neutrophil function during infection.
Thu Feb 01 00:00:00 EST 2018
Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium.
Laryngoscope investigative otolaryngology
Goldstein BJ,Choi R,Goss GM
17-1171 was used for magnetic cell selection to investigate epigenetic mechanisms contributing to regulation of cellular renewal and neurogenesis in adult olfactory epithelium.
Mon Oct 01 00:00:00 EDT 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
17-1171 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
mTOR complexes differentially orchestrates eosinophil development in allergy.
Scientific reports
Zhu C,Xia L,Li F,Zhou L,Weng Q,Li Z,Wu Y,Mao Y,Zhang C,Wu Y,Li M,Ying S,Chen Z,Shen H,Li W
17-1171 was used in Flow cytometry/Cell sorting to investigate the role of mTOR in eosinophil differentiation in the context of asthmatic pathogenesis.
Wed May 02 00:00:00 EDT 2018
c-Kit+ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells.
Scientific reports
Kwak M,Ninche N,Klein S,Saur D,Ghazizadeh S
17-1171 was used in Flow cytometry/Cell sorting to study whether c-Kit is a reliable marker for salivary gland stem cells.
Fri Sep 21 00:00:00 EDT 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
17-1171 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 EST 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
17-1171 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
17-1171 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
17117182 was used in flow cytometry to demonstrate that SAMHD1 reduces nucleoside analog cytarabine cytotoxicity in acute myeloid leukemia cells
Wed Feb 01 00:00:00 EST 2017
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Nature medicine
Hahm E,Wei C,Fernandez I,Li J,Tardi NJ,Tracy M,Wadhwani S,Cao Y,Peev V,Zloza A,Lusciks J,Hayek SS,O'Connor C,Bitzer M,Gupta V,Sever S,Sykes DB,Scadden DT,Reiser J
17-1171 was used in Flow cytometry/Cell sorting to demonstrate a direct pathogenic role of suPAR as a circulating mediator of kidney disease, such as focal segmental glomerulosclerosis.
Sun Jan 01 00:00:00 EST 2017
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
17-1171 was used in Flow cytometry/Cell sorting to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 EST 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
17-1171 was used in Flow cytometry/Cell sorting to study the effects of combined Hoxa9/Meis1 over-expression on intracellular signalling, and whether cells transformed by Hoxa9 and Meis1 become addicted to targetable signalling processes.
Mon Apr 10 00:00:00 EDT 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
17-1171 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Cell stem cell
Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R
17-1171 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.
Thu Jun 01 00:00:00 EDT 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
17-1171 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
Nucleic acids research
Stanulovic VS,Cauchy P,Assi SA,Hoogenkamp M
17-1171 was used in Flow cytometry/Cell sorting to show that Lmo2-/- mouse embryonic stem cells differentiated to Flk-1+ haemangioblasts, but less efficiently to haemogenic endothelium.
Fri Sep 29 00:00:00 EDT 2017
Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.
Oxidative medicine and cellular longevity
Zhang J,Xue X,Han X,Li Y,Lu L,Li D,Fan S
Thu Mar 16 00:00:00 EDT 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
17-1171 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.
eLife
Delás MJ,Sabin LR,Dolzhenko E,Knott SR,Munera Maravilla E,Jackson BT,Wild SA,Kovacevic T,Stork EM,Zhou M,Erard N,Lee E,Kelley DR,Roth M,Barbosa IA,Zuber J,Rinn JL,Smith AD,Hannon GJ
17-1171 was used in Flow cytometry/Cell sorting to assess lncRNA function via an in vivo RNAi screen in a model of acute myeloid leukemia.
Wed Sep 06 00:00:00 EDT 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
17-1171 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 EST 2017
Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium.
PloS one
Kurtenbach S,Ding W,Goss GM,Hare JM,Goldstein BJ,Shehadeh LA
Tue Nov 28 00:00:00 EST 2017
Comparing the in vivo and in vitro effects of hypoxia (3% O2) on directly derived cells from murine cardiac explants versus murine cardiosphere derived cells.
Journal of stem cells & regenerative medicine
Amirrasouli MM,Shamsara M
17-1171 was used in Flow cytometry/Cell sorting to compare explant-derived cells with cardiosphere-derived cells, and assess the effect of hypoxic reconditioning on their pro-angiogenic potential.
Tue Sep 29 00:00:00 EDT 2020
Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture.
