Product References
Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells.
iScience
Qin G,Park ES,Chen X,Han S,Xiang D,Ren F,Liu G,Chen H,Yuan GC,Li Z
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Jan 20 00:00:00 EST 2023
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
Nature communications
Athanasouli P,Balli M,De Jaime-Soguero A,Boel A,Papanikolaou S,van der Veer BK,Janiszewski A,Vanhessche T,Francis A,El Laithy Y,Nigro AL,Aulicino F,Koh KP,Pasque V,Cosma MP,Verfaillie C,Zwijsen A,Heindryckx B,Nikolaou C,Lluis F
12-1401-81 was used in Flow cytometry/Cell sorting to demonstrate that transcriptional repression exerted by Wnt/TCF7L1 promotes PE differentiation of mESCs and in preimplantation inner cell mass.
Fri Mar 03 00:00:00 EST 2023
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
Nature communications
Athanasouli P,Balli M,De Jaime-Soguero A,Boel A,Papanikolaou S,van der Veer BK,Janiszewski A,Vanhessche T,Francis A,El Laithy Y,Nigro AL,Aulicino F,Koh KP,Pasque V,Cosma MP,Verfaillie C,Zwijsen A,Heindryckx B,Nikolaou C,Lluis F
12-1401-81 was used in Flow cytometry/Cell sorting to demonstrate that transcriptional repression exerted by Wnt/TCF7L1 promotes PE differentiation of mESCs and in preimplantation inner cell mass.
Fri Mar 03 00:00:00 EST 2023
Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells.
JCI insight
Dada LA,Welch LC,Magnani ND,Ren Z,Han H,Brazee PL,Celli D,Flozak AS,Weng A,Herrerias MM,Kryvenko V,Vadász I,Runyan CE,Abdala-Valencia H,Shigemura M,Casalino-Matsuda SM,Misharin AV,Budinger GRS,Gottardi CJ,Sznajder JI
12-1401-81 was used in Flow cytometry/Cell sorting to show that constitutive activation of β-catenin signaling in AT2 cells or treatment of organoid cultures with recombinant WNT3A protein bypasses the inhibitory effects of hypercapnia. Inhibition of AT2 proliferation in hypercapnic patients may contribute to impaired lung repair after injury, preventing sealing of the epithelial barrier, increasing lung flooding, ventilator dependency and mortality..
Wed Feb 22 00:00:00 EST 2023
Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears.
Cell death discovery
Lin X,Wang P,Wang W,Zhou H,Zhu S,Feng S,Chen Y,Zhou H,Wang Q,Xin H,Shao X,Wang J
12-1401-81 was used in Flow cytometry/Cell sorting to demonstrate that suppressed Akt/GSK-3β/β-catenin signaling increased PPARγ expression and thus contributed to excessive adipogenesis in RCT-FAPs.
Fri Aug 25 00:00:00 EDT 2023
Identification of astrocyte regulators by nucleic acid cytometry.
Nature
Clark IC,Wheeler MA,Lee HG,Li Z,Sanmarco LM,Thaploo S,Polonio CM,Shin SW,Scalisi G,Henry AR,Rone JM,Giovannoni F,Charabati M,Akl CF,Aleman DM,Zandee SEJ,Prat A,Douek DC,Boritz EA,Quintana FJ,Abate AR
12-1401-81 was used in Flow cytometry/Cell sorting to develop focused interrogation of cells by nucleic acid detection and sequencing (FIND-seq), a high-throughput microfluidic cytometry method that combines encapsulation of cells in droplets, PCR-based detection of target nucleic acids and droplet sorting to enable in-depth transcriptomic analyses of cells of interest at single-cell resolution.
Wed Feb 01 00:00:00 EST 2023
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.
Cell reports
Cossec JC,Traboulsi T,Sart S,Loe-Mie Y,Guthmann M,Hendriks IA,Theurillat I,Nielsen ML,Torres-Padilla ME,Baroud CN,Dejean A
12-1401-81 was used in Flow cytometry/Cell sorting to show that mouse embryonic stem cells (ESCs) solely exposed to chemical inhibition of SUMOylation generate embryo-like structures comprising anterior neural and trunk-associated regions.
