Product References
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate for the first time that CalD is a novel anti-inflammatory natural compound for allergic asthma that modulates AM function.
Sat Apr 01 00:00:00 EDT 2023
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Nature cell biology
Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E
17-0112-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.
Sun Jan 01 00:00:00 EST 2023
Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15.
The Journal of biological chemistry
Vaitaitis GM,Wagner DH
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate interactions between CD40 and integrin CD11a/CD18, which complicates the understanding of the inflammatory nexus and how to prevent autoinflammation.
Mon May 01 00:00:00 EDT 2023
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.
NPJ Regenerative medicine
Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q
17-0112-82 was used in Flow Cytometry to suggest that BMP2pp may be a potential option for treating prosthetic loosening induced by wear debris from prostheses.
Thu Feb 09 00:00:00 EST 2023
CD11c+ microglia promote white matter repair after ischemic stroke.
Cell death & disease
Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M
17-0112-82 was used in Flow cytometry/Cell sorting to suggest that spontaneous white matter repair occurs after ischemic stroke, while CD11c+ microglia play critical roles in this white matter restorative progress.
Fri Feb 24 00:00:00 EST 2023
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovascular research
Liu T,Meng Z,Liu J,Li J,Zhang Y,Deng Z,Luo S,Wang M,Huang Q,Zhang S,Fendt P,Devouassoux J,Li D,McKenzie ANJ,Nahrendorf M,Libby P,Guo J,Shi GP
17-0112-82 was used in Flow cytometry/Cell sorting to reveal an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
Tue May 02 00:00:00 EDT 2023
A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency.
Frontiers in immunology
Li H,Hu M,Huang Z,Wang Y,Xu Y,Deng J,Zhu M,Feng W,Xu X
17-0112-82 was used in Flow cytometry/Cell sorting to provide novel insights into meningeal immunity, which is a less studied aspect of neuroimmune interactions in Mecp2-mutated diseases, and offer an essential resource for comparative analyses and data exploration to better understand the functional role of meningeal immunity in RTT.
Tue Jan 31 00:00:00 EST 2023
Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases.
eLife
Bi Y,Su J,Zhou S,Zhao Y,Zhang Y,Zhang H,Liu M,Zhou A,Xu J,Pan M,Zhao Y,Li F
17-0112-82 was used in Flow cytometry/Cell sorting to suggest that IgG effector function contributes to the clearance of autoantibody-Ag complexes, which is harmful in thrombotic thrombocytopenic purpura, but beneficial in pemphigus foliaceus and may provide new therapeutic opportunity.
Wed Aug 03 00:00:00 EDT 2022
In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection.
EMBO molecular medicine
Dumigan A,Cappa O,Morris B,Sá Pessoa J,Calderon-Gonzalez R,Mills G,Lancaster R,Simpson D,Kissenpfennig A,Bengoechea JA
17-0112-82 was used in Flow cytometry/Cell sorting to identify interstitial macrophages (IMs) as the main population of lung macrophages associated with Klebsiella.
Wed Dec 07 00:00:00 EST 2022
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Cell reports
Wang Y,Wang Y,Ding L,Ren X,Wang B,Wang L,Zhao S,Yue X,Wu Z,Li C,Liang X,Ma C,Gao L
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that Tim-4 suppresses type I IFN signaling by enhancing SREBP2 activation, delineating the role of Tim-4 in antiviral innate immunity and cholesterol metabolism, which sheds light on the mechanism by which Tim-4 orchestrates macrophage homeostasis.
Tue Nov 29 00:00:00 EST 2022
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.
Cell death and differentiation
Hajjar S,Nathan N,Joseph J,Mottawea W,Ariana A,Pyatibrat S,Harper ME,Alain T,Blais A,Russell RC,Sad S
17-0112-82 was used in Flow cytometry/Cell sorting to show that Foxo3a restricts the abundance of colitogenic microbiota in IL-10-deficient mice.
Tue Mar 01 00:00:00 EST 2022
ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation.
Autophagy
Bai D,Du J,Bu X,Cao W,Sun T,Zhao J,Zhao Y,Lu N
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that the glycolytic enzyme ALDOA maintained NLRP3 inflammasome activation by monitoring the glycolytic flux to control AMPK activation during the classical activation of NLRP3.
Fri Jul 01 00:00:00 EDT 2022
Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.
Cell reports
Feriotti C,Sá-Pessoa J,Calderón-González R,Gu L,Morris B,Sugisawa R,Insua JL,Carty M,Dumigan A,Ingram RJ,Kissenpfening A,Bowie AG,Bengoechea JA
17-0112-82 was used in Flow cytometry/Cell sorting to illustrate an anti-immunology strategy deployed by a human pathogen.
Tue Aug 09 00:00:00 EDT 2022
Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration.
NPJ Regenerative medicine
Krawetz RJ,Abubacker S,Leonard C,Masson AO,Shah S,Narendran N,Tailor P,Regmi SC,Labit E,Ninkovic N,Corpuz JM,Ito K,Underhill TM,Salo PT,Schmidt TA,Biernaskie JA
17-0112-82 was used in Flow cytometry/Cell sorting to propose that rhPRG4 may represent a potential therapy to mitigate scar and improve wound healing.
Fri Jun 24 00:00:00 EDT 2022
NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina.
Glia
Palazzo I,Todd LJ,Hoang TV,Reh TA,Blackshaw S,Fischer AJ
17-0112-82 was used in Immunohistochemistry to conclude that NFkB is a key signaling hub that is activated in Müller glia (MG) after damage, mediates the accumulation of immune cells, and suppresses the neurogenic potential of MG.
Fri Jul 01 00:00:00 EDT 2022
NFkB-signaling promotes glial reactivity and suppresses Müller glia-mediated neuron regeneration in the mammalian retina.
Glia
Palazzo I,Todd LJ,Hoang TV,Reh TA,Blackshaw S,Fischer AJ
17-0112-82 was used in Immunohistochemistry to conclude that NFkB is a key signaling hub that is activated in Müller glia (MG) after damage, mediates the accumulation of immune cells, and suppresses the neurogenic potential of MG.
Fri Jul 01 00:00:00 EDT 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Cell reports
Vogel A,Martin K,Soukup K,Halfmann A,Kerndl M,Brunner JS,Hofmann M,Oberbichler L,Korosec A,Kuttke M,Datler H,Kieler M,Musiejovsky L,Dohnal A,Sharif O,Schabbauer G
17-0112-82 was used in Flow Cytometry to conclude that DC-intrinsic JAK1 promotes peripheral tolerance, suggesting potential unwarranted DC-mediated effects of Jakinibs in autoimmune diseases.
Tue Feb 22 00:00:00 EST 2022
Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Meng J,Han L,Zheng N,Wang T,Xu H,Jiang Y,Wang Z,Liu Z,Zheng Q,Zhang X,Luo H,Can D,Lu J,Xu H,Zhang YW
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate a crucial role of microglial TMEM59 in early neuronal development and provide new insight into the etiology of autism spectrum disorders (ASDs).
Wed Jun 22 00:00:00 EDT 2022
Microglial AIM2 alleviates antiviral-related neuro-inflammation in mouse models of Parkinson's disease.
Glia
Rui WJ,Li S,Yang L,Liu Y,Fan Y,Hu YC,Ma CM,Wang BW,Shi JP
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate microglial AIM2 to inhibit the antiviral-related neuro-inflammation associated with PD and provide for a foundation upon which to identify new therapeutic targets for treatment of the disease.
Thu Dec 01 00:00:00 EST 2022
Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice.
Science advances
Liu J,Lane S,Lall R,Russo M,Farrell L,Debreli Coskun M,Curtin C,Araujo-Gutierrez R,Scherrer-Crosbie M,Trachtenberg BH,Kim J,Tolosano E,Ghigo A,Gerszten RE,Asnani A
17-0112-82 was used in Flow Cytometry to investigate if heme-binding protein hemopexin induction represents a compensatory response during doxorubicin treatment.
Fri Dec 23 00:00:00 EST 2022
Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions.
Journal of neuroinflammation
Wilmes M,Pinto Espinoza C,Ludewig P,Stabernack J,Liesz A,Nicke A,Gelderblom M,Gerloff C,Falzoni S,Tolosa E,Di Virgilio F,Rissiek B,Plesnilla N,Koch-Nolte F,Magnus T
17-0112-82 was used in Flow cytometry/Cell sorting to show that there is a substantial increase of ATP locally after stroke and that blockage of the ATP receptor P2X7 by icv injected P2X7-specific nbs can reduce ischemic tissue damage.
Wed Oct 12 00:00:00 EDT 2022
RAGE Inhibitors as Alternatives to Dexamethasone for Managing Cerebral Edema Following Brain Tumor Surgery.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Liu S,Song Y,Zhang IY,Zhang L,Gao H,Su Y,Yang Y,Yin S,Zheng Y,Ren L,Yin HH,Pillai R,Nath A,Medina EF,Cosgrove PA,Bild AH,Badie B
17-0112-82 was used in Flow cytometry/Cell sorting to study the role of the receptor for advanced glycation end products (RAGE) and its ligands on inflammatory responses to neurosurgical injury in mice and humans.
Tue Mar 01 00:00:00 EST 2022
CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Battis K,Florio JB,Mante M,Lana A,Naumann I,Gauer C,Lambrecht V,Müller SJ,Cobo I,Fixsen B,Kim HY,Masliah E,Glass CK,Schlachetzki JCM,Rissman RA,Winkler J,Hoffmann A
17-0112-82 was used in Flow cytometry/Cell sorting to analyze the gene expression profile of microglia in a mouse model of MSA (MBP29-hα-syn) and identified a disease-associated expression profile and upregulation of the colony-stimulating factor 1 (Csf1).
Wed Oct 05 00:00:00 EDT 2022
Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions.
Translational psychiatry
Reemst K,Kracht L,Kotah JM,Rahimian R,van Irsen AAS,Congrains Sotomayor G,Verboon LN,Brouwer N,Simard S,Turecki G,Mechawar N,Kooistra SM,Eggen BJL,Korosi A
17-0112-82 was used in Flow cytometry/Cell sorting to reveal persistent effects of ELS on microglial function and suggest that altered microglial phagocytic capacity is a key contributor to ELS-induced phenotypes.
Thu Dec 08 00:00:00 EST 2022
SYK coordinates neuroprotective microglial responses in neurodegenerative disease.
Cell
Ennerfelt H,Frost EL,Shapiro DA,Holliday C,Zengeler KE,Voithofer G,Bolte AC,Lammert CR,Kulas JA,Ulland TK,Lukens JR
17-0112-82 was used in flow cytometry to study the critical intracellular molecules that orchestrate neuroprotective functions of microglia.
Thu Oct 27 00:00:00 EDT 2022
Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.
Cellular & molecular immunology
Duan H,Zhao S,Xiang J,Ju C,Chen X,Gramaglia I,Yan X
17-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that CD146 expressed on BBB endothelial cells but not immune cells is a novel therapeutic target in a mouse model of experimental cerebral malaria (eCM).
Fri Oct 01 00:00:00 EDT 2021
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.
The Journal of clinical investigation
Yu W,Zhong L,Yao L,Wei Y,Gui T,Li Z,Kim H,Holdreith N,Jiang X,Tong W,Dyment N,Liu XS,Yang S,Choi Y,Ahn J,Qin L
17-0112 was used in Flow cytometry/Cell sorting to identify MALPs as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
Tue Jan 19 00:00:00 EST 2021
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Molecular cell
Huang Z,Liang N,Goñi S,Damdimopoulos A,Wang C,Ballaire R,Jager J,Niskanen H,Han H,Jakobsson T,Bracken AP,Aouadi M,Venteclef N,Kaikkonen MU,Fan R,Treuter E
17-0112-82 was used in Flow Cytometry to investigate a corepressor complex containing GPS2 and SMRT both genome-wide and at the Ccl2 locus, encoding the chemokine CCL2 (MCP-1).
Thu Mar 04 00:00:00 EST 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
17-0112-82 was used in Flow Cytometry to identify a new role for AIM2 in controlling the onset of EAE.
Mon May 03 00:00:00 EDT 2021
A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis.
Biomaterials
Keum H,Kim D,Kim J,Kim TW,Whang CH,Jung W,Jon S
17-0112-82 was used in Flow Cytometry to report the therapeutic potential of nanoparticles derived from the endogenous antioxidant and anti-inflammatory bile acid, bilirubin (BRNPs), in treating pulmonary fibrosis in a bleomycin-induced mouse model of the disease.