Stem cell reports
Batsivari A,Rybtsov S,Souilhol C,Binagui-Casas A,Hills D,Zhao S,Travers P,Medvinsky A
17-1171 was used in Flow cytometry/Cell sorting to observe time-specific changes in intra-aortic hematopoietic clusters corresponding to HSC maturation stages.
Tue Jun 06 00:00:00 EDT 2017
Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.
International journal of molecular sciences
Han X,Xue X,Zhao Y,Li Y,Liu W,Zhang J,Fan S
17-1171 was used in Magnetic cell separation to demonstrate that rutin-enriched coriander extract is able to ameliorate ionising radiation-induced haematopoietic injury partly by reducing ionising radiation-induced oxidative stress.
Sat Apr 29 00:00:00 EDT 2017
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Cell
Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I
17-1171 was used in Magnetic cell separation to establish CRISP-seq as a broadly applicable, comprehensive, and unbiased approach for elucidating mammalian regulatory circuits.
Thu Dec 15 00:00:00 EST 2016
Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.
Cell research
Liu Q,Yang R,Huang X,Zhang H,He L,Zhang L,Tian X,Nie Y,Hu S,Yan Y,Zhang L,Qiao Z,Wang QD,Lui KO,Zhou B
17-1171 was used in Flow cytometry/Cell sorting to show that genetic lineage tracing can identify in-situ Kit expressing cardiomyocytes.
Fri Jan 01 00:00:00 EST 2016
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
The EMBO journal
Hagemeyer N,Kierdorf K,Frenzel K,Xue J,Ringelhan M,Abdullah Z,Godin I,Wieghofer P,Costa Jordão MJ,Ulas T,Yorgancioglu G,Rosenbauer F,Knolle PA,Heikenwalder M,Schultze JL,Prinz M
17-1171 was used in Immunohistochemistry-Immunofluorescence to study the cellular and molecular mechanisms which govern the origin and developmental pathways of tissue macrophages.
Mon Aug 15 00:00:00 EDT 2016
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.
Aging cell
Wang Y,Wang X,Flores ER,Yu J,Chang S
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that in mouse models, both p53-dependent and p53-independent apoptosis are important to suppressing tumor formation.
Mon Aug 01 00:00:00 EDT 2016
Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo.
Development (Cambridge, England)
Goldstein BJ,Goss GM,Choi R,Saur D,Seidler B,Hare JM,Chaudhari N
17-1171 was used in Affinity Purification to establish expansion-competent olfactory epithelium stem cell cultures to facilitate further study of the mechanisms and cell populations important in olfactory epithelium renewal.
Thu Dec 01 00:00:00 EST 2016
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
17-1171 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
Physiological and hypoxic oxygen concentration differentially regulates human c-Kit+ cardiac stem cell proliferation and migration.
American journal of physiology. Heart and circulatory physiology
Bellio MA,Rodrigues CO,Landin AM,Hatzistergos KE,Kuznetsov J,Florea V,Valasaki K,Khan A,Hare JM,Schulman IH
17-1171 was used in Flow cytometry/Cell sorting to investigate how hypoxia impairs cell proliferation, survival, and migration of human cardiac stem cells relative to physiological and room air oxygen concentrations.
Thu Dec 01 00:00:00 EST 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
17-1171 was used in Flow cytometry/Cell sorting to study how several signalling pathways interact to regulate the emergence of haematopoietic stem cells in the aorta.
Tue Mar 08 00:00:00 EST 2016
In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.
PloS one
Guo H,Cooper S,Friedman AD
17-1171 was used in Flow cytometry/Cell sorting to study how the in vivo deletion of the Cebpa +37kb enhancer reduces Cebpa mRNA in myeloid progenitors but not in non-hematopoietic tissues impairing granulopoiesis.
Mon Aug 01 00:00:00 EDT 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
17-1171 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.
Cell death & disease
Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH
17-1171 was used in Flow cytometry/Cell sorting to explore the role of SHP2 as a regulator of eosinophil differentiation and assess the impact of inhibition of SHP2 on airway inflammation.
Thu Apr 07 00:00:00 EDT 2016
p38 MAPK Inhibitor Insufficiently Attenuates HSC Senescence Administered Long-Term after 6 Gy Total Body Irradiation in Mice.
International journal of molecular sciences
Lu L,Wang YY,Zhang JL,Li DG,Meng AM
17-1171 was used in Flow cytometry/Cell sorting to investigate the effects of SB203580 on long-term TBI-induced myelosuppression.