Tue Apr 25 00:00:00 EDT 2023
An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model.
JCI insight
Potluri T,Taylor MJ,Stulberg JJ,Lieber RL,Zhao H,Bulun SE
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2022
Hematopoietic-Mesenchymal Signals Regulate the Properties of Mesenchymal Stem Cells.
International journal of molecular sciences
Kanazawa S,Okada H,Riu D,Mabuchi Y,Akazawa C,Iwata J,Hoshi K,Hikita A
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Jul 26 00:00:00 EDT 2022
PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis.
Nature communications
Geng Y,Li L,Yan J,Liu K,Yang A,Zhang L,Shen Y,Gao H,Wu X,Noth I,Huang Y,Liu J,Fan X
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Sat Nov 19 00:00:00 EST 2022
PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis.
Nature communications
Geng Y,Li L,Yan J,Liu K,Yang A,Zhang L,Shen Y,Gao H,Wu X,Noth I,Huang Y,Liu J,Fan X
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Sat Nov 19 00:00:00 EST 2022
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function.
Nature communications
Wang Y,Elsherbiny A,Kessler L,Cordero J,Shi H,Serke H,Lityagina O,Trogisch FA,Mohammadi MM,El-Battrawy I,Backs J,Wieland T,Heineke J,Dobreva G
12-1401-81 was used in Flow cytometry/Cell sorting to show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis.
Fri Nov 04 00:00:00 EDT 2022
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function.
Nature communications
Wang Y,Elsherbiny A,Kessler L,Cordero J,Shi H,Serke H,Lityagina O,Trogisch FA,Mohammadi MM,El-Battrawy I,Backs J,Wieland T,Heineke J,Dobreva G
12-1401-81 was used in Flow cytometry/Cell sorting to show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis.
Fri Nov 04 00:00:00 EDT 2022
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
Nature
Sanmarco LM,Wheeler MA,Gutiérrez-Vázquez C,Polonio CM,Linnerbauer M,Pinho-Ribeiro FA,Li Z,Giovannoni F,Batterman KV,Scalisi G,Zandee SEJ,Heck ES,Alsuwailm M,Rosene DL,Becher B,Chiu IM,Prat A,Quintana FJ
12-1401-81 was used in Flow Cytometry to show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
Mon Feb 01 00:00:00 EST 2021
In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues.
Stem cells (Dayton, Ohio)
Hussain A,Deleuze V,El Kebriti L,Turali H,Pirot N,Glasson Y,Mathieu D,Pinet V
12-1401 was used in Flow cytometry/Cell sorting to highlight the major structural role of the adipose tissue vascular niche in coordinating stem cell self-renewal and differentiation into adipocytes.
Fri Jan 01 00:00:00 EST 2021
IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis.
JCI insight
He H,Snowball J,Sun F,Na CL,Whitsett JA
12-1401-81 was used in Flow cytometry/Cell sorting to demonstrate that IGF1 receptor gene (Igf1r) expression by a subset of pulmonary fibroblasts is required for normal alveologenesis in mice.
Mon Mar 22 00:00:00 EDT 2021
IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis.
JCI insight
He H,Snowball J,Sun F,Na CL,Whitsett JA
12-1401-81 was used in Flow cytometry/Cell sorting to demonstrate that IGF1 receptor gene (Igf1r) expression by a subset of pulmonary fibroblasts is required for normal alveologenesis in mice.
Mon Mar 22 00:00:00 EDT 2021
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Nature communications
Nishina T,Deguchi Y,Ohshima D,Takeda W,Ohtsuka M,Shichino S,Ueha S,Yamazaki S,Kawauchi M,Nakamura E,Nishiyama C,Kojima Y,Adachi-Akahane S,Hasegawa M,Nakayama M,Oshima M,Yagita H,Shibuya K,Mikami T,Inohara N,Matsushima K,Tada N,Nakano H
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Apr 16 00:00:00 EDT 2021
Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype.
