Product References
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Nature cell biology
Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E
25-0112-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.
Sun Jan 01 00:00:00 EST 2023
Mast cells link immune sensing to antigen-avoidance behaviour.
Nature
Plum T,Binzberger R,Thiele R,Shang F,Postrach D,Fung C,Fortea M,Stakenborg N,Wang Z,Tappe-Theodor A,Poth T,MacLaren DAA,Boeckxstaens G,Kuner R,Pitzer C,Monyer H,Xin C,Bonventre JV,Tanaka S,Voehringer D,Vanden Berghe P,Strid J,Feyerabend TB,Rodewald HR
25-0112-82 was used in Flow Cytometry to identify the immunological sensor cell linking antigen recognition to avoidance behaviour.
Tue Aug 01 00:00:00 EDT 2023
Differential requirement of neutralizing antibodies and T cells on protective immunity to SARS-CoV-2 variants of concern.
NPJ vaccines
Azevedo PO,Hojo-Souza NS,Faustino LP,Fumagalli MJ,Hirako IC,Oliveira ER,Figueiredo MM,Carvalho AF,Doro D,Benevides L,Durigon E,Fonseca F,Machado AM,Fernandes AP,Teixeira SR,Silva JS,Gazzinelli RT
25-0112-82 was used in Flow cytometry/Cell sorting to evaluate the efficacy of a Spike-based DNA vaccine (pCTV-WS) for protection against different VOCs using existing pre-clinical models of severe and moderate COVID-19.
Mon Feb 13 00:00:00 EST 2023
Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.
Pharmaceutics
D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A
25-0112-82 was used in Flow cytometry/Cell sorting to provide a novel strategy for the development of new tumor immunotherapies in vivo.
Mon Jun 12 00:00:00 EDT 2023
T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway.
Immunology
Ding L,Liang Y,Wang Y,Tong Z,Liu W,Tan S,Zhang J,Wang Y,Wu Z,Liang X,Ma C,Gao L
25-0112-82 was used in Flow cytometry/Cell sorting to reveal that maintainence of adipose tissue homeostasis occurs via Tim-4 by regulating macrophage polarization via NF-κB pathway.
Sun Jan 01 00:00:00 EST 2023
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Immunity
Simpson DS,Pang J,Weir A,Kong IY,Fritsch M,Rashidi M,Cooney JP,Davidson KC,Speir M,Djajawi TM,Hughes S,Mackiewicz L,Dayton M,Anderton H,Doerflinger M,Deng Y,Huang AS,Conos SA,Tye H,Chow SH,Rahman A,Norton RS,Naderer T,Nicholson SE,Burgio G,Man SM,Groom JR,Herold MJ,Hawkins ED,Lawlor KE,Strasser A,Silke J,Pellegrini M,Kashkar H,Feltham R,Vince JE
25-0112-82 was used in Flow Cytometry to reveal that iNOS selectively licenses programmed cell death, which may explain how nitric oxide impacts disease severity in SARS-CoV-2 infection and other iNOS-associated inflammatory conditions.
Tue Mar 08 00:00:00 EST 2022
Epithelial colonization by gut dendritic cells promotes their functional diversification.
Immunity
Rivera CA,Randrian V,Richer W,Gerber-Ferder Y,Delgado MG,Chikina AS,Frede A,Sorini C,Maurin M,Kammoun-Chaari H,Parigi SM,Goudot C,Cabeza-Cabrerizo M,Baulande S,Lameiras S,Guermonprez P,Reis e Sousa C,Lecuit M,Moreau HD,Helft J,Vignjevic DM,Villablanca EJ,Lennon-Duménil AM
25-0112-82 was used in Flow cytometry/Cell sorting to investigate How tissue-specific cues orchestrate Dendritic cells diversification.
Tue Jan 11 00:00:00 EST 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
25-0112-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
25-0112-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
25-0112-82 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 EDT 2022
Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart.
The Journal of cell biology
Liu K,Jin H,Tang M,Zhang S,Tian X,Zhang M,Han X,Liu X,Tang J,Pu W,Li Y,He L,Yang Z,Lui KO,Zhou B
25-0112-82 was used in Flow Cytometry to generate new genetic tools to trace endocardial cells and reassessed their potential contribution to hematopoietic cells in the developing heart. Fate-mapping analyses revealed that the endocardium contributed minimally to cardiac macrophages and circulating blood cells.
Mon Jun 06 00:00:00 EDT 2022
CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging.
Nature neuroscience
Kaya T,Mattugini N,Liu L,Ji H,Cantuti-Castelvetri L,Wu J,Schifferer M,Groh J,Martini R,Besson-Girard S,Kaji S,Liesz A,Gokce O,Simons M
25-0112-82 was used in Flow cytometry/Cell sorting to provide evidence that CD8+ T-cell-induced, IFN-responsive oligodendrocytes and microglia are important modifiers of white matter aging.
Tue Nov 01 00:00:00 EDT 2022
The Time Course of Monocytes Infiltration After Acoustic Overstimulation.
Frontiers in cellular neuroscience
Shin SH,Jung J,Park HR,Sim NS,Choi JY,Bae SH
25-0112-82 was used in Flow cytometry/Cell sorting to investigate time-dependent immune cell infiltration, macrophage transformation, and neutrophil involvement following acoustic stimulation.
Sat Jul 16 00:00:00 EDT 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
25-0112-82 was used in Flow cytometry/Cell sorting to show that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth.
Wed Aug 31 00:00:00 EDT 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
25-0112-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.
Cell host & microbe
Pandey SP,Bender MJ,McPherson AC,Phelps CM,Sanchez LM,Rana M,Hedden L,Sangani KA,Chen L,Shapira JH,Siller M,Goel C,Verdú EF,Jabri B,Chang A,Chandran UR,Mullett SJ,Wendell SG,Singhi AD,Tilstra JS,Pierre JF,Arteel GE,Hinterleitner R,Meisel M
25-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that I3A is required for L. reuteri-induced Tc1 cell differentiation in vitro and AIH-like pathology in vivo, both of which are restrained by Tet2 within CD8 T cells.
Wed Jul 13 00:00:00 EDT 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
25-0112-82 was used in Flow cytometry/Cell sorting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
Interleukin-4 receptor signaling modulates neuronal network activity.
The Journal of experimental medicine
Hanuscheck N,Thalman C,Domingues M,Schmaul S,Muthuraman M,Hetsch F,Ecker M,Endle H,Oshaghi M,Martino G,Kuhlmann T,Bozek K,van Beers T,Bittner S,von Engelhardt J,Vogt J,Vogelaar CF,Zipp F
25-0112-82 was used in Flow cytometry/Cell sorting to conclude that neuronal IL-4Rα and its presynaptic prevalence appear relevant for maintaining homeostasis of CNS synaptic function.
Mon Jun 06 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
25-0112-82 was used in Flow cytometry/Cell sorting to suggest that a hematopoietic-mesenchymal signal exists, and that the state of the HSCs is important for the stability of MSC properties.
Tue Jul 26 00:00:00 EDT 2022
In vivo temporal resolution of acute promyelocytic leukemia progression reveals a role of Klf4 in suppressing early leukemic transformation.
Genes & development
Mas G,Santoro F,Blanco E,Gamarra Figueroa GP,Le Dily F,Frigè G,Vidal E,Mugianesi F,Ballaré C,Gutierrez A,Sparavier A,Marti-Renom MA,Minucci S,Di Croce L
25-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that ectopic Klf4 overexpression can suppress self-renewal and reverse the differentiation block induced by PML-RARα in leukemogenesis.
Fri Apr 01 00:00:00 EDT 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
25-0112-82 was used in Flow Cytometry to evaluate the effect of CB-5083 on the immune response in mice by using the lymphocytic choriomeningitis virus (LCMV) as an infection model.
Thu Dec 01 00:00:00 EST 2022
The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands.
Immunity
Czimmerer Z,Halasz L,Daniel B,Varga Z,Bene K,Domokos A,Hoeksema M,Shen Z,Berger WK,Cseh T,Jambrovics K,Kolostyak Z,Fenyvesi F,Varadi J,Poliska S,Hajas G,Szatmari I,Glass CK,Bacsi A,Nagy L
25-0112-82 was used in Flow cytometry/Cell sorting to establish that IL-4-induced epigenetic reprogramming is responsible for the development of inflammatory hyperresponsiveness to TLR activation and contributes to lung pathologies.
Tue Nov 08 00:00:00 EST 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Cell
Leonardi I,Gao IH,Lin WY,Allen M,Li XV,Fiers WD,De Celie MB,Putzel GG,Yantiss RK,Johncilla M,Colak D,Iliev ID
25-0112-82 was used in Flow cytometry/Cell sorting to characterize the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
Thu Mar 03 00:00:00 EST 2022
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
25-0112-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
25-0112-82 was used in Flow Cytometry to demonstrate that ID2 sets a threshold for TCF1 during NK cell development, thus controlling the balance of immature and terminally differentiated cells that support future NK cell responses.