Wed Jun 08 00:00:00 EDT 2016
Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells.
PloS one
Schibler J,Tomanek-Chalkley AM,Reedy JL,Zhan F,Spitz DR,Schultz MK,Goel A
17-1171 was used in Flow cytometry/Cell sorting to a novel strategy of oxidative stress-induced cytotoxic killing of MM cells.
Thu Jul 06 00:00:00 EDT 2017
Histone deacetylase 1 plays a predominant pro-oncogenic role in Eμ-myc driven B cell lymphoma.
Scientific reports
Pillonel V,Reichert N,Cao C,Heideman MR,Yamaguchi T,Matthias G,Tzankov A,Matthias P
17-1171 was used in Flow cytometry/Cell sorting to investigate the functional role of two histone deacetylases, Hdac1 and Hdac2, using the Eµ-myc mouse model of B cell lymphoma.
Fri Nov 25 00:00:00 EST 2016
Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells.
Stem cell research & therapy
Gao S,Tao L,Hou X,Xu Z,Liu W,Zhao K,Guo M,Wang H,Cai T,Tian J,Gao S,Chang G
17-1171 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of haematopoietic progenitor and stem cell reprogramming into induced pluripotent stem cells.
Tue Mar 15 00:00:00 EDT 2016
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Nature medicine
Wen QJ,Yang Q,Goldenson B,Malinge S,Lasho T,Schneider RK,Breyfogle LJ,Schultz R,Gilles L,Koppikar P,Abdel-Wahab O,Pardanani A,Stein B,Gurbuxani S,Mullally A,Levine RL,Tefferi A,Crispino JD
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that megakaryocytes drive fibrosis in PMF and that targeting them with AURKA inhibitors has the potential for therapeutic benefit.
Tue Dec 01 00:00:00 EST 2015
A microfluidic device for epigenomic profiling using 100 cells.
Nature methods
Cao Z,Chen C,He B,Tan K,Lu C
17-1171 was used in Flow cytometry/Cell sorting to demonstrate the effectiveness of a microfluidics-based ChIP-Seq protocol to uncover several novel enhancers in hematopoietic stem and progenitor cells.
Thu Oct 01 00:00:00 EDT 2015
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.
Blood
Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J
17-1171 was used in Flow cytometry/Cell sorting to identify a novel role for Pak2 as an important regulator of megakaryopoiesis, polyploidization and cytoskeletal mechanics in developing megakaryocytes.
Thu May 07 00:00:00 EDT 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
17-1171 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
17-1171 was used in Flow cytometry/Cell sorting to investigate the critical niche components and resident signals required for hematopoietic stem cell induction and self-renewal ex vivo.
Fri May 01 00:00:00 EDT 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
17-1171 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
17-1171 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Prigge JR,Hoyt TR,Dobrinen E,Capecchi MR,Schmidt EE,Meissner N
17-1171 was used in Flow cytometry/Cell sorting to highlight how distal fungal infections can have profound systemic effects that impair hematopoiesis.
Tue Dec 01 00:00:00 EST 2015
Limited miR-17-92 overexpression drives hematologic malignancies.
Leukemia research
Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E
17-1171 was used in Flow cytometry/Cell sorting to show limited miR-17-92 overexpression can drive hematologic malignancies.
Sun Mar 01 00:00:00 EST 2015
Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.
Biology open
Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE
17117182 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.
Fri May 15 00:00:00 EDT 2015
High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.
Stem cell research
Rao TN,Marks-Bluth J,Sullivan J,Gupta MK,Chandrakanthan V,Fitch SR,Ottersbach K,Jang YC,Piao X,Kulkarni RN,Serwold T,Pimanda JE,Wagers AJ
17-1171 was used in Flow cytometry/Cell sorting to indicate that high-level expression of GPR56 by primitive HSPCs is largely dispensable for steady-state and regenerative hematopoiesis.
Fri May 01 00:00:00 EDT 2015
Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFRα(+) mesenchymal cells from bone marrow.
Scientific reports
Aikawa E,Fujita R,Kikuchi Y,Kaneda Y,Tamai K
17-1171 was used in Flow cytometry/Cell sorting to investigate the function of HMGB1-mobilised mesenchymal cells in the regeneration of mouse skin grafts.
Fri Jun 05 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
17-1171 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation.
