Product References
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression.
International journal of molecular sciences
Li N,Wang Y,Wang A,Zhang J,Jia C,Yu C,Song Z,Wang S,Liu L,Yi J,Bao Y,Huang Y,Sun L
Published figure using CD135 (Flt3) monoclonal antibody (Product # 13-1351-82) in Flow Cytometry
Fri Feb 03 00:00:00 EST 2023
Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.
Cancer discovery
Wu HC,Rérolle D,Berthier C,Hleihel R,Sakamoto T,Quentin S,Benhenda S,Morganti C,Wu C,Conte L,Rimsky S,Sebert M,Clappier E,Souquere S,Gachet S,Soulier J,Durand S,Trowbridge JJ,Bénit P,Rustin P,El Hajj H,Raffoux E,Ades L,Itzykson R,Dombret H,Fenaux P,Espeli O,Kroemer G,Brunetti L,Mak TW,Lallemand-Breitenbach V,Bazarbachi A,Falini B,Ito K,Martelli MP,de Thé H
13-1351-82 was used in Flow Cytometry to demonstrate that an oncogenic mutant form of NPM1 impairs mitochondrial function in acute myeloid leukaemia.
Wed Dec 01 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
13-1351-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
13-1351-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to uncover a mechanism that controls myeloid regeneration and early lineage decisions in HSCs and could be targeted in LSCs to normalize leukemic myeloid cell production.
Mon Mar 02 00:00:00 EST 2020
Zinc finger and BTB domain-containing protein 46 is essential for survival and proliferation of acute myeloid leukemia cell line but dispensable for normal hematopoiesis.
Chinese medical journal
Liu YY,Xiao FF,Yang BJ,Li X,Xu SN,Chen ZW,Li P,Huang YX,Fu XM,Huang XQ,Zheng GL,Chen JP,Hou Y
Published figure using CD135 (Flt3) monoclonal antibody (Product # 13-1351-82) in Flow Cytometry
Mon Jul 20 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
13-1351 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.
Thu Sep 17 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
13-1351 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.
Thu Sep 17 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD135 (Flt3) monoclonal antibody (Product # 13-1351-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using CD135 (Flt3) monoclonal antibody (Product # 13-1351-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
13-1351-82 was used in Flow Cytometry to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.
Proceedings of the National Academy of Sciences of the United States of America
Fujita K,Chakarov S,Kobayashi T,Sakamoto K,Voisin B,Duan K,Nakagawa T,Horiuchi K,Amagai M,Ginhoux F,Nagao K
13-1351-82 was used in Flow Cytometry to reveal cDC2s as FLT3L sources and highlight a cell-autonomous mechanism that may enhance FLT3L accessibility for cDC2 development and survival.
Tue Jul 16 00:00:00 EDT 2019
Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.
Experimental hematology
Malouf C,Ottersbach K
13-1351-82 was used in Flow Cytometry to assess if the cell-of-origin of t(4;11) MLL-AF4 acute leukemia is sensitive to a viral or bacterial mimic and if maternal immune activation can lead to a full-blown leukemia.
Thu Aug 01 00:00:00 EDT 2019
Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps.
Journal of visualized experiments : JoVE
Morganti C,Bonora M,Ito K
Published figure using CD135 (Flt3) monoclonal antibody (Product # 13-1351-82) in Flow Cytometry
Tue Jul 30 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
13-1351-82 was used in Flow Cytometry to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Nature medicine
Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G
13-1351 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.
Tue May 01 00:00:00 EDT 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
13-1351 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.
Cell
Isoda T,Moore AJ,He Z,Chandra V,Aida M,Denholtz M,Piet van Hamburg J,Fisch KM,Chang AN,Fahl SP,Wiest DL,Murre C
13-1351-82 was used in T-Cell Activation to study the repositioning of the Bcl11b enhancer to dictate the fate of developing T cells.
Thu Sep 21 00:00:00 EDT 2017
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Immunity
Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S
Tue May 16 00:00:00 EDT 2017
Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function.
PloS one
Halvarsson C,Eliasson P,Jönsson JI
13-1351 was used in Flow cytometry/Cell sorting to determine the role of PDK1 in hematopoiesis and the engraftment of HSCs and multipotent progenitors during transplantation.