Mon Jun 07 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
25-0112-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
CD36 deficiency ameliorates drug-induced acute liver injury in mice.
Molecular medicine (Cambridge, Mass.)
Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q
25-0112-82 was used in Flow Cytometry to demonstrate that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation.
Sun Jun 06 00:00:00 EDT 2021
Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.
Frontiers in cell and developmental biology
Ying L,Zhang M,Ma X,Si Y,Li X,Su J,Yin J,Bao Y
25-0112-82 was used in Flow Cytometry to study the metabolic function of LAMTOR1 from macrophages using LAMTOR1 macrophage-specific knockout (MKO) mice.
Tue Jun 08 00:00:00 EDT 2021
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H
25-0112-82 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.
Mon Mar 01 00:00:00 EST 2021
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
25-0112-82 was used in Flow Cytometry to investigate whether the tolerogenic potential of immunodominant myelin T-cell epitopes can be improved by conjugation to the synthetic carrier polyethylene glycol (PEG) in an experimental autoimmune encephalomyelitis (EAE) mouse model for chronic MS (MOG C57BL/6).
Tue Nov 07 00:00:00 EST 2023
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
25-0112-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway.
Cell death discovery
Li M,Ling T,Teng F,Hu C,Su Z,Zhang C,Li X,Zhao T,Mu X,Li Y,Pan J,You Q
25-0112-82 was used in Flow Cytometry to reveal that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.
Mon Nov 08 00:00:00 EST 2021
Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing.
STAR protocols
Liu L,Besson-Girard S,Ji H,Gehring K,Bulut B,Kaya T,Usifo F,Simons M,Gokce O
25-0112-82 was used in Flow Cytometry to describe an enzymatic dissociation method for mouse brain that prevents dissociation artifacts and lowers technical variations with standardized steps.
Fri Jun 18 00:00:00 EDT 2021
Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis.
Nutrients
Knopp T,Bieler T,Jung R,Ringen J,Molitor M,Jurda A,Münzel T,Waisman A,Wenzel P,Karbach SH,Wild J
25-0112-82 was used in Flow Cytometry to study the influence of dietary protein on psoriasis-like skin disease in mice.
Mon May 31 00:00:00 EDT 2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Nature communications
Clement CC,D'Alessandro A,Thangaswamy S,Chalmers S,Furtado R,Spada S,Mondanelli G,Ianni F,Gehrke S,Gargaro M,Manni G,Cara LCL,Runge P,Tsai WL,Karaman S,Arasa J,Fernandez-Rodriguez R,Beck A,Macchiarulo A,Gadina M,Halin C,Fallarino F,Skobe M,Veldhoen M,Moretti S,Formenti S,Demaria S,Soni RK,Galarini R,Sardella R,Lauvau G,Putterman C,Alitalo K,Grohmann U,Santambrogio L
25-0112-82 was used in Flow cytometry/Cell sorting to show tryptophan-mediated immune tolerance is dependent on the amine 3-hydroxy-L-kynurenamine.
Wed Jul 21 00:00:00 EDT 2021
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
25-0112-82 was used in Flow cytometry/Cell sorting to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 EST 2021
Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.
Cells
Rubinstein L,Paul AM,Houseman C,Abegaz M,Tabares Ruiz S,O'Neil N,Kunis G,Ofir R,Cohen J,Ronca AE,Globus RK,Tahimic CGT
25-0112-82 was used in Flow Cytometry to support the therapeutic potential of placenta-derived stromal cells for select physiological deficits during simulated spaceflight.
Mon Apr 19 00:00:00 EDT 2021
Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma.
Frontiers in immunology
Ma M,Li G,Qi M,Jiang W,Zhou R
25-0112-82 was used in Flow Cytometry to show that NLRP3 in myeloid cells promoted the development and progression of allergic asthma in an inflammasome-dependent manner.
Fri Dec 17 00:00:00 EST 2021
Isolation of myeloid cells from mouse brain tumors for single-cell RNA-seq analysis.
STAR protocols
Dang MT,Mafra F,Haldar M
25-0112-82 was used in Flow Cytometry to produce a protocol for rapid isolation of myeloid cells from tumor-harboring mouse cerebellum without cell sorting to minimize cell damage for scRNA-seq.
Fri Dec 17 00:00:00 EST 2021
Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate.
Frontiers in cell and developmental biology
Tang W,He J,Huang T,Bai Z,Wang C,Wang H,Yang R,Ni Y,Hou J,Wang J,Zhou J,Yao Y,Gong Y,Hou S,Liu B,Lan Y
25-0112-82 was used in Flow cytometry/Cell sorting to develop an Hlf-tdTomato reporter mouse model and detected Hlf-tdTomato expression exclusively in the hematopoietic cells including part of the immunophenotypic CD45- and CD45+ pre-HSCs in the embryonic day (E) 10.5 AGM region.
Fri Oct 01 00:00:00 EDT 2021
Hypothermia modulates myeloid cell polarization in neonatal hypoxic-ischemic brain injury.
Journal of neuroinflammation
Seitz M,Köster C,Dzietko M,Sabir H,Serdar M,Felderhoff-Müser U,Bendix I,Herz J
25-0112-82 was used in Flow Cytometry to investigate the impact of therapeutic hypothermia on the temporal and spatial dynamics of microglia/macrophage polarization after neonatal hypoxia-ischemia in newborn mice.
Sat Nov 13 00:00:00 EST 2021
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.
Nature communications
Lima LG,Ham S,Shin H,Chai EPZ,Lek ESH,Lobb RJ,Müller AF,Mathivanan S,Yeo B,Choi Y,Parker BS,Möller A
25-0112-82 was used in Flow Cytometry to show that microenvironmental cytokines, particularly CCL2, decorate cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
Thu Jun 10 00:00:00 EDT 2021
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.
Nature communications
Lima LG,Ham S,Shin H,Chai EPZ,Lek ESH,Lobb RJ,Müller AF,Mathivanan S,Yeo B,Choi Y,Parker BS,Möller A
25-0112-82 was used in Flow Cytometry to show that microenvironmental cytokines, particularly CCL2, decorate cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
Thu Jun 10 00:00:00 EDT 2021
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
25-0112-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Cell
Sadik A,Somarribas Patterson LF,Öztürk S,Mohapatra SR,Panitz V,Secker PF,Pfänder P,Loth S,Salem H,Prentzell MT,Berdel B,Iskar M,Faessler E,Reuter F,Kirst I,Kalter V,Foerster KI,Jäger E,Guevara CR,Sobeh M,Hielscher T,Poschet G,Reinhardt A,Hassel JC,Zapatka M,Hahn U,von Deimling A,Hopf C,Schlichting R,Escher BI,Burhenne J,Haefeli WE,Ishaque N,Böhme A,Schäuble S,Thedieck K,Trump S,Seiffert M,Opitz CA
25-0112 was used in Flow cytometry/Cell sorting to show that IL4I1 blockade opens new avenues for cancer therapy.
Thu Sep 03 00:00:00 EDT 2020
Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.
Cell
Chikina AS,Nadalin F,Maurin M,San-Roman M,Thomas-Bonafos T,Li XV,Lameiras S,Baulande S,Henri S,Malissen B,Lacerda Mariano L,Barbazan J,Blander JM,Iliev ID,Matic Vignjevic D,Lennon-Duménil AM
25-0112 was used in Flow cytometry/Cell sorting to describe a mechanism by which the innate immune system allows rapid quality check of absorbed fluids to avoid intoxication of colonocytes.
Thu Oct 15 00:00:00 EDT 2020
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.
Immunity
Wang X,Ni L,Wan S,Zhao X,Ding X,Dejean A,Dong C
25-0112 was used in Flow cytometry/Cell sorting to show that febrile temperature selectively regulated Th17 cell differentiation in vitro in enhancing interleukin-17 (IL-17), IL-17F, and IL-22 expression.
Tue Feb 18 00:00:00 EST 2020
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Immunity
Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H
25-0112 was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.
Tue Dec 15 00:00:00 EST 2020
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Nature immunology
Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT
25-0112 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.
Fri May 01 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
Brain : a journal of neurology
Koronyo-Hamaoui M,Sheyn J,Hayden EY,Li S,Fuchs DT,Regis GC,Lopes DHJ,Black KL,Bernstein KE,Teplow DB,Fuchs S,Koronyo Y,Rentsendorj A
25-0112 was used in Flow cytometry/Cell sorting to explore the impact of selective and transient angiotensin-converting enzyme overexpression on macrophage behaviour and the relative contribution of bone marrow-derived ACE10 macrophages, but not microglia, in attenuating disease progression.
