Product References
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Fri Feb 03 00:00:00 EST 2023
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing.
Nature cell biology
Mitchell CA,Verovskaya EV,Calero-Nieto FJ,Olson OC,Swann JW,Wang X,Hérault A,Dellorusso PV,Zhang SY,Svendsen AF,Pietras EM,Bakker ST,Ho TT,Göttgens B,Passegué E
12-1351-82 was used in Flow cytometry/Cell sorting to characterize the inflammatory milieu that drives both niche and haematopoietic remodelling.
Sun Jan 01 00:00:00 EST 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
12-1351-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
12-1351-82 was used in Flow cytometry/Cell sorting to demonstrate the effects of myeloid cell leukemia 1 (MCL-1) inhibitor on the intramedullary and extramedullary hematopoietic lineages, which is important for the selection of combinations of antitumor drugs and the prevention of adverse hematopoiesis-related effects.
Tue Mar 28 00:00:00 EDT 2023
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
Nature medicine
Ganan-Gomez I,Yang H,Ma F,Montalban-Bravo G,Thongon N,Marchica V,Richard-Carpentier G,Chien K,Manyam G,Wang F,Alfonso A,Chen S,Class C,Kanagal-Shamanna R,Ingram JP,Ogoti Y,Rose A,Loghavi S,Lockyer P,Cambo B,Muftuoglu M,Schneider S,Adema V,McLellan M,Garza J,Marchesini M,Giuliani N,Pellegrini M,Wang J,Walker J,Li Z,Takahashi K,Leverson JD,Bueso-Ramos C,Andreeff M,Clise-Dwyer K,Garcia-Manero G,Colla S
12-1351-82 was used in Flow Cytometry to study the biological mechanisms that drive hypomethylating agent therapy failure at the stem-cell level to uncover vulnerabilities in the disease and halt its evolution.
Tue Mar 01 00:00:00 EST 2022
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.
Cancer cell
Ueda K,Kumari R,Schwenger E,Wheat JC,Bohorquez O,Narayanagari SR,Taylor SJ,Carvajal LA,Pradhan K,Bartholdy B,Todorova TI,Goto H,Sun D,Chen J,Shan J,Song Y,Montagna C,Xiong S,Lozano G,Pellagatti A,Boultwood J,Verma A,Steidl U
12-1351-82 was used in Flow cytometry/Cell sorting to identify MDMX overexpression as a pervasive preleukemic-to-AML transition mechanism in different genetically driven disease subtypes, and reveal Wnt/β-Catenin as a non-canonical MDMX-driven pathway with therapeutic potential for progression prevention and cancer interception.
Mon Apr 12 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity.
eLife
Tak T,Prevedello G,Simon G,Paillon N,Benlabiod C,Marty C,Plo I,Duffy KR,Perié L
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that fate decisions of cells are largely inherited from ancestor cells, indicating the importance of common ancestor effects.
Tue May 18 00:00:00 EDT 2021
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress.
Cell death & disease
Tung LT,Wang H,Belle JI,Petrov JC,Langlais D,Nijnik A
12-1351-82 was used in Flow Cytometry to analyze the in vivo transcriptional response of hematopoietic stem and progenitor cells to genotoxic stress in a mouse whole-body irradiation model and characterize the p53-dependent and p53-independent branches of this transcriptional response.
Fri Oct 08 00:00:00 EDT 2021
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B,Harbeson DJ,Shannon CP,Cai B,He D,Ben-Othman R,Francis F,Huang J,Varankovich N,Liu A,Bao W,Bjerregaard-Andersen M,Schaltz-Buchholzer F,Sanca L,Golding CN,Larsen KL,Levy O,Kampmann B,Tan R,Charles A,Wynn JL,Shann F,Aaby P,Benn CS,Tebbutt SJ,Kollmann TR,Amenyogbe N
12-1351 was used in Flow cytometry/Cell sorting to show that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration.
Wed May 06 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
12-1351 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
12-1351 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
Oncogene
Karra L,Romero-Moya D,Ksionda O,Krush M,Gu Z,Mues M,Depeille P,Mullighan C,Roose JP
12-1351 was used in Flow cytometry/Cell sorting to expand RASGRP1 expression surveys in pediatric T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells.