Sun Aug 01 00:00:00 EDT 2021
Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.
Autophagy
Wang Z,Zhou H,Zheng H,Zhou X,Shen G,Teng X,Liu X,Zhang J,Wei X,Hu Z,Zeng F,Hu Y,Hu J,Wang X,Chen S,Cheng J,Zhang C,Gui Y,Zou S,Hao Y,Zhao Q,Wu W,Zhou Y,Cui K,Huang N,Wei Y,Li W,Li J
17-0112-82 was used in ow Cytometry to study HMGB1-associated autosecretion in cutaneous inammation.
Mon Feb 01 00:00:00 EST 2021
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Autophagy
Liu ZZ,Hong CG,Hu WB,Chen ML,Duan R,Li HM,Yue T,Cao J,Wang ZX,Chen CY,Hu XK,Wu B,Liu HM,Tan YJ,Liu JH,Luo ZW,Zhang Y,Rao SS,Luo MJ,Yin H,Wang YY,Xia K,Xu L,Tang SY,Hu RG,Xie H
17-0112-82 was used in Flow Cytometry to identify Optn as a critical molecule of cell fate decision for bone marrow mesenchymal stem cells (MSCs), whose expression decreased in aged mice.
Fri Oct 01 00:00:00 EDT 2021
S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells.
Frontiers in oncology
Meng L,Tang Q,Zhao J,Wang Z,Wei L,Wei Q,Yin L,Luo S,Song J
17-0112-82 was used in Flow Cytometry to examine the effects of myeloid cells on bone marrow cells of multiple myeloma patients by scRNA-seq transcriptome analysis and reveal a high-resolution gene profile of myeloma cells and myeloma-associated myeloid cells.
Tue Jun 22 00:00:00 EDT 2021
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer's disease mouse model.
STAR protocols
Lau SF,Wu W,Seo H,Fu AKY,Ip NY
17-0112 was used in Flow cytometry/Cell sorting to present a flow cytometry-based method for investigating the Aβ phagocytic capacity of microglia in vivo.
Fri Mar 19 00:00:00 EDT 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
17-0112 was used in Flow cytometry/Cell sorting to report enhanced toxicity of combined MDM2i and BETi towards AML cell lines, primary human blasts and mouse models, resulting from BETi's ability to evict an unexpected repressive form of BRD4 from p53 target genes, and hence potentiate MDM2i-induced p53 activation.
Mon Jan 11 00:00:00 EST 2021
Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.
Nature communications
Honda M,Kadohisa M,Yoshii D,Komohara Y,Hibi T
17-0112-82 was used in Flow cytometry/Cell sorting to show, using spinning-disk confocal microscopy, that large F4/80hiGATA6+ peritoneal cavity macrophages promptly accumulate at damaged intestinal sites upon intestinal thermal injury and upon dextran sodium sulfate induced colitis in mice via a direct route from the peritoneal cavity.
Wed Dec 15 00:00:00 EST 2021
Riclinoctaose Attenuates Renal Ischemia-Reperfusion Injury by the Regulation of Macrophage Polarization.
Frontiers in pharmacology
Zhao Y,Ding Z,Ge W,Liu J,Xu X,Cheng R,Zhang J
17-0112-82 was used in Flow cytometry/Cell sorting to investigate whether riclinoctaose protects against renal ischemia-reperfusion injury.
Tue Nov 02 00:00:00 EDT 2021
Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress.
JCI insight
Devenport SN,Singhal R,Radyk MD,Taranto JG,Kerk SA,Chen B,Goyert JW,Jain C,Das NK,Oravecz-Wilson K,Zhang L,Greenson JK,Chen YE,Soleimanpour SA,Reddy P,Lyssiotis CA,Shah YM
17-0112-82 was used in Flow Cytometry to demonstrate a cell-autonomous dependency of autophagy for cell growth in colorectal cancer.
Thu Jun 17 00:00:00 EDT 2021
Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.
Frontiers in pharmacology
Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X
17-0112-82 was used in Flow cytometry/Cell sorting to employ βENaC-overexpressing mice bearing COPD-like pulmonary abnormality, and exposed them to ENDS.
Sat Apr 02 00:00:00 EDT 2022
Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice.
Kidney360
Aloria EJG,Song CJ,Li Z,Croyle MJ,Mrug M,Zimmerman KA,Yoder BK
17-0112-82 was used in Flow Cytometry to study how Ccr2-dependent, Ly6chi infiltrating macrophages promote cyst progression in the injury-accelerated, adult-induced, conditional Ift88 model of cystic disease.
Thu Jun 24 00:00:00 EDT 2021
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis.
JCI insight
Deng J,Kang Y,Cheng CC,Li X,Dai B,Katz MH,Men T,Kim MP,Koay EA,Huang H,Brekken RA,Fleming JB
17-0112-82 was used in Flow Cytometry to highlight the critical contribution of collagen I-DDR1 interaction in the formation of an immune microenvironment that promotes PDAC metastasis.
Wed Sep 08 00:00:00 EDT 2021
Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.
Nature communications
Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B
17-0112-82 was used in Flow Cytometry to report a dual recombinase-mediated genetic system designed to trace cavity macrophages in vivo by intersectional detection of two characteristic markers.
Mon May 17 00:00:00 EDT 2021
Cell barrier function of resident peritoneal macrophages in post-operative adhesions.
Nature communications
Ito T,Shintani Y,Fields L,Shiraishi M,Podaru MN,Kainuma S,Yamashita K,Kobayashi K,Perretti M,Lewis-McDougall F,Suzuki K
17-0112-82 was used in Proximity Ligation Assay to highlight a previously unidentified cell barrier function of a specific macrophage subset, also proposing an innovative approach to prevent post-operative adhesions.
Wed Apr 14 00:00:00 EDT 2021
Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
eLife
Olivera GC,Ross EC,Peuckert C,Barragan A
17-0112-82 was used in Flow cytometry/Cell sorting to reveal that the initial passage of T. gondii to the central nervous system occurs principally across cortical capillaries and that the integrity of the microvascular BBB restricts parasite transit, which conversely is exacerbated by the inflammatory response.
Wed Dec 08 00:00:00 EST 2021
Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.
Nature communications
Ding X,Wang J,Huang M,Chen Z,Liu J,Zhang Q,Zhang C,Xiang Y,Zen K,Li L
17-0112-82 was used in Flow cytometry/Cell sorting to investigate the role of SIRPα in neurodegeneration.
Thu Apr 01 00:00:00 EDT 2021
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nature communications
Dunker C,Polke M,Schulze-Richter B,Schubert K,Rudolphi S,Gressler AE,Pawlik T,Prada Salcedo JP,Niemiec MJ,Slesiona-Künzel S,Swidergall M,Martin R,Dandekar T,Jacobsen ID
17-0112-82 was used in Flow Cytometry to challenge the long-standing hypothesis that hyphae are essential for pathogenesis of systemic candidiasis by C. albicans.
Wed Jun 23 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
17-0112 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
17-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 EDT 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
17-0112-82 was used in Flow Cytometry to profile cellular transcriptomes of lung tumours at different stages.
Mon Aug 10 00:00:00 EDT 2020
Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice.
The Journal of clinical investigation
Bosnakovski D,Shams AS,Yuan C,da Silva MT,Ener ET,Baumann CW,Lindsay AJ,Verma M,Asakura A,Lowe DA,Kyba M
17-0112-82 was used in Flow Cytometry to demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.
Fri May 01 00:00:00 EDT 2020
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B,Harbeson DJ,Shannon CP,Cai B,He D,Ben-Othman R,Francis F,Huang J,Varankovich N,Liu A,Bao W,Bjerregaard-Andersen M,Schaltz-Buchholzer F,Sanca L,Golding CN,Larsen KL,Levy O,Kampmann B,Tan R,Charles A,Wynn JL,Shann F,Aaby P,Benn CS,Tebbutt SJ,Kollmann TR,Amenyogbe N
17-0112 was used in Flow cytometry/Cell sorting to show that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration.
Wed May 06 00:00:00 EDT 2020
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
The Journal of experimental medicine
Fachi JL,Sécca C,Rodrigues PB,Mato FCP,Di Luccia B,Felipe JS,Pral LP,Rungue M,Rocha VM,Sato FT,Sampaio U,Clerici MTPS,Rodrigues HG,Câmara NOS,Consonni SR,Vieira AT,Oliveira SC,Mackay CR,Layden BT,Bortoluci KR,Colonna M,Vinolo MAR
17-0112 was used in Flow cytometry/Cell sorting to study the impact of a microbiota-derived metabolite, short-chain fatty acid acetate, on an acute mouse model of CDI.
Mon Mar 02 00:00:00 EST 2020
Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
The EMBO journal
Dumas AA,Pomella N,Rosser G,Guglielmi L,Vinel C,Millner TO,Rees J,Aley N,Sheer D,Wei J,Marisetty A,Heimberger AB,Bowman RL,Brandner S,Joyce JA,Marino S
17-0112-82 was used in Flow Cytometry to show that GBM-initiating cells induce mTOR signalling in the microglia but not bone marrow-derived macrophages in both in vitro and in vivo GBM mouse models.
Mon Aug 03 00:00:00 EDT 2020
Infiltrating Mast Cell-Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype.
Cancer research
Majorini MT,Cancila V,Rigoni A,Botti L,Dugo M,Triulzi T,De Cecco L,Fontanella E,Jachetti E,Tagliabue E,Chiodoni C,Tripodo C,Colombo MP,Lecis D
17-0112-82 was used in Flow Cytometry to support the notion that MCs influence the phenotype of breast cancer cells by stimulating a luminal phenotype and ultimately modifying the outcome of the disease.
Mon Jun 01 00:00:00 EDT 2020
IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.
Arteriosclerosis, thrombosis, and vascular biology
Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that IgE deficiency reduced atherosclerosis lesion burden, lesion lipid deposition, smooth muscle cell and endothelial cell contents, chemokine MCP (monocyte chemoattractant protein)-1 expression and macrophage accumulation.
Sun Mar 01 00:00:00 EST 2020
Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury.
Mucosal immunology
Wang C,Li Q,Lv J,Sun X,Cao Y,Yu K,Miao C,Zhang ZS,Yao Z,Wang Q
17-0112 was used in Flow cytometry/Cell sorting to study the role of GM-CSF in HlyA-mediated kidney injury.
Wed Jan 01 00:00:00 EST 2020
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
17-0112 was used in Flow cytometry/Cell sorting to determine the extent of MG proliferation and M infiltration in areas with retinal ischemia and RNV in Cx3cr1CreERT2 :Rosa26-tdTomato mice and examine the transcriptional profile of MG in the mouse model of oxygen-induced retinopathy (OIR).
Tue Sep 01 00:00:00 EDT 2020
Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Eixarch H,Calvo-Barreiro L,Costa C,Reverter-Vives G,Castillo M,Gil V,Del Río JA,Montalban X,Espejo C
17-0112-82 was used in Flow Cytometry to suggest a role for BMPs in early immune events that take place in myelin oligodendrocyte glycoprotein (MOG)-induced EAE.
Thu Oct 01 00:00:00 EDT 2020
Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP
17-0112 was used in Flow cytometry/Cell sorting to support a direct role of IgE in abdominal aortic aneurysm by promoting lesion chemokine expression, inflammatory cell accumulation, MAPK signalling and cytokine expression in mice.
Sat Feb 01 00:00:00 EST 2020
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.
The American journal of pathology
Stahl EC,Delgado ER,Alencastro F,LoPresti ST,Wilkinson PD,Roy N,Haschak MJ,Skillen CD,Monga SP,Duncan AW,Brown BN
17-0112-82 was used in Flow Cytometry to perform a comprehensive study of lipid content and inflammatory signature of livers in 19-month-old aged female mice.
Sat Feb 01 00:00:00 EST 2020
Mycobacterium tuberculosis Heat-Shock Protein 16.3 Induces Macrophage M2 Polarization Through CCRL2/CX3CR1.
Inflammation
Zhang Y,Li S,Liu Q,Long R,Feng J,Qin H,Li M,Liu L,Luo J
17-0112 was used in Flow cytometry/Cell sorting to provides evidence that Mycobacterium tuberculosis (MTB) Hsp16.3 promotes macrophages to M2 phenotype and explores its underlying mechanism.
Wed Apr 01 00:00:00 EDT 2020
Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case.