Cell reports
Ma S,McGuire MH,Mangala LS,Lee S,Stur E,Hu W,Bayraktar E,Villar-Prados A,Ivan C,Wu SY,Yokoi A,Dasari SK,Jennings NB,Liu J,Lopez-Berestein G,Ram P,Sood AK
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Feb 09 00:00:00 EST 2021
Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype.
Cell reports
Ma S,McGuire MH,Mangala LS,Lee S,Stur E,Hu W,Bayraktar E,Villar-Prados A,Ivan C,Wu SY,Yokoi A,Dasari SK,Jennings NB,Liu J,Lopez-Berestein G,Ram P,Sood AK
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Feb 09 00:00:00 EST 2021
Extracellular vesicles synchronize cellular phenotypes of differentiating cells.
Journal of extracellular vesicles
Minakawa T,Matoba T,Ishidate F,Fujiwara TK,Takehana S,Tabata Y,Yamashita JK
12-1401-81 was used in Flow cytometry and Immunocytochemistry to perform a co-culture of Control-ESCs and PKA-ESCs.
Wed Sep 01 00:00:00 EDT 2021
Extracellular vesicles synchronize cellular phenotypes of differentiating cells.
Journal of extracellular vesicles
Minakawa T,Matoba T,Ishidate F,Fujiwara TK,Takehana S,Tabata Y,Yamashita JK
12-1401-81 was used in Flow cytometry and Immunocytochemistry to perform a co-culture of Control-ESCs and PKA-ESCs.
Wed Sep 01 00:00:00 EDT 2021
Extracellular vesicles synchronize cellular phenotypes of differentiating cells.
Journal of extracellular vesicles
Minakawa T,Matoba T,Ishidate F,Fujiwara TK,Takehana S,Tabata Y,Yamashita JK
12-1401-81 was used in Flow cytometry and Immunocytochemistry to perform a co-culture of Control-ESCs and PKA-ESCs.
Wed Sep 01 00:00:00 EDT 2021
Mesothelial cells are not a source of adipocytes in mice.
Cell reports
Westcott GP,Emont MP,Li J,Jacobs C,Tsai L,Rosen ED
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Jul 13 00:00:00 EDT 2021
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis.
Nature communications
Jarmas AE,Brunskill EW,Chaturvedi P,Salomonis N,Kopan R
12-1401-81 was used in Miscellaneous to investigate the precise signaling mechanisms that drive the coordinated exit of nephron progenitor cells from all nephrogenic niches at the time of cessation of nephrogenesis.
Wed Nov 03 00:00:00 EDT 2021
MAFG-driven astrocytes promote CNS inflammation.
Nature
Wheeler MA,Clark IC,Tjon EC,Li Z,Zandee SEJ,Couturier CP,Watson BR,Scalisi G,Alkwai S,Rothhammer V,Rotem A,Heyman JA,Thaploo S,Sanmarco LM,Ragoussis J,Weitz DA,Petrecca K,Moffitt JR,Becher B,Antel JP,Prat A,Quintana FJ
12-1401-81 was used in Flow Cytometry to identify candidate therapeutic targets in multiple sclerosis.
Sat Feb 01 00:00:00 EST 2020
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
Cell stem cell
McCarthy N,Manieri E,Storm EE,Saadatpour A,Luoma AM,Kapoor VN,Madha S,Gaynor LT,Cox C,Keerthivasan S,Wucherpfennig K,Yuan GC,de Sauvage FJ,Turley SJ,Shivdasani RA
12-1401 was used in Flow cytometry/Cell sorting to identify three distinct PDGFRA+ mesenchymal cell types.
Thu Mar 05 00:00:00 EST 2020
Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.
The Journal of clinical investigation
Li R,Li X,Hagood J,Zhu MS,Sun X
12-1401 was used in Flow cytometry/Cell sorting to show that inactivation of myosin light chain kinase (MLCK), a key factor required for myofibroblast contraction, disrupted septa formation, supporting the myofibroblast contraction model of alveologenesis.