Wed Jan 01 00:00:00 EST 2020
Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Cancer research
Abdul Pari AA,Singhal M,Hübers C,Mogler C,Schieb B,Gampp A,Gengenbacher N,Reynolds LE,Terhardt D,Géraud C,Utikal J,Thomas M,Goerdt S,Hodivala-Dilke KM,Augustin HG,Felcht M
25-0112-82 was used in Flow Cytometry to reveal that tumor cells can be a source of ANGPT2 in the tumor microenvironment and that tumor cell-derived ANGPT2 augments metastatic colonization by protecting tumor cells from oxidative stress.
Mon Jun 15 00:00:00 EDT 2020
Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.
European journal of immunology
Dietschmann A,Schruefer S,Krappmann S,Voehringer D
25-0112-82 was used in Flow Cytometry to use a mouse model of ABPA to investigate the role of eosinophils and T cell-derived IL-4/IL-13 for induction of allergic lung inflammation.
Wed Jul 01 00:00:00 EDT 2020
Intratumoral Monocyte Transfer to Examine Monocyte Differentiation in the Tumor Microenvironment.
STAR protocols
Devalaraja S,Haldar M
25-0112-82 was used in Flow cytometry/Cell sorting to describe an approach of intratumoral monocyte transfer that circumvents these limitations by using negative selection and fluorescent reporter mice.
Fri Dec 18 00:00:00 EST 2020
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.
Cell reports
Mohebiany AN,Ramphal NS,Karram K,Di Liberto G,Novkovic T,Klein M,Marini F,Kreutzfeldt M,Härtner F,Lacher SM,Bopp T,Mittmann T,Merkler D,Waisman A
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of tumor-necrosis-factor-alpha-induced protein 3 in the central nervous system (CNS).
Tue Feb 04 00:00:00 EST 2020
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.
Immunity
Perner C,Flayer CH,Zhu X,Aderhold PA,Dewan ZNA,Voisin T,Camire RB,Chow OA,Chiu IM,Sokol CL
25-0112-82 was used in flow cytometry to conclude that sensory neurons act as primary sensors of allergens, linking exposure to activation of allergic-skewing DCs and the initiation of an allergic immune response.
Tue Nov 17 00:00:00 EST 2020
Environmental arginine controls multinuclear giant cell metabolism and formation.
Nature communications
Brunner JS,Vulliard L,Hofmann M,Kieler M,Lercher A,Vogel A,Russier M,Brüggenthies JB,Kerndl M,Saferding V,Niederreiter B,Junza A,Frauenstein A,Scholtysek C,Mikami Y,Klavins K,Krönke G,Bergthaler A,O'Shea JJ,Weichhart T,Meissner F,Smolen JS,Cheng P,Yanes O,Menche J,Murray PJ,Sharif O,Blüml S,Schabbauer G
25-0112 was used in Flow cytometry/Cell sorting to establish how environmental amino acids control the metabolic fate of polykaryons and suggest metabolic ways to manipulate multinucleated giant cell (MGC)-associated pathologies and bone remodelling.
Wed Jan 22 00:00:00 EST 2020
Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.
Frontiers in immunology
Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD
25-0112 was used in Flow cytometry/Cell sorting to provide evidence that lipin-1 transcriptional co-regulatory activity contributes to macrophage polarization and influences wound healing in vivo.
Mon Mar 29 00:00:00 EDT 2021
Chitinase 3-like 1 is neurotoxic in primary cultured neurons.
Scientific reports
Matute-Blanch C,Calvo-Barreiro L,Carballo-Carbajal I,Gonzalo R,Sanchez A,Vila M,Montalban X,Comabella M
25-0112 was used in Flow cytometry/Cell sorting to investigate the potential neurotoxic effect of CHI3L1 by adding recombinant CHI3L1 in vitro to primary cultures of mouse cortical neurons.
Tue Apr 28 00:00:00 EDT 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
25-0112 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
25-0112-82 was used in Flow Cytometry to investigate the distribution of follicular T helper cells during disease progression towards understanding their role in autoimmune neuroinflammation.
Tue Nov 24 00:00:00 EST 2020
Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.
ImmunoHorizons
Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD
25-0112 was used in Flow cytometry/Cell sorting to show that lipin-1 is required for increased oxidative phosphorylation in IL-4 stimulated mouse (Mus musculus) macrophages.
Mon Oct 19 00:00:00 EDT 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
25-0112 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 EDT 2020
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.
eLife
Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ
25-0112 was used in Flow cytometry/Cell sorting to analyse the inflammatory response to sciatic nerve injury.
Wed Dec 02 00:00:00 EST 2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
25-0112 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 EST 2020
Resident macrophages acquire innate immune memory in staphylococcal skin infection.
eLife
Feuerstein R,Forde AJ,Lohrmann F,Kolter J,Ramirez NJ,Zimmermann J,Gomez de Agüero M,Henneke P
25-0112 was used in Flow cytometry/Cell sorting to show that resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.
Wed Jul 08 00:00:00 EDT 2020
Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.
Cell reports
Alam Z,Devalaraja S,Li M,To TKJ,Folkert IW,Mitchell-Velasquez E,Dang MT,Young P,Wilbur CJ,Silverman MA,Li X,Chen YH,Hernandez PT,Bhattacharyya A,Bhattacharya M,Levine MH,Haldar M
25-0112 was used in Flow cytometry/Cell sorting to uncover a pathway wherein counter-regulation of Spic by NF-κB and STATs attune inflammatory responses and iron metabolism in macrophages.
Tue Jun 30 00:00:00 EDT 2020
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Nature metabolism
Covarrubias AJ,Kale A,Perrone R,Lopez-Dominguez JA,Pisco AO,Kasler HG,Schmidt MS,Heckenbach I,Kwok R,Wiley CD,Wong HS,Gibbs E,Iyer SS,Basisty N,Wu Q,Kim IJ,Silva E,Vitangcol K,Shin KO,Lee YM,Riley R,Ben-Sahra I,Ott M,Schilling B,Scheibye-Knudsen M,Ishihara K,Quake SR,Newman J,Brenner C,Campisi J,Verdin E
25-0112 was used in Flow cytometry/Cell sorting to uncover a new causal link among resident tissue macrophages, cellular senescence and tissue NAD decline during ageing and offer novel therapeutic opportunities to maintain NAD levels during ageing.
Sun Nov 01 00:00:00 EDT 2020
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Nature communications
Lang J,Bohn P,Bhat H,Jastrow H,Walkenfort B,Cansiz F,Fink J,Bauer M,Olszewski D,Ramos-Nascimento A,Duhan V,Friedrich SK,Becker KA,Krawczyk A,Edwards MJ,Burchert A,Huber M,Friebus-Kardash J,Göthert JR,Hardt C,Probst HC,Schumacher F,Köhrer K,Kleuser B,Babiychuk EB,Sodeik B,Seibel J,Greber UF,Lang PA,Gulbins E,Lang KS
25-0112-82 was used in Flow Cytometry to show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs).
Thu Mar 12 00:00:00 EDT 2020
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding.
Cell stem cell
Pei W,Shang F,Wang X,Fanti AK,Greco A,Busch K,Klapproth K,Zhang Q,Quedenau C,Sauer S,Feyerabend TB,Höfer T,Rodewald HR
25-0112 was used in Flow cytometry/Cell sorting to develop the PolyloxExpress allele, enabling Cre-recombinase-dependent RNA barcoding in situ.
Thu Sep 03 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
25-0112-82 was used in Flow Cytometry to conclude that PEGylation of antigenic peptides is an effective and feasible strategy to improve Treg-inducing, peptide-based vaccines with potential use for the treatment of autoimmune diseases, allergies, and transplant rejection.
Thu Apr 29 00:00:00 EDT 2021
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y
25-0112-82 was used in Flow Cytometry to unravel a promising biphotonic strategy for precision treatment of cancer.
Tue Dec 01 00:00:00 EST 2020
Metabolic regulation of gene expression by histone lactylation.
Nature
Zhang D,Tang Z,Huang H,Zhou G,Cui C,Weng Y,Liu W,Kim S,Lee S,Perez-Neut M,Ding J,Czyz D,Hu R,Ye Z,He M,Zheng YG,Shuman HA,Dai L,Ren B,Roeder RG,Becker L,Zhao Y
25-0112 was used in Flow cytometry/Cell sorting to show that lactate-derived lactylation of histone lysine residues serves as an epigenetic modification that directly stimulates gene transcription from chromatin.
Tue Oct 01 00:00:00 EDT 2019
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Immunity
Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN
25-0112 was used in Flow cytometry/Cell sorting to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.
Tue May 21 00:00:00 EDT 2019
Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis.