Mediators of inflammation
Abouelasrar Salama S,De Bondt M,Berghmans N,Gouwy M,de Oliveira VLS,Oliveira SC,Amaral FA,Proost P,Van Damme J,Struyf S,De Buck M
17-0112-82 was used in Flow Cytometry to conclude that experimental results obtained when using proteins recombinantly expressed in bacteria should always be interpreted with care.
Mon Jul 19 00:00:00 EDT 2021
Immunotherapy of Bacillus Calmette‑Guérin by targeting macrophages against bladder cancer in a NOD/scid IL2Rg‑/‑ mouse model.
Molecular medicine reports
Tan QL,Zhou CY,Cheng L,Luo M,Liu CP,Xu WX,Zhang X,Zeng X
17-0112 was used in Flow cytometry/Cell sorting to investigate the role and potential mechanism of Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer (BCa).
Wed Jul 01 00:00:00 EDT 2020
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
17-0112 was used in Flow cytometry/Cell sorting to reveal previously underappreciated role of dietary glucose concentration in establishing regulatory properties in intestinal DCs, thereby extending a potential therapeutic module against intestinal inflammation.
Mon Apr 19 00:00:00 EDT 2021
Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.
Frontiers in immunology
Hsu CY,Lin YC,Chang LY,Huang SK,Huang CH,Yang CK,Huang CT,Lin CY
17-0112-82 was used in Flow Cytometry to investigate the role of myeloid-derived suppressor cells in acetaminophen-induced liver failure and the possible therapeutic application.
Tue Jun 15 00:00:00 EDT 2021
Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Kidney360
Zimmerman KA,Huang J,He L,Revell DZ,Li Z,Hsu JS,Fitzgibbon WR,Hazard ES,Hardiman G,Mrug M,Bell PD,Yoder BK,Saigusa T
17-0112 was used in Flow cytometry/Cell sorting to suggest that Irf5 promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.
Sun Mar 01 00:00:00 EST 2020
Eosinophils improve cardiac function after myocardial infarction.
Nature communications
Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP
17-0112-82 was used in Flow Cytometry to establish a cardioprotective role of eosinophils in post-MI hearts.
Wed Dec 16 00:00:00 EST 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
17-0112 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.
Thu Sep 17 00:00:00 EDT 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
17-0112 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 EDT 2020
BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.
eLife
Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A
17-0112-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.
Thu Dec 03 00:00:00 EST 2020
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.
Cell reports
Wagner JA,Wong P,Schappe T,Berrien-Elliott MM,Cubitt C,Jaeger N,Lee M,Keppel CR,Marin ND,Foltz JA,Marsala L,Neal CC,Sullivan RP,Schneider SE,Keppel MP,Saucier N,Cooper MA,Fehniger TA
17-0112 was used in Flow cytometry/Cell sorting to develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice.
Tue Jun 02 00:00:00 EDT 2020
Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.
Cancers
Kuziel G,Thompson V,D'Amato JV,Arendt LM
17-0112 was used in Flow cytometry/Cell sorting to suggest that chronic inflammation induced by CCL2 significantly enhances tumor growth and promotes the formation of a desmoplastic stroma through early recruitment of macrophages and fibrocytes into the tumor microenvironment.
Tue Jul 28 00:00:00 EDT 2020
SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Cell reports
Joshi JC,Joshi B,Rochford I,Rayees S,Akhter MZ,Baweja S,Chava KR,Tauseef M,Abdelkarim H,Natarajan V,Gaponenko V,Mehta D
17-0112 was used in Flow cytometry/Cell sorting to demonstrate the anti-inflammatory regulation of monocyte-derived macrophages by acting on type 1 interferon gene signalling.
Tue Mar 24 00:00:00 EDT 2020
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity.
Cell reports
Khouili SC,Cook ECL,Hernández-García E,Martínez-López M,Conde-Garrosa R,Iborra S
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that SHP-1 inhibition improves CD11c+ cell-based vaccination against the parasite.
Tue Dec 01 00:00:00 EST 2020
Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.
Frontiers in immunology
de Melo CVB,Hermida MD,Mesquita BR,Fontes JLM,Koning JJ,Solcà MDS,Benevides BB,Mota GBS,Freitas LAR,Mebius RE,Dos-Santos WLC
17-0112 was used in Flow cytometry/Cell sorting to emphasize the potential role of spleen remodeling in the control of severe forms of Visceral leishmaniasis (VL) and highlight features potentially involved in this process.
Thu Apr 01 00:00:00 EDT 2021
Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain.
eLife
Cabañero D,Ramírez-López A,Drews E,Schmöle A,Otte DM,Wawrzczak-Bargiela A,Huerga Encabo H,Kummer S,Ferrer-Montiel A,Przewlocki R,Zimmer A,Maldonado R
17-0112 was used in Flow cytometry/Cell sorting to study the role of the cannabinoid 2 receptor in regulating spontaneous neuropathic pain through allowing self administration of a CB2 agonist in wildtype and CB2 knockout mice models.
Mon Jul 20 00:00:00 EDT 2020
IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging.
Frontiers in immunology
Bhaskaran N,Faddoul F,Paes da Silva A,Jayaraman S,Schneider E,Mamileti P,Weinberg A,Pandiyan P
17-0112-82 was used in Flow Cytometry to identify IL-1β/MyD88/Treg axis as a new component that modulates inflammatory responses in oral mucosa.
Mon Jun 28 00:00:00 EDT 2021
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
17-0112 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
STAR protocols
Lou F,Sun Y,Wang H
17-0112-82 was used in Flow Cytometry to establish a mouse model of psoriasis and flow cytometric detection of immune cells in the inflamed epidermis and dermis.
Fri Dec 18 00:00:00 EST 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
17-0112 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-0112 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter.
Cell reports
Eastman AE,Chen X,Hu X,Hartman AA,Pearlman Morales AM,Yang C,Lu J,Kueh HY,Guo S
17-0112 was used in Flow cytometry/Cell sorting to describe a genetically encoded fluorescent reporter that captures live-cell cycle speed using a single measurement.
Tue Jun 23 00:00:00 EDT 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
17-0112-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Cancers
Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G
17-0112 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.
Sat Apr 11 00:00:00 EDT 2020
Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.
Frontiers in immunology
Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR
17-0112 was used in Flow cytometry/Cell sorting to show dendritic cell PTPN2 might explain the central role for PTPN2 in the immune system to maintain immune tolerance.
Mon Apr 12 00:00:00 EDT 2021
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.
Communications biology
Chucair-Elliott AJ,Ocañas SR,Stanford DR,Ansere VA,Buettner KB,Porter H,Eliason NL,Reid JJ,Sharpe AL,Stout MB,Beckstead MJ,Miller BF,Richardson A,Freeman WM
17-0112 was used in Flow cytometry/Cell sorting to demonstrate and validate a Nuclear Tagging and Translating Ribosome Affinity Purification (NuTRAP) approach for temporally controlled labeling and isolation of ribosomes and nuclei, and thus RNA and DNA, from specific central nervous system cell types.
Thu Nov 19 00:00:00 EST 2020
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
eLife
Zhong L,Yao L,Tower RJ,Wei Y,Miao Z,Park J,Shrestha R,Wang L,Yu W,Holdreith N,Huang X,Zhang Y,Tong W,Gong Y,Ahn J,Susztak K,Dyment N,Li M,Long F,Chen C,Seale P,Qin L
17-0112 was used in Flow cytometry/Cell sorting to computationally define mesenchymal progenitors at different stages and delineate their bi-lineage differentiation paths in young, adult and aging mice.
Tue Apr 14 00:00:00 EDT 2020
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Cell
Luan HH,Wang A,Hilliard BK,Carvalho F,Rosen CE,Ahasic AM,Herzog EL,Kang I,Pisani MA,Yu S,Zhang C,Ring AM,Young LH,Medzhitov R
17-0112 was used in Flow cytometry/Cell sorting to show that GDF15 coordinates tolerance to inflammatory damage through regulation of triglyceride metabolism.
Thu Aug 22 00:00:00 EDT 2019
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
17-0112-82 was used in Immunocytochemistry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
17-0112 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease.
Cell metabolism
Baik SH,Kang S,Lee W,Choi H,Chung S,Kim JI,Mook-Jung I
17-0112-82 was used in Flow Cytometry to examine microglial metabolic function in regulating signalling cascades for potential Alzheimer's treatment.
Tue Sep 03 00:00:00 EDT 2019
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
Nature cell biology
Salvagno C,Ciampricotti M,Tuit S,Hau CS,van Weverwijk A,Coffelt SB,Kersten K,Vrijland K,Kos K,Ulas T,Song JY,Ooi CH,Rüttinger D,Cassier PA,Jonkers J,Schultze JL,Ries CH,de Visser KE
17-0112-82 was used in Flow Cytometry to investigate the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy.
Mon Apr 01 00:00:00 EDT 2019
Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice.
Cellular & molecular immunology
Du X,Wu Z,Xu Y,Liu Y,Liu W,Wang T,Li C,Zhang C,Yi F,Gao L,Liang X,Ma C
17-0112 was used in Flow cytometry/Cell sorting to analyze Tim-3 expression on different subpopulations of liver macrophages and further investigate the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice.
Fri Nov 01 00:00:00 EDT 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
17-0112-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.
Mon Nov 04 00:00:00 EST 2019
Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression.
Cancer research
Wettersten HI,Weis SM,Pathria P,Von Schalscha T,Minami T,Varner JA,Cheresh DA
17-0112 was used in Flow cytometry/Cell sorting to suggest that anti-αvβ3 represents a promising immunotherapeutic approach to redirect TAMs to serve as tumor killers for late-stage or drug-resistant cancers.
Tue Oct 01 00:00:00 EDT 2019
Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain.
CNS neuroscience & therapeutics
Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y
17-0112-82 was used in Flow Cytometry to examine the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, particularly with regards to the contribution of these cells to the phagocytic clearance of dead/dying cells (efferocytosis) in the poststroke brain.
Sun Dec 01 00:00:00 EST 2019
Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps.
International journal of oncology
Li Y,Yang Y,Gan T,Zhou J,Hu F,Hao N,Yuan B,Chen Y,Zhang M
17-0112 was used in Flow cytometry/Cell sorting to investigate the cross‚talk of tumor exRNAs and neutrophil extracellular traps in lung cancer.
Mon Jul 01 00:00:00 EDT 2019
Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hirakata T,Lee HC,Ohba M,Saeki K,Okuno T,Murakami A,Matsuda A,Yokomizo T
17-0112 was used in Flow cytometry/Cell sorting to show that the levels of ω-6-derived proinflammatory lipid mediators, including those with chemoattractant properties for eosinophils, were markedly reduced in the conjunctivae of ω-3 diet-fed mice.
Fri Mar 01 00:00:00 EST 2019
Trafficking of a multifunctional protein by endosomal microautophagy: linking two independent unconventional secretory pathways.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Chauhan AS,Kumar M,Chaudhary S,Dhiman A,Patidar A,Jakhar P,Jaswal P,Sharma K,Sheokand N,Malhotra H,Raje CI,Raje M
17-0112-82 was used in Immunocytochemistry to demonstrates that GAPDH mobilized to the PM, and the ECM does not utilize the classic endoplasmic reticulum-Golgi route of secretion.
Mon Apr 01 00:00:00 EDT 2019
Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis.
Journal of immunology research
Zhao Z,Luo Z,Yang Q,Chang H,Liu P,Li Z,Guo S,Zhou C,Song J,Cao W
17-0112-82 was used in Flow Cytometry to examine the importance of neutrophils and the neutrophil-derived DAMP protein, MRP14, in antibody production.
Tue Jun 25 00:00:00 EDT 2019
2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence.
Infection and immunity
Bartholomew TL,Kidd TJ,Sá Pessoa J,Conde Álvarez R,Bengoechea JA
17-0112 was used in Flow cytometry/Cell sorting to suggest that LpxO is a candidate for the development of anti-A. baumannii drugs.
Mon Apr 01 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
17-0112 was used in Flow cytometry/Cell sorting to investigate the antitumor and immunomodulatory effects of CS2164.
Tue Oct 01 00:00:00 EDT 2019
Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H
17-0112-82 was used in Flow Cytometry to reveal a critical role of Lys376-mediated ubiquitination of RIPK1 in suppressing RIPK1 kinase activity-dependent lethal pathways during embryogenesis and RIPK3-dependent inflammation postnatally.
Fri Sep 13 00:00:00 EDT 2019
Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.