Mon Jun 01 00:00:00 EDT 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Jan 07 00:00:00 EST 2020
Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner.
Cell reports
Santini MP,Malide D,Hoffman G,Pandey G,D'Escamard V,Nomura-Kitabayashi A,Rovira I,Kataoka H,Ochando J,Harvey RP,Finkel T,Kovacic JC
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis.
JCI insight
Redente EF,Chakraborty S,Sajuthi S,Black BP,Edelman BL,Seibold MA,Riches DW
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Nature communications
Wang S,Cao S,Arhatte M,Li D,Shi Y,Kurz S,Hu J,Wang L,Shao J,Atzberger A,Wang Z,Wang C,Zang W,Fleming I,Wettschureck N,Honoré E,Offermanns S
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
Bim expression modulates the pro-inflammatory phenotype of retinal astroglial cells.
PloS one
Falero-Perez J,Sheibani N,Sorenson CM
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Jul 31 00:00:00 EDT 2020
Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age.
JCI insight
Wu R,Ma F,Tosevska A,Farrell C,Pellegrini M,Deb A
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Thu Dec 17 00:00:00 EST 2020
Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.
Cell & bioscience
Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Nestin-GFP transgene labels skeletal progenitors in the periosteum.
Bone
Tournaire G,Stegen S,Giacomini G,Stockmans I,Moermans K,Carmeliet G,van Gastel N
12-1401-81 was used in Flow Cytometry to show that in adult mice, Nes-GFP cells are present in the periosteum and localize closely to blood vessels, but periosteal Nes-GFP cells express SSC and progenitor markers differently compared to Nes-GFP cells in the bone marrow.
Wed Apr 01 00:00:00 EDT 2020
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Cell
Chao CC,Gutiérrez-Vázquez C,Rothhammer V,Mayo L,Wheeler MA,Tjon EC,Zandee SEJ,Blain M,de Lima KA,Takenaka MC,Avila-Pacheco J,Hewson P,Liu L,Sanmarco LM,Borucki DM,Lipof GZ,Trauger SA,Clish CB,Antel JP,Prat A,Quintana FJ
12-1401-81 was used in Flow Cytometry to define a novel immunometabolic mechanism that drives pro-inflammatory astrocyte activities.
Thu Dec 12 00:00:00 EST 2019
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment.
PLoS pathogens
Naipauer J,Rosario S,Gupta S,Premer C,Méndez-Solís O,Schlesinger M,Ponzinibbio V,Jain V,Gay L,Renne R,Chan HL,Morey L,Salyakina D,Abba M,Williams S,Hare JM,Goldschmidt-Clermont PJ,Mesri EA
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Garcia-Agudo LF,Janova H,Sendler LE,Arinrad S,Steixner AA,Hassouna I,Balmuth E,Ronnenberg A,Schopf N,van der Flier FJ,Begemann M,Martens H,Weber MS,Boretius S,Nave KA,Ehrenreich H
12-1401 was used in Flow cytometry/Cell sorting to conclude that even though microglia depletion is temporarily beneficial and worth pursuing, complementary treatment strategies are needed for full and lasting recovery.
Mon Jul 01 00:00:00 EDT 2019
Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes.
The Journal of biological chemistry
Huang X,Feng T,Jiang Z,Meng J,Kou S,Lu Z,Chen W,Lin CP,Zhou B,Zhang H
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri May 31 00:00:00 EDT 2019
Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.
International journal of molecular sciences
Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Mar 05 00:00:00 EST 2019
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
12-1401-81 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.
Thu Sep 26 00:00:00 EDT 2019
Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity.
eLife
Alexander JM,Guan J,Li B,Maliskova L,Song M,Shen Y,Huang B,Lomvardas S,Weiner OD
12-1401-81 was used in Flow Cytometry to visualize the spatial organization and transcriptional output of the key pluripotency regulator Sox2 and its essential enhancer Sox2 Control Region (SCR) in living embryonic stem cells (ESCs).
Fri May 24 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.