Sun Nov 01 00:00:00 EDT 2020
Zinc finger and BTB domain-containing protein 46 is essential for survival and proliferation of acute myeloid leukemia cell line but dispensable for normal hematopoiesis.
Chinese medical journal
Liu YY,Xiao FF,Yang BJ,Li X,Xu SN,Chen ZW,Li P,Huang YX,Fu XM,Huang XQ,Zheng GL,Chen JP,Hou Y
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Mon Jul 20 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis.
Cell reports
Zhang C,Xu Z,Yang S,Sun G,Jia L,Zheng Z,Gu Q,Tao W,Cheng T,Li C,Cheng H
12-1351-82 was used in Flow Cytometry to introduce a low-input tagmentation-based Hi-C (tagHi-C) method to capture the chromatin structures of hundreds of cells.
Tue Sep 29 00:00:00 EDT 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
12-1351 was used in Flow cytometry/Cell sorting to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 EDT 2020
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
12-1351-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
12-1351 was used in Flow cytometry/Cell sorting to identify two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets.
Thu Oct 31 00:00:00 EDT 2019
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using CD135 (Flt3) monoclonal antibody (Product # 12-1351-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro.
Cell stem cell
Luchsinger LL,Strikoudis A,Danzl NM,Bush EC,Finlayson MO,Satwani P,Sykes M,Yazawa M,Snoeck HW
12-1351 was used in Flow cytometry/Cell sorting to reveal a physiological feature of HSCs that can be harnessed to improve their maintenance in vitro.
Thu Aug 01 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
12-1351 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
12-1351 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
12-1351 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.
Fri Jun 01 00:00:00 EDT 2018
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Nature medicine
Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G
12-1351 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.
Tue May 01 00:00:00 EDT 2018
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
12-1351-82 was used in Functional assay to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.
Immunity
Evrard M,Kwok IWH,Chong SZ,Teng KWW,Becht E,Chen J,Sieow JL,Penny HL,Ching GC,Devi S,Adrover JM,Li JLY,Liong KH,Tan L,Poon Z,Foo S,Chua JW,Su IH,Balabanian K,Bachelerie F,Biswas SK,Larbi A,Hwang WYK,Madan V,Koeffler HP,Wong SC,Newell EW,Hidalgo A,Ginhoux F,Ng LG
12-1351 was used in Flow cytometry/Cell sorting to identifies specialised bone marrow granulocytic populations that ensure supply under homeostasis and stress responses.
Tue Feb 20 00:00:00 EST 2018
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.
Nature genetics
Gozdecka M,Meduri E,Mazan M,Tzelepis K,Dudek M,Knights AJ,Pardo M,Yu L,Choudhary JS,Metzakopian E,Iyer V,Yun H,Park N,Varela I,Bautista R,Collord G,Dovey O,Garyfallos DA,De Braekeleer E,Kondo S,Cooper J,Göttgens B,Bullinger L,Northcott PA,Adams D,Vassiliou GS,Huntly BJP
12-1351 was used in Flow cytometry/Cell sorting to demonstrate concomitant loss/mutation of KDM6A (UTX) and UTY in multiple human cancers.
Fri Jun 01 00:00:00 EDT 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
12-1351 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.
Frontiers in immunology
Sun L,Rautela J,Delconte RB,Souza-Fonseca-Guimaraes F,Carrington EM,Schenk RL,Herold MJ,Huntington ND,Lew AM,Xu Y,Zhan Y
12-1351 was used in Flow cytometry/Cell sorting to study whether the dosage of GM-CSF regulates the development of three types of myeloid cells from cultured bone marrow cells.
Fri Sep 20 00:00:00 EDT 2019
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
Fri Jun 22 00:00:00 EDT 2018
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
12-1351 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that the effects of cytokines regulating haematopoietic stem cell functions are dependent on the producing cell sources.
Wed Mar 01 00:00:00 EST 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-1351-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice.
Haematologica
Cañete A,Carmona R,Ariza L,Sánchez MJ,Rojas A,Muñoz-Chápuli R
12135182 was used in flow cytometry to utilize a G2-Gata4Cre;R26REYFP mouse line to track the developmental fate of the G2-Gata4 cell lineage
Sat Apr 01 00:00:00 EDT 2017
Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment.