Cell reports
Tuit S,Salvagno C,Kapellos TS,Hau CS,Seep L,Oestreich M,Klee K,de Visser KE,Ulas T,Schultze JL
17-0112 was used in Flow cytometry/Cell sorting to show that a transgenic mouse tumor model can yield a TAM signature relevant for human breast cancer outcome prognosis and provide a generalizable strategy for determining and applying immune cell signatures provided the murine model reflects the human disease.
Tue Oct 29 00:00:00 EDT 2019
Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.
International journal of medical sciences
Kim HR,Rahman FU,Kim KS,Kim EK,Cho SM,Lee K,Moon OS,Seo YW,Yoon WK,Won YS,Kang H,Kim HC,Nam KH
17-0112-82 was used in Flow Cytometry to suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.
Thu Apr 30 00:00:00 EDT 2020
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
17-0112 was used in Flow cytometry/Cell sorting to provide genetic evidence supporting that NKG2A and the inhibitory members of Ly49 family receptors synergize to regulate NK cell education.
Fri Nov 01 00:00:00 EDT 2019
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Nature communications
Zhong L,Xu Y,Zhuo R,Wang T,Wang K,Huang R,Wang D,Gao Y,Zhu Y,Sheng X,Chen K,Wang N,Zhu L,Can D,Marten Y,Shinohara M,Liu CC,Du D,Sun H,Wen L,Xu H,Bu G,Chen XF
17-0112-82 was used in Flow Cytometry to demonstrate a protective role of sTREM2 against amyloid pathology and related toxicity and suggests that increasing sTREM2 can be explored for Alzheimer's disease therapy.
Mon Mar 25 00:00:00 EDT 2019
CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota.
Cell reports
Zhang H,Carnevale G,Polese B,Simard M,Thurairajah B,Khan N,Gentile ME,Fontes G,Vinh DC,Pouliot R,King IL
17-0112-82 was used in Flow Cytometry to provide insight into the regulation of the skin IL-23/IL-17 immune axis and how homeostasis is maintained at this important barrier site.
Tue Oct 08 00:00:00 EDT 2019
Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction.
Stem cell research & therapy
Lu D,Liao Y,Zhu SH,Chen QC,Xie DM,Liao JJ,Feng X,Jiang MH,He W
17-0112 was used in Flow cytometry/Cell sorting to show that Nestin is a useful marker for the identification of functional BMSCs and indicate that Nestin+ BMSCs could be a better therapeutic candidate for cardiac repair.
Sat Apr 27 00:00:00 EDT 2019
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model.
Nature communications
Rosenzweig N,Dvir-Szternfeld R,Tsitsou-Kampeli A,Keren-Shaul H,Ben-Yehuda H,Weill-Raynal P,Cahalon L,Kertser A,Baruch K,Amit I,Weiner A,Schwartz M
17-0112 was used in Flow cytometry/Cell sorting to demonstrate immunotherapy techniques to combat diseases such as Alzheimer's disease and dementia, by targeting the PD-1/PD-L1 pathway.
Mon Jan 28 00:00:00 EST 2019
The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.
Scientific reports
Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC
17-0112-82 was used in Flow Cytometry to show that nBMP2 plays a role in Ca2+ response.
Wed Jan 30 00:00:00 EST 2019
TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection.
Vaccines
Choi A,Christopoulou I,Saelens X,García-Sastre A,Schotsaert M
17-0112 was used in Flow cytometry/Cell sorting to establish a mouse vaccination model that allows control of disease severity after influenza virus infection despite inefficient induction of virus-neutralizing antibody titers by vaccination.
Thu Sep 12 00:00:00 EDT 2019
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.
Cancer cell
Lu B,Klingbeil O,Tarumoto Y,Somerville TDD,Huang YH,Wei Y,Wai DC,Low JKK,Milazzo JP,Wu XS,Cao Z,Yan X,Demerdash OE,Huang G,Mackay JP,Kinney JB,Shi J,Vakoc CR
17-0112-82 was used in Flow Cytometry to demonstrate how a sequence anomaly of an oncogene promoter can impose a transcriptional addiction in cancer.
Mon Dec 10 00:00:00 EST 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
17-0112 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.
Tue Jan 02 00:00:00 EST 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
17-0112 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
Oxidative medicine and cellular longevity
Bai YD,Yang YR,Mu XP,Lin G,Wang YP,Jin S,Chen Y,Wang MJ,Zhu YC
17-0112-82 was used in Magnetic cell separation to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia.
Wed Dec 19 00:00:00 EST 2018
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.
Nature communications
Lorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D
17-0112 was used in Flow cytometry/Cell sorting to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo.
Thu Apr 26 00:00:00 EDT 2018
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell stem cell
Tadokoro Y,Hoshii T,Yamazaki S,Eto K,Ema H,Kobayashi M,Ueno M,Ohta K,Arai Y,Hara E,Harada K,Oshima M,Oshima H,Arai F,Yoshimura A,Nakauchi H,Hirao A
17-0112-82 was used in Flow Cytometry to demonstrate the involvement of diet-induced stress on hematopoietic stem cell self-renewal.
Thu May 03 00:00:00 EDT 2018
Corticosterone Production during Repeated Social Defeat Causes Monocyte Mobilization from the Bone Marrow, Glucocorticoid Resistance, and Neurovascular Adhesion Molecule Expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Niraula A,Wang Y,Godbout JP,Sheridan JF
17-0112-82 was used in Flow cytometry/Cell sorting to delineate the role of HPA activation and corticosterone production in the immunological responses to stress in male C57BL/6 mice.
Wed Feb 28 00:00:00 EST 2018
Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.
Cell reports
Omata Y,Frech M,Primbs T,Lucas S,Andreev D,Scholtysek C,Sarter K,Kindermann M,Yeremenko N,Baeten DL,Andreas N,Kamradt T,Bozec A,Ramming A,Krönke G,Wirtz S,Schett G,Zaiss MM
17-0112 was used in Flow cytometry/Cell sorting to elucidate the role of group 2 innate lymphoid cells in arthritis.
Tue Jul 03 00:00:00 EDT 2018
Endogenous Mobilization of Bone-Marrow Cells Into the Murine Retina Induces Fusion-Mediated Reprogramming of Müller Glia Cells.
EBioMedicine
Pesaresi M,Bonilla-Pons SA,Simonte G,Sanges D,Di Vicino U,Cosma MP
17-0112 was used in Flow cytometry/Cell sorting to study the effects of N-Methyl-D-Aspartate damage on the cellular programming of murine müller glial cells.
Sun Apr 01 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
17-0112 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 EDT 2018
Systemic inflammation induced by lipopolysaccharide aggravates inherited retinal dystrophy.
Cell death & disease
Noailles A,Maneu V,Campello L,Lax P,Cuenca N
17-0112 was used in Flow cytometry/Cell sorting to indicate that chronic exacerbation of the inflammatory response in response to LPS accelerates neurodegeneration in dystrophic P23H rats, suggesting that in patients with ocular neurodegenerative diseases, peripheral damage, as a systemic infection or chronic inflammatory process, could accelerate disease progression and should be taken into account in order to select an appropriate therapy to revert, block or slow-down the degenerative process.
Fri Mar 02 00:00:00 EST 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
17-0112 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 EDT 2018
CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.
Cell discovery
Li D,Hu M,Liu Y,Ye P,Du P,Li CS,Cheng L,Liu P,Jiang J,Su L,Wang S,Zheng P,Liu Y
17-0112-82 was used in Flow cytometry/Cell sorting to show that targeted mutation of Cd24 dramatically increased HCC burden while reducing intrahepatic macrophages and DEN-induced hepatocyte apoptosis.
Thu Oct 01 00:00:00 EDT 2020
Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.
JCI insight
Arifuzzaman M,Ang WXG,Choi HW,Nilles ML,St John AL,Abraham SN
17-0112-82 was used in Flow Cytometry to examine how Yersinia pestis converts immunocytes recruited by host to contain the pathogen into vehicles for bacterial dispersal and the role of immune cell death in this context.
Thu Sep 20 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
17-0112 was used in Flow cytometry/Cell sorting to provide molecular insights into the role of Rho GTPases in TGFβ signalling and understanding of mesenchymal stem cells in fibriosis.
Fri Jun 15 00:00:00 EDT 2018
Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints.
International journal of molecular sciences
Deloch L,Rückert M,Fietkau R,Frey B,Gaipl US
17-0112 was used in Flow cytometry/Cell sorting to show that low-dose radiotherapy with particularly a single dose of 0.5 Gray has no harmful effects on cells of healthy joints.
Tue Oct 16 00:00:00 EDT 2018
MiR-486 promotes proliferation and suppresses apoptosis in myeloid cells by targeting Cebpa in vitro.
Cancer medicine
Jiang J,Gao Q,Gong Y,Huang L,Lin H,Zhou X,Liang X,Guo W
17-0112 was used in Flow cytometry/Cell sorting to identify micro-RNAs that regulate the proliferation and differentiation of monocytic myeloid-derived suppressor cells.
Sat Sep 01 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
17-0112 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Cell
Keren-Shaul H,Spinrad A,Weiner A,Matcovitch-Natan O,Dvir-Szternfeld R,Ulland TK,David E,Baruch K,Lara-Astaiso D,Toth B,Itzkovitz S,Colonna M,Schwartz M,Amit I
17-0112-82 was used in Flow Cytometry to map all immune populations in wild-type and Alzheimer's disease-transgenic mouse brains.
Thu Jun 15 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
17-0112 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Cell stem cell
Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R
17-0112 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.
Thu Jun 01 00:00:00 EDT 2017
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
The Journal of clinical investigation
Li H,Liu P,Xu S,Li Y,Dekker JD,Li B,Fan Y,Zhang Z,Hong Y,Yang G,Tang T,Ren Y,Tucker HO,Yao Z,Guo X
17-0112 was used in Flow cytometry/Cell sorting to investigate ageing of MSCs, showing that FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
Mon Apr 03 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
17-0112 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-0112 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Vijay R,Fehr AR,Janowski AM,Athmer J,Wheeler DL,Grunewald M,Sompallae R,Kurup SP,Meyerholz DK,Sutterwala FS,Narumiya S,Perlman S
17-0112 was used in Flow cytometry/Cell sorting to study the role of Prostaglandin D2 signalling in optimal microglia/macrophage activation and interferon expression after infection with a neurotropic coronavirus.
Mon Jul 03 00:00:00 EDT 2017
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene
Sochalska M,Schuler F,Weiss JG,Prchal-Murphy M,Sexl V,Villunger A
17-0112 was used in Flow cytometry/Cell sorting to analyse the role of the anti-apoptotic protein, BCL2A1/A1, in blood cancers driven by either the MYC or ABL kinases.
Sat Apr 01 00:00:00 EDT 2017
Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection.
Mucosal immunology
Valanparambil RM,Tam M,Jardim A,Geary TG,Stevenson MM
17-0112 was used in Flow cytometry/Cell sorting to study the exact identity and role of the F4/80-CD11b+Gr+ cells accumulating around encysting larvae in intestinal tissue during primary Heligmosomoides polygyrus bakeri infection in mice.
Sun Jan 01 00:00:00 EST 2017
Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium.
Blood advances
Mei Y,Feng G,Rahimi N,Zhao B,Zhang J,Cao L,Yang J,Gao J,Chen Y,Sumagin R,Muller WA,Zhang L,Ji P
17-0112 was used in Flow cytometry/Cell sorting to investigate if mDia1 knockout mice show cell-autonomously increased CD11b expression on neutrophils in the peripheral blood and bone marrow.
Tue Sep 12 00:00:00 EDT 2017
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
PLoS pathogens
Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM
17-0112 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.
Sun Oct 01 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
17-0112 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
ZEB1-regulated inflammatory phenotype in breast cancer cells.
Molecular oncology
Katsura A,Tamura Y,Hokari S,Harada M,Morikawa M,Sakurai T,Takahashi K,Mizutani A,Nishida J,Yokoyama Y,Morishita Y,Murakami T,Ehata S,Miyazono K,Koinuma D
17-0112 was used in Flow cytometry/Cell sorting to investigate a ZEB1-regulated inflammatory phenotype in breast cancer cells.
Fri Sep 01 00:00:00 EDT 2017
Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.
Journal of lipid research
De Giorgi M,Enjyoji K,Jiang G,Csizmadia E,Mitsuhashi S,Gumina RJ,Smolenski RT,Robson SC
17-0112 was used in Flow cytometry/Cell sorting to further investigate the complex, potentially divergent roles of Cd39 in the development of atherosclerosis in mice.