Nature medicine
Roswall P,Bocci M,Bartoschek M,Li H,Kristiansen G,Jansson S,Lehn S,Sjölund J,Reid S,Larsson C,Eriksson P,Anderberg C,Cortez E,Saal LH,Orsmark-Pietras C,Cordero E,Haller BK,Häkkinen J,Burvenich IJG,Lim E,Orimo A,Höglund M,Rydén L,Moch H,Scott AM,Eriksson U,Pietras K
12-1401 was used in Immunohistochemistry-immunofluorescence to study the role of cancer-associated fibroblasts as determinants of the molecular subtype of breast cancer.
Tue May 01 00:00:00 EDT 2018
Early lineage segregation of multipotent embryonic mammary gland progenitors.
Nature cell biology
Wuidart A,Sifrim A,Fioramonti M,Matsumura S,Brisebarre A,Brown D,Centonze A,Dannau A,Dubois C,Van Keymeulen A,Voet T,Blanpain C
12-1401 was used in Flow cytometry/Cell sorting to study the timing and mechanisms mediating early lineage segregation of multipotent progenitors during mammary gland development.
Fri Jun 01 00:00:00 EDT 2018
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer.
The Journal of experimental medicine
Raz Y,Cohen N,Shani O,Bell RE,Novitskiy SV,Abramovitz L,Levy C,Milyavsky M,Leider-Trejo L,Moses HL,Grisaru D,Erez N
12-1401-81 was used in Flow Cytometry to conclude that PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics.
Mon Dec 03 00:00:00 EST 2018
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Nature communications
Chagraoui H,Kristiansen MS,Ruiz JP,Serra-Barros A,Richter J,Hall-Ponselé E,Gray N,Waithe D,Clark K,Hublitz P,Repapi E,Otto G,Sopp P,Taylor S,Thongjuea S,Vyas P,Porcher C
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Dec 18 00:00:00 EST 2018
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.
Stem cell reports
Yoon C,Song H,Yin T,Bausch-Fluck D,Frei AP,Kattman S,Dubois N,Witty AD,Hewel JA,Guo H,Emili A,Wollscheid B,Keller G,Zandstra PW
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Jan 09 00:00:00 EST 2018
Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response.
eLife
Li R,Bernau K,Sandbo N,Gu J,Preissl S,Sun X
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Sep 04 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Dec 11 00:00:00 EST 2018
PPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle Regeneration.
International journal of molecular sciences
Dammone G,Karaz S,Lukjanenko L,Winkler C,Sizzano F,Jacot G,Migliavacca E,Palini A,Desvergne B,Gilardi F,Feige JN
12-1401 was used in Flow cytometry/Cell sorting to study muscle regeneration and tissue-resident muscle stem cell function in whole body Pparg null mice generated by epiblast-specific Cre/lox deletion (PpargΔ/Δ).
Fri Jul 13 00:00:00 EDT 2018
Pulmonary pericytes regulate lung morphogenesis.
Nature communications
Kato K,Diéguez-Hurtado R,Park DY,Hong SP,Kato-Azuma S,Adams S,Stehling M,Trappmann B,Wrana JL,Koh GY,Adams RH
12-1401-81 was used in Flow Cytometry to establish that pericytes coordinate the behavior of epithelial and vascular cells during lung morphogenesis.
Fri Jun 22 00:00:00 EDT 2018
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
12-1401 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion.
The Journal of investigative dermatology
Donovan P,Dubey OA,Kallioinen S,Rogers KW,Muehlethaler K,Müller P,Rimoldi D,Constam DB
12-1401 was used in Immunocytochemistry to test whether a potential tumorigenic role for Activin signaling in melanoma may be curtailed in xenografts by the absence of a functional immune system.
Fri Dec 01 00:00:00 EST 2017
p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.
Disease models & mechanisms
Bosnakovski D,Gearhart MD,Toso EA,Recht OO,Cucak A,Jain AK,Barton MC,Kyba M
12-1401 was used in Flow cytometry/Cell sorting to study p53 dependence of DUX4 in models of facioscapulohumeral muscular dystrophy.