Immunity
Deniset JF,Belke D,Lee WY,Jorch SK,Deppermann C,Hassanabad AF,Turnbull JD,Teng G,Rozich I,Hudspeth K,Kanno Y,Brooks SR,Hadjantonakis AK,O'Shea JJ,Weber GF,Fedak PWM,Kubes P
25-0112-82 was used in Flow Cytometry to find that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling.
Tue Jul 16 00:00:00 EDT 2019
Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
Cancer cell
Dangaj D,Bruand M,Grimm AJ,Ronet C,Barras D,Duttagupta PA,Lanitis E,Duraiswamy J,Tanyi JL,Benencia F,Conejo-Garcia J,Ramay HR,Montone KT,Powell DJ,Gimotty PA,Facciabene A,Jackson DG,Weber JS,Rodig SJ,Hodi SF,Kandalaft LE,Irving M,Zhang L,Foukas P,Rusakiewicz S,Delorenzi M,Coukos G
25-0112-82 was used in Flow Cytometry to investigate the role of chemokines in regulating T cell accumulation in solid tumors.
Mon Jun 10 00:00:00 EDT 2019
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Cell metabolism
Bieniasz-Krzywiec P,Martín-Pérez R,Ehling M,García-Caballero M,Pinioti S,Pretto S,Kroes R,Aldeni C,Di Matteo M,Prenen H,Tribulatti MV,Campetella O,Smeets A,Noel A,Floris G,Van Ginderachter JA,Mazzone M
25-0112-82 was used in Flow cytometry/Cell sorting to investigate if podoplanin is involved in the attachment of tumor-associated macrophages subset to lymphatic endothelial cells (LECs).
Tue Nov 05 00:00:00 EST 2019
Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.
Cell host & microbe
Thanabalasuriar A,Scott BNV,Peiseler M,Willson ME,Zeng Z,Warrener P,Keller AE,Surewaard BGJ,Dozier EA,Korhonen JT,Cheng LI,Gadjeva M,Stover CK,DiGiandomenico A,Kubes P
25-0112 was used in Flow cytometry/Cell sorting to conclude that blocking both Psl and T3SS together with antibiotic treatment broke down the biofilm and reversed keratitis, suggesting future therapeutic strategies for this intractable infection.
Wed Apr 10 00:00:00 EDT 2019
Central nervous system regeneration is driven by microglia necroptosis and repopulation.
Nature neuroscience
Lloyd AF,Davies CL,Holloway RK,Labrak Y,Ireland G,Carradori D,Dillenburg A,Borger E,Soong D,Richardson JC,Kuhlmann T,Williams A,Pollard JW,des Rieux A,Priller J,Miron VE
25-0112-82 was used in Flow Cytometry to reveal that remyelination is driven by pro-inflammatory microglia necroptosis and repopulation to a regenerative state.
Mon Jul 01 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα.
Cellular & molecular immunology
Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK
25-0112 was used in Flow cytometry/Cell sorting to study the influence of miR-99a on macrophage phenotype and tissue inflammation.
Wed May 01 00:00:00 EDT 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
25-0112-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.
The Journal of clinical investigation
Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH
25-0112 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.
Fri Mar 01 00:00:00 EST 2019
Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.
Journal of the American Society of Nephrology : JASN
Higashi AY,Aronow BJ,Dressler GR
25-0112 was used in Flow cytometry/Cell sorting to investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis.
Tue Jan 01 00:00:00 EST 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
25-0112-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 EST 2019
Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro.
Frontiers in cellular neuroscience
Muth C,Hartmann A,Sepulveda-Falla D,Glatzel M,Krasemann S
25-0112 was used in Flow cytometry/Cell sorting to show that ApoE4 intrinsically affects microglia physiology by upregulating motility and phagocytic behavior in vitro and may therefore specifically contribute to microglia dysregulation in AD.
Thu Oct 01 00:00:00 EDT 2020
Hemozoin produced by mammals confers heme tolerance.
eLife
Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I
25-0112-82 was used in Flow Cytometry to show that mice deficient for the heme transporter SLC48A1 (also known as HRG1) accumulate over ten-fold excess heme in reticuloendothelial macrophage lysosomes that are 10 to 100 times larger than normal.
Tue Oct 01 00:00:00 EDT 2019
Exposure to Cigarette Smoke Augments Post-ischemic Brain Injury and Inflammation via Mobilization of Neutrophils and Monocytes.
Frontiers in immunology
Li H,Li X,Gao S,Wang D,Gao X,Li Y,Wang X,Cui Z,Ma H,Liu Q,Li M
25-0112 was used in Flow cytometry/Cell sorting to suggest that cigarette smoke-induced mobilization of peripheral neutrophils and monocytes augments ischemic brain injury.
Mon Sep 28 00:00:00 EDT 2020
CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age.
Cells
Lieschke S,Zechmeister B,Haupt M,Zheng X,Jin F,Hein K,Weber MS,Hermann DM,Bähr M,Kilic E,Doeppner TR
25-0112-82 was used in Flow Cytometry to demonstrate that CCL11 is a key player in mediating secondary cell injury under stroke conditions in mice, suggesting CCL11 inhibitors as a potential treatment for stroke patients.
Thu Dec 26 00:00:00 EST 2019
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.
Molecular metabolism
Yang H,Xie T,Li D,Du X,Wang T,Li C,Song X,Xu L,Yi F,Liang X,Gao L,Yang X,Ma C
25-0112 was used in Flow cytometry/Cell sorting to study T cell immunoglobulin domain and mucin domain-3 as a regulator in renal inflammation.
Wed May 01 00:00:00 EDT 2019
TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP.
Cell death & disease
Knop J,Spilgies LM,Rufli S,Reinhart R,Vasilikos L,Yabal M,Owsley E,Jost PJ,Marsh RA,Wajant H,Robinson MD,Kaufmann T,Wong WW
25-0112 was used in Flow cytometry/Cell sorting to support the targeting of TNFR2 specifically to reduce IL-18 release in XLP-2 patients and to reduce priming of the inflammasome components.
Fri Sep 20 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
25-0112 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Nature
Meisel M,Hinterleitner R,Pacis A,Chen L,Earley ZM,Mayassi T,Pierre JF,Ernest JD,Galipeau HJ,Thuille N,Bouziat R,Buscarlet M,Ringus DL,Wang Y,Li Y,Dinh V,Kim SM,McDonald BD,Zurenski MA,Musch MW,Furtado GC,Lira SA,Baier G,Chang EB,Eren AM,Weber CR,Busque L,Godley LA,Verdú EF,Barreiro LB,Jabri B
25-0112 was used in Flow cytometry/Cell sorting to study the role played by bacterial translocation and increased interleukin-6 production in the development of pre-leukaemic myeloproliferation.
Tue May 01 00:00:00 EDT 2018
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
25-0112 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.
Cell metabolism
Tucey TM,Verma J,Harrison PF,Snelgrove SL,Lo TL,Scherer AK,Barugahare AA,Powell DR,Wheeler RT,Hickey MJ,Beilharz TH,Naderer T,Traven A
25-0112 was used in Flow cytometry/Cell sorting to support the importance of maintaining glucose homeostasis for immune cell survival during Candida challenge and for host survival in systemic infection.
Tue May 01 00:00:00 EDT 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
25-0112 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.
Disease models & mechanisms
Kim YE,Lee M,Gu H,Kim J,Jeong S,Yeo S,Lee YJ,Im SH,Sung YC,Kim HJ,Weissman IL,Ahn GO
25-0112 was used in Flow cytometry/Cell sorting to study the role of hypoxia-inducible factor in the progression of inflammatory bowel disease.
Mon Jul 30 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
25-0112 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.
Sat Sep 01 00:00:00 EDT 2018
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.
Journal of neuroinflammation
Stoolman JS,Duncker PC,Huber AK,Giles DA,Washnock-Schmid JM,Soulika AM,Segal BM
25-0112 was used in Flow cytometry/Cell sorting to show a new mechanism by which IFNγ and CXCL2 interact to direct regional recruitment of leukocytes in the central nervous system.
Mon Jul 16 00:00:00 EDT 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
25-0112 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell stem cell
Tadokoro Y,Hoshii T,Yamazaki S,Eto K,Ema H,Kobayashi M,Ueno M,Ohta K,Arai Y,Hara E,Harada K,Oshima M,Oshima H,Arai F,Yoshimura A,Nakauchi H,Hirao A
25-0112-82 was used in Flow Cytometry to demonstrate the involvement of diet-induced stress on hematopoietic stem cell self-renewal.
Thu May 03 00:00:00 EDT 2018
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells.
Nature communications
Tosic M,Allen A,Willmann D,Lepper C,Kim J,Duteil D,Schüle R
25-0112 was used in Flow cytometry/Cell sorting to show that elevated levels of lysine-specific demethylase 1 have a beneficial effect on muscle regeneration and recovery after injury.