Sat Jul 01 00:00:00 EDT 2017
Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice.
Journal of virology
Seleme MC,Kosmac K,Jonjic S,Britt WJ
17-0112 was used in Flow cytometry/Cell sorting to show that during cytomegalovirus (HCMV) infection in infants, tumor necrosis factor alpha plays a key role in brain inflammation and abnormal neurodevelopment. Targeting TNF-α with neutralising antibodies normalized neurodevelopment in infant mice.
Sat Apr 15 00:00:00 EDT 2017
The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Aziz MH,Cui K,Das M,Brown KE,Ardell CL,Febbraio M,Pluskota E,Han J,Wu H,Ballantyne CM,Smith JD,Cathcart MK,Yakubenko VP
17-0112 was used in Flow cytometry/Cell sorting to study the mechanism by which inflammation mediated CD11d upregulation contributes to macrophage retention at inflammatory sites during atherogenesis.
Thu Jun 15 00:00:00 EDT 2017
The skeletal impact of the chemotherapeutic agent etoposide.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Koh AJ,Sinder BP,Entezami P,Nilsson L,McCauley LK
17-0112 was used in Flow cytometry/Cell sorting to study the effect of etoposide on the skeleton.
Tue Aug 01 00:00:00 EDT 2017
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis.
Frontiers in neurology
Peake K,Manning J,Lewis CA,Tran K,Rossi F,Krieger C
17-0112 was used in Flow cytometry/Cell sorting to indicate that establishment of high levels of blood and BM chimerism alone is not sufficient to induce BMDC accumulation within the CNS.
Thu Oct 01 00:00:00 EDT 2020
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.
Oncoimmunology
Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE
17-0112 was used in Flow cytometry/Cell sorting to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17–neutrophil axis.
Sat Jan 29 00:00:00 EST 2022
DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.
Nature communications
Kim HS,Nam ST,Mun SH,Lee SK,Kim HW,Park YH,Kim B,Won KJ,Kim HR,Park YM,Kim HS,Beaven MA,Kim YM,Choi WS
17-0112 was used in Flow cytometry/Cell sorting to study the role of DJ-1 in bone homeostasis in both normal physiology and in bone-associated pathology.
Wed Nov 15 00:00:00 EST 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
17011282 was used in flow cytometry to test the effect of paeoniflorin in experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis
Mon Feb 06 00:00:00 EST 2017
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.
Nature communications
Guo W,Liu W,Chen Z,Gu Y,Peng S,Shen L,Shen Y,Wang X,Feng GS,Sun Y,Xu Q
17-0112 was used in an ELISA assay to explore the mechanisms behind NLRP3 inflammasome regulation.
Mon Dec 18 00:00:00 EST 2017
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Oncoimmunology
Ehx G,Fransolet G,de Leval L,D'Hondt S,Lucas S,Hannon M,Delens L,Dubois S,Drion P,Beguin Y,Humblet-Baron S,Baron F
17-0112 was used in Flow cytometry/Cell sorting to investigate the impact of 5-azacytidine on xenogeneic graft-vs.-host disease and graft-vs.-leukaemia effects in a humanised murine model of transplantation.
Tue Jan 12 00:00:00 EST 2021
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Scientific reports
Soukup K,Halfmann A,Dillinger B,Poyer F,Martin K,Blauensteiner B,Kauer M,Kuttke M,Schabbauer G,Dohnal AM
17-0112 was used in Flow cytometry/Cell sorting to suggest that MAPK-activated protein kinase 2 deletion leads to an expansion of stimulatory CD103+ dendritic cells, mounting a potent CD8+ T cell anti-tumour response in mice.
Mon Sep 18 00:00:00 EDT 2017
Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.
Frontiers in microbiology
Lai CY,Strange DP,Wong TAS,Lehrer AT,Verma S
17-0112 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo.
Tue Sep 29 00:00:00 EDT 2020
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
17-0112 was used in Flow cytometry/Cell sorting to show that therapeutic vaccination against DLK1 results in slowed tumour growth, and compensatory expression of DLK2 by tumour-associated pericytes.
Tue Jan 12 00:00:00 EST 2021
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Hara T,Nakaoka HJ,Hayashi T,Mimura K,Hoshino D,Inoue M,Nagamura F,Murakami Y,Seiki M,Sakamoto T
17-0112-82 was used in Flow cytometry/Cell sorting to report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth.
Tue May 30 00:00:00 EDT 2017
MafB is a critical regulator of complement component C1q.
Nature communications
Tran MTN,Hamada M,Jeon H,Shiraishi R,Asano K,Hattori M,Nakamura M,Imamura Y,Tsunakawa Y,Fujii R,Usui T,Kulathunga K,Andrea CS,Koshida R,Kamei R,Matsunaga Y,Kobayashi M,Oishi H,Kudo T,Takahashi S
17-0112 was used in Flow cytometry/Cell sorting to study the function of MafB in the context of regulation of C1q.
Wed Nov 22 00:00:00 EST 2017
C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis.
Frontiers in pharmacology
Khameneh HJ,Ho AW,Laudisi F,Derks H,Kandasamy M,Sivasankar B,Teng GG,Mortellaro A
17-0112 was used in Flow cytometry/Cell sorting to study the role of monosodium urate-mediated complement activation in IL-1B release and the molecular characteristics of the complement cascade.
Fri Apr 08 00:00:00 EDT 2022
IL-17C is required for lethal inflammation during systemic fungal infection.
Cellular & molecular immunology
Huang J,Meng S,Hong S,Lin X,Jin W,Dong C
17-0112 was used in Flow cytometry/Cell sorting to elucidate the function of the IL-17 family members in anti-fungal immunity.
Fri Jul 01 00:00:00 EDT 2016
NLRP2 controls age-associated maternal fertility.
The Journal of experimental medicine
Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M
17-0112 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.
Mon Dec 12 00:00:00 EST 2016
G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers.
Protein & cell
Li W,Zhang X,Chen Y,Xie Y,Liu J,Feng Q,Wang Y,Yuan W,Ma J
17-0112 was used in Flow cytometry/Cell sorting to indicate that G-CSF is a critical regulating molecule in the migration, proliferation and functional maintenance of myeloid derived suppressor cells.
Mon Feb 01 00:00:00 EST 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
17-0112 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Proceedings of the National Academy of Sciences of the United States of America
Fu AK,Hung KW,Yuen MY,Zhou X,Mak DS,Chan IC,Cheung TH,Zhang B,Fu WY,Liew FY,Ip NY
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of IL-33/ST2 signalling in the pathogenesis of Alzheimer's disease, showing that treatment with IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Tue May 10 00:00:00 EDT 2016
Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Arteriosclerosis, thrombosis, and vascular biology
Yan H,Zhou HF,Akk A,Hu Y,Springer LE,Ennis TL,Pham CTN
17-0112 was used in Flow cytometry/Cell sorting to determine whether the AAA-promoting effect of DPPI is mediated by neutrophil serine proteases.
Mon Aug 01 00:00:00 EDT 2016
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
17-0112 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.
Molecular metabolism
Johnson AR,Qin Y,Cozzo AJ,Freemerman AJ,Huang MJ,Zhao L,Sampey BP,Milner JJ,Beck MA,Damania B,Rashid N,Galanko JA,Lee DP,Edin ML,Zeldin DC,Fueger PT,Dietz B,Stahl A,Wu Y,Mohlke KL,Makowski L
17-0112 was used in Flow cytometry/Cell sorting to outline a novel mechanism for regulating adipose tissue homoeostasis and inflammation through metabolic reprogramming of macrophages; directed by fatty acid transport protein 1.
Fri Jul 01 00:00:00 EDT 2016
Blockade of MK2 is protective in inflammation-associated colorectal cancer development.
International journal of cancer
Ray AL,Castillo EF,Morris KT,Nofchissey RA,Weston LL,Samedi VG,Hanson JA,Gaestel M,Pinchuk IV,Beswick EJ
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of MAPK-activated protein kinase 2 in development of colitis-associated colon cancer.
Mon Feb 01 00:00:00 EST 2016
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.
Disease models & mechanisms
Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.
Fri Apr 01 00:00:00 EDT 2016
Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation.
The FEBS journal
Jin X,Liu L,Zhou Z,Ge J,Yao T,Shen C
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that pioglitazone blocks classical activation of macrophages and attenuates inflammation in mouse models of diabetes.
Wed Jun 01 00:00:00 EDT 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
17-0112 was used in Flow cytometry/Cell sorting to study how Ccr5 is crucial in directing T cells toward the LGTV-infected brain, as well as in suppressing neutrophil-mediated inflammation within the CNS.
Wed Jun 01 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
17-0112 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Molecular and cellular biology
Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA
17-0112 was used in Flow cytometry/Cell sorting to provide direct evidence that Pcbp1 and Pcpb2 individually provide an essential function in the mammalian genome.
Fri Jan 15 00:00:00 EST 2016
Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression.
Journal of diabetes research
Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen C
17-0112 was used in Flow cytometry/Cell sorting to investigate the use of metformin to treat AGEs-induced inflammatory response in macrophages.
Tue Jun 06 00:00:00 EDT 2017
Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis.
Stem cell research & therapy
Bravo B,Gallego MI,Flores AI,Bornstein R,Puente-Bedia A,Hernández J,de la Torre P,García-Zaragoza E,Perez-Tavarez R,Grande J,Ballester A,Ballester S
17-0112 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of DMSCs for treatment of autoimmune disorders.
Thu Mar 17 00:00:00 EDT 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
17-0112 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.
Mon Feb 01 00:00:00 EST 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
17-0112 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.
Nature communications
Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X
17-0112 was used in Flow cytometry/Cell sorting to explore a role of REGγ in the regulation of NFκB and the effect of this on the development of bowel inflammation and associated tumour formation.
Mon Feb 22 00:00:00 EST 2016
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria journal
Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P
17-0112 was used in Flow cytometry/Cell sorting to evaluate the effect of artemisinins and cysteamine combination therapy on malarial phenotypes.
Fri May 06 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
17-0112 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma.
Oncotarget
Binsfeld M,Muller J,Lamour V,De Veirman K,De Raeve H,Bellahcène A,Van Valckenborgh E,Baron F,Beguin Y,Caers J,Heusschen R
17-0112 was used in Flow cytometry/Cell sorting to study the contribution of myeloid derived suppressor cell subsets to different disease-promoting aspects in multiple myeloma.
Tue Jun 21 00:00:00 EDT 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
17-0112 was used in Immunofluorescence to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
17-0112 was used in Immunofluorescence to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.
JCI insight
Collins SL,Chan-Li Y,Oh M,Vigeland CL,Limjunyawong N,Mitzner W,Powell JD,Horton MR
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that lung-directed immunotherapy induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis.
Thu Apr 07 00:00:00 EDT 2016
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice.
PloS one
Schmidt D,Peterlik D,Reber SO,Lechner A,Männel DN
17-0112 was used in Flow cytometry/Cell sorting to observe the immunological effects of chronic psychosocial stress in mice.
Fri Aug 18 00:00:00 EDT 2017
Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.
Oncoimmunology
Jiang X,Zhou T,Xiao Y,Yu J,Dou S,Chen G,Wang R,Xiao H,Hou C,Wang W,Shi Q,Feng J,Ma Y,Shen B,Li Y,Han G
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that Tim-3 polarizes macrophages by directly binding to STAT1 via residue Y256 and Y263 in its intracellular tail and inhibiting the STAT1-miR-155-SOCS1 signaling axis.
Wed Nov 09 00:00:00 EST 2022
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-0112 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model.
Scientific reports
Bazett M,Bergeron ME,Haston CK
17-0112 was used in Flow cytometry/Cell sorting to reveal a potential intestinal microbiome influence on lung response in BALB/c Cftr(tm1UNC) mice.
Tue Jan 12 00:00:00 EST 2016
Pro-inflammatory effect of a traditional Chinese medicine formula with potent anti-cancer activity in vitro impedes tumor inhibitory potential in vivo.
Molecular and clinical oncology
Xia L,Plachynta M,Liu T,Xiao X,Song J,Li X,Zhang M,Yao Y,Luo H,Hao X,Ben-David Y
17-0112 was used in Flow cytometry/Cell sorting to highlight the complexity of Chinese medicinal compounds and the need to thoroughly analyze their systemic effects at high concentrations in vivo.
Thu Dec 01 00:00:00 EST 2016
Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner.