Sun Oct 01 00:00:00 EDT 2017
Gli1 identifies osteogenic progenitors for bone formation and fracture repair.
Nature communications
Shi Y,He G,Lee WC,McKenzie JA,Silva MJ,Long F
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Mon Dec 11 00:00:00 EST 2017
Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm.
Nature cell biology
Anderson KGV,Hamilton WB,Roske FV,Azad A,Knudsen TE,Canham MA,Forrester LM,Brickman JM
12-1401-81 was used in Flow cytometry/Cell sorting to study the effects of insulin on endoderm differentiation and the self-renewal in pluripotent cells.
Sun Oct 01 00:00:00 EDT 2017
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.
Nature medicine
Lukjanenko L,Jung MJ,Hegde N,Perruisseau-Carrier C,Migliavacca E,Rozo M,Karaz S,Jacot G,Schmidt M,Li L,Metairon S,Raymond F,Lee U,Sizzano F,Wilson DH,Dumont NA,Palini A,Fässler R,Steiner P,Descombes P,Rudnicki MA,Fan CM,von Maltzahn J,Feige JN,Bentzinger CF
12140181 was used in flow cytometry to show that the loss of stem cell adhesion to fibronectin is a mechanism of aging
Mon Aug 01 00:00:00 EDT 2016
Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene.
Circulation research
Lombardi R,Chen SN,Ruggiero A,Gurha P,Czernuszewicz GZ,Willerson JT,Marian AJ
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Jun 24 00:00:00 EDT 2016
Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells.
Genes & development
Wuidart A,Ousset M,Rulands S,Simons BD,Van Keymeulen A,Blanpain C
12-1401 was used in Flow cytometry/Cell sorting to assess the lineage relationship and SC fate in different organs and tissues.
Wed Jun 01 00:00:00 EDT 2016
Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration.
The Journal of cell biology
Chiapparo G,Lin X,Lescroart F,Chabab S,Paulissen C,Pitisci L,Bondue A,Blanpain C
12-1401 was used in Flow cytometry/Cell sorting to identify the molecular interface controlled by Mesp1 that links CP specification and cell migration.
Mon May 23 00:00:00 EDT 2016
Genetic lineage tracing defines myofibroblast origin and function in the injured heart.
Nature communications
Kanisicak O,Khalil H,Ivey MJ,Karch J,Maliken BD,Correll RN,Brody MJ,J Lin SC,Aronow BJ,Tallquist MD,Molkentin JD
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Jul 22 00:00:00 EDT 2016
mTOR inhibition and BMP signaling act synergistically to reduce muscle fibrosis and improve myofiber regeneration.
JCI insight
Agarwal S,Cholok D,Loder S,Li J,Breuler C,Chung MT,Sung HH,Ranganathan K,Habbouche J,Drake J,Peterson J,Priest C,Li S,Mishina Y,Levi B
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Thu Dec 08 00:00:00 EST 2016
Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Cell reports
Williams CA,Fernandez-Alonso R,Wang J,Toth R,Gray NS,Findlay GM
12-1401 was used in Flow cytometry/Cell sorting to investigate the mechanisms that control naive-primed pluripotent transition of embryonic stem cells.
Tue Aug 16 00:00:00 EDT 2016
Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.
The Journal of biological chemistry
Topalovski M,Hagopian M,Wang M,Brekken RA
Fri Oct 14 00:00:00 EDT 2016
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Nature
Najm FJ,Madhavan M,Zaremba A,Shick E,Karl RT,Factor DC,Miller TE,Nevin ZS,Kantor C,Sargent A,Quick KL,Schlatzer DM,Tang H,Papoian R,Brimacombe KR,Shen M,Boxer MB,Jadhav A,Robinson AP,Podojil JR,Miller SD,Miller RH,Tesar PJ
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Thu Jun 11 00:00:00 EDT 2015
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Cell stem cell
Caputo L,Witzel HR,Kolovos P,Cheedipudi S,Looso M,Mylona A,van IJcken WF,Laugwitz KL,Evans SM,Braun T,Soler E,Grosveld F,Dobreva G
12-1401 was used in Chromatin immunoprecipitation to show how the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
Thu Sep 03 00:00:00 EDT 2015
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Cell stem cell
Caputo L,Witzel HR,Kolovos P,Cheedipudi S,Looso M,Mylona A,van IJcken WF,Laugwitz KL,Evans SM,Braun T,Soler E,Grosveld F,Dobreva G
12-1401 was used in Chromatin immunoprecipitation to show how the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
Thu Sep 03 00:00:00 EDT 2015
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
The Journal of clinical investigation
Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
Mon Dec 14 00:00:00 EST 2015
Multicongenic fate mapping quantification of dynamics of thymus colonization.