Thu Jan 25 00:00:00 EST 2018
Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection.
Journal of the American Heart Association
Ohno-Urabe S,Aoki H,Nishihara M,Furusho A,Hirakata S,Nishida N,Ito S,Hayashi M,Yasukawa H,Imaizumi T,Akashi H,Tanaka H,Fukumoto Y
25-0112 was used in Flow cytometry/Cell sorting to characterise the pathological and molecular events triggered by aortic stress, which can lead to aortic dissection.
Wed Jan 17 00:00:00 EST 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
25-0112 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
25-0112-82 was used in Flow cytometry/Cell sorting to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
25-0112 was used in Flow cytometry/Cell sorting to identify the mechanism by which activating transcription factor 3 mediates a cross-regulation in the barrier to maintain mucosal homeostasis and immunity.
Thu Sep 26 00:00:00 EDT 2019
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Nature communications
Yuzhalin AE,Gordon-Weeks AN,Tognoli ML,Jones K,Markelc B,Konietzny R,Fischer R,Muth A,O'Neill E,Thompson PR,Venables PJ,Kessler BM,Lim SY,Muschel RJ
25-0112 was used in Flow cytometry/Cell sorting to examine the potential for peptidylarginine deiminase 4-dependant citrullination to drive the progression of colorectal cancer liver metastasis.
Wed Nov 14 00:00:00 EST 2018
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
25-0112 was used in Flow cytometry/Cell sorting to highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity.
Thu May 18 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.
Frontiers in immunology
Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL
25-0112 was used in Flow cytometry/Cell sorting to provide "proof-of-concept" for the development of a cryptococcal vaccine that provides cross-protection against multiple disparate serotypes of Cryptococcus.
Wed Nov 20 00:00:00 EST 2019
Ethanol, TLR3, and TLR4 Agonists Have Unique Innate Immune Responses in Neuron-Like SH-SY5Y and Microglia-Like BV2.
Alcoholism, clinical and experimental research
Lawrimore CJ,Crews FT
25-0112 was used in Flow cytometry/Cell sorting to identify a novel mechanism of EtOH, TLR3, and TLR4 signaling in neuron-like SH-SY5Y and microglia-like BV2 that likely contributes to the complexity of brain neuroimmune signaling.
Mon May 01 00:00:00 EDT 2017
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
PLoS neglected tropical diseases
Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG
25-0112 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.
Sun Oct 01 00:00:00 EDT 2017
Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.
Nature communications
Buscher K,Ehinger E,Gupta P,Pramod AB,Wolf D,Tweet G,Pan C,Mills CD,Lusis AJ,Ley K
25-0112 was used in Flow cytometry/Cell sorting to highlight natural activation diversity as a disease relevant dimension in macrophage biology.
Mon Jul 24 00:00:00 EDT 2017
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment.
Journal for immunotherapy of cancer
Steggerda SM,Bennett MK,Chen J,Emberley E,Huang T,Janes JR,Li W,MacKinnon AL,Makkouk A,Marguier G,Murray PJ,Neou S,Pan A,Parlati F,Rodriguez MLM,Van de Velde LA,Wang T,Works M,Zhang J,Zhang W,Gross MI
25-0112 was used in Flow cytometry/Cell sorting to demonstrate key role of arginase 1 (Arg1), characteristically expressed among myeloid cells in tumors, as a mediator of immune suppression; and explore the therapeutic potential of CB-1158 as a potent inhibitor of Arg1.
Tue Dec 19 00:00:00 EST 2017
MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.
Particle and fibre toxicology
Winkler HC,Kornprobst J,Wick P,von Moos LM,Trantakis I,Schraner EM,Bathke B,Hochrein H,Suter M,Naegeli H
Fri Jun 23 00:00:00 EDT 2017
Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.
Cell reports
Boulianne B,Robinson ME,May PC,Castellano L,Blighe K,Thomas J,Reid A,Müschen M,Apperley JF,Stebbing J,Feldhahn N
25-0112 was used in Flow cytometry/Cell sorting to demonstrate lineage-specific transcription predisposes genes in B cells to DNA damage.
Tue Feb 14 00:00:00 EST 2017
Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature.
PloS one
Muley A,Odaka Y,Lewkowich IP,Vemaraju S,Yamaguchi TP,Shawber C,Dickie BH,Lang RA
25-0112 was used in Flow cytometry/Cell sorting to establish that Wnt ligands from macrophages play an important role in development of the lymphatic capillary vessels.
Thu Oct 19 00:00:00 EDT 2017
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
25-0112 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.
Thu Aug 24 00:00:00 EDT 2017
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.
Frontiers in cellular and infection microbiology
Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H
25-0112 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.
Mon Feb 26 00:00:00 EST 2018
Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.
Cell research
Liu Q,Yang R,Huang X,Zhang H,He L,Zhang L,Tian X,Nie Y,Hu S,Yan Y,Zhang L,Qiao Z,Wang QD,Lui KO,Zhou B
25-0112 was used in Flow cytometry/Cell sorting to show that genetic lineage tracing can identify in-situ Kit expressing cardiomyocytes.
Fri Jan 01 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
25-0112 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Early life stress perturbs the maturation of microglia in the developing hippocampus.
Brain, behavior, and immunity
Delpech JC,Wei L,Hao J,Yu X,Madore C,Butovsky O,Kaffman A
25-0112 was used in Flow cytometry/Cell sorting to study the effect of early life stress on the maturation of microgila in the developing hippocampus, and to identify the key regulatory transcription factors involved in maturation.
Sat Oct 01 00:00:00 EDT 2016
Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Oncogene
Lim SY,Yuzhalin AE,Gordon-Weeks AN,Muschel RJ
25011282 was used in flow cytometry to implicate S100A8 and S100A9 messenger RNAs as important mediators of tumor cell aggressiveness, and highlights their therapeutic potential for interference of metastasis
Thu Nov 03 00:00:00 EDT 2016
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
The Journal of investigative dermatology
Rak GD,Osborne LC,Siracusa MC,Kim BS,Wang K,Bayat A,Artis D,Volk SW
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC response and that abrogation of this response can impair efficient wound closure.
Mon Feb 01 00:00:00 EST 2016
Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Yang E,Singh BK,Paustian AM,Kambayashi T
25-0112 was used in Flow cytometry/Cell sorting to investigate methods to enhance NK cell function, showing that diacylglycerol kinase ζ is a target for enhancement of NK function.
Mon Aug 01 00:00:00 EDT 2016
Postnatal Hematopoiesis and Gut Microbiota in NOD Mice Deviate from C57BL/6 Mice.
Journal of diabetes research
Damlund DS,Metzdorff SB,Hasselby JP,Wiese M,Lundsager M,Nielsen DS,Buschard KS,Hansen AK,Frøkiær H
25-0112 was used in Flow cytometry/Cell sorting to investigate whether NOD mice differ to C57BL/6 mice with respect to postnatal microbiota and/or hematopoiesis.
Mon Oct 24 00:00:00 EDT 2016
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.
Experimental eye research
Liyanage SE,Gardner PJ,Ribeiro J,Cristante E,Sampson RD,Luhmann UF,Ali RR,Bainbridge JW
25-0112 was used in Flow cytometry/Cell sorting to demonstrate a standardised method for the identification and quantification of myeloid cells in diseased tissues.
Sat Oct 01 00:00:00 EDT 2016
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.
Scientific reports
Filtjens J,Keirsse J,Van Ammel E,Taveirne S,Van Acker A,Kerre T,Taghon T,Vandekerckhove B,Plum J,Van Ginderachter JA,Leclercq G
25-0112 was used in Flow cytometry/Cell sorting to study the involvement of the inhibitory Ly49E NK cell receptor and its activating molecule uPA in skin, lung, and liver tumorigenesis.
Fri Jul 29 00:00:00 EDT 2016
Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity.
Journal of neuroinflammation
Bracchi-Ricard V,Zha J,Smith A,Lopez-Rodriguez DM,Bethea JR,Andreansky S
25-0112 was used in Flow cytometry/Cell sorting to show that chronic SCI causes severe morbidity and mortality in mice infected with influenza A virus by compromising antibody and CD8+ T cell responses.
Tue May 31 00:00:00 EDT 2016
Infection-Mediated Priming of Phagocytes Protects against Lethal Secondary Aspergillus fumigatus Challenge.
PloS one
Savers A,Rasid O,Parlato M,Brock M,Jouvion G,Ryffel B,Cavaillon JM,Eberl G,Ibrahim-Granet O
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of infection-mediated priming in protection against a secondary lethal challenge.
Thu Sep 01 00:00:00 EDT 2016
Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice.