Immunity, inflammation and disease
Owusu-Boaitey N,Bauckman KA,Zhang T,Mysorekar IU
17-0112 was used in Flow cytometry/Cell sorting to determine whether macrophages, in response to uropathogenic Escherichia coli infection, retain extracellular siderophore-bound and free iron.
Thu Dec 01 00:00:00 EST 2016
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Oncotarget
Yong CS,John LB,Devaud C,Prince MH,Johnstone RW,Trapani JA,Darcy PK,Kershaw MH
17-0112 was used in Flow cytometry/Cell sorting to characterise the function of leukocytes from transgenic mice expressing a chimeric antigen receptor under the control of vav, and determine the ability of these mice to respond to ERB-expressing tumours.
Tue Jun 07 00:00:00 EDT 2016
MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.
PloS one
Lakshminarayanan V,Supekar NT,Wei J,McCurry DB,Dueck AC,Kosiorek HE,Trivedi PP,Bradley JM,Madsen CS,Pathangey LB,Hoelzinger DB,Wolfert MA,Boons GJ,Cohen PA,Gendler SJ
17-0112 was used in Flow cytometry/Cell sorting to investigate vaccines against MUC1.
Fri Jul 29 00:00:00 EDT 2016
Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Cell reports
Möhle L,Mattei D,Heimesaat MM,Bereswill S,Fischer A,Alutis M,French T,Hambardzumyan D,Matzinger P,Dunay IR,Wolf SA
17-0112 was used in Flow cytometry/Cell sorting to detect that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention.
Tue May 31 00:00:00 EDT 2016
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.
Science translational medicine
Hu-Lieskovan S,Mok S,Homet Moreno B,Tsoi J,Robert L,Goedert L,Pinheiro EM,Koya RC,Graeber TG,Comin-Anduix B,Ribas A
17-0112 was used in Flow cytometry/Cell sorting to investigate the use of BRAF and MEK inhibitors with immunotherapy in patients with BRAF(V600E) melanoma.
Wed Mar 18 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
17-0112 was used in Flow cytometry/Cell sorting to exhibit a novel vaccine platform for inducing robust T cell responses capable of protecting against heterologous influenza A challenges.
Fri Jul 10 00:00:00 EDT 2015
Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages.
Frontiers in immunology
Wex K,Schmid U,Just S,Wang X,Wurm R,Naumann M,Schlüter D,Nishanth G
17-0112 was used in Flow cytometry/Cell sorting to explore the role of CYLD on RIPK2-dependent antibacterial immune responses in macrophages.
Tue Feb 02 00:00:00 EST 2016
Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases.
Breast cancer research : BCR
Tabariès S,Ouellet V,Hsu BE,Annis MG,Rose AA,Meunier L,Carmona E,Tam CE,Mes-Masson AM,Siegel PM
17-0112 was used in Flow cytometry/Cell sorting to examined whether breast cancer cell metastasis to the lung, liver or bone is dependent on distinct patterns of immune cell infiltration.
Fri Mar 27 00:00:00 EDT 2015
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.
Glia
Verheijden S,Beckers L,Casazza A,Butovsky O,Mazzone M,Baes M
17-0112-82 was used in Flow Cytometry to demonstrate that chronic activation of resident microglia does not necessarily lead to phagocytosis nor overt neurotoxicity.
Tue Sep 01 00:00:00 EDT 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
17-0112 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 EDT 2015
CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice.
Journal of immunology (Baltimore, Md. : 1950)
Burrack KS,Montgomery SA,Homann D,Morrison TE
17-0112 was used in Flow cytometry/Cell sorting to demonstrate an important but limited and tissue-specific role for CD8+ T lymphocytes in the control of pathogenic RRV infection.
Thu Jan 15 00:00:00 EST 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
17-0112 was used in Flow cytometry/Cell sorting to identify a novel leukocyte receptor, TARM1, and investigate the mechanisms underlying its proinflammatory effects.
Thu Oct 01 00:00:00 EDT 2015
Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production.
Journal of immunology (Baltimore, Md. : 1950)
Li W,Yu R,Ma B,Yang Y,Jiao X,Liu Y,Cao H,Dong W,Liu L,Ma K,Fukuda T,Liu Q,Ma T,Wang Z,Gu J,Zhang J,Taniguchi N
17-0112 was used in Flow cytometry/Cell sorting to investigate core fucosylation of IgG B cell receptor's role in antigen recognition and antibody production.
Sun Mar 15 00:00:00 EDT 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
17-0112 was used in Flow cytometry/Cell sorting to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.
Sun Feb 15 00:00:00 EST 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
17-0112 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 EDT 2015
Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.
Mediators of inflammation
Ribeiro LR,Loures FV,de Araújo EF,Feriotti C,Costa TA,Serezani CH,Jancar S,Calich VL
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of CysLT in the pulmonary infection developed by resistant and susceptible mice.
Wed Nov 02 00:00:00 EDT 2016
Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection.
Cell transplantation
Wang S,Zhang X,Zhang L,Bryant J,Kheradmand T,Hering BJ,Miller SD,Luo X
17-0112 was used in Flow cytometry/Cell sorting to investigate the compatibility of a tolerance regimen with commonly used immunosuppressive drugs.
Mon Mar 07 00:00:00 EST 2016
Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.
BioMed research international
Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C
17-0112 was used in Flow cytometry/Cell sorting to assess the effects of AGEs on macrophage polarization.
Fri Mar 18 00:00:00 EDT 2016
Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis.
BMC immunology
Tokieda S,Komori M,Ishiguro T,Iwakura Y,Takahara K,Inaba K
17-0112 was used in Immunohistochemistry on frozen tissues to investigate the role of Dcir1 in intestinal immune responses during colitis.
Fri Oct 23 00:00:00 EDT 2015
Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney.
International journal of molecular sciences
Hu Z,Pei G,Wang P,Yang J,Zhu F,Guo Y,Wang M,Yao Y,Zeng R,Liao W,Xu G
17-0112 was used in Flow cytometry/Cell sorting to investigate the effect of BVRA on macrophage activation and polarisation in injured renal microenvironment.
Fri Sep 18 00:00:00 EDT 2015
Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.
Nature communications
Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN
17-0112 was used in Flow cytometry/Cell sorting to suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone loss following ART initiation.
Tue Sep 22 00:00:00 EDT 2015
Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.
Journal of neuroinflammation
Febinger HY,Thomasy HE,Pavlova MN,Ringgold KM,Barf PR,George AM,Grillo JN,Bachstetter AD,Garcia JA,Cardona AE,Opp MR,Gemma C
17-0112 was used in Flow cytometry/Cell sorting to evaluate the range of effects resulting from the genetic deletion of CX3CR1.
Wed Sep 02 00:00:00 EDT 2015
Bone marrow macrophages support prostate cancer growth in bone.
Oncotarget
Soki FN,Cho SW,Kim YW,Jones JD,Park SI,Koh AJ,Entezami P,Daignault-Newton S,Pienta KJ,Roca H,McCauley LK
17-0112 was used in Flow cytometry/Cell sorting to determine the role of macrophages in prostate cancer skeletal metastasis using two in vivo mouse models of conditional macrophage depletion.
Tue Nov 03 00:00:00 EST 2015
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nature communications
Ito M,Shichita T,Okada M,Komine R,Noguchi Y,Yoshimura A,Morita R
17-0112 was used in Flow cytometry/Cell sorting to report that Bruton's tyrosine kinase (BTK) is an essential component of the NLRP3 inflammasome, in which BTK physically interacts with ASC and NLRP3.
Wed Jun 10 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
17-0112 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.
PloS one
Grosjean F,Nasi S,Schneider P,Chobaz V,Liu A,Mordasini V,Moullec K,Vezzoni P,Lavanchy C,Busso N,Acha-Orbea H,Ehirchiou D
17-0112 was used in Flow cytometry/Cell sorting to investigate the pathogenesis of Langerhans cell histiocytosis, showing that dendritic cells cause bone lesions in a new mouse model of the disease.
Tue May 17 00:00:00 EDT 2016
GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease.
Glia
Kamphuis W,Kooijman L,Orre M,Stassen O,Pekny M,Hol EM
17-0112-82 was used in Flow cytometry/Cell sorting to show that absence of GFAP, or both GFAP and VIM, alters AD-induced changes in gene expression profile of astrocytes, showing a compensation of the decrease of neuronal support genes and a trend for a slightly higher inflammatory expression profile.
Mon Jun 01 00:00:00 EDT 2015
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
PloS one
Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH
17-0112 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.
Wed Jun 08 00:00:00 EDT 2016
Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
PloS one
Yu H,Sui Y,Wang Y,Sato N,Frey B,Xia Z,Waldmann TA,Berzofsky J
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of IL-15 in regulating differentiation of T helper cell subsets, showing that it constrains mucosal T helper 17 cell generation.
Mon Jun 20 00:00:00 EDT 2016
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
17-0112 was used in Flow cytometry/Cell sorting to show that a subset of alveolar macrophages (AMs) attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.
Thu Feb 27 00:00:00 EST 2014
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
The Journal of allergy and clinical immunology
Shi M,Shi G,Tang J,Kong D,Bao Y,Xiao B,Zuo C,Wang T,Wang Q,Shen Y,Wang H,Funk CD,Zhou J,Yu Y
17-0112 was used in Flow cytometry/Cell sorting to characterise myeloid-derived suppressor cell accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice.
Sat Nov 01 00:00:00 EDT 2014
Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance.
EMBO molecular medicine
Wueest S,Mueller R,Blüher M,Item F,Chin AS,Wiedemann MS,Takizawa H,Kovtonyuk L,Chervonsky AV,Schoenle EJ,Manz MG,Konrad D
17-0112 was used in Flow cytometry/Cell sorting to demonstrate an unanticipated crosstalk between myeloid cells and skeletal muscle in the development of obesity-associated insulin resistance.
Wed Jan 01 00:00:00 EST 2014
Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Devaud C,Westwood JA,John LB,Flynn JK,Paquet-Fifield S,Duong CP,Yong CS,Pegram HJ,Stacker SA,Achen MG,Stewart TJ,Snyder LA,Teng MW,Smyth MJ,Darcy PK,Kershaw MH
17-0112 was used in Flow cytometry/Cell sorting to explore the relationship between tumour microenvironments and efficacy of immunotherapy.
Wed Jan 01 00:00:00 EST 2014
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.
Molecular metabolism
Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN
17-0112 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.
Mon Sep 01 00:00:00 EDT 2014
A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy.
mAbs
Goh AX,Bertin-Maghit S,Ping Yeo S,Ho AW,Derks H,Mortellaro A,Wang CI
17-0112 was used in Flow cytometry/Cell sorting to report the generation and engineering of a new fully human antibody that binds tightly to IL-1β with a neutralization potency more than 10 times higher than that of the marketed antibody canakinumab.
Tue May 12 00:00:00 EDT 2015
Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease.
Immune network
Ju JM,Lee H,Oh K,Lee DS,Choi EY
17-0112 was used in Flow cytometry/Cell sorting to study production of IFN-γ and IL-17 by CD4 and CD8 T cells during graft-versus-host disease progression.
Tue Apr 01 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
17-0112 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
Viral MHC class I-like molecule allows evasion of NK cell effector responses in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Pyzik M,Dumaine A,Charbonneau B,Fodil-Cornu N,Jonjic S,Vidal SM
17-0112 was used in Flow cytometry/Cell sorting to show that recognition of the viral protein m157 by the inhibitory Ly49C receptor allows escape from natural killer cell control of viral replication.
Mon Dec 15 00:00:00 EST 2014
FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Boross P,van Montfoort N,Stapels DA,van der Poel CE,Bertens C,Meeldijk J,Jansen JH,Verbeek JS,Ossendorp F,Wubbolts R,Leusen JH
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of FcRγ-chain ITAM signalling.
Mon Dec 01 00:00:00 EST 2014
HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling.
American journal of physiology. Heart and circulatory physiology
Demos-Davies KM,Ferguson BS,Cavasin MA,Mahaffey JH,Williams SM,Spiltoir JI,Schuetze KB,Horn TR,Chen B,Ferrara C,Scellini B,Piroddi N,Tesi C,Poggesi C,Jeong MY,McKinsey TA
17-0112 was used in Flow cytometry/Cell sorting to define novel roles for HDAC6 in striated muscle and demonstrate potential for HDAC6-selective inhibitors for the treatment of cardiac dysfunction.