The Journal of experimental medicine
Ziętara N,Łyszkiewicz M,Puchałka J,Witzlau K,Reinhardt A,Förster R,Pabst O,Prinz I,Krueger A
12-1401 was used in Flow cytometry/Cell sorting to quantify multicongenic fate maps of dynamic thymus colonisation.
Mon Sep 21 00:00:00 EDT 2015
Brg1 modulates enhancer activation in mesoderm lineage commitment.
Development (Cambridge, England)
Alexander JM,Hota SK,He D,Thomas S,Ho L,Pennacchio LA,Bruneau BG
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Wed Apr 15 00:00:00 EDT 2015
Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer.
Cell cycle (Georgetown, Tex.)
Qin Y,Qin J,Zhou C,Li J,Gao WQ
12-1401 was used in Flow cytometry/Cell sorting to demonstrates that ESCs can be generated from the adipose tissue by somatic cell nuclear transfer (SCNT) and suggests that ADCs can be a new donor-cell type for potential therapeutic cloning.
Tue Jan 26 00:00:00 EST 2016
Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.
Human molecular genetics
Sohn J,Lu A,Tang Y,Wang B,Huard J
12-1401 was used in Flow cytometry/Cell sorting to study the cellular origin and the environmental cues responsible for ectopic calcification, fatty and fibrotic infiltration during Duchenne muscular dystrophy progression.
Wed Jul 01 00:00:00 EDT 2015
Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
Cell transplantation
Nakatsuka R,Matsuoka Y,Uemura Y,Sumide K,Iwaki R,Takahashi M,Fujioka T,Sasaki Y,Sonoda Y
12-1401 was used in Flow cytometry/Cell sorting to demonstrate that prospectively isolated murine PDGFRα and Sca-1 double-positive dental pulp stem cells could support primitive human CD34+ and CD34- hematopoietic stem cells in vitro.
Wed Sep 16 00:00:00 EDT 2015
Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models.
Stem cell reports
Djelloul M,Holmqvist S,Boza-Serrano A,Azevedo C,Yeung MS,Goldwurm S,Frisén J,Deierborg T,Roybon L
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Tue Aug 11 00:00:00 EDT 2015
Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair.
Circulation research
Furtado MB,Costa MW,Pranoto EA,Salimova E,Pinto AR,Lam NT,Park A,Snider P,Chandran A,Harvey RP,Boyd R,Conway SJ,Pearson J,Kaye DM,Rosenthal NA
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Apr 25 00:00:00 EDT 2014
Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.
Proceedings of the National Academy of Sciences of the United States of America
Donati G,Proserpio V,Lichtenberger BM,Natsuga K,Sinclair R,Fujiwara H,Watt FM
12-1401 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which the epidermis can regulate adipogenesis.
Tue Apr 15 00:00:00 EDT 2014
Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors.
Proceedings of the National Academy of Sciences of the United States of America
Donati G,Proserpio V,Lichtenberger BM,Natsuga K,Sinclair R,Fujiwara H,Watt FM
12-1401 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which the epidermis can regulate adipogenesis.
Tue Apr 15 00:00:00 EDT 2014
Recruitment of bone marrow-derived cells to periodontal tissue defects.
Frontiers in cell and developmental biology
Kimura Y,Komaki M,Iwasaki K,Sata M,Izumi Y,Morita I
12-1401 was used in Flow cytometry/Cell sorting to reveal that BMCs are mobilised to periodontal tissue defects, and could be a new target of periodontal treatment.