Nature communications
Choukrallah MA,Song S,Rolink AG,Burger L,Matthias P
17-1171 was used in Flow cytometry/Cell sorting to revisit the prevalent model about epigenetic reprogramming during hematopoiesis and give insights into the formation of gene regulatory networks.
Mon Oct 19 00:00:00 EDT 2015
Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.
PloS one
Zoch A,Mayerl S,Schulz A,Greither T,Frappart L,Rübsam J,Heuer H,Giovannini M,Morrison H
17-1171 was used in Flow cytometry/Cell sorting to elucidate the function of two major, NF2-encoded isoforms of Merlin.
Mon May 23 00:00:00 EDT 2016
EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.
PloS one
Charmsaz S,Beckett K,Smith FM,Bruedigam C,Moore AS,Al-Ejeh F,Lane SW,Boyd AW
17-1171 was used in Flow cytometry/Cell sorting to explore the role of EphA2 in haematopoiesis and leukaemogenesis.
Tue May 03 00:00:00 EDT 2016
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that Csnk1a1 inhibition causes reduced Rps6 phosphorylation and activation of p53, resulting in selective elimination of leukemia cells.
Mon Apr 07 00:00:00 EDT 2014
Smurf2 regulates hematopoietic stem cell self-renewal and aging.
Aging cell
Ramkumar C,Kong Y,Trabucco SE,Gerstein RM,Zhang H
17-1171 was used in Flow cytometry/Cell sorting to suggest that Smurf2 plays an important role in regulating HSC self-renewal and ageing.
Sun Jun 01 00:00:00 EDT 2014
Characteristic of c-Kit+ progenitor cells in explanted human hearts.
Clinical research in cardiology : official journal of the German Cardiac Society
Matuszczak S,Czapla J,Jarosz-Biej M,Wiśniewska E,Cichoń T,Smolarczyk R,Kobusińska M,Gajda K,Wilczek P,Sliwka J,Zembala M,Zembala M,Szala S
17-1171 was used in Flow cytometry/Cell sorting to determine the presence of self-renewing, multipotent, and clonogenic progenitor cells within human myocardium.
Mon Sep 01 00:00:00 EDT 2014
F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
Molecular & cellular proteomics : MCP
Honarpour N,Rose CM,Brumbaugh J,Anderson J,Graham RL,Sweredoski MJ,Hess S,Coon JJ,Deshaies RJ
17-1171 was used in Flow cytometry/Cell sorting to identify Fbxl16 as a repressor of the formation of FLK1+ progenitor cells, one of the earliest steps in the cardiovascular program.
Sat Mar 01 00:00:00 EST 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
17-1171 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell
Yamamoto R,Morita Y,Ooehara J,Hamanaka S,Onodera M,Rudolph KL,Ema H,Nakauchi H
17-1171 was used in Flow cytometry/Cell sorting to identify multipotent progenitors of myeloid cells and study differentiation pathways giving rise to common myeloid cells.
Thu Aug 29 00:00:00 EDT 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
17-1171 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 EDT 2013
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.
The Journal of clinical investigation
Kook S,Cho J,Lee SB,Lee BC
17-1171 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism governing the migration of haematopoietic stem progenitor cells under stress.
Thu Aug 01 00:00:00 EDT 2013
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
17-1171 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 EST 2013
p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
Leukemia
Raman R,Kumar RS,Hinge A,Kumar S,Nayak R,Xu J,Szczur K,Cancelas JA,Filippi MD
17-1171 was used in Flow cytometry/Cell sorting to show that p190-B regulates the conditions for normal haematopoiesis during development.
Fri Nov 01 00:00:00 EDT 2013
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.
Journal of leukocyte biology
Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ
17-1171 was used in Flow cytometry/Cell sorting to develop a novel murine strain to allow a better definition of the role of eosinophils in health and disease.
Mon Jul 01 00:00:00 EDT 2013
Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.
The American journal of pathology
Guijarro MV,Dahiya S,Danielson LS,Segura MF,Vales-Lara FM,Menendez S,Popiolek D,Mittal K,Wei JJ,Zavadil J,Cordon-Cardo C,Pandolfi PP,Hernando E
17-1171 was used in Flow cytometry/Cell sorting to elucidate the mechanisms driving cytogenetically complex sarcoma development.
Sat Jun 01 00:00:00 EDT 2013
Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.
Journal of immunology (Baltimore, Md. : 1950)
Zook EC,Zhang S,Gerstein RM,Witte PL,Le PT
17-1171 was used in Flow cytometry/Cell sorting to report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg.