International journal of molecular sciences
Mooney CJ,Cunningham A,Tsapogas P,Toellner KM,Brown G
12-1351 was used in Flow cytometry/Cell sorting to investigate the functional heterogeneity of hematopoietic stem and progenitor cell populations.
Fri May 12 00:00:00 EDT 2017
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Cell
Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K
12-1351 was used in Flow cytometry/Cell sorting to suggest that HSCs accumulate discrete memory stages over their divisional history and identify cellular memory in HSC aging.
Thu Nov 17 00:00:00 EST 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
12-1351 was used in Flow cytometry/Cell sorting to investigate how PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Sun May 15 00:00:00 EDT 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
12-1351 was used in Flow cytometry/Cell sorting to reveal a role for Tsc1-dependent inhibition of mTORC1 activation during immature NK cell development.
Wed Sep 07 00:00:00 EDT 2016
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Blood
Hu W,Dooley J,Chung SS,Chandramohan D,Cimmino L,Mukherjee S,Mason CE,de Strooper B,Liston A,Park CY
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that miR-29a is critical for maintaining HSC function through its negative regulation of Dnmt3a.
Thu Apr 02 00:00:00 EDT 2015
Index sorting resolves heterogeneous murine hematopoietic stem cell populations.
Experimental hematology
Schulte R,Wilson NK,Prick JC,Cossetti C,Maj MK,Gottgens B,Kent DG
12-1351 was used in Flow cytometry/Cell sorting to indicate that when used in combination with single-cell functional assays, index sorting is a powerful tool for refining cell isolation strategies.
Tue Sep 01 00:00:00 EDT 2015
EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.
PloS one
Charmsaz S,Beckett K,Smith FM,Bruedigam C,Moore AS,Al-Ejeh F,Lane SW,Boyd AW
12-1351 was used in Flow cytometry/Cell sorting to explore the role of EphA2 in haematopoiesis and leukaemogenesis.
Tue May 03 00:00:00 EDT 2016
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
12-1351 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
12-1351 was used in Flow cytometry/Cell sorting to assess the potential of antisense splice-correcting oligonucleotides targeting mutated Bruton's tyrosine kinase transcripts for treating X-linked agammaglobulinemia.
Mon Sep 01 00:00:00 EDT 2014
Smurf2 regulates hematopoietic stem cell self-renewal and aging.
Aging cell
Ramkumar C,Kong Y,Trabucco SE,Gerstein RM,Zhang H
12-1351 was used in Flow cytometry/Cell sorting to suggest that Smurf2 plays an important role in regulating HSC self-renewal and ageing.
Sun Jun 01 00:00:00 EDT 2014
Discriminating cellular heterogeneity using microwell-based RNA cytometry.
Nature communications
Dimov IK,Lu R,Lee EP,Seita J,Sahoo D,Park SM,Weissman IL,Lee LP
12-1351 was used in Flow cytometry/Cell sorting to develop a two-stage system to determine cellular heterogeneity.
Tue Mar 25 00:00:00 EDT 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
12-1351 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
12-1351 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
The Journal of experimental medicine
Tesio M,Oser GM,Baccelli I,Blanco-Bose W,Wu H,Göthert JR,Kogan SC,Trumpp A
12-1351 was used in Flow cytometry/Cell sorting to investigate the effect of PTEN deletion in bone marrow, showing that it leads to G-CSF-mediated hematopoietic stem cell mobilisation.
Mon Oct 21 00:00:00 EDT 2013
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
12-1351 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.
Fri Nov 01 00:00:00 EDT 2013
Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.
Journal of immunology (Baltimore, Md. : 1950)
Zook EC,Zhang S,Gerstein RM,Witte PL,Le PT
12-1351 was used in Flow cytometry/Cell sorting to report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg.
Sun Dec 01 00:00:00 EST 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
12-1351 was used in Flow cytometry/Cell sorting to demonstrate the broad effects that the Kit(W-sh) mutation has on key steps in myelopoiesis.
Sat Jun 01 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
12-1351 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
12-1351 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.
Blood
Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F
12-1351 was used in Flow cytometry/Cell sorting to investigate how variation in Pax5 expression influences hematopoietic development, showing that biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5 could be targets for BAL.
Thu Nov 01 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
12-1351 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.