PloS one
Menasria R,Canivet C,Piret J,Gosselin J,Boivin G
25-0112 was used in Flow cytometry/Cell sorting to study how CCR2 expressed on cells of the CNS is important for the control of HSV-1 replication and the inflammatory environment during experimental encephalitis.
Tue Jul 18 00:00:00 EDT 2017
The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.
Cell
Karreth FA,Reschke M,Ruocco A,Ng C,Chapuy B,Léopold V,Sjoberg M,Keane TM,Verma A,Ala U,Tay Y,Wu D,Seitzer N,Velasco-Herrera Mdel C,Bothmer A,Fung J,Langellotto F,Rodig SJ,Elemento O,Shipp MA,Adams DJ,Chiarle R,Pandolfi PP
25-0112 was used in Flow cytometry/Cell sorting to find that transcriptional or genomic aberrations of BRAFP1 occur frequently in multiple human cancers, including B cell lymphomas.
Thu Apr 09 00:00:00 EDT 2015
Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.
Immunity
Bruttger J,Karram K,Wörtge S,Regen T,Marini F,Hoppmann N,Klein M,Blank T,Yona S,Wolf Y,Mack M,Pinteaux E,Müller W,Zipp F,Binder H,Bopp T,Prinz M,Jung S,Waisman A
25-0112 was used in Flow cytometry/Cell sorting to study how microglia have the potential for efficient self-renewal without the contribution of peripheral myeloid cells, and IL-1R signaling participates in this restorative proliferation process.
Tue Jul 21 00:00:00 EDT 2015
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Cancer research
Ngiow SF,Young A,Jacquelot N,Yamazaki T,Enot D,Zitvogel L,Smyth MJ
25-0112 was used in Flow cytometry/Cell sorting to provide a framework to interrogate intra-tumour CD8(+) T-cell PD1 and immune PDL1 levels and response in human cancer.
Tue Sep 15 00:00:00 EDT 2015
B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
Annals of neurology
Lehmann-Horn K,Sagan SA,Bernard CC,Sobel RA,Zamvil SS
25-0112 was used in Flow cytometry/Cell sorting to report that the selective inhibition of VLA-4 expression on B cells impedes CNS accumulation of B cells, and recruitment of Th17 cells and macrophages.
Fri May 01 00:00:00 EDT 2015
Early virus-host interactions dictate the course of a persistent infection.
PLoS pathogens
Sullivan BM,Teijaro JR,de la Torre JC,Oldstone MB
25-0112 was used in Flow cytometry/Cell sorting to investigate the very early host-virus interactions that determine the establishment of viral persistence.
Thu Jan 01 00:00:00 EST 2015
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rice RA,Spangenberg EE,Yamate-Morgan H,Lee RJ,Arora RP,Hernandez MX,Tenner AJ,West BL,Green KN
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that microglia exert beneficial effects during a diphtheria toxin-induced neuronal lesion, but impede recovery following insult.
Wed Jul 08 00:00:00 EDT 2015
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
Journal of virology
Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T
25-0112 was used in Flow cytometry/Cell sorting to demonstrate the enormous functional and genetic plasticity of monocytes infiltrating the liver after inflammation.
Fri May 01 00:00:00 EDT 2015
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
Journal of molecular medicine (Berlin, Germany)
Peng H,Li C,Kadow S,Henry BD,Steinmann J,Becker KA,Riehle A,Beckmann N,Wilker B,Li PL,Pritts T,Edwards MJ,Zhang Y,Gulbins E,Grassmé H
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of the mammalian acid sphingomyelinase (Asm)/ceramide system in the development of lung edema caused by S. aureus.
Mon Jun 01 00:00:00 EDT 2015
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 EDT 2015
Perivascular mast cells regulate vein graft neointimal formation and remodeling.
PeerJ
Wu J,Grassia G,Cambrook H,Ialenti A,MacRitchie N,Carberry J,Wadsworth RM,Lawrence C,Kennedy S,Maffia P
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of perivascular mast cells in vascular inflammatory and proliferative responses and subsequent vein graft neointimal formation and remodeling.
Fri Aug 28 00:00:00 EDT 2015
Alveolar macrophage phenotype expression in airway-instilled bone marrow cells in mice.
SpringerPlus
Okui M,Goto T,Asakura K,Kamiyama I,Ohtsuka T
25-0112 was used in Flow cytometry/Cell sorting to study how intratracheally instilled bone marrow cells adapt to the surrounding microenvironment, directly differentiating into alveolar macrophages, and remain in the alveolar space for at least 3 months.
Mon Dec 21 00:00:00 EST 2015
Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi.
PloS one
Silva RR,Mariante RM,Silva AA,dos Santos AL,Roffê E,Santiago H,Gazzinelli RT,Lannes-Vieira J
25-0112 was used in Flow cytometry/Cell sorting to investigate the effect of IFNγ in the central nervous system and on astrocytes during Chagas disease.
Thu Dec 31 00:00:00 EST 2015
Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen.
Immunity, inflammation and disease
Kristensen MB,Metzdorff SB,Bergström A,Damlund DS,Fink LN,Licht TR,Frøkiær H
25-0112 was used in Flow cytometry/Cell sorting to assess the microbial influence on postnatal haematopoiesis.
Tue Sep 01 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
25-0112 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Vesicles from different Trypanosoma cruzi strains trigger differential innate and chronic immune responses.
Journal of extracellular vesicles
Nogueira PM,Ribeiro K,Silveira AC,Campos JH,Martins-Filho OA,Bela SR,Campos MA,Pessoa NL,Colli W,Alves MJ,Soares RP,Torrecilhas AC
25-0112 was used in Flow cytometry/Cell sorting to reveal polymorphisms in the vesicles surface may be determinant in the immunopathologic events throughout infection.
Sat Nov 28 00:00:00 EST 2015
Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis.
PloS one
Menasria R,Canivet C,Piret J,Boivin G
25-0112 was used in Flow cytometry/Cell sorting to suggest that blood monocyte-derived macrophages infiltrate the CNS and may contribute, with resident microglia, to the innate immune response seen during experimental HSE.
Wed Aug 17 00:00:00 EDT 2016
Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors.
Cell & bioscience
Wang Y,Jiang M,Li Z,Wang J,Du C,Yanyang L,Yu Y,Wang X,Zhang N,Zhao M,Wang L,Li M,Luo F
25-0112 was used in Flow cytometry/Cell sorting to investigate anti-tumour treatment using endostatin and mechanisms of resistance to the treatment.
Fri Dec 25 00:00:00 EST 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
25-0112 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.
Cell death & disease
Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D
25-0112 was used in Flow cytometry/Cell sorting to define the clearance of infected neutrophils by dendritic cells as central to the early immune evasion strategies of L. major.
Thu Dec 10 00:00:00 EST 2015
Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.
Scientific reports
Shon WJ,Lee YK,Shin JH,Choi EY,Shin DM
25-0112 was used in Flow cytometry/Cell sorting to explore the role of IDO1 in producing inflammatory responses and modulating transcriptional networks during the development of colitis.
Fri Nov 27 00:00:00 EST 2015
Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model.
Oncotarget
Ito H,Ando T,Seishima M
25-0112 was used in Flow cytometry/Cell sorting to investigate how the inhibition of iNOS expression could enhance the therapeutic efficacy of GalCer via the increase of tumor antigen-specific immune response and the suppression of MDSCs.
Tue Dec 08 00:00:00 EST 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation.
Circulation research
Ali SR,Ranjbarvaziri S,Talkhabi M,Zhao P,Subat A,Hojjat A,Kamran P,Müller AM,Volz KS,Tang Z,Red-Horse K,Ardehali R
25-0112 was used in Flow cytometry/Cell sorting to study the developmental origins of cardiac fibroblasts and characterise their corresponding phenotypes, to aid in determining the proliferation rates of each developmental subset.
Fri Sep 12 00:00:00 EDT 2014
LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.
The Journal of clinical investigation
Nakamura T,Hamuro J,Takaishi M,Simmons S,Maruyama K,Zaffalon A,Bentley AJ,Kawasaki S,Nagata-Takaoka M,Fullwood NJ,Itami S,Sano S,Ishii M,Barrandon Y,Kinoshita S
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of corneal stem cells in cornea homeostasis, showing that LRIG1 inhibits STAT3-dependent inflammation to maintain homeostasis.
Wed Jan 01 00:00:00 EST 2014
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.
Science translational medicine
Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW
25-0112 was used in Flow cytometry/Cell sorting to demonstrate asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection.
Wed Oct 01 00:00:00 EDT 2014
Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.
Hepatology (Baltimore, Md.)
Huang H,Nace GW,McDonald KA,Tai S,Klune JR,Rosborough BR,Ding Q,Loughran P,Zhu X,Beer-Stolz D,Chang EB,Billiar T,Tsung A
25-0112 was used in Flow cytometry/Cell sorting to determine the role of intracellular HMGB1 in hepatocytes after liver ischaemia-reperfusion.