Tue Jul 15 00:00:00 EDT 2014
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Molecular and cellular biology
Nobuhisa I,Osawa M,Uemura M,Kishikawa Y,Anani M,Harada K,Takagi H,Saito K,Kanai-Azuma M,Kanai Y,Iwama A,Taga T
17-0112 was used in Flow cytometry/Cell sorting to investigate how cells in intra-aortic clusters maintain their HSC phenotype, showing that they are maintained by Sox17.
Sun Jun 01 00:00:00 EDT 2014
DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression.
Journal of neuroimmunology
Cusick MF,Libbey JE,Doty DJ,Fujinami RS
17-0112 was used in Flow cytometry/Cell sorting to investigate how a few changes in the genome of a non-lethal virus can lead to altered and potentially lethal disease.
Mon Dec 15 00:00:00 EST 2014
A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function.
Journal of immunological methods
Graves CL,Harden SW,LaPato M,Nelson M,Amador B,Sorenson H,Frazier CJ,Wallet SM
17-0112 was used in Flow cytometry/Cell sorting to demonstrate a novel culture method for more appropriate study of intestinal epithelial cells as innate immune effectors.
Mon Dec 01 00:00:00 EST 2014
Cervico-vaginal immunoglobulin G levels increase post-ovulation independently of neutrophils.
PloS one
Schaefer K,Brown N,Kaye PM,Lacey CJ
17-0112 was used in Flow cytometry/Cell sorting to conclude that neutrophil influx and IgG accumulation are independent events that occur in the FRT during the reproductive cycle.
Mon Apr 25 00:00:00 EDT 2016
Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ.
The Journal of biological chemistry
Hanihara-Tatsuzawa F,Miura H,Kobayashi S,Isagawa T,Okuma A,Manabe I,MaruYama T
17-0112 was used in Flow cytometry/Cell sorting to indicate that IκB-ζ regulates TLR-mediated class switch recombination by inducing activation-induced cytidine deaminase.
Fri Nov 07 00:00:00 EST 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
17-0112 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 EDT 2014
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
17-0112 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 EST 2016
Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus.
Cell host & microbe
Thurlow LR,Joshi GS,Clark JR,Spontak JS,Neely CJ,Maile R,Richardson AR
17-0112 was used in Flow cytometry/Cell sorting to demonstrate the functional modularity of the arginine catabolic mobile element and its contribution to the success of USA300 CA-MRSA.
Wed Jan 16 00:00:00 EST 2013
The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition.
Blood
Fleischman AG,Maxson JE,Luty SB,Agarwal A,Royer LR,Abel ML,MacManiman JD,Loriaux MM,Druker BJ,Tyner JW
17-0112 was used in Flow cytometry/Cell sorting to show that a mutation causes a lethal neutrophilic neoplasma in mice that is responsive to JAK inhibition.
Thu Nov 21 00:00:00 EST 2013
Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.
The Journal of experimental medicine
Heizmann B,Kastner P,Chan S
17-0112 was used in Flow cytometry/Cell sorting to investigate the transcriptional programs that drive pre-B cell differentiation, showing that Ikaros is absolutely required by attenuating IL-7 signals.
Mon Dec 16 00:00:00 EST 2013
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene
Baumgartner F,Woess C,Pedit V,Tzankov A,Labi V,Villunger A
17-0112 was used in Flow cytometry/Cell sorting to show that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation in mice.
Thu Jan 31 00:00:00 EST 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
17-0112 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.
Journal of leukocyte biology
Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ
17-0112 was used in Flow cytometry/Cell sorting to develop a novel murine strain to allow a better definition of the role of eosinophils in health and disease.
Mon Jul 01 00:00:00 EDT 2013
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
Journal of immunology (Baltimore, Md. : 1950)
Yang X,Jiang X,Chen G,Xiao Y,Geng S,Kang C,Zhou T,Li Y,Guo X,Xiao H,Hou C,Wang R,Lin Z,Li X,Feng J,Ma Y,Shen B,Li Y,Han G
17-0112 was used in Flow cytometry/Cell sorting to demonstrate a regulatory role for Tim-3 as part of a novel protective mechanism in sepsis victims.
Fri Mar 01 00:00:00 EST 2013
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.
Endocrinology
Panjwani N,Mulvihill EE,Longuet C,Yusta B,Campbell JE,Brown TJ,Streutker C,Holland D,Cao X,Baggio LL,Drucker DJ
17-0112 was used in Flow cytometry/Cell sorting to illustrate the actions of GLP-1R agonists on atherosclerosis, and indirect GLP-1R actions for the control of hepatic lipid accumulation.
Tue Jan 01 00:00:00 EST 2013
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration.
Investigative ophthalmology & visual science
Zhao H,Roychoudhury J,Doggett TA,Apte RS,Ferguson TA
17-0112 was used in Flow cytometry/Cell sorting to examine the effect of aging on Fas ligand function in a mouse model of choroidal neovascularization.
Wed Aug 07 00:00:00 EDT 2013
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
RNA biology
Feuermann Y,Kang K,Gavrilova O,Haetscher N,Jang SJ,Yoo KH,Jiang C,Gonzalez FJ,Robinson GW,Hennighausen L
17-0112 was used in Flow cytometry/Cell sorting to investigate the contributions of two microRNAs to the development of brown adipose tissue in vivo using mouse genetics.
Sun Dec 01 00:00:00 EST 2013
High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.
PLoS neglected tropical diseases
Aulner N,Danckaert A,Rouault-Hardoin E,Desrivot J,Helynck O,Commere PH,Munier-Lehmann H,Späth GF,Shorte SL,Milon G,Prina E
17-0112 was used in Flow cytometry/Cell sorting to develop a novel phenotypic screening assay using virulent Leishmania amastigotes growing inside primary macrophage to identify new chemical entities with bona fide drug potential.
Thu Nov 14 00:00:00 EST 2013
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
The Journal of biological chemistry
Jacobson LS,Lima H,Goldberg MF,Gocheva V,Tsiperson V,Sutterwala FS,Joyce JA,Gapp BV,Blomen VA,Chandran K,Brummelkamp TR,Diaz-Griffero F,Brojatsch J
17-0112 was used in Flow cytometry/Cell sorting to investigate how adjuvant-mediated necrotic cell death controls adjuvant-mediated immunity and how this may alter our design of more powerful, safer adjuvants.
Fri Mar 15 00:00:00 EDT 2013
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.
PloS one
Schmid MC,Franco I,Kang SW,Hirsch E,Quilliam LA,Varner JA
17-0112 was used in Flow cytometry/Cell sorting to suggest novel avenues for cancer therapy by manipulating the PI3Kγ-Rap1a-dependent pathway.
Wed Oct 30 00:00:00 EDT 2013
Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration.
The Journal of biological chemistry
Yoshida T,Galvez S,Tiwari S,Rezk BM,Semprun-Prieto L,Higashi Y,Sukhanov S,Yablonka-Reuveni Z,Delafontaine P
17-0112 was used in Flow cytometry/Cell sorting to elucidate the mechanism by which angiotensin II impairs normal skeletal muscle regeneration.
Fri Aug 16 00:00:00 EDT 2013
Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.
Blood
Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F
17-0112 was used in Flow cytometry/Cell sorting to investigate how variation in Pax5 expression influences hematopoietic development, showing that biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5 could be targets for BAL.
Thu Nov 01 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
17-0112-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
The Journal of experimental medicine
von Brühl ML,Stark K,Steinhart A,Chandraratne S,Konrad I,Lorenz M,Khandoga A,Tirniceriu A,Coletti R,Köllnberger M,Byrne RA,Laitinen I,Walch A,Brill A,Pfeiler S,Manukyan D,Braun S,Lange P,Riegger J,Ware J,Eckart A,Haidari S,Rudelius M,Schulz C,Echtler K,Brinkmann V,Schwaiger M,Preissner KT,Wagner DD,Mackman N,Engelmann B,Massberg S
17-0112 was used in Flow cytometry/Cell sorting to investigate a novel mouse model of deep vein thrombosis as a useful tool to study the sequence of disease events.
Mon Apr 09 00:00:00 EDT 2012
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
The Journal of experimental medicine
Thornton EE,Looney MR,Bose O,Sen D,Sheppard D,Locksley R,Huang X,Krummel MF
17-0112 was used in Flow cytometry/Cell sorting to track the sites and timing of antigen uptake or subsequent antigen presentation to effector T cells after allergen challenge in asthma.
Mon Jun 04 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
17-0112 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
The EMBO journal
Kasler HG,Lim HW,Mottet D,Collins AM,Lee IS,Verdin E
17-0112 was used in Flow cytometry/Cell sorting to examine the effect of blocking TCR-dependent nuclear export of HDAC7 during thymic selection, showing that HDAC7 is required for immune self-tolerance.
Wed Nov 28 00:00:00 EST 2012
Regulatory T cells stimulate B7-H1 expression in myeloid-derived suppressor cells in ret melanomas.
The Journal of investigative dermatology
Fujimura T,Ring S,Umansky V,Mahnke K,Enk AH
17-0112 was used in Flow cytometry/Cell sorting to suggest the existence of a cross-talk between regulatory T-cells and myeloid-derived suppressor cells.
Sun Apr 01 00:00:00 EDT 2012
Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system.
Journal of immunology (Baltimore, Md. : 1950)
O'Connor RA,Li X,Blumerman S,Anderton SM,Noelle RJ,Dalton DK
17-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which adjuvant immunotherapy with Freund's Complete Adjuvant attenuates experimental autoimmune encephalomyelitis in mice.
Thu Mar 01 00:00:00 EST 2012
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B
17-0112 was used in Flow cytometry/Cell sorting to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.
Wed Aug 01 00:00:00 EDT 2012
In vivo imaging of differences in early donor cell proliferation in graft-versus-host disease hosts with different pre-conditioning doses.
Molecules and cells
Song MG,Kang B,Jeon JY,Chang J,Lee S,Min CK,Youn H,Choi EY
17-0112 was used in Flow cytometry/Cell sorting to explore the effects of preconditioning irradiation doses on donor cell dynamics in allogeneic graft-versus-host disease hosts.
Sun Jan 01 00:00:00 EST 2012
Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.
Frontiers in immunology
Fuertes Marraco SA,Grosjean F,Duval A,Rosa M,Lavanchy C,Ashok D,Haller S,Otten LA,Steiner QG,Descombes P,Luber CA,Meissner F,Mann M,Szeles L,Reith W,Acha-Orbea H
17-0112 was used in Flow cytometry/Cell sorting to report the generation of new murine DC lines, named MutuDC, originating from cultures of splenic CD8α conventional DC (cDC) tumours.
Tue Nov 20 00:00:00 EST 2012
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.
PloS one
Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS
17-0112 was used in Flow cytometry/Cell sorting to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.
Thu Jun 20 00:00:00 EDT 2013
Role of suppressor of cytokine signaling-1 in murine atherosclerosis.
PloS one
Grothusen C,Schuett H,Hillmer A,Lumpe S,Grote K,Ballmaier M,Bleich A,Glage S,Tietge UJ,Luchtefeld M,Schieffer B
17-0112 was used in Flow cytometry/Cell sorting to investigate the impact of systemic SOCS-1 deficiency on atherogenesis in the low-density lipoprotein receptor deficient murine model of atherosclerosis.
Wed Jul 17 00:00:00 EDT 2013
Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis.
The Journal of biological chemistry
Ryu MJ,Liu Y,Zhong X,Du J,Peterson N,Kong G,Li H,Wang J,Salamat S,Chang Q,Zhang J
17-0112 was used in Flow cytometry/Cell sorting to determine how Ras signalling in neurones promotes gliosis and astrocytoma formation in a cell nonautonomous manner.
Fri Jun 29 00:00:00 EDT 2012
Debridement increases survival in a mouse model of subcutaneous anthrax.
PloS one
Weiner ZP,Boyer AE,Gallegos-Candela M,Cardani AN,Barr JR,Glomski IJ
17-0112 was used in Flow cytometry/Cell sorting to develop a mouse model of debridement to evaluate its effectiveness in the treatment of Bacillus anthracis soft tissue infections.
Mon Jul 23 00:00:00 EDT 2012
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
17-0112 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 EDT 2011
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
17-0112 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
17-0112 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.
Thu Sep 01 00:00:00 EDT 2011
Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin.
Blood
Bennett CL,Fallah-Arani F,Conlan T,Trouillet C,Goold H,Chorro L,Flutter B,Means TK,Geissmann F,Chakraverty R
17-0112 was used in Flow cytometry/Cell sorting to explore the role of Langerhans cells in the development of tissue injury using a tractable model of cutaneous graft-versus-host disease.