Sun Dec 01 00:00:00 EST 2013
Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis.
Journal of immunology (Baltimore, Md. : 1950)
Shiraishi Y,Jia Y,Domenico J,Joetham A,Karasuyama H,Takeda K,Gelfand EW
17-1171 was used in Flow cytometry/Cell sorting to demonstrate how the development of allergic rhinitis has two distinct stages: histamine release from FcεRI-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity.
Tue Jan 15 00:00:00 EST 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
17-1171 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.
Journal of tissue engineering and regenerative medicine
Peter Y,Sen N,Levantini E,Keller S,Ingenito EP,Ciner A,Sackstein R,Shapiro SD
17-1171 was used in Flow cytometry/Cell sorting to study the relationship between stem/progenitor cells that proliferate or differentiate and somatic cells of the lung, showing anchorage-independent adult progenitor cells that do not express integrin proteins α5, β3 and β7.
Mon Jul 01 00:00:00 EDT 2013
Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model.
PloS one
Krelin Y,Berkovich L,Amit M,Gil Z
17-1171 was used in Flow cytometry/Cell sorting to compare the tumorigenic potential and cell fate of cells with self-renewing potential in an in vivo melanoma model.
Tue Nov 26 00:00:00 EST 2013
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.
PloS one
Park SO,Wamsley HL,Bae K,Hu Z,Li X,Choe SW,Slayton WB,Oh SP,Wagner KU,Sayeski PP
17-1171 was used in Flow cytometry/Cell sorting to understand the role played by Jak2 at varying stages of prenatal and postnatal life.
Tue Sep 17 00:00:00 EDT 2013
Ionizing radiation-induced expression of INK4a/ARF in murine bone marrow-derived stromal cell populations interferes with bone marrow homeostasis.
Blood
Carbonneau CL,Despars G,Rojas-Sutterlin S,Fortin A,Le O,Hoang T,Beauséjour CM
17-1171 was used in Flow cytometry/Cell sorting to investigate the effect of ionizing radiation on murine bone marrow-derived stromal cell populations, and overall bone marrow homeostasis.
Thu Jan 19 00:00:00 EST 2012
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.
Blood
Greenbaum AM,Revollo LD,Woloszynek JR,Civitelli R,Link DC
17-1171 was used in Flow cytometry/Cell sorting to investigate whether N-cadherin expression on osteoblast lineage cells regulates HSC function and quiescence, showing that it is not required.
Thu Jul 12 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
17-1171 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.
Thu May 10 00:00:00 EDT 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
17-1171-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
17-1171 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Shokeen M,Zheleznyak A,Wilson JM,Jiang M,Liu R,Ferdani R,Lam KS,Schwarz JK,Anderson CJ
17-1171 was used in Flow cytometry/Cell sorting to study bone marrow-derived cellular expression of VEGFR1 and VLA-4 in the development of a premetastatic niche.
Tue May 01 00:00:00 EDT 2012
NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.
Stem cells (Dayton, Ohio)
Urao N,McKinney RD,Fukai T,Ushio-Fukai M
17-1171 was used in Flow cytometry/Cell sorting to show that hindlimb ischemia of mice increases ROS production in both the endosteal and central region of BM tissue in situ, which is almost completely abolished in Nox2 knockout (KO) mice.
Tue May 01 00:00:00 EDT 2012
Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells.
PloS one
Komada Y,Yamane T,Kadota D,Isono K,Takakura N,Hayashi S,Yamazaki H
17-1171 was used in Flow cytometry/Cell sorting to investigate whether mesechymal cells arise from neural crest or mesoderm, revealing the origins and properties of dental, thymic, and bone marrow mesenchymal cells.
Tue May 14 00:00:00 EDT 2013
Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
PloS one
Wartman LD,Welch JS,Uy GL,Klco JM,Lamprecht T,Varghese N,Nagarajan R,Ley TJ
17-1171 was used in Flow cytometry/Cell sorting to study PML-RARA expression to better understand its mechanism of contribution to APL.
Tue Jun 11 00:00:00 EDT 2013
Contribution of an aged microenvironment to aging-associated myeloproliferative disease.
PloS one
Vas V,Wandhoff C,Dörr K,Niebel A,Geiger H
17-1171 was used in Flow cytometry/Cell sorting to investigate the contribution of an aged bone marrow niche to the age-associated increase in leukemia incidence.