Thu May 01 00:00:00 EDT 2014
Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America
Teijaro JR,Walsh KB,Rice S,Rosen H,Oldstone MB
25-0112 was used in Flow cytometry/Cell sorting to show that sphingosine-1-phosphate-1 receptor agonist treatment suppresses global cytokine amplification during influenza virus infection.
Tue Mar 11 00:00:00 EDT 2014
Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Stoolman JS,Duncker PC,Huber AK,Segal BM
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of CXCL2 in atypical EAE, showing that site-specific chemokine expression regulates CNS inflammation and determines clinical phenotype.
Tue Jul 15 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
25-0112 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
Genetic control of susceptibility to Candida albicans in SM/J mice.
Journal of immunology (Baltimore, Md. : 1950)
Radovanovic I,Leung V,Iliescu A,Bongfen SE,Mullick A,Langlais D,Gros P
25-0112 was used in Flow cytometry/Cell sorting to identify loci associated with increased susceptibility to infection by Candida albicans.
Fri Aug 01 00:00:00 EDT 2014
Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Simmons SB,Liggitt D,Goverman JM
25-0112 was used in Flow cytometry/Cell sorting to investigate the pathways that determine whether damage occurs in the brain or spinal cord in multiple sclerosis, showing that cytokine-regulated neutrophil recruitment is required for brain but not spinal cord.
Tue Jul 15 00:00:00 EDT 2014
Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.
International immunology
Honjo K,Kubagawa Y,Suzuki Y,Takagi M,Ohno H,Bucy RP,Izui S,Kubagawa H
25-0112 was used in Flow cytometry/Cell sorting to determine the impact of Fcmr ablation on autoimmunity.
Mon Dec 01 00:00:00 EST 2014
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Molecular and cellular biology
Nobuhisa I,Osawa M,Uemura M,Kishikawa Y,Anani M,Harada K,Takagi H,Saito K,Kanai-Azuma M,Kanai Y,Iwama A,Taga T
25-0112 was used in Flow cytometry/Cell sorting to investigate how cells in intra-aortic clusters maintain their HSC phenotype, showing that they are maintained by Sox17.
Sun Jun 01 00:00:00 EDT 2014
Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitis.
Infection and immunity
Spees AM,Kingsbury DD,Wangdi T,Xavier MN,Tsolis RM,Bäumler AJ
25-0112 was used in Flow cytometry/Cell sorting to identify the cells responsible for IFN-γ production in the cecal mucosa during the acute phase of an S. Typhimurium infection.
Tue Apr 01 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
25-0112-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.
BioMed research international
Wang H,Yang YL,Zhang H,Yan H,Wu XJ,Zhang CZ
25-0112 was used in Flow cytometry/Cell sorting to examine if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.
Mon Mar 30 00:00:00 EDT 2015
Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression.
Journal of neuroinflammation
Zha J,Smith A,Andreansky S,Bracchi-Ricard V,Bethea JR
25-0112 was used in Flow cytometry/Cell sorting to investigate CD8+ T-cell function by up-regulating programmed cell death-1 expression in chronic thoracic spinal cord injury.
Tue Apr 01 00:00:00 EDT 2014
IKKα negatively regulates ASC-dependent inflammasome activation.
Nature communications
Martin BN,Wang C,Willette-Brown J,Herjan T,Gulen MF,Zhou H,Bulek K,Franchi L,Sato T,Alnemri ES,Narla G,Zhong XP,Thomas J,Klinman D,Fitzgerald KA,Karin M,Nuñez G,Dubyak G,Hu Y,Li X
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of IκB kinase α in inflammasome activation, showing that it negatively regulates ASC-dependent activation.
Tue Sep 30 00:00:00 EDT 2014
Discriminating cellular heterogeneity using microwell-based RNA cytometry.
Nature communications
Dimov IK,Lu R,Lee EP,Seita J,Sahoo D,Park SM,Weissman IL,Lee LP
25-0112 was used in Flow cytometry/Cell sorting to develop a two-stage system to determine cellular heterogeneity.
Tue Mar 25 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
25-0112 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.
Nature immunology
Ji Q,Castelli L,Goverman JM
25-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the role of CD8(+) T cells in the pathogenesis of multiple sclerosis.
Fri Mar 01 00:00:00 EST 2013
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.
The Journal of clinical investigation
Kook S,Cho J,Lee SB,Lee BC
25-0112 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism governing the migration of haematopoietic stem progenitor cells under stress.
Thu Aug 01 00:00:00 EDT 2013
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.
Arteriosclerosis, thrombosis, and vascular biology
Ait-Oufella H,Herbin O,Lahoute C,Coatrieux C,Loyer X,Joffre J,Laurans L,Ramkhelawon B,Blanc-Brude O,Karabina S,Girard CA,Payré C,Yamamoto K,Binder CJ,Murakami M,Tedgui A,Lambeau G,Mallat Z
25-0112 was used in Flow cytometry/Cell sorting to study the proatherogenic properties of PLA2G10, a type of several secreted phospholipase A2.
Fri Mar 01 00:00:00 EST 2013
PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.
Mucosal immunology
Lewkowich IP,Lajoie S,Stoffers SL,Suzuki Y,Richgels PK,Dienger K,Sproles AA,Yagita H,Hamid Q,Wills-Karp M
25-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which PD-L2 modulates asthma severity in human and mouse lung samples.
Mon Jul 01 00:00:00 EDT 2013
Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system.
PLoS pathogens
Nayak D,Johnson KR,Heydari S,Roth TL,Zinselmeyer BH,McGavern DB
25-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms that underlie the dynamic programming of innate immune sentinels during viral infection.
Mon Dec 09 00:00:00 EST 2013
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
PLoS pathogens
Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P
25-0112 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.
Tue Feb 18 00:00:00 EST 2014
The viral chemokine MCK-2 of murine cytomegalovirus promotes infection as part of a gH/gL/MCK-2 complex.
PLoS pathogens
Wagner FM,Brizic I,Prager A,Trsan T,Arapovic M,Lemmermann NA,Podlech J,Reddehase MJ,Lemnitzer F,Bosse JB,Gimpfl M,Marcinowski L,MacDonald M,Adler H,Koszinowski UH,Adler B
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that MCK-2 has a dual role in cytomegalovirus infection, as a regulator of immune response and also in promoting viral entry into cells.
Tue Feb 18 00:00:00 EST 2014
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Chen HW,Evankovich J,Yan W,Rosborough BR,Nace GW,Ding Q,Loughran P,Beer-Stolz D,Billiar TR,Esmon CT,Tsung A
25-0112 was used in Flow cytometry/Cell sorting to investigate the cellular processes that drive sterile inflammatory injury after hepatic ischaemia/reperfusion injury.
Sun Sep 01 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
25-0112 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
25-0112 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
Aeroallergen challenge promotes dendritic cell proliferation in the airways.
Journal of immunology (Baltimore, Md. : 1950)
Veres TZ,Voedisch S,Spies E,Valtonen J,Prenzler F,Braun A
25-0112 was used in Flow cytometry/Cell sorting to study dendritic cell proliferation in the airways of mice in the steady state and after local aeroallergen provocation.
Fri Feb 01 00:00:00 EST 2013
Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes.
Scientific reports
Ando T,Ito H,Ohtaki H,Seishima M
25-0112 was used in Flow cytometry/Cell sorting to explore the effects of the costimulation of GalCer and TLR agonists on the immune system and cytokine production.
Fri Feb 14 00:00:00 EST 2014
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
25-0112 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
25-0112-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Macritchie N,Grassia G,Sabir SR,Maddaluno M,Welsh P,Sattar N,Ialenti A,Kurowska-Stolarska M,McInnes IB,Brewer JM,Garside P,Maffia P
25-0112 was used in Flow cytometry/Cell sorting to identify a potential role for pDC targeting in the control of the pathology of coronary artery disease.
Thu Nov 01 00:00:00 EDT 2012
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
25-0112 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment.
Journal of innate immunity
Day SB,Ledford JR,Zhou P,Lewkowich IP,Page K
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of German cockroach frass proteases in modulating factors that regulate pulmonary dendritic cells in asthma.
Mon Apr 16 00:00:00 EDT 2012
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Chenoweth MJ,Mian MF,Barra NG,Alain T,Sonenberg N,Bramson J,Lichty BD,Richards CD,Ma A,Ashkar AA
25-0112 was used in Flow cytometry/Cell sorting to study the mechanisms of how IL-15 signals to drive RANTES production by myeloid cells.
Tue May 01 00:00:00 EDT 2012
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
PloS one
Buchwald ZS,Kiesel JR,DiPaolo R,Pagadala MS,Aurora R
25-0112 was used in Flow cytometry/Cell sorting to demonstrate the effects of activated CD8 T cell-produced cytokines on osteoclast activity.