Thu May 10 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
12-1351 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
12-1351 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
Proceedings of the National Academy of Sciences of the United States of America
Purtha WE,Swiecki M,Colonna M,Diamond MS,Bhattacharya D
12-1351 was used in Flow cytometry/Cell sorting to study the functional role of interferon regulatory factor-5 in human autoimmune disease pathogenesis.
Tue Apr 10 00:00:00 EDT 2012
The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
Journal of immunology (Baltimore, Md. : 1950)
Sudo T,Yokota T,Oritani K,Satoh Y,Sugiyama T,Ishida T,Shibayama H,Ezoe S,Fujita N,Tanaka H,Maeda T,Nagasawa T,Kanakura Y
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that the intensity of ESAM expression is useful to trace activated HSCs.
Sun Jul 01 00:00:00 EDT 2012
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.
PloS one
Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C
12-1351 was used in Flow cytometry/Cell sorting to establish a functional role for non-canonical Wnt signalling in hematopoiesis through a pathway involving Wnt4, Fz6, Rac1 and Jnk kinases.
Tue Apr 26 00:00:00 EDT 2011
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
12-1351 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
12-1351 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP-Chip.
Biological procedures online
Weishaupt H,Attema JL
12-1351 was used in Flow cytometry/Cell sorting to document the genome-wide chromatin states of low abundant populations that comprise hematopoietic stem cells.
Sat May 15 00:00:00 EDT 2010
Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.
The Journal of biological chemistry
Åhsberg J,Tsapogas P,Qian H,Zetterblad J,Zandi S,Månsson R,Jönsson JI,Sigvardsson M
12-1351 was used in Flow cytometry/Cell sorting to suggest that although Il-7 induced Stat-5 phosphorylation, Flt-3L caused activation of the ERK and AKT signaling pathways.
Fri Nov 19 00:00:00 EST 2010
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.
Blood
Levi BP,Yilmaz OH,Duester G,Morrison SJ
12-1351 was used in Flow cytometry/Cell sorting to demonstrate Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice.
Thu Feb 19 00:00:00 EST 2009
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.
The Journal of experimental medicine
Chorro L,Sarde A,Li M,Woollard KJ,Chambon P,Malissen B,Kissenpfennig A,Barbaroux JB,Groves R,Geissmann F
12-1351 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in Langerhans cell development and homeostasis.
Mon Dec 21 00:00:00 EST 2009
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
The Journal of experimental medicine
Auffray C,Fogg DK,Narni-Mancinelli E,Senechal B,Trouillet C,Saederup N,Leemput J,Bigot K,Campisi L,Abitbol M,Molina T,Charo I,Hume DA,Cumano A,Lauvau G,Geissmann F
12-1351 was used in Flow cytometry/Cell sorting to show that macrophage/DC precursors give rise to conventional DCs,.
Mon Mar 16 00:00:00 EDT 2009
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
12-1351 was used in Flow cytometry/Cell sorting to provide insight as to how HSC replacement can occur despite the residence of endogenous HSCs in niches.
Mon Nov 23 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
12-1351 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
12-1351 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.
Fri Aug 01 00:00:00 EDT 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
12-1351 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.
Sat Nov 01 00:00:00 EDT 2008
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3.
Nature immunology
Taghon T,Yui MA,Rothenberg EV
12-1351 was used in Flow cytometry/Cell sorting to assess both Notch-dependent and Notch-independent roles of GATA-3 in monolayer culture systems with OP9 stromal cells.
Wed Aug 01 00:00:00 EDT 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-1351-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
T/B lineage choice occurs prior to intrathymic Notch signaling.
Blood
Harman BC,Jenkinson WE,Parnell SM,Rossi SW,Jenkinson EJ,Anderson G
12-1351 was used in Flow cytometry/Cell sorting to analyse the T-cell/B-cell lineage potential of precursors that have been recruited to the foetal mouse thymus, showing that lineage choice occurs prior to intrathymic Notch signaling.
Mon Aug 01 00:00:00 EDT 2005
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
Blood
Lawrence HJ,Christensen J,Fong S,Hu YL,Weissman I,Sauvageau G,Humphries RK,Largman C
12-1351 was used in Flow cytometry/Cell sorting to suggest that Hoxa-9 is specifically required for normal hematopoietic stem cell function both in vitro and in vivo.
Thu Dec 01 00:00:00 EST 2005