Fri Jun 29 00:00:00 EDT 2012
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
17-1171 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
17-1171 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.
Thu Sep 01 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
17-1171 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse.
Blood
Ou X,Chae HD,Wang RH,Shelley WC,Cooper S,Taylor T,Kim YJ,Deng CX,Yoder MC,Broxmeyer HE
17-1171 was used in Flow cytometry/Cell sorting to investigate SIRT1 activities in embryonic and adult stages of hematopoietic and endothelial development in mice.
Thu Jan 13 00:00:00 EST 2011
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
17-1171 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.
Thu Aug 25 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
17-1171 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.
The Journal of allergy and clinical immunology
Arias K,Chu DK,Flader K,Botelho F,Walker T,Arias N,Humbles AA,Coyle AJ,Oettgen HC,Chang HD,Van Rooijen N,Waserman S,Jordana M
17-1171 was used in Flow cytometry/Cell sorting to investigate the relative contribution of immunoglobulin-dependent effector pathways to anaphylactic responses to food.
Wed Jun 01 00:00:00 EDT 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
17-1171 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 EDT 2011
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England)
Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ
17-1171 was used in Flow cytometry/Cell sorting to further define the functional role for ER71 in cell lineage decisions using genetically modified mouse models.
Tue Nov 01 00:00:00 EDT 2011
Retroviral insertional mutagenesis can contribute to immortalization of mature T lymphocytes.
Molecular medicine (Cambridge, Mass.)
Newrzela S,Cornils K,Heinrich T,Schläger J,Yi JH,Lysenko O,Kimpel J,Fehse B,von Laer D
17-1171 was used in Flow cytometry/Cell sorting to investigate possible inducers of the malignant transformation of mature T lymphocytes.
Fri Aug 03 00:00:00 EDT 2012
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
MacNamara KC,Oduro K,Martin O,Jones DD,McLaughlin M,Choi K,Borjesson DL,Winslow GM
17-1171 was used in Flow cytometry/Cell sorting to provide evidence that IFN-γ acts to control infection by directly promoting myeloid cell differentiation.
Sat Jan 15 00:00:00 EST 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
17-1171 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 EDT 2011
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nel HJ,Hams E,Saunders SP,Mangan NE,Smith P,Atzberger A,Flavell RA,Akira S,McKenzie AN,Fallon PG
17-1171 was used in Flow cytometry/Cell sorting to investigate the age-dependence of helminth-induced type 2 immune responses in adult and juvenile mice.
Fri Apr 15 00:00:00 EDT 2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
17-1171 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 EDT 2011
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PloS one
Ohno T,Oboki K,Morita H,Kajiwara N,Arae K,Tanaka S,Ikeda M,Iikura M,Akiyama T,Inoue J,Matsumoto K,Sudo K,Azuma M,Okumura K,Kamradt T,Saito H,Nakae S
17-1171 was used in Flow cytometry/Cell sorting to show that exogenous IL-33 potentiates LPS-mediated cytokine production by macrophages.
Mon Apr 11 00:00:00 EDT 2011
Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.
Journal of molecular biology
Corpora T,Roudaia L,Oo ZM,Chen W,Manuylova E,Cai X,Chen MJ,Cierpicki T,Speck NA,Bushweller JH
17-1171 was used in Flow cytometry/Cell sorting to elucidate the structure and function of the AML1-ETO NHR3-PKA(RIIα) complex.
Fri Sep 24 00:00:00 EDT 2010
Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
von Vietinghoff S,Asagiri M,Azar D,Hoffmann A,Ley K
17-1171 was used in Flow cytometry/Cell sorting to conclude that severe NF-kappaB deficiency facilitates neutrophil mobilization, ultimately leading to spontaneous inflammation.
Thu Jul 01 00:00:00 EDT 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
17-1171 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.
Nature
Lancrin C,Sroczynska P,Stephenson C,Allen T,Kouskoff V,Lacaud G
17-1171 was used in Flow cytometry/Cell sorting to merge the two a priori conflicting theories on the origin of haematopoietic development into a single linear developmental process.
Thu Feb 12 00:00:00 EST 2009
Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.
Circulation
Sun J,Zhang J,Lindholt JS,Sukhova GK,Liu J,He A,Abrink M,Pejler G,Stevens RL,Thompson RW,Ennis TL,Gurish MF,Libby P,Shi GP
17-1171 was used in Immunohistochemistry to study the contribution of mast cell chymase to the pathogenesis of human abdominal aortic aneurysm.