Mon Nov 03 00:00:00 EST 2014
The roles of testicular c-kit positive cells in de novo morphogenesis of testis.
Scientific reports
Zhang M,Zhou H,Zheng C,Xiao J,Zuo E,Liu W,Xie D,Shi Y,Wu C,Wang H,Li D,Li J
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Mon Aug 04 00:00:00 EDT 2014
Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast.
Nature communications
Cambuli F,Murray A,Dean W,Dudzinska D,Krueger F,Andrews S,Senner CE,Cook SJ,Hemberger M
12-1401 was used in Flow cytometry/Cell sorting to interrogate the progression of reprogramming in ES cell models with regulatable Oct4 and Cdx2 transgenes or conditional Erk1/2 activation.
Wed Nov 26 00:00:00 EST 2014
Dynamic and nuclear expression of PDGFRα and IGF-1R in alveolar Rhabdomyosarcoma.
Molecular cancer research : MCR
Aslam MI,Hettmer S,Abraham J,Latocha D,Soundararajan A,Huang ET,Goros MW,Michalek JE,Wang S,Mansoor A,Druker BJ,Wagers AJ,Tyner JW,Keller C
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
Totipotent embryonic stem cells arise in ground-state culture conditions.
Cell reports
Morgani SM,Canham MA,Nichols J,Sharov AA,Migueles RP,Ko MS,Brickman JM
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Thu Jun 27 00:00:00 EDT 2013
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.
The EMBO journal
Lapouge G,Beck B,Nassar D,Dubois C,Dekoninck S,Blanpain C
12-1401 was used in Flow cytometry/Cell sorting to investigate the frequency of tumour propagating cells at different stages of tumour progression.
Wed Dec 12 00:00:00 EST 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation.
The Journal of cell biology
Bondue A,Tännler S,Chiapparo G,Chabab S,Ramialison M,Paulissen C,Beck B,Harvey R,Blanpain C
12-1401 was used in Flow cytometry/Cell sorting to identify the early MCPs residing at the top of the cellular hierarchy of cardiovascular lineages during ESC differentiation.
Mon Mar 07 00:00:00 EST 2011
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England)
Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ
Tue Nov 01 00:00:00 EDT 2011
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England)
Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ
Tue Nov 01 00:00:00 EDT 2011
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.
Cell stem cell
Kattman SJ,Witty AD,Gagliardi M,Dubois NC,Niapour M,Hotta A,Ellis J,Keller G
12-1401 was used in Flow cytometry/Cell sorting to show that individual mouse and human pluripotent stem cell lines require optimization of Activin/Nodal and BMP signaling for efficient cardiac differentiation.
Fri Feb 04 00:00:00 EST 2011
CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland.
Stem cells (Dayton, Ohio)
LaMarca HL,Visbal AP,Creighton CJ,Liu H,Zhang Y,Behbod F,Rosen JM
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Wed Mar 31 00:00:00 EDT 2010
Bioluminescence imaging of Olig2-neural stem cells reveals improved engraftment in a demyelination mouse model.
Stem cells (Dayton, Ohio)
Sher F,van Dam G,Boddeke E,Copray S
Published figure using CD140a (PDGFRA) monoclonal antibody (Product # 12-1401-81) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2009
Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells.
Stem cells (Dayton, Ohio)
Zhang H,Fraser ST,Papazoglu C,Hoatlin ME,Baron MH
12-1401 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of Mixl1-mediated transcriptional regulation.
Tue Dec 01 00:00:00 EST 2009
Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Mukouyama YS,Deneen B,Lukaszewicz A,Novitch BG,Wichterle H,Jessell TM,Anderson DJ
Tue Jan 31 00:00:00 EST 2006
Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Miyawaki T,Uemura A,Dezawa M,Yu RT,Ide C,Nishikawa S,Honda Y,Tanabe Y,Tanabe T
Wed Sep 15 00:00:00 EDT 2004