Thu Jun 30 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
17-0112 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine
Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C
17-0112 was used in Flow cytometry/Cell sorting to validate sensitised phenotypic screening of segmental aneuploidy lines as a strategy for systematically identifying disease susceptibility genes in mice.
Sat Jan 01 00:00:00 EST 2011
Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth.
Cancer research
Schmid MC,Avraamides CJ,Foubert P,Shaked Y,Kang SW,Kerbel RS,Varner JA
17-0112 was used in Flow cytometry/Cell sorting to show that stromal cell-derived growth factor 1 alpha and interleukin 1 beta collaborate with myeloid cell integrin-α4β1 to promote tumor inflammation and growth.
Tue Nov 15 00:00:00 EST 2011
Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α.
Proceedings of the National Academy of Sciences of the United States of America
Berda-Haddad Y,Robert S,Salers P,Zekraoui L,Farnarier C,Dinarello CA,Dignat-George F,Kaplanski G
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that nonphagocytosed endothelial apoptotic bodies constitute a unique mechanism for sterile inflammation.
Tue Dec 20 00:00:00 EST 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
17-0112 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
Lineage-committed osteoclast precursors circulate in blood and settle down into bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Muto A,Mizoguchi T,Udagawa N,Ito S,Kawahara I,Abiko Y,Arai A,Harada S,Kobayashi Y,Nakamichi Y,Penninger JM,Noguchi T,Takahashi N
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that receptor activator of NF-κB-positive cells isolated from bone marrow and peripheral blood possess characteristics of quiescent osteoclast precursors in mice.
Thu Dec 01 00:00:00 EST 2011
Effects of Pre-conditioning Dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation.
Immune network
Choi JH,Yoon H,Min CK,Choi EY
17-0112 was used in Flow cytometry/Cell sorting to analyse chimerism formation and immune kinetics of leukocytes during graft-versus-host disease.
Tue Feb 01 00:00:00 EST 2011
Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan IM,Morisot S,Heiser D,Cheng WC,Kim MJ,Civin CI
17-0112 was used in Flow cytometry/Cell sorting to characterise hematopoiesis in TTP KO mice to show that TTP is a master regulator of inflammatory cytokine expression during homeostasis that controls granulocyte production.
Tue Mar 01 00:00:00 EST 2011
Differential expression of NLRP3 among hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950)
Guarda G,Zenger M,Yazdi AS,Schroder K,Ferrero I,Menu P,Tardivel A,Mattmann C,Tschopp J
17-0112 was used in Flow cytometry/Cell sorting to characterize NOD-like receptor pyrin domain 3 (NLRP3) expression due to importance in health and disease.
Tue Feb 15 00:00:00 EST 2011
SIRPα/CD172a regulates eosinophil homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Verjan Garcia N,Umemoto E,Saito Y,Yamasaki M,Hata E,Matozaki T,Murakami M,Jung YJ,Woo SY,Seoh JY,Jang MH,Aozasa K,Miyasaka M
17-0112 was used in Flow cytometry/Cell sorting to study the expression of an inhibitory receptor signal regulatory protein and CD36 in intestinal eosinophils.
Thu Sep 01 00:00:00 EDT 2011
Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950)
Kasler HG,Young BD,Mottet D,Lim HW,Collins AM,Olson EN,Verdin E
17-0112 was used in Flow cytometry/Cell sorting to study the regulation of cell survival and TCR signaling in CD4/CD8 double-positive thymocytes by histone deacetylase 7.
Fri Apr 15 00:00:00 EDT 2011
Alterations in marginal zone macrophages and marginal zone B cells in old mice.
Journal of immunology (Baltimore, Md. : 1950)
Birjandi SZ,Ippolito JA,Ramadorai AK,Witte PL
17-0112 was used in Flow cytometry/Cell sorting to study the alterations in marginal zone macrophages and marginal zone B cells in old mice, and investigate how this may affect their ability to clear blood-borne antigens and mount an appropriate immune response.
Tue Mar 15 00:00:00 EDT 2011
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.
Molecular and cellular biology
Chan WI,Hannah RL,Dawson MA,Pridans C,Foster D,Joshi A,Göttgens B,Van Deursen JM,Huntly BJ
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of Cbp in adult HSC maintenance, and the cellular and molecular mechanisms underlying its function.
Thu Dec 01 00:00:00 EST 2011
Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.
PloS one
Fuertes Marraco SA,Scott CL,Bouillet P,Ives A,Masina S,Vremec D,Jansen ES,O'Reilly LA,Schneider P,Fasel N,Shortman K,Strasser A,Acha-Orbea H
17-0112 was used in Flow cytometry/Cell sorting to elucidate the possible apoptotic mechanisms that control activated dendritic cell lifespan in response to PAMPs.
Fri Sep 30 00:00:00 EDT 2011
Unraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biology.
PloS one
Lindqvist M,Nookaew I,Brinkenberg I,Samuelson E,Thörn K,Nielsen J,Harandi AM
17-0112 was used in Flow cytometry/Cell sorting to identify molecular signatures that can be used as biomarkers for mucosal adjuvant potency.
Fri Dec 09 00:00:00 EST 2011
Study of camelpox virus pathogenesis in athymic nude mice.
PloS one
Duraffour S,Matthys P,van den Oord JJ,De Schutter T,Mitera T,Snoeck R,Andrei G
17-0112 was used in Flow cytometry/Cell sorting to confirm that NMRI immunocompetent mice are resistant to intranasal (i.n.) CMLV infection.
Thu Dec 01 00:00:00 EST 2011
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Nature immunology
Berger M,Krebs P,Crozat K,Li X,Croker BA,Siggs OM,Popkin D,Du X,Lawson BR,Theofilopoulos AN,Xia Y,Khovananth K,Moresco EM,Satoh T,Takeuchi O,Akira S,Beutler B
17-0112 was used in Flow cytometry/Cell sorting to investigate a new mutation in Slfn2, which causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.
Thu Apr 01 00:00:00 EDT 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
17-0112 was used in Flow cytometry/Cell sorting to investigate whether and how T cells can affect myelopoiesis, showing that eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Thu Oct 07 00:00:00 EDT 2010
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation
Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R
17-0112 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.
Mon Nov 01 00:00:00 EDT 2010
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction.
Critical care (London, England)
Zhang Y,Zhou Y,Lou J,Li J,Bo L,Zhu K,Wan X,Deng X,Cai Z
17-0112 was used in Flow cytometry/Cell sorting to investigate the function and mechanism of action of PD-L1 in experimental sepsis in mice.
Thu Jan 26 00:00:00 EST 2012
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK
17-0112 was used in Flow cytometry/Cell sorting to investigate the significance of interactions between TIM-4 and phophatidylserine, showing that TIM-4 deficiency leads to T and B cell hyperactivity and autoimmunity.
Tue May 11 00:00:00 EDT 2010
IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae.
Journal of immunology (Baltimore, Md. : 1950)
Shriner AK,Liu H,Sun G,Guimond M,Alugupalli KR
17-0112 was used in Flow cytometry/Cell sorting to indicate that activating the IL-7 signaling pathway could restore impaired TI responses in the young.
Thu Jul 01 00:00:00 EDT 2010
Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S
17-0112 was used in Flow cytometry/Cell sorting to assess the role of MCP-1 in immunity to acute pneumonia caused by gram-negative bacteria.
Mon Feb 01 00:00:00 EST 2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Journal of immunology (Baltimore, Md. : 1950)
Anthony DA,Andrews DM,Chow M,Watt SV,House C,Akira S,Bird PI,Trapani JA,Smyth MJ
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that granzymes should be considered as potential key regulators of inflammation.
Sun Aug 01 00:00:00 EDT 2010
Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses.
Journal of immunology (Baltimore, Md. : 1950)
Larson RP,Zimmerli SC,Comeau MR,Itano A,Omori M,Iseki M,Hauser C,Ziegler SF
17-0112 was used in Flow cytometry/Cell sorting to demonstrate a role for TSLP in a Th2 model of contact hypersensitivity in mice.
Mon Mar 15 00:00:00 EDT 2010
T-cell-independent immune responses do not require CXC ligand 13-mediated B1 cell migration.
Infection and immunity
Colombo MJ,Sun G,Alugupalli KR
17-0112 was used in Flow cytometry/Cell sorting to demonstrate that homing of B1 cells into the coelomic cavity is not required for generating protective TI antibody responses.
Wed Sep 01 00:00:00 EDT 2010
CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.
Infection and immunity
Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT
17-0112 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.
Sat May 01 00:00:00 EDT 2010
Interactive changes between macrophages and adipocytes.
Clinical and vaccine immunology : CVI
Xie L,Ortega MT,Mora S,Chapes SK
17-0112 was used in Flow cytometry/Cell sorting to determine whether communication between macrophages and adipocytes disrupts their function and affects insulin resistance.
Thu Apr 01 00:00:00 EDT 2010
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Blood
Roudaia L,Cheney MD,Manuylova E,Chen W,Morrow M,Park S,Lee CT,Kaur P,Williams O,Bushweller JH,Speck NA
17-0112 was used in Flow cytometry/Cell sorting to validate the AML1-ETO and TEL-AML1 chimeric protein Runt domain/CBFbeta interaction as a therapeutic target in core binding factor leukemias.
Thu Mar 26 00:00:00 EDT 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
17-0112 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Inflammatory regulation by TLR3 in acute hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Xiao X,Zhao P,Rodriguez-Pinto D,Qi D,Henegariu O,Alexopoulou L,Flavell RA,Wong FS,Wen L
17-0112 was used in Immunohistochemistry to observe a novel role for TLR3 in hepatocyte damage in the absence of a viral stimulus in a murine model of hepatitis.
Tue Sep 15 00:00:00 EDT 2009
Adsorbed serum albumin is permissive to macrophage attachment to perfluorocarbon polymer surfaces in culture.
Journal of biomedical materials research. Part A
Godek ML,Michel R,Chamberlain LM,Castner DG,Grainger DW
17-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which macrophages bind to albumin-coated substrates and hydrophobic fluorinated surfaces in culture.
Sun Feb 01 00:00:00 EST 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
17-0112 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
Stratification of Antigen-presenting Cells within the Normal Cornea.
Ophthalmology and eye diseases
Knickelbein JE,Watkins SC,McMenamin PG,Hendricks RL
17-0112 was used in Immunofluorescence on wholemounted tissues to investigate the presence of antigen-presenting cells within the non-inflamed cornea.
Wed Nov 25 00:00:00 EST 2009
Neutrophil-selective CD18 silencing using RNA interference in vivo.
Blood
Cullere X,Lauterbach M,Tsuboi N,Mayadas TN
17-0112 was used in Flow cytometry/Cell sorting to analyse leukocyte populations from transgenic mice with CD18-deficient neutrophils, generated using an miRNA approach.
Tue Apr 01 00:00:00 EDT 2008
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
The American journal of pathology
Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG
17-0112 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.
Wed Oct 01 00:00:00 EDT 2008
Dendritic cells prime natural killer cells by trans-presenting interleukin 15.
Immunity
Lucas M,Schachterle W,Oberle K,Aichele P,Diefenbach A
17-0112 was used in Flow cytometry/Cell sorting to study an in vivo role of dendritic cells for the priming of natural killer cells by trans-presenting interleukin 15.
Sun Apr 01 00:00:00 EDT 2007
Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice.
Alcohol (Fayetteville, N.Y.)
Jerrells TR,Pavlik JA,DeVasure J,Vidlak D,Costello A,Strachota JM,Wyatt TA
17-0112 was used in Flow cytometry/Cell sorting to test whether people who abuse alcohol are more susceptible to respiratory viral infections.
Wed Aug 01 00:00:00 EDT 2007
ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.
Blood
Li Y,Brazzell J,Herrera A,Walcheck B
17-0112 was used in Flow cytometry/Cell sorting to investigate the role of Adam17 in L-selectin shedding by mature neutrophils, showing that deficiency by mature neutrophils has differential effects on L-selectin shedding.
Sun Oct 01 00:00:00 EDT 2006
Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.
Blood
Sakamoto H,Dai G,Tsujino K,Hashimoto K,Huang X,Fujimoto T,Mucenski M,Frampton J,Ogawa M
17-0112 was used in Flow cytometry/Cell sorting to investigate the functional role of c-Myb in hematopoietic cell development from endothelial cells, showing that proper levels of c-Myb are discretely defined at distinct steps of development.
Tue Aug 01 00:00:00 EDT 2006