Tue Sep 15 00:00:00 EDT 2009
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
17-1171 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 EST 2009
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Cell stem cell
Somervaille TC,Matheny CJ,Spencer GJ,Iwasaki M,Rinn JL,Witten DM,Chang HY,Shurtleff SA,Downing JR,Cleary ML
17-1171 was used in Flow cytometry/Cell sorting to link the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer, namely myeloid leukemia.
Fri Feb 06 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
17-1171 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.
Journal of immunology (Baltimore, Md. : 1950)
Ota T,Aoki-Ota M,Duong BH,Nemazee D
17-1171 was used in Flow cytometry/Cell sorting to reveal implications for the optimal design of safe and effective anti-IgE therapies and suggest that the IgE memory B cells may be targeted by such genetic Ab therapies.
Mon Jun 15 00:00:00 EDT 2009
T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Smith E,von Vietinghoff S,Stark MA,Zarbock A,Sanders JM,Duley A,Rivera-Nieves J,Bender TP,Ley K
17-1171 was used in Flow cytometry/Cell sorting to investigate the requirement of the thymus and VDJ recombination in T cell lineages.
Sun Nov 01 00:00:00 EDT 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
17-1171 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
17-1171 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.
International immunology
Ohno S,Sato T,Kohu K,Takeda K,Okumura K,Satake M,Habu S
17-1171 was used in Flow cytometry/Cell sorting to investigate the role of Runx family proteins in NK cells, showing that they are involved in regulation of CD122, Ly49 family and IFN-gamma expression during differentiation.
Tue Jan 01 00:00:00 EST 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
17-1171 was used in Flow cytometry/Cell sorting to develop a method to study intracellular signaling in murine HSC/progenitor cell (HPC)-enriched populations, showing agonist and temporal differences in responses of HSC/HPC.
Tue Feb 10 00:00:00 EST 2009
Tumor growth decreases NK and B cells as well as common lymphoid progenitor.
PloS one
Richards J,McNally B,Fang X,Caligiuri MA,Zheng P,Liu Y
17-1171 was used in Flow cytometry/Cell sorting to analyse the effects of tumour growth on lymphopoiesis in mice.
Thu Sep 11 00:00:00 EDT 2008
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
17-1171-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
TEL-AML1 preleukemic activity requires the DNA binding domain of AML1 and the dimerization and corepressor binding domains of TEL.
Oncogene
Morrow M,Samanta A,Kioussis D,Brady HJ,Williams O
17-1171 was used in Flow cytometry/Cell sorting to study the role of TEL-AML1 in perturbing multiple pathways during haematopoiesis.
Thu Jun 28 00:00:00 EDT 2007
IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
Journal of leukocyte biology
Ho LH,Ohno T,Oboki K,Kajiwara N,Suto H,Iikura M,Okayama Y,Akira S,Saito H,Galli SJ,Nakae S
17-1171 was used in Flow cytometry/Cell sorting to reveal potential roles for IL-33 in mast cell- and Th2 cytokine-associated immune responses and disorders.
Sat Dec 01 00:00:00 EST 2007
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.
The Journal of experimental medicine
Onai N,Obata-Onai A,Tussiwand R,Lanzavecchia A,Manz MG
17-1171 was used in Flow cytometry/Cell sorting to propose a demand-regulated, cytokine-driven dendritic cell and type I interferon-producing cell regeneration model.
Mon Jan 23 00:00:00 EST 2006
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.
Genes & development
Iwasaki H,Mizuno S,Arinobu Y,Ozawa H,Mori Y,Shigematsu H,Takatsu K,Tenen DG,Akashi K
17-1171 was used in Flow cytometry/Cell sorting to show that the expression timing of GATA-2 and CCAAT enhancer-binding protein alpha can differentially control their lineage commitment.
Wed Nov 01 00:00:00 EST 2006
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
17-1171 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells.
Proceedings of the National Academy of Sciences of the United States of America
Kalesnikoff J,Rios EJ,Chen CC,Nakae S,Zabel BA,Butcher EC,Tsai M,Tam SY,Galli SJ
17-1171 was used in Flow cytometry/Cell sorting to investigate how RabGEF1 can regulate signaling events and biological responses in mast cells.
Tue Feb 21 00:00:00 EST 2006