Thu Nov 08 00:00:00 EST 2012
Shape-based tracking allows functional discrimination of two immune cell subsets expressing the same fluorescent tag in mouse lung explant.
PloS one
Fiole D,Touvrey C,Quesnel-Hellmann A,Douady J,Tournier JN
25-0112 was used in Flow cytometry/Cell sorting to demonstrate a novel method for discrimination between DCs and closely related cell lineages in mouse lungs.
Fri Nov 30 00:00:00 EST 2012
Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.
PloS one
Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L
25-0112 was used in Flow cytometry/Cell sorting to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.
Thu Jan 10 00:00:00 EST 2013
Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells.
Molecular & cellular proteomics : MCP
Klimmeck D,Hansson J,Raffel S,Vakhrushev SY,Trumpp A,Krijgsveld J
25-0112 was used in Flow cytometry/Cell sorting to discern the distinct signatures of multipotent progenitors and myeloid committed cells.
Wed Aug 01 00:00:00 EDT 2012
Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.
PloS one
Gray KS,Collins CM,Speck SH
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of the omentum in gammaherpesvirus pathogenesis during early MHV68 infection and long-term latency.
Tue Feb 19 00:00:00 EST 2013
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.
Cell
Teijaro JR,Walsh KB,Cahalan S,Fremgen DM,Roberts E,Scott F,Martinborough E,Peach R,Oldstone MB,Rosen H
25-0112 was used in Flow cytometry/Cell sorting to elucidate cellular and signalling mechanisms that are important in initiating cytokine storm.
Fri Sep 16 00:00:00 EDT 2011
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization.
The Journal of experimental medicine
Miyamoto K,Yoshida S,Kawasumi M,Hashimoto K,Kimura T,Sato Y,Kobayashi T,Miyauchi Y,Hoshi H,Iwasaki R,Miyamoto H,Hao W,Morioka H,Chiba K,Kobayashi T,Yasuda H,Penninger JM,Toyama Y,Suda T,Miyamoto T
25-0112 was used in Flow cytometry/Cell sorting to investigate how osteoclasts and the bone marrow cavity regulate hematopoiesis.
Mon Oct 24 00:00:00 EDT 2011
Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection.
The Journal of experimental medicine
Kang SS,Herz J,Kim JV,Nayak D,Stewart-Hutchinson P,Dustin ML,McGavern DB
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that CTLs are poised to divide in transit and that their numbers can be influenced locally at the site of infection through interactions with cells displaying cognate antigen.
Mon Apr 11 00:00:00 EDT 2011
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.
The Journal of allergy and clinical immunology
Arias K,Chu DK,Flader K,Botelho F,Walker T,Arias N,Humbles AA,Coyle AJ,Oettgen HC,Chang HD,Van Rooijen N,Waserman S,Jordana M
25-0112 was used in Flow cytometry/Cell sorting to investigate the relative contribution of immunoglobulin-dependent effector pathways to anaphylactic responses to food.
Wed Jun 01 00:00:00 EDT 2011
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.
Mucosal immunology
Eri RD,Adams RJ,Tran TV,Tong H,Das I,Roche DK,Oancea I,Png CW,Jeffery PL,Radford-Smith GL,Cook MC,Florin TH,McGuckin MA
25-0112 was used in Flow cytometry/Cell sorting to characterise the immune response to the intestinal dysfunction caused by the Muc2 mutation carried by Winnie mice.
Sun May 01 00:00:00 EDT 2011
MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bosmann M,Patel VR,Russkamp NF,Pache F,Zetoune FS,Sarma JV,Ward PA
25-0112 was used in Flow cytometry/Cell sorting to study the expression and release of IL-17F and its regulation by the complement system.
Thu Dec 01 00:00:00 EST 2011
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Lees RK,Voyle RB,Held W,MacDonald HR
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.
Fri Jul 01 00:00:00 EDT 2011
Identification of a novel antigen cross-presenting cell type in spleen.
Journal of cellular and molecular medicine
Tan JK,Quah BJ,Griffiths KL,Periasamy P,Hey YY,O'Neill HC
25-0112 was used in Flow cytometry/Cell sorting to study a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen.
Sun May 01 00:00:00 EDT 2011
Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant.
Transplant immunology
Kinnier CV,Martinu T,Gowdy KM,Nugent JL,Kelly FL,Palmer SM
25-0112 was used in Flow cytometry/Cell sorting to suggest a novel pathway in which the innate antiviral response to a single viral PAMP can potentiate pulmonary GVHD after allogeneic HCT.
Sat Jan 15 00:00:00 EST 2011
Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation.
Respiratory research
Lewkowich IP,Day SB,Ledford JR,Zhou P,Dienger K,Wills-Karp M,Page K
25-0112 was used in Flow cytometry/Cell sorting to suggest a role for allergen activation of PAR-2 on myeloid dendritic cells causing Th2/Th17 cytokine production and allergic airway responses.
Wed Sep 21 00:00:00 EDT 2011
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.
Nature medicine
Aikawa Y,Katsumoto T,Zhang P,Shima H,Shino M,Terui K,Ito E,Ohno H,Stanley ER,Singh H,Tenen DG,Kitabayashi I
25-0112 was used in Flow cytometry/Cell sorting to investigate methods to treat acute myeloid leukemia.
Sat May 01 00:00:00 EDT 2010
B cell depletion reduces the development of atherosclerosis in mice.
The Journal of experimental medicine
Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z
25-0112 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.
Mon Aug 02 00:00:00 EDT 2010
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Aging cell
Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C
25-0112 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.
Fri Oct 01 00:00:00 EDT 2010
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Journal of immunology (Baltimore, Md. : 1950)
Chen G,Wan H,Luo F,Zhang L,Xu Y,Lewkowich I,Wills-Karp M,Whitsett JA
25-0112 was used in Flow cytometry/Cell sorting to demonstrate that selective expression of Foxa2 plays a key role in regulating Th2 cell-mediated pulmonary inflammation.
Tue Jun 01 00:00:00 EDT 2010
Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung.
Journal of immunology (Baltimore, Md. : 1950)
Small CL,Shaler CR,McCormick S,Jeyanathan M,Damjanovic D,Brown EG,Arck P,Jordana M,Kaushic C,Ashkar AA,Xing Z
25-0112 was used in Flow cytometry/Cell sorting to identify weakened NK cell response in the lung to be a critical mechanism for flu-mediated susceptibility to bacterial superinfection.
Mon Feb 15 00:00:00 EST 2010
Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Hinson ER,Joshi NS,Chen JH,Rahner C,Jung YW,Wang X,Kaech SM,Cresswell P
25-0112 was used in Flow cytometry/Cell sorting to analyse viperin expression in vivo during two conditions which induce high and low levels of type 1 IFNs respectively.
Sat May 15 00:00:00 EDT 2010
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.
Experimental hematology
Challen GA,Goodell MA
25-0112 was used in Flow cytometry/Cell sorting to study how Runx1 isoforms hold similar functions in adult hematopoietic stem cells, but show differential expression patterns during hematopoietic development.
Sat May 01 00:00:00 EDT 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
25-0112 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis.
Nature
Kim JV,Kang SS,Dustin ML,McGavern DB
25-0112 was used in Flow cytometry/Cell sorting to conclude that CD8(+) T-cell-dependent disorders can occur without T-cell effector mechanisms and proceed by cytotoxic T lymphocytes-recruited myelomonocytic cells.
Thu Jan 08 00:00:00 EST 2009
Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor.
Journal of leukocyte biology
Evans DL,Connor MA,Moss LD,Lackay S,Leary JH,Krunkosky T,Jaso-Friedmann L
25-0112 was used in Flow cytometry/Cell sorting to identify and investigate the function of a H1x-like protein.
Wed Jul 01 00:00:00 EDT 2009
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.
Journal of immunology (Baltimore, Md. : 1950)
Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
25-0112 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.
Wed Jul 15 00:00:00 EDT 2009
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
25-0112 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112.
Infection and immunity
Hall JD,Woolard MD,Gunn BM,Craven RR,Taft-Benz S,Frelinger JA,Kawula TH
25-0112 was used in Flow cytometry/Cell sorting to investigate the impact of Francisella tularensis inhalation on host cell repertoire and function in the lung.
Mon Dec 01 00:00:00 EST 2008
Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice.
Alcohol (Fayetteville, N.Y.)
Jerrells TR,Pavlik JA,DeVasure J,Vidlak D,Costello A,Strachota JM,Wyatt TA
25-0112 was used in Flow cytometry/Cell sorting to test whether people who abuse alcohol are more susceptible to respiratory viral infections.
Wed Aug 01 00:00:00 EDT 2007