Thu Sep 07 00:00:00 EDT 2017
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Nature biotechnology
Palchaudhuri R,Saez B,Hoggatt J,Schajnovitz A,Sykes DB,Tate TA,Czechowicz A,Kfoury Y,Ruchika F,Rossi DJ,Verdine GL,Mansour MK,Scadden DT
13-1351 was used in Flow cytometry/Cell sorting to show that CD45-SAP efficiently conditions immunocompetent mice for autologous HSCT in a way that minimises toxicity and promotes rapid immunological recovery.
Fri Jul 01 00:00:00 EDT 2016
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Cell
Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K
13-1351 was used in Flow cytometry/Cell sorting to suggest that HSCs accumulate discrete memory stages over their divisional history and identify cellular memory in HSC aging.
Thu Nov 17 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.
Cancer science
Naka K,Ishihara K,Jomen Y,Jin CH,Kim DH,Gu YK,Jeong ES,Li S,Krause DS,Kim DW,Bae E,Takihara Y,Hirao A,Oshima H,Oshima M,Ooshima A,Sheen YY,Kim SJ,Kim DK
13-1351 was used in Flow cytometry/Cell sorting to indicate that EW-7197 may be a promising candidate for a new combination therapeutic that can greatly benefit CML patients.
Mon Feb 01 00:00:00 EST 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
13-1351 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Jomen Y,Ishihara K,Kim J,Ishimoto T,Bae EJ,Mohney RP,Stirdivant SM,Oshima H,Oshima M,Kim DW,Nakauchi H,Takihara Y,Kato Y,Ooshima A,Kim SJ
13-1351 was used in Flow cytometry/Cell sorting to investigate how survival signalling is regulated in chronic myelogenous leukaemia stem cells, showing that dipeptide species regulate p38MAPK-Smad3 signalling to maintain stem cells.
Thu Aug 20 00:00:00 EDT 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
13-1351 was used in Flow cytometry/Cell sorting to determine that haematopoietic progenitors are particularly sensitive to replication stress.
Mon Oct 12 00:00:00 EDT 2015
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Nature
Flach J,Bakker ST,Mohrin M,Conroy PC,Pietras EM,Reynaud D,Alvarez S,Diolaiti ME,Ugarte F,Forsberg EC,Le Beau MM,Stohr BA,Méndez J,Morrison CG,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to study functional decline in ageing haematopoietic stem cells due to replicative stress.
Thu Aug 14 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
13-1351 was used in Flow cytometry/Cell sorting to show how FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Thu Feb 21 00:00:00 EST 2013
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
13-1351 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 EST 2013
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.
The Journal of clinical investigation
Charles JF,Hsu LY,Niemi EC,Weiss A,Aliprantis AO,Nakamura MC
13-1351 was used in Flow cytometry/Cell sorting to identify a CD11b(-/lo)Ly6C(hi) bone marrow population with osteoclast precursor activity.
Sat Dec 01 00:00:00 EST 2012
The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.
European journal of immunology
Luche H,Ardouin L,Teo P,See P,Henri S,Merad M,Ginhoux F,Malissen B
13-1351 was used in Flow cytometry/Cell sorting to provide evidence that myeloid-restricted progenitors generate the whole constellation of DCs present in the body, including the thymus.
Mon Aug 01 00:00:00 EDT 2011
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.
Molecular and cellular biology
Chan WI,Hannah RL,Dawson MA,Pridans C,Foster D,Joshi A,Göttgens B,Van Deursen JM,Huntly BJ
13-1351 was used in Flow cytometry/Cell sorting to investigate the role of Cbp in adult HSC maintenance, and the cellular and molecular mechanisms underlying its function.
Thu Dec 01 00:00:00 EST 2011
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
13-1351 was used in Flow cytometry/Cell sorting to provide insight as to how HSC replacement can occur despite the residence of endogenous HSCs in niches.
Mon Nov 23 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
13-1351 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity
Nagai Y,Garrett KP,Ohta S,Bahrun U,Kouro T,Akira S,Takatsu K,Kincade PW
13-1351 was used in Flow cytometry/Cell sorting to investigate the expression of toll-like receptors on different hematopoietic stem cells and the mechanism by which they stimulate innate immune system replenishment.
Thu Jun 01 00:00:00 EDT 2006
